Delving into the Latest Updates on Advenchen Laboratories Nanjing Ltd. with Synapse

Overview

Tags

Neoplasms

Digestive System Disorders

Respiratory Diseases

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	7
Endocrinology and Metabolic Disease	4
Immune System Diseases	2
Hemic and Lymphatic Diseases	2

Top 5 Drug Type	Count

Small molecule drug	7

Top 5 Target	Count

PI3Kα x mTOR	1
PI3Ks x mTOR	1
Aurora B x FGFRs x VEGFR	1
FGFR1 x FGFR2 x VEGFR1 x VEGFR2 x VEGFR3	1
c-Met(Hepatocyte growth factor receptor)	1

主要目的评价AL8326片单药治疗二线及以上系统性方案治疗后复发或进展的小细胞肺癌患者的总生存期（OS）疗效。次要目的评价AL8326片单药在二线及以上系统性方案治疗后复发或进展的小细胞肺癌患者中的无进展生存期（PFS）和其他有效性指标.

[Translation]

Primary objective To evaluate the overall survival (OS) efficacy of AL8326 tablets as a single agent in patients with small cell lung cancer who have relapsed or progressed after second-line or higher systemic treatment. Secondary objective To evaluate the progression-free survival (PFS) and other efficacy indicators of AL8326 tablets as a single agent in patients with small cell lung cancer who have relapsed or progressed after second-line or higher systemic treatment.

Start Date30 Nov 2023

Sponsor / Collaborator

Hangzhou Edcheng Pharmaceutical Technology Co., Ltd.

[+2]

NCT06247605

/ RecruitingPhase 3

Phase III Clinical Study of AL8326 Tablets in Patients With Advanced or Recurrent Small Cell Lung Cancer After at Least Prior Second-line Treatment

This is a multicenter, randomized, double-blind, placebo-controlled, phase III study to evaluate the efficacy and safety of AL8326 tablets in small cell lung cancer (SCLC) patients with disease progression or recurrence after receiving at least second-line treatment regimens.

Start Date26 Oct 2023

Sponsor / Collaborator

Advenchen Laboratories Nanjing Ltd.

CTR20244102

/ RecruitingPhase 4

盐酸安罗替尼胶囊治疗晚期甲状腺髓样癌患者的真实世界研究方案

[Translation] Real-world study protocol of anlotinib hydrochloride capsules in the treatment of patients with advanced medullary thyroid cancer

在真实世界中，对比观察组患者（未接受同类药物治疗），评价盐酸安罗替尼胶囊在晚期甲状腺髓样癌患者中的有效性和安全性。

[Translation]

In the real world, the efficacy and safety of anlotinib hydrochloride capsules in patients with advanced medullary thyroid cancer were evaluated by comparing them with patients in the observation group (who did not receive similar drug treatment).

Start Date13 Jun 2023

Sponsor / Collaborator

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

[+1]

100 Clinical Results associated with Advenchen Laboratories Nanjing Ltd.

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0 Patents (Medical) associated with Advenchen Laboratories Nanjing Ltd.

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100 Deals associated with Advenchen Laboratories Nanjing Ltd.

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100 Translational Medicine associated with Advenchen Laboratories Nanjing Ltd.

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Pipeline

Pipeline Snapshot as of 04 Jun 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

1

Preclinical

Phase 1 Clinical

1

4

Phase 3 Clinical

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Vilzemetkib ( c-Met )	Refractory Differentiated Thyroid Gland Carcinoma More	Phase 3
Anlotinib Dihydrochloride ( FGFRs x PDGFRs x Tyrosine kinase x VEGFR1 x VEGFR2 x VEGFR3 x c-Kit )	Ovarian Cancer More	Phase 3
AL-8326 ( Aurora B x FGFRs x VEGFR )	Small Cell Lung Cancer More	Phase 3
Lucitanib ( FGFR1 x FGFR2 x VEGFR1 x VEGFR2 x VEGFR3 )	Colonic Cancer More	Phase 3
AL58805 ( PI3Ks x mTOR )	Lung Cancer More	Phase 1