Last update 01 Nov 2024

Oxygen compounds

Last update 01 Nov 2024

Basic Info

Synonyms-

Introduction-

Drugs associated with Oxygen compounds

Trans-Sodium Crocetinate

Target

Oxygen compounds

Mechanism

Oxygen compounds modulators

Active Org.-

Originator Org.

University of Virginia Foundation

Active Indication-

Inactive Indication

COVID-19 [+5]

Drug Highest PhaseDiscontinued

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Oxygen compounds

JPRN-UMIN000048733 / Completed

Effects of crocetin on sleep - Sleep test

Start Date01 Sep 2022

Sponsor / Collaborator

CALBEE, Inc.

JPRN-UMIN000046791 / Completed

A randomized, placebo-controlled, double-blind, parallel-group study of the skin-protective effects of crocetin against UV exposure - A randomized, placebo-controlled, double-blind, parallel-group study of the skin-protective effects of crocetin against UV exposure

Start Date09 Feb 2022

Sponsor / Collaborator

Riken Vitamin Co., Ltd.

NCT05079126 / TerminatedPhase 2

Double-Blind, Placebo-Controlled Study of Trans Sodium Crocetinate in Patients With Interstitial Lung Disease

This is a randomized, placebo-controlled study of Trans Sodium Crocetinate (TSC) in patients with Interstitial Lung Disease (ILD), age 30-85 (inclusive). The primary objective of the study is to determine the effect of TSC on lung function as measured by diffusing capacity of the lungs for carbon monoxide (DLCO) in patients with ILD; the secondary objectives are to determine the effect of TSC on the 6-minute walk test (6MWT), heart rate recovery (HRR), and Borg Scale in patients with ILD.

Start Date02 Dec 2021

Sponsor / Collaborator

Diffusion Pharmaceuticals, Inc.

100 Clinical Results associated with Oxygen compounds

100 Translational Medicine associated with Oxygen compounds

0 Patents (Medical) associated with Oxygen compounds

Literatures (Medical) associated with Oxygen compounds

25 Oct 2023·Sheng wu gong cheng xue bao = Chinese journal of biotechnology

[Advances in regulation of hypoxia on adipocyte development and lipid metabolism].

Article

Author: Li, Huixia ; Liu, Yuan

The growth, differentiation and proliferation of adipose cells run through the whole life process. Dysregulation of lipid metabolism in adipose cells affects adipose tissue immunity and systemic energy metabolism. Increasingly available data suggest that lipid metabolism is involved in regulating the occurrence and development of various diseases, such as hyperlipidemia, nonalcoholic fatty liver disease, diabetes and cancer, which pose a major threat to human and animal health. Hypoxia inducible factor (HIF) is a major transcription factor mediating oxygen receptors in tissues and organs. HIF can induce disease by regulating lipid synthesis, fatty acid metabolism and lipid droplet formation. However, due to the difference of hypoxia degree, time and mode of action, there is no conclusive conclusion whether it has harmful or beneficial effects on the development of adipocytes and lipid metabolism. This article summarizes the regulation of hypoxia stress mediated transcription regulators and regulation of adipocyte development and lipid metabolism, aiming to reveal the potential mechanism of hypoxia induced changes in adipocyte metabolism pathways.

01 Oct 2015·Acta HistochemicaQ4 · BIOLOGY

Expression patterns and quantitative assessment of neurochemical markers in the lung of the gray bichir, Polypterus senegalus (Cuvier, 1829)

Q4 · BIOLOGY

Article

Author: Alfa, Maria ; Alesci, Alessio ; Satora, Leszek ; Icardo, Jose Manuel ; Zaccone, Daniele ; Lauriano, Eugenia Rita ; Zaccone, Giacomo ; Kuciel, Michal

Anatomical and functional studies of the autonomic innervation and the putative oxygen receptors-the neuroepithelial (NEC)-like cells of the bichirs are lacking. The present paper describes the distribution of both NEC-like cells and the polymorphous granular cells (PGCs) that populate the mucociliated epithelium of the lung in the air breathing fish Polypterus senegalus. By using confocal immunohistochemistry we determined the coexpression of specific neurochemical markers. Colocalization studies showed that 5HT is coexpressed with calbindin and nNOS in the NEC-like cells and PGCs, and choline acetyltransferase (ChAT) is coexpressed with nNOS in both the two types of cells. Distribution of neurotransmitters (5HT, NO) and neurochemical marker ChAT is also investigated in the lung muscle. The role of these transmitters may be the autonomic control of circulation and respiration. However, the importance of these signals for the respiratory responses in the species studied is still not known. The present study also shows for the first time the simultaneous occurrence of piscidin 1 and 5HT in the PGCs. The function of these cells being equivalent to ones found in fish gill subepithelial parenchyma, is still not known. Due to the importance of piscidin 1 in local immune defense, more research is useful to understand a possible interaction of PGCs with immune response in the bichir lung.

01 Nov 2005·EMBO reportsQ1 · BIOLOGY

Reversion of lethality and growth defects in Fatiga oxygen‐sensor mutant flies by loss of Hypoxia‐Inducible Factor‐α/Sima

Q1 · BIOLOGY

Article

Author: Wappner, Pablo ; Centanin, Lázaro ; Ratcliffe, Peter J

Hypoxia‐Inducible Factor (HIF) prolyl hydroxylase domains (PHDs) have been proposed to act as sensors that have an important role in oxygen homeostasis. In the presence of oxygen, they hydroxylate two specific prolyl residues in HIF‐α polypeptides, thereby promoting their proteasomal degradation. So far, however, the developmental consequences of the inactivation of PHDs in higher metazoans have not been reported. Here, we describe novel loss‐of‐function mutants of fatiga, the gene encoding the Drosophila PHD oxygen sensor, which manifest growth defects and lethality. We also report a null mutation in dHIF‐α/sima, which is unable to adapt to hypoxia but is fully viable in normoxic conditions. Strikingly, loss‐of‐function mutations of sima rescued the developmental defects observed in fatiga mutants and enabled survival to adulthood. These results indicate that the main functions of Fatiga in development, including control of cell size, involve the regulation of dHIF/Sima.

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Oxygen compounds

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