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Last update 08 May 2025

UBASH3B

Last update 08 May 2025

Basic Info

Synonyms

Cbl-interacting protein p70, KIAA1959, STS-1

+ [9]

Introduction

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.

Drugs associated with UBASH3B

Rebamipide

Target

UBASH3B

Mechanism

UBASH3B inhibitors

Active Org.

Otsuka Pharmaceutical Co., Ltd. [+4]

Originator Org.

Otsuka Pharmaceutical Co., Ltd.

Active Indication

Gastritis [+2]

Inactive Indication

Acute gastritis [+11]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

Japan

First Approval Date28 Sep 1990

143

Clinical Trials associated with UBASH3B

CTR20243901

/ CompletedNot Applicable

健康受试者空腹和餐后状态下单次口服瑞巴派特片的随机、开放、两序列、两制剂、两周期、双交叉设计的生物等效性试验

[Translation] A randomized, open-label, two-sequence, two-formulation, two-period, double-crossover bioequivalence study of a single oral dose of rebamipide tablets in healthy subjects in the fasting and fed state

主要研究目的：研究空腹和餐后状态下单次口服受试制剂瑞巴派特片（规格：0.1g，浙江浙北药业有限公司生产）与参比制剂瑞巴派特片（Mucosta®，规格：0.1g，大塚制药株式会社生产）在健康成年受试者体内的药代动力学，评价空腹和餐后状态口服两种制剂的生物等效性。次要研究目的：评价健康受试者在空腹和餐后状态下，单次口服瑞巴派特片受试制剂和参比制剂后的安全性。

[Translation]

Main research purpose: To study the single oral administration of the test preparation Rebamipide Tablets (specification: 0.1g, produced by Zhejiang Zhebei Pharmaceutical Co., Ltd.) and the reference preparation Rebamipide Tablets (Mucosta®, Specification: 0.1g, produced by Otsuka Pharmaceutical Co., Ltd.) in healthy adult subjects to evaluate the bioequivalence of the two oral preparations in fasting and postprandial states. Secondary study purpose: To evaluate the safety of healthy subjects after a single oral administration of the test preparation and reference preparation of rebamipide tablets in fasting and postprandial states.

Start Date04 Dec 2024

Sponsor / Collaborator

Zhejiang Zhebei Pharmaceutical Co. Ltd.

CTR20242604

/ CompletedNot Applicable

瑞巴派特片采用单中心、随机、开放、单剂量、两制剂、两周期、两序列交叉设计，分为空腹给药和餐后给药的人体生物等效性研究。

[Translation] Rebamipide tablets were studied in a single-center, randomized, open-label, single-dose, two-formulation, two-period, two-sequence crossover design, divided into a human bioequivalence study with fasting administration and postprandial administration.

本试验旨在研究单次空腹和餐后口服安徽省先锋制药有限公司研制、生产的瑞巴派特片（100 mg）的药代动力学特征；以大塚製薬株式会社生产的瑞巴派特片（Mucosta®，100 mg）为参比制剂，比较两制剂中药动学参数Cmax、AUC0-t、AUC0-∞，评价两制剂的人体生物等效性。

[Translation]

This trial aims to study the pharmacokinetic characteristics of rebamipide tablets (100 mg) developed and produced by Anhui Pioneer Pharmaceutical Co., Ltd. after a single fasting and postprandial oral administration; The special tablet (Mucosta®, 100 mg) is the reference preparation. The pharmacokinetic parameters Cmax, AUC0-t, and AUC0-∞ of the two preparations are compared to evaluate the human bioequivalence of the two preparations.

Start Date14 Aug 2024

Sponsor / Collaborator

Anhui Pioneer Pharmaceutical Co. Ltd.

CTR20240809

/ CompletedNot Applicable

健康受试者单次口服瑞巴派特片的随机、开放、两周期、两序列、双交叉，空腹和高脂餐后给药条件下的人体生物等效性试验。

[Translation] A randomized, open-label, two-period, two-sequence, double-crossover bioequivalence study of a single oral dose of rebamipide tablets in healthy subjects under fasting and high-fat meal administration conditions.

主要目的：以药代动力学参数为终点指标，比较空腹和高脂餐后给药条件下，安徽金太阳生化药业有限公司生产的瑞巴派特片与OTSUKA PHARMACEUTICAL Co.,Ltd.（大塚制薬株式会社）原研的瑞巴派特片在健康成年人群中吸收程度和速度的差异，对两制剂的生物等效性进行评价。次要目的：评价空腹和高脂餐后给药条件下，安徽金太阳生化药业有限公司生产的瑞巴派特片在健康成年人群中的安全性。

[Translation]

Main purpose: Using pharmacokinetic parameters as endpoints, compare rebamipide tablets produced by Anhui Golden Sun Biochemical Pharmaceutical Co., Ltd. and OTSUKA PHARMACEUTICAL Co., Ltd. under fasting and high-fat postprandial administration conditions. The bioequivalence of the two preparations was evaluated based on the differences in the degree and rate of absorption of rebamipide tablets originally developed by Tsuka Seiki Co., Ltd. in healthy adults. Secondary purpose: To evaluate the safety of rebamipide tablets produced by Anhui Golden Sun Biochemical Pharmaceutical Co., Ltd. in healthy adults under fasting and high-fat meal administration conditions.

Start Date13 Mar 2024

Sponsor / Collaborator

Anhui Golden Sun Biochemical Pharmaceutical Co. Ltd.

100 Clinical Results associated with UBASH3B

100 Translational Medicine associated with UBASH3B

0 Patents (Medical) associated with UBASH3B

131

Literatures (Medical) associated with UBASH3B

01 Mar 2025·Genes to Cells

Vacuolar Sts1 Degradation‐Induced Cytoplasmic Proteasome Translocation Restores Cell Proliferation

Article

Author: Hirayama, Shoshiro ; Yashiroda, Hideki ; Murata, Shigeo ; Ohigashi, Noritaka

ABSTRACTThe proteasome is a large multicatalytic complex conserved across eukaryotes that regulates multiple cellular processes through the degradation of ubiquitinated proteins. The proteasome is predominantly localized to the nucleus in proliferating cells and translocates to the cytoplasm in the stationary phase. Sts1 reportedly plays a vital role in the nuclear import of the proteasome during proliferation in yeast Saccharomyces cerevisiae. However, the mechanisms underlying cytoplasmic translocation of the proteasome in the stationary phase remain unknown. Here, we showed that the ubiquitin ligase Hul5 promotes vacuolar sequestration of Sts1 in a catalytic activity‐dependent manner and thus suppresses the nuclear import of the proteasome during the stationary phase. We further demonstrated that cytoplasmic translocation of the proteasome plays a vital role in the clearance of ubiquitinated protein aggregates, mitochondrial quality control, and resuming proliferation from cellular quiescence. Our results provide insights into the mechanisms and significance of the cytoplasmic localization of proteasomes in cellular quiescence.

01 Dec 2024·Journal of Plant Physiology

Tripartite interactions between grapevine, viruses, and arbuscular mycorrhizal fungi provide insights into modulation of oxidative stress responses

Article

Author: Kujundžić, Daniel ; Čarija, Mate ; Gambino, Giorgio ; Radić, Tomislav ; Balestrini, Raffaella ; Vuković, Rosemary ; Gaši, Emanuel ; Sillo, Fabiano ; Hančević, Katarina

Arbuscular mycorrhizal fungi (AMF) can be beneficial for plants exposed to abiotic and biotic stressors. Although widely present in agroecosystems, AMF influence on crop responses to virus infection is underexplored, particularly in woody plant species such as grapevine. Here, a two-year greenhouse experiment was set up to test the hypothesis that AMF alleviate virus-induced oxidative stress in grapevine. The 'Merlot' cultivar was infected with three grapevine-associated viruses and subsequently colonized with two AMF inocula, containing one or three species, respectively. Five and fifteen months after AMF inoculation, lipid peroxidation - LPO as an indicator of oxidative stress and indicators of antioxidative response (proline, ascorbate - AsA, superoxide dismutase - SOD, ascorbate- APX and guaiacol peroxidases - GPOD, polyphenol oxidase - PPO, glutathione reductase - GR) were analysed. Expression of genes coding for a stilbene synthase (STS1), an enhanced disease susceptibility (EDS1) and a lipoxygenase (LOX) were determined in the second harvesting. AMF induced reduction of AsA and SOD over both years, which, combined with not AMF-triggered APX and GR, suggests decreased activation of the ascorbate-glutathione cycle. In the mature phase of the AM symbiosis establishment GPOD emerged as an important mechanism for scavenging H₂O₂ accumulation. These results, together with reduction in STS1 and increase in EDS1 gene expression, suggest more efficient reactive oxygen species scavenging in plants inoculated with AMF. Composition of AMF inocula was important for proline accumulation. Overall, our study improves the knowledge on ubiquitous grapevine-virus-AMF systems in the field, highlighting that established functional AM symbiosis could reduce virus-induced stress.

01 Apr 2024·Gene

Genome-wide mining of diversity and evolutionary signatures revealed selective hotspots in Indian Sahiwal cattle

Article

Author: Ghosh, A K ; Ghildiyal, Kanika ; Rajawat, Divya ; Sivalingam, Jayakumar ; Panigrahi, Manjit ; Parida, Subhashree ; Singh, Umesh ; Dutt, Triveni ; Sharma, Anurodh ; Kumar, Shive ; Bhushan, Bharat ; Sonejita Nayak, Sonali

The Sahiwal cattle breed is the best indigenous dairy cattle breed, and it plays a pivotal role in the Indian dairy industry. This is due to its exceptional milk-producing potential, adaptability to local tropical conditions, and its resilience to ticks and diseases. The study aimed to identify selective sweeps and estimate intrapopulation genetic diversity parameters in Sahiwal cattle using ddRAD sequencing-based genotyping data from 82 individuals. After applying filtering criteria, 78,193 high-quality SNPs remained for further analysis. The population exhibited an average minor allele frequency of 0.221 ± 0.119. Genetic diversity metrics, including observed (0.597 ± 0.196) and expected heterozygosity (0.433 ± 0.096), nucleotide diversity (0.327 ± 0.114), the proportion of polymorphic SNPs (0.726), and allelic richness (1.323 ± 0.134), indicated ample genomic diversity within the breed. Furthermore, an effective population size of 74 was observed in the most recent generation. The overall mean linkage disequilibrium (r²) for pairwise SNPs was 0.269 ± 0.057. Moreover, a greater proportion of short Runs of Homozygosity (ROH) segments were observed suggesting that there may be low levels of recent inbreeding in this population. The genomic inbreeding coefficients, computed using different inbreeding estimates (F_HOM, F_UNI, F_ROH, and F_GROM), ranged from -0.0289 to 0.0725. Subsequently, we found 146 regions undergoing selective sweeps using five distinct statistical tests: Tajima's D, CLR, |iHS|, |iHH12|, and ROH. These regions, located in non-overlapping 500 kb windows, were mapped and revealed various protein-coding genes associated with enhanced immune systems and disease resistance (IFNL3, IRF8, BLK), as well as production traits (NRXN1, PLCE1, GHR). Notably, we identified interleukin 2 (IL2) on Chr17: 35217075-35223276 as a gene linked to tick resistance and uncovered a cluster of genes (HSPA8, UBASH3B, ADAMTS18, CRTAM) associated with heat stress. These findings indicate the evolutionary impact of natural and artificial selection on the environmental adaptation of the Sahiwal cattle population.

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UBASH3B

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