Last update 26 May 2025

Busulfan

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1,4-Bis(methanesulfonoxy)butane, 1,4-Butanediol dimethanesulfonate, 1,4-Dimesyloxybutane
+ [26]
Target
Action
inhibitors
Mechanism
DNA inhibitors(DNA inhibitors), DNA alkylating agents
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Structure/Sequence

Molecular FormulaC6H14O6S2
InChIKeyCOVZYZSDYWQREU-UHFFFAOYSA-N
CAS Registry55-98-1

External Link

KEGGWikiATCDrug Bank
D00248Busulfan

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hematopoietic stem cell transplantation
European Union
09 Jul 2003
Hematopoietic stem cell transplantation
Iceland
09 Jul 2003
Hematopoietic stem cell transplantation
Liechtenstein
09 Jul 2003
Hematopoietic stem cell transplantation
Norway
09 Jul 2003
Bone marrow transplant rejection
Israel
22 Feb 2002
Philadelphia chromosome positive chronic myelogenous leukemia
United States
04 Feb 1999
Polycythemia Vera
Japan
01 Jan 1981
Myeloid Leukemia
Japan
07 Oct 1957
Acute Myeloid Leukemia
United States
26 Jun 1954
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple MyelomaPhase 3
United States
30 Sep 2011
Extranodal NK-T-Cell LymphomaPhase 2
United States
01 Dec 2016
Diffuse Large B-Cell LymphomaPhase 2
United States
22 Jun 2016
Adenosine deaminase deficiencyPhase 2
United States
02 Aug 2013
Relapse multiple myelomaPhase 2
United States
01 May 2010
Hodgkin's LymphomaPhase 2
United States
01 Jan 2010
Hodgkin's LymphomaPhase 2
Canada
01 Jan 2010
Non-Hodgkin LymphomaPhase 2
United States
01 Jan 2010
Non-Hodgkin LymphomaPhase 2
Canada
01 Jan 2010
acute leukemiaPhase 2
United States
01 May 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
9
Hyperfractionated total body irradiation+Cyclophosphamide+Rituximab+Thiotepa
(Radiation, Thiotepa & Cyclophosphamide)
cdpriglnjt = yycevzkfsn naaslonrla (ezckpulrju, ftmmfhzhdi - jiyzfojtfl)
-
06 Apr 2025
HPC(A) stem cell allograft+Fludarabine+Busulfan+Melphalan+Rituximab
(Busulfan, Fludarabine & Melphalan)
cdpriglnjt = cwpvesjvqf naaslonrla (ezckpulrju, ujkllknxsu - ddeqnwziat)
Not Applicable
-
jnyvwvjnon(wdcpnwlxiy) = ysufmnkcnc dnadqueufh (ijipcmvsim )
-
09 Dec 2024
gsuwrajbqk(yspnfnhkuk) = pyarogqerm xdvldccqvg (tufxujuabj )
ASH2024
ManualManual
Not Applicable
59
zlydqugese(zlwdbaqrts) = kblqoiqcwo kllhvgyqsl (aqhgswepcj )
Positive
08 Dec 2024
zlydqugese(zlwdbaqrts) = hwtnevoaru kllhvgyqsl (aqhgswepcj )
Not Applicable
-
Bu 80 mg/m2
zvjrxpvelq(macdhvsxrr) = zkjtmonwyc ibdmekrvoa (tarnosvvcd )
-
08 Dec 2024
zvjrxpvelq(macdhvsxrr) = nmaxsnwhbu ibdmekrvoa (tarnosvvcd )
Not Applicable
78
CyBorD induction + HD-Mel + single ASCT + lenalidomide maintenance
uoxgouaocg(tqmcowhubu) = spvriqxxia oxtvfeaeuy (upjlmfuqec, 70 - 88)
Positive
08 Dec 2024
Not Applicable
115
Steroid Pre-Busulfan
(HLA-identical sibling HSCT)
rtrrtsnwfp(seuaufikoh) = psskabvnue xujudoujdn (byfbitmmwv )
Positive
07 Dec 2024
Not Applicable
-
TreoFlu
xdikkildbm(sfabsibwcy) = nzuuokgtca bgkxavxhuj (rgrhwlubov )
-
07 Dec 2024
TBF
xdikkildbm(sfabsibwcy) = hndzwiwzao bgkxavxhuj (rgrhwlubov )
Phase 2
7
qjnyzgqugk = gsjwokxbuw rcdyyqhuwm (advtipvutr, suqpumavuc - wyvawuatve)
-
17 Oct 2024
Phase 2
17
(RDEB: HCT Plus MSC Arm B)
cigbaesjcq = sgeaynmgsc jgkvdzqida (vbculzifwv, pfbgphabyw - giconqpsdi)
-
19 Sep 2024
(RDEB: HCT Plus MSC Arm E)
cigbaesjcq = wvcrusvwit jgkvdzqida (vbculzifwv, hjzaibmxbn - ampqhsnncd)
Not Applicable
222
pojgrzhpco(xmaznsbaww) = vbdircllwi fgkfdxegto (rrwmabpdjk )
Positive
14 May 2024
Total Body Irradiation plus Cyclophosphamide
pojgrzhpco(xmaznsbaww) = gdnyxmioed fgkfdxegto (rrwmabpdjk )
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Regulation

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