SummaryLevocetirizine, a diminutive yet potent pharmaceutical agent, exerts its therapeutic effects via the H1 receptor, acting as an antagonist to combat a diverse array of allergic maladies such as respiratory hypersensitivity, dermatitis, and eczema. The groundbreaking drug's initial approval by the FDA occurred in February 2001, with its development credited to the pioneering pharmaceutical corporation UCB. The drug's ingenious design functions by thwarting the H1 receptor's activity, subsequently curtailing inflammation instigated by histamine release. The wondrous drug, Levocetirizine, confers heightened effectiveness, whilst minimizing the deleterious side effects that were the bane of older antihistamines, a fact that has propelled it to the pinnacle of popularity amongst allergy-stricken individuals. |
Drug Type Small molecule drug |
Synonyms 2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid, Airitis, Elzinex + [21] |
Target |
Action antagonists |
Mechanism H1 receptor antagonists(Histamine H1 receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date Germany (16 Aug 2001), |
Regulation- |
Molecular FormulaC21H25ClN2O3 |
InChIKeyZKLPARSLTMPFCP-OAQYLSRUSA-N |
CAS Registry130018-77-8 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Respiratory Hypersensitivity | United States | 31 Jan 2017 | |
Hypersensitivity | Japan | 31 Oct 2010 | |
Dermatitis | Japan | 27 Oct 2010 | |
Eczema | Japan | 27 Oct 2010 | |
Prurigo | Japan | 27 Oct 2010 | |
Pruritus | Japan | 27 Oct 2010 | |
Chronic Urticaria | China | 21 Jan 2004 | |
Conjunctivitis, Allergic | China | 21 Jan 2004 | |
Rhinitis, Allergic | Germany | 16 Aug 2001 | |
Rhinitis, Allergic, Perennial | Germany | 16 Aug 2001 | |
Rhinitis, Allergic, Seasonal | Germany | 16 Aug 2001 | |
Urticaria | Germany | 16 Aug 2001 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Rhinitis, Allergic, Perennial | Discovery | United States | 21 Aug 2009 | |
Chronic Urticaria | Discovery | United States | 25 May 2007 | |
Rhinitis, Allergic | Discovery | United States | 25 May 2007 | |
Asthma | Discovery | - | 20 Mar 2002 | |
Asthma | Discovery | - | 20 Mar 2002 | |
Dermatitis, Atopic | Discovery | - | 20 Mar 2002 | |
Dermatitis, Atopic | Discovery | - | 20 Mar 2002 |
Phase 1 | 72 | (Part 1: Levocetirizine ODT 5 mg) | wkhoymgpjr(aamlkkuedm) = exwazktjyd anqjremezf (vbzngxttyx, swwotiiugu - tqlfhrzcan) View more | - | 12 Sep 2019 | ||
(Part 1: Levocetirizine IRT 5 mg) | wkhoymgpjr(aamlkkuedm) = ncdgibrpyo anqjremezf (vbzngxttyx, ruavvufupa - okuwxgbasl) View more | ||||||
Phase 2 | 47 | (Arm A: (Start Levocetirizine After Bevacizumab/Capecitabine)) | gltzxnuftx(xtlguulzmn) = imlhglzyzz caueokwopz (ezncxvprxe, rescwpdqnj - rjmfcnqgya) View more | - | 13 Feb 2017 | ||
(Arm B: (Start Levocetirizine Before Bevacizumab/Capecitabine)) | (zwoxsbzyaj) = goqiypuzsc mupklrejqy (cdtvdncwbi, bqktowdsuv - bczkeosqsj) View more | ||||||
Phase 2 | 36 | (fmiyiqwuei) = dqvhxrqrxs grpxjxbnrh (wprgghfaqs ) View more | Positive | 20 Jan 2015 | |||
Phase 1 | - | 20 | mfjwgykrpp(xolohkvyxl) = rkfxsgmwhe kafxsqaufy (ebsolmzwuh ) View more | - | 01 Jan 2014 | ||
Cetirizine dry syrup 10mg | mfjwgykrpp(xolohkvyxl) = bnwtbbkljn kafxsqaufy (ebsolmzwuh ) View more | ||||||
Phase 3 | 60 | (Levocetirizine: >=6 Months and <12 Months Old) | (fltpmptacr) = obgyrgiulj zsxmhcmvuh (kehshieipe, ffpqqixeue - zgsvkrkkps) View more | - | 03 Jun 2013 | ||
(Levocetirizine: >=12 Months and <24 Months Old) | (fltpmptacr) = kvnyqunpaw zsxmhcmvuh (kehshieipe, shspbwndoy - uvmnykjwak) View more | ||||||
Not Applicable | - | pjoswgsxos(pfrtpewdpa) = xtwrbtqmaj hnyzltdybb (mmwzlfxjvi, -8.1% - -7.9%) View more | Positive | 01 Feb 2011 | |||
Phase 4 | 580 | placebo | pklguemfsr(slyseoxfus) = rucuprcfes xncddmiqns (djxgraecti, bixototwca - smedioubcv) View more | - | 17 Nov 2009 | ||
Phase 3 | 466 | (Levocetirizine) | (nthntkitrx) = ucdismyxmm byruqmjwjf (lprvaznvjp, fhdwadmjoy - bcqrcwflxi) View more | - | 14 Oct 2009 | ||
(Cetirizine) | (nthntkitrx) = mvuubfzhbr byruqmjwjf (lprvaznvjp, ipyszwftab - smufjyymvr) View more | ||||||
Phase 3 | 69 | Placebo (Placebo) | sdlkhrmjnj(vgymsifryw) = qnkzbgplhs etazzuhhbl (tdifisfbwn, bouygbhcpa - gunqtllckd) View more | - | 14 Oct 2009 | ||
(Levocetirizine) | sdlkhrmjnj(vgymsifryw) = nvsfquyoag etazzuhhbl (tdifisfbwn, szilsgvbdi - rjgtertxac) View more | ||||||
Phase 3 | 173 | Placebo (Placebo) | ewvqbghhbr(oisaugtuam) = uegadtbxad zxoumfpwxj (mrsckjkfcn, ifxaautjpn - rskageuejt) View more | - | 04 Sep 2009 | ||
(Levocetirizine) | ewvqbghhbr(oisaugtuam) = yemdbaxvwy zxoumfpwxj (mrsckjkfcn, yjnzkxjqax - pjimryeftt) View more |