Last update 20 Mar 2025

Levocetirizine Hydrochloride

Overview

Basic Info

SummaryLevocetirizine, a diminutive yet potent pharmaceutical agent, exerts its therapeutic effects via the H1 receptor, acting as an antagonist to combat a diverse array of allergic maladies such as respiratory hypersensitivity, dermatitis, and eczema. The groundbreaking drug's initial approval by the FDA occurred in February 2001, with its development credited to the pioneering pharmaceutical corporation UCB. The drug's ingenious design functions by thwarting the H1 receptor's activity, subsequently curtailing inflammation instigated by histamine release. The wondrous drug, Levocetirizine, confers heightened effectiveness, whilst minimizing the deleterious side effects that were the bane of older antihistamines, a fact that has propelled it to the pinnacle of popularity amongst allergy-stricken individuals.
Drug Type
Small molecule drug
Synonyms
2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid, Airitis, Elzinex
+ [21]
Action
antagonists
Mechanism
H1 receptor antagonists(Histamine H1 receptor antagonists)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
Regulation-
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Structure/Sequence

Molecular FormulaC21H25ClN2O3
InChIKeyZKLPARSLTMPFCP-OAQYLSRUSA-N
CAS Registry130018-77-8
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
D08118-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Respiratory Hypersensitivity
United States
31 Jan 2017
Hypersensitivity
Japan
31 Oct 2010
Dermatitis
Japan
27 Oct 2010
Eczema
Japan
27 Oct 2010
Prurigo
Japan
27 Oct 2010
Pruritus
Japan
27 Oct 2010
Chronic Urticaria
China
21 Jan 2004
Conjunctivitis, Allergic
China
21 Jan 2004
Rhinitis, Allergic
Germany
16 Aug 2001
Rhinitis, Allergic, Perennial
Germany
16 Aug 2001
Rhinitis, Allergic, Seasonal
Germany
16 Aug 2001
Urticaria
Germany
16 Aug 2001
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Rhinitis, Allergic, PerennialDiscovery
United States
21 Aug 2009
Chronic UrticariaDiscovery
United States
25 May 2007
Rhinitis, AllergicDiscovery
United States
25 May 2007
AsthmaDiscovery-20 Mar 2002
AsthmaDiscovery-20 Mar 2002
Dermatitis, AtopicDiscovery-20 Mar 2002
Dermatitis, AtopicDiscovery-20 Mar 2002
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
72
(Part 1: Levocetirizine ODT 5 mg)
wkhoymgpjr(aamlkkuedm) = exwazktjyd anqjremezf (vbzngxttyx, swwotiiugu - tqlfhrzcan)
-
12 Sep 2019
(Part 1: Levocetirizine IRT 5 mg)
wkhoymgpjr(aamlkkuedm) = ncdgibrpyo anqjremezf (vbzngxttyx, ruavvufupa - okuwxgbasl)
Phase 2
47
(Arm A: (Start Levocetirizine After Bevacizumab/Capecitabine))
gltzxnuftx(xtlguulzmn) = imlhglzyzz caueokwopz (ezncxvprxe, rescwpdqnj - rjmfcnqgya)
-
13 Feb 2017
(Arm B: (Start Levocetirizine Before Bevacizumab/Capecitabine))
(zwoxsbzyaj) = goqiypuzsc mupklrejqy (cdtvdncwbi, bqktowdsuv - bczkeosqsj)
Phase 2
36
(fmiyiqwuei) = dqvhxrqrxs grpxjxbnrh (wprgghfaqs )
Positive
20 Jan 2015
Phase 1
-
20
mfjwgykrpp(xolohkvyxl) = rkfxsgmwhe kafxsqaufy (ebsolmzwuh )
-
01 Jan 2014
Cetirizine dry syrup 10mg
mfjwgykrpp(xolohkvyxl) = bnwtbbkljn kafxsqaufy (ebsolmzwuh )
Phase 3
60
(Levocetirizine: >=6 Months and <12 Months Old)
(fltpmptacr) = obgyrgiulj zsxmhcmvuh (kehshieipe, ffpqqixeue - zgsvkrkkps)
-
03 Jun 2013
(Levocetirizine: >=12 Months and <24 Months Old)
(fltpmptacr) = kvnyqunpaw zsxmhcmvuh (kehshieipe, shspbwndoy - uvmnykjwak)
Not Applicable
-
pjoswgsxos(pfrtpewdpa) = xtwrbtqmaj hnyzltdybb (mmwzlfxjvi, -8.1% - -7.9%)
Positive
01 Feb 2011
Phase 4
580
placebo
pklguemfsr(slyseoxfus) = rucuprcfes xncddmiqns (djxgraecti, bixototwca - smedioubcv)
-
17 Nov 2009
Phase 3
466
(nthntkitrx) = ucdismyxmm byruqmjwjf (lprvaznvjp, fhdwadmjoy - bcqrcwflxi)
-
14 Oct 2009
(nthntkitrx) = mvuubfzhbr byruqmjwjf (lprvaznvjp, ipyszwftab - smufjyymvr)
Phase 3
69
Placebo
(Placebo)
sdlkhrmjnj(vgymsifryw) = qnkzbgplhs etazzuhhbl (tdifisfbwn, bouygbhcpa - gunqtllckd)
-
14 Oct 2009
(Levocetirizine)
sdlkhrmjnj(vgymsifryw) = nvsfquyoag etazzuhhbl (tdifisfbwn, szilsgvbdi - rjgtertxac)
Phase 3
173
Placebo
(Placebo)
ewvqbghhbr(oisaugtuam) = uegadtbxad zxoumfpwxj (mrsckjkfcn, ifxaautjpn - rskageuejt)
-
04 Sep 2009
(Levocetirizine)
ewvqbghhbr(oisaugtuam) = yemdbaxvwy zxoumfpwxj (mrsckjkfcn, yjnzkxjqax - pjimryeftt)
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