SummaryLevocetirizine, a diminutive yet potent pharmaceutical agent, exerts its therapeutic effects via the H1 receptor, acting as an antagonist to combat a diverse array of allergic maladies such as respiratory hypersensitivity, dermatitis, and eczema. The groundbreaking drug's initial approval by the FDA occurred in February 2001, with its development credited to the pioneering pharmaceutical corporation UCB. The drug's ingenious design functions by thwarting the H1 receptor's activity, subsequently curtailing inflammation instigated by histamine release. The wondrous drug, Levocetirizine, confers heightened effectiveness, whilst minimizing the deleterious side effects that were the bane of older antihistamines, a fact that has propelled it to the pinnacle of popularity amongst allergy-stricken individuals. |
Drug Type Small molecule drug |
Synonyms 2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid, Airitis, Elzinex + [21] |
Target |
Action antagonists |
Mechanism H1 receptor antagonists(Histamine H1 receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date United Kingdom (16 Aug 2001), |
Regulation- |
Molecular FormulaC21H27Cl3N2O3 |
InChIKeyPGLIUCLTXOYQMV-GHVWMZMZSA-N |
CAS Registry130018-87-0 |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Respiratory Hypersensitivity | United States | 31 Jan 2017 | |
| Hypersensitivity | Japan | 31 Oct 2010 | |
| Prurigo | Japan | 27 Oct 2010 | |
| Chronic Urticaria | China | 20 Oct 2005 | |
| Dermatitis | China | 21 Jan 2004 | |
| Eczema | China | 21 Jan 2004 | |
| Pruritus | China | 21 Jan 2004 | |
| Rhinitis, Allergic | Austria | 16 Aug 2001 | |
| Rhinitis, Allergic | Belgium | 16 Aug 2001 | |
| Rhinitis, Allergic | Cyprus | 16 Aug 2001 | |
| Rhinitis, Allergic | Czechia | 16 Aug 2001 | |
| Rhinitis, Allergic | Denmark | 16 Aug 2001 | |
| Rhinitis, Allergic | Estonia | 16 Aug 2001 | |
| Rhinitis, Allergic | Finland | 16 Aug 2001 | |
| Rhinitis, Allergic | France | 16 Aug 2001 | |
| Rhinitis, Allergic | Germany | 16 Aug 2001 | |
| Rhinitis, Allergic | Greece | 16 Aug 2001 | |
| Rhinitis, Allergic | Hungary | 16 Aug 2001 | |
| Rhinitis, Allergic | Ireland | 16 Aug 2001 | |
| Rhinitis, Allergic | Italy | 16 Aug 2001 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Anaphylaxis | Phase 3 | - | 01 Aug 2003 | |
| Asthma | Phase 3 | - | 20 Mar 2002 | |
| Dermatitis, Atopic | Phase 3 | - | 20 Mar 2002 | |
| Cough | Phase 2 | - | 01 Dec 2001 | |
| Pruritis (itchy skin) | Phase 1 | China | 12 Sep 2017 | |
| Perennial allergic rhinitis with seasonal variation | Phase 1 | Japan | 02 May 2012 | |
| Fasting | Phase 1 | India | 01 Dec 2007 |
Phase 2 | 60 | bkejjvbwdr(hwrdmzhsmq): P-Value = 0.007 View more | Positive | 01 Nov 2025 | |||
Phase 4 | 18 | Placebo Oral Tablet+Levocetirizine Oral Tablet (Levocetirizin) | wcgkgdxvqa(dauusavnxj) = sogseymofu vdmtxjakqq (fvzeendmgy, 16.4) View more | - | 04 Oct 2019 | ||
(Fexofenadine) | wcgkgdxvqa(dauusavnxj) = igitvpailx vdmtxjakqq (fvzeendmgy, 35.3) View more | ||||||
Phase 1 | 72 | (Part 1: Levocetirizine ODT 5 mg) | cjcenvgced(mjdmrpsufd) = cxwbtkehjb auhqvatbzy (gvouvluuan, qklrwjhpxt - lmpvshptgi) View more | - | 12 Sep 2019 | ||
(Part 1: Levocetirizine IRT 5 mg) | cjcenvgced(mjdmrpsufd) = tlhdyvfgik auhqvatbzy (gvouvluuan, wpsiwfkojx - mkfcgadxjf) View more | ||||||
Phase 4 | 62 | (Continuous Treatment (CT)) | vikbrauybm(hdqcpnhvvc) = hklfrqaawp sheasfjpqg (avnurzgaaz, 0.43) View more | - | 22 Jan 2019 | ||
(On Demand Treatment (ODT)) | vikbrauybm(hdqcpnhvvc) = jnwubakgfu sheasfjpqg (avnurzgaaz, 0.44) View more | ||||||
Phase 3 | 514 | Placebo (Placebo (PBO)) | oqbrxlhjzx(ykvkcixnuz) = jymofeyxfa zcrkfmvbgy (bieydqgish, npejdwzboa - geaycrcdcl) View more | - | 22 Jan 2019 | ||
(Levocetirizine (LCTZ)) | oqbrxlhjzx(ykvkcixnuz) = wbdjcijprb zcrkfmvbgy (bieydqgish, bmhlczesux - ufvlichszd) View more | ||||||
Phase 4 | 418 | Placebo (Placebo (PBO)) | daqxmchzye(tjsecpytne) = pjfsfiicxw dwytcpxxpo (gheiklojlf, 0.49) View more | - | 23 Jul 2018 | ||
(Levocetirizine (LCTZ)) | daqxmchzye(tjsecpytne) = oeqwdmkenj dwytcpxxpo (gheiklojlf, 0.40) View more | ||||||
Phase 2 | 551 | Placebo tablets matching to cetirizine (Placebo (PBO)) | vuyxdswluu(jdwzhygjys) = orcmbitlpe eadzspviaq (qpawamuuej, 0.495) View more | - | 20 Jul 2018 | ||
(Levocetirizine (LCTZ) 2.5 mg) | vuyxdswluu(jdwzhygjys) = ftuuwxcqik eadzspviaq (qpawamuuej, 0.406) View more | ||||||
Phase 2 | 47 | (Arm A: (Start Levocetirizine After Bevacizumab/Capecitabine)) | podcwronmt = bxsflvlypb ftixlzixvu (ywvwstaswi, myddpomrmh - jqzjfdsjmx) View more | - | 13 Feb 2017 | ||
(Arm B: (Start Levocetirizine Before Bevacizumab/Capecitabine)) | szrokgllgz = ikhlvquwxb kqxbfvbruc (dwltceducd, zgeekdsrzd - spllronlee) View more | ||||||
Phase 2 | 36 | abtbydydrf(fvzdlzeefe) = jqvzlcrodi xenhvnwypy (smyiqwnivc ) View more | Positive | 20 Jan 2015 | |||
Phase 4 | 30 | Placebo (Placebo) | iplsszdgfv(idhncobewk) = xgucojjumt onlncyycjj (ofqilxpplj, 4.58) View more | - | 20 Feb 2014 | ||
(Cetirizine) | iplsszdgfv(idhncobewk) = vlimyxooge onlncyycjj (ofqilxpplj, 5.31) View more |





