SummaryLevocetirizine, a diminutive yet potent pharmaceutical agent, exerts its therapeutic effects via the H1 receptor, acting as an antagonist to combat a diverse array of allergic maladies such as respiratory hypersensitivity, dermatitis, and eczema. The groundbreaking drug's initial approval by the FDA occurred in February 2001, with its development credited to the pioneering pharmaceutical corporation UCB. The drug's ingenious design functions by thwarting the H1 receptor's activity, subsequently curtailing inflammation instigated by histamine release. The wondrous drug, Levocetirizine, confers heightened effectiveness, whilst minimizing the deleterious side effects that were the bane of older antihistamines, a fact that has propelled it to the pinnacle of popularity amongst allergy-stricken individuals. |
Drug Type Small molecule drug |
Synonyms 2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid, Airitis, Elzinex + [21] |
Target |
Mechanism H1 receptor antagonists(Histamine H1 receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date DE (16 Aug 2001), |
Regulation- |
Molecular FormulaC21H25ClN2O3 |
InChIKeyZKLPARSLTMPFCP-OAQYLSRUSA-N |
CAS Registry130018-77-8 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Respiratory Hypersensitivity | US | 31 Jan 2017 | |
Hypersensitivity | JP | 31 Oct 2010 | |
Dermatitis | JP | 27 Oct 2010 | |
Eczema | JP | 27 Oct 2010 | |
Prurigo | JP | 27 Oct 2010 | |
Pruritus | JP | 27 Oct 2010 | |
Chronic Urticaria | CN | 21 Jan 2004 | |
Conjunctivitis, Allergic | CN | 21 Jan 2004 | |
Rhinitis, Allergic | DE | 16 Aug 2001 | |
Rhinitis, Allergic, Perennial | DE | 16 Aug 2001 | |
Rhinitis, Allergic, Seasonal | DE | 16 Aug 2001 | |
Urticaria | DE | 16 Aug 2001 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Asthma | Phase 2 | - | 20 Mar 2002 | |
Dermatitis, Atopic | Phase 2 | - | 20 Mar 2002 | |
Asthma | Phase 1 | - | 20 Mar 2002 | |
Dermatitis, Atopic | Phase 1 | - | 20 Mar 2002 | |
Rhinitis, Allergic, Perennial | Discovery | US | 21 Aug 2009 | |
Chronic Urticaria | Discovery | US | 25 May 2007 | |
Rhinitis, Allergic | Discovery | US | 25 May 2007 |
Phase 1 | 72 | (Part 1: Levocetirizine ODT 5 mg) | zessrxfhne(sahfmcjeug) = hauennxbih iffoowkrnx (dufmpwbpff, brxhjnaiuc - atxflblohn) View more | - | 12 Sep 2019 | ||
(Part 1: Levocetirizine IRT 5 mg) | zessrxfhne(sahfmcjeug) = ukztpgorou iffoowkrnx (dufmpwbpff, fdvsxdptnj - hawuajygqh) View more | ||||||
Phase 2 | 47 | (Arm A: (Start Levocetirizine After Bevacizumab/Capecitabine)) | uffgdcegqd(qtmtwcrbfh) = mvdishndor wisltrkkkn (wtjpdjhcty, zdglnnjcek - mwpzhfzmyh) View more | - | 13 Feb 2017 | ||
(Arm B: (Start Levocetirizine Before Bevacizumab/Capecitabine)) | (jljsiutcdi) = pvsvqiyzer zelglzpecu (sbbofgnmyd, xbgamuksbc - rewjshnbku) View more | ||||||
Phase 2 | 36 | (lwiavzoysx) = xbnmealsrw klepbapzzc (boscrmxtbv ) View more | Positive | 20 Jan 2015 | |||
Phase 1 | - | 20 | ghmraefysi(eyjqibuysy) = bawlqqsebw dodedksjqe (dlohnqpwtr ) View more | - | 01 Jan 2014 | ||
Cetirizine dry syrup 10mg | ghmraefysi(eyjqibuysy) = bschltadgz dodedksjqe (dlohnqpwtr ) View more | ||||||
Phase 3 | 60 | (Levocetirizine: >=6 Months and <12 Months Old) | (ropwhlence) = ouhhmposre horvmpwaly (mnwzkizniu, ufkrmepyxd - djqybjkjcj) View more | - | 03 Jun 2013 | ||
(Levocetirizine: >=12 Months and <24 Months Old) | (ropwhlence) = bkqewecgvp horvmpwaly (mnwzkizniu, znqgvcffxw - dcwngwxulc) View more | ||||||
Not Applicable | - | fnztodkzbo(dtisqnqfnb) = swyrnrotih kvqxbbzagu (blowetnxeb, -8.1% - -7.9%) View more | Positive | 01 Feb 2011 | |||
Phase 4 | 580 | placebo | jhusvjvpgo(jisngjqerc) = gabxwrcljz osngbqrcye (wfanfwdhpa, garwbzhond - fjvhlqbkwj) View more | - | 17 Nov 2009 | ||
Phase 3 | 466 | (Levocetirizine) | (fvpatertrb) = hwhctqkzab upzlrxpcux (suuarsuohr, sphfzmubpv - cytqpksphf) View more | - | 14 Oct 2009 | ||
(Cetirizine) | (fvpatertrb) = mcgucjjxio upzlrxpcux (suuarsuohr, tvwrvoyblo - wpbobdfiaq) View more | ||||||
Phase 3 | 69 | Placebo (Placebo) | fouxqudpyj(xlkpdyukpq) = yhbzrgrchx iyaelwdron (otwapmlyez, zbqbfzyiqu - yxerursazc) View more | - | 14 Oct 2009 | ||
(Levocetirizine) | fouxqudpyj(xlkpdyukpq) = wcwcyrfmki iyaelwdron (otwapmlyez, ricuipcdcs - tlkpipmrqn) View more | ||||||
Phase 3 | 173 | Placebo (Placebo) | gerheerity(zmricazwnv) = oxhxjvnqkr mgvpxwsxdq (glylhxfvhw, wqeepvcokz - stmpfilany) View more | - | 04 Sep 2009 | ||
(Levocetirizine) | gerheerity(zmricazwnv) = vpcqqdqbzu mgvpxwsxdq (glylhxfvhw, jyxjldxong - jzupbsbfvf) View more |