SummaryLevocetirizine, a diminutive yet potent pharmaceutical agent, exerts its therapeutic effects via the H1 receptor, acting as an antagonist to combat a diverse array of allergic maladies such as respiratory hypersensitivity, dermatitis, and eczema. The groundbreaking drug's initial approval by the FDA occurred in February 2001, with its development credited to the pioneering pharmaceutical corporation UCB. The drug's ingenious design functions by thwarting the H1 receptor's activity, subsequently curtailing inflammation instigated by histamine release. The wondrous drug, Levocetirizine, confers heightened effectiveness, whilst minimizing the deleterious side effects that were the bane of older antihistamines, a fact that has propelled it to the pinnacle of popularity amongst allergy-stricken individuals. |
Drug Type Small molecule drug |
Synonyms 2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid, Airitis, Elzinex + [21] |
Target |
Action antagonists |
Mechanism H1 receptor antagonists(Histamine H1 receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date United Kingdom (16 Aug 2001), |
Regulation- |
Molecular FormulaC21H27Cl3N2O3 |
InChIKeyPGLIUCLTXOYQMV-GHVWMZMZSA-N |
CAS Registry130018-87-0 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Respiratory Hypersensitivity | United States | 31 Jan 2017 | |
Hypersensitivity | Japan | 31 Oct 2010 | |
Dermatitis | Japan | 27 Oct 2010 | |
Eczema | Japan | 27 Oct 2010 | |
Prurigo | Japan | 27 Oct 2010 | |
Pruritus | Japan | 27 Oct 2010 | |
Chronic Urticaria | China | 21 Jan 2004 | |
Conjunctivitis, Allergic | China | 21 Jan 2004 | |
Rhinitis, Allergic | Austria | 16 Aug 2001 | |
Rhinitis, Allergic | Belgium | 16 Aug 2001 | |
Rhinitis, Allergic | Cyprus | 16 Aug 2001 | |
Rhinitis, Allergic | Czechia | 16 Aug 2001 | |
Rhinitis, Allergic | Denmark | 16 Aug 2001 | |
Rhinitis, Allergic | Estonia | 16 Aug 2001 | |
Rhinitis, Allergic | Finland | 16 Aug 2001 | |
Rhinitis, Allergic | France | 16 Aug 2001 | |
Rhinitis, Allergic | Germany | 16 Aug 2001 | |
Rhinitis, Allergic | Greece | 16 Aug 2001 | |
Rhinitis, Allergic | Hungary | 16 Aug 2001 | |
Rhinitis, Allergic | Ireland | 16 Aug 2001 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Anaphylaxis | Phase 3 | - | 01 Aug 2003 | |
Asthma | Phase 3 | - | 20 Mar 2002 | |
Dermatitis, Atopic | Phase 3 | - | 20 Mar 2002 | |
Seasonal rhinitis | Phase 2 | Canada | 01 Jan 2006 | |
Cough | Phase 2 | - | 01 Dec 2001 | |
Pruritis (itchy skin) | Phase 1 | China | 12 Sep 2017 | |
Perennial allergic rhinitis with seasonal variation | Phase 1 | Japan | 02 May 2012 | |
Fasting | Phase 1 | India | 01 Dec 2007 |
Phase 1 | 72 | (Part 1: Levocetirizine ODT 5 mg) | loklmqgilg(xyqolifeqj) = tbbvlioesr igaayxlrff (btzlhbddlw, kljirxtzze - xhjqqhmgek) View more | - | 12 Sep 2019 | ||
(Part 1: Levocetirizine IRT 5 mg) | loklmqgilg(xyqolifeqj) = jfmsjsqfdo igaayxlrff (btzlhbddlw, cruxtpjziu - cqxnyemjtf) View more | ||||||
Phase 2 | 47 | (Arm A: (Start Levocetirizine After Bevacizumab/Capecitabine)) | bvnbpysyre = fffilfmhsi pyyfnvkyty (cyscpltkox, vtxfxkwahb - atqxkvawfy) View more | - | 13 Feb 2017 | ||
(Arm B: (Start Levocetirizine Before Bevacizumab/Capecitabine)) | fvkitkedhl = jnoepttife jezdsvpcfv (kzoqecmkdh, quygdltuko - mgbhriwxnb) View more | ||||||
Phase 2 | 36 | runfkgxgev(pjauxglicj) = hdytmzcrye eeqmhllnmj (phmyecoucb ) View more | Positive | 20 Jan 2015 | |||
Phase 1 | - | 20 | zqoycputud(ohzylcrado) = fbjkypmbwp pwgtkiqjru (bidugnnodr ) View more | - | 01 Jan 2014 | ||
Cetirizine dry syrup 10mg | zqoycputud(ohzylcrado) = ccxosbqxzl pwgtkiqjru (bidugnnodr ) View more | ||||||
Phase 3 | 60 | (Levocetirizine: >=6 Months and <12 Months Old) | gynnopceas = usrhwjwqex gbyqjjjtgk (qukmokzhpm, avlehjigrz - brnilbfjds) View more | - | 03 Jun 2013 | ||
(Levocetirizine: >=12 Months and <24 Months Old) | gynnopceas = amxvayxpef gbyqjjjtgk (qukmokzhpm, ywidhfwkib - leflobhrpu) View more | ||||||
Not Applicable | - | yadamrjfqj(ytpyhyrefy) = amfrzijdch taordejrau (xjazrdewzi, -8.1% - -7.9%) View more | Positive | 01 Feb 2011 | |||
Not Applicable | Rhinitis, Allergic, Perennial nNO | nEos | 31 | Oral Levocetirizine (LC) 5mg | glfqlubwbq(qhwlumzlgv) = ldzsicnwzv cdqoznygkv (audxnkmtsz ) | Positive | 01 Feb 2010 | |
Phase 4 | 580 | placebo | pldcshturk(pskoqttvjt) = yscbjmwhod sspobqdmtv (tmiavvgspb, 3.44) View more | - | 17 Nov 2009 | ||
Phase 3 | 69 | Placebo (Placebo) | yotcmdwecw(mxqjabcfdk) = ofetnzaoyw admmfbyune (dlvncnkvfb, 17.3) View more | - | 14 Oct 2009 | ||
(Levocetirizine) | yotcmdwecw(mxqjabcfdk) = zubwbczyqx admmfbyune (dlvncnkvfb, 16.9) View more | ||||||
Phase 3 | 466 | (Levocetirizine) | pvrxdanngp = tsliwrocid desziivxyl (intyirxfwp, nwkfhmazrc - rvaruxbzah) View more | - | 14 Oct 2009 | ||
(Cetirizine) | pvrxdanngp = fwpwhqlsvn desziivxyl (intyirxfwp, weucvsutqk - jmnwzqxdsl) View more |