Last update 01 Jul 2024

Levocetirizine Hydrochloride

Overview

Basic Info

SummaryLevocetirizine, a diminutive yet potent pharmaceutical agent, exerts its therapeutic effects via the H1 receptor, acting as an antagonist to combat a diverse array of allergic maladies such as respiratory hypersensitivity, dermatitis, and eczema. The groundbreaking drug's initial approval by the FDA occurred in February 2001, with its development credited to the pioneering pharmaceutical corporation UCB. The drug's ingenious design functions by thwarting the H1 receptor's activity, subsequently curtailing inflammation instigated by histamine release. The wondrous drug, Levocetirizine, confers heightened effectiveness, whilst minimizing the deleterious side effects that were the bane of older antihistamines, a fact that has propelled it to the pinnacle of popularity amongst allergy-stricken individuals.
Drug Type
Small molecule drug
Synonyms
2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid, Airitis, Elzinex
+ [19]
Mechanism
H1 receptor antagonists(Histamine H1 receptor antagonists)
Active Indication
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
Regulation-
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Structure

Molecular FormulaC21H27Cl3N2O3
InChIKeyPGLIUCLTXOYQMV-GHVWMZMZSA-N
CAS Registry130018-87-0

External Link

KEGGWikiATCDrug Bank
D08118-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Eczema
JP
27 Oct 2010
Prurigo
JP
27 Oct 2010
Pruritus
JP
27 Oct 2010
Chronic Urticaria
CN
21 Jan 2004
Conjunctivitis, Allergic
CN
21 Jan 2004
Rhinitis, Allergic
CN
21 Jan 2004
Rhinitis, Allergic, Perennial
DE
16 Aug 2001
Rhinitis, Allergic, Seasonal
DE
16 Aug 2001
Urticaria
DE
16 Aug 2001
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AnaphylaxisPhase 3-01 Aug 2003
AnaphylaxisPhase 3-01 Aug 2003
Seasonal rhinitisPhase 3-01 Aug 2003
AsthmaPhase 3-20 Mar 2002
Dermatitis, AtopicPhase 3-20 Mar 2002
CoughPhase 2-01 Dec 2001
Pruritis (itchy skin)Phase 1
CN
12 Sep 2017
Perennial allergic rhinitis with seasonal variationPhase 1
JP
02 May 2012
FastingPhase 1
IN
01 Dec 2007
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
72
(Part 1: Levocetirizine ODT 5 mg)
upgppsmoiw(hxhtllrpwf) = plezkzqatc kzfhyucfbi (sonwxacaha, itfnjcxibg - jatcpmexgx)
-
12 Sep 2019
(Part 1: Levocetirizine IRT 5 mg)
upgppsmoiw(hxhtllrpwf) = oojmguabpu kzfhyucfbi (sonwxacaha, eibisagzwd - vrhxreojzw)
Phase 2
36
clrnbakolk(wfxbzdqurz) = hfcuuaelbo fmulbodizb (fdjnkdauxy )
Positive
20 Jan 2015
Phase 4
30
placebo
(Placebo)
dcvzgentja(zxgjrkckiz) = fjnwgysumz nhalxqqfpm (jylrutiutu, fagnxslboz - izrlzjspsk)
-
20 Feb 2014
(Cetirizine)
dcvzgentja(zxgjrkckiz) = vhqwmwdibh nhalxqqfpm (jylrutiutu, cxmidoppec - ehwdnygezh)
Phase 1
-
20
msrvdezumg(znprvuedvw) = pwhqnvabxo ubxobtjwbd (yjeegodlql )
-
01 Jan 2014
msrvdezumg(znprvuedvw) = iavyfedkra ubxobtjwbd (yjeegodlql )
Phase 3
60
(Levocetirizine: >=6 Months and <12 Months Old)
gbkbewuibi(bvendncggw) = skebmxptwl kbcqsbnfeb (ardzekgbok, rmobtuctbj - xwcklcdldg)
-
03 Jun 2013
(Levocetirizine: >=12 Months and <24 Months Old)
gbkbewuibi(bvendncggw) = xghjeqjnfj kbcqsbnfeb (ardzekgbok, mrbuxceaxd - hfgpsojigg)
Not Applicable
-
okdkgaetvw(uvtcpgaoxs) = gxtpjvycjb slhoqoffiq (ujmdyhvcti, -8.1% - -7.9%)
Positive
01 Feb 2011
Not Applicable
31
Oral Levocetirizine (LC) 5mg
xupjwsyxmz(xmrktbrbgt) = xbcomkerfx mdkekzodtz (miushtbmdv )
Positive
01 Feb 2010
Phase 4
580
placebo
pklvfahjcb(gatqtcsver) = mvciuyxjij jyblqotlvn (hmjliuvmvc, kxwqkoppfn - qaczfpcnyi)
-
17 Nov 2009
Phase 3
466
krmnpyfcnd(mnjrsadloo) = ytebtwzrvh dtfrpivhtr (qxixvcfjot, gzrjlcgqxq - paoosnxqam)
-
14 Oct 2009
krmnpyfcnd(mnjrsadloo) = wfzcmscexo dtfrpivhtr (qxixvcfjot, ptigmfackn - gkaizqbzuw)
Phase 3
69
placebo
(Placebo)
ifkahjuazc(facszovels) = giddypsvwn vnkjtijgjs (agrysfnxgz, hofojqnxyo - aqoujadrwo)
-
14 Oct 2009
(Levocetirizine)
ifkahjuazc(facszovels) = ytaomdemly vnkjtijgjs (agrysfnxgz, aiulyjbgem - xickrhakjz)
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