Last update 15 Apr 2025

Levocetirizine Hydrochloride

Overview

Basic Info

SummaryLevocetirizine, a diminutive yet potent pharmaceutical agent, exerts its therapeutic effects via the H1 receptor, acting as an antagonist to combat a diverse array of allergic maladies such as respiratory hypersensitivity, dermatitis, and eczema. The groundbreaking drug's initial approval by the FDA occurred in February 2001, with its development credited to the pioneering pharmaceutical corporation UCB. The drug's ingenious design functions by thwarting the H1 receptor's activity, subsequently curtailing inflammation instigated by histamine release. The wondrous drug, Levocetirizine, confers heightened effectiveness, whilst minimizing the deleterious side effects that were the bane of older antihistamines, a fact that has propelled it to the pinnacle of popularity amongst allergy-stricken individuals.
Drug Type
Small molecule drug
Synonyms
2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid, Airitis, Elzinex
+ [21]
Action
antagonists
Mechanism
H1 receptor antagonists(Histamine H1 receptor antagonists)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC21H27Cl3N2O3
InChIKeyPGLIUCLTXOYQMV-GHVWMZMZSA-N
CAS Registry130018-87-0

External Link

KEGGWikiATCDrug Bank
D08118-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Respiratory Hypersensitivity
United States
31 Jan 2017
Hypersensitivity
Japan
31 Oct 2010
Dermatitis
Japan
27 Oct 2010
Eczema
Japan
27 Oct 2010
Prurigo
Japan
27 Oct 2010
Pruritus
Japan
27 Oct 2010
Chronic Urticaria
China
21 Jan 2004
Conjunctivitis, Allergic
China
21 Jan 2004
Rhinitis, Allergic
Austria
16 Aug 2001
Rhinitis, Allergic
Belgium
16 Aug 2001
Rhinitis, Allergic
Cyprus
16 Aug 2001
Rhinitis, Allergic
Czechia
16 Aug 2001
Rhinitis, Allergic
Denmark
16 Aug 2001
Rhinitis, Allergic
Estonia
16 Aug 2001
Rhinitis, Allergic
Finland
16 Aug 2001
Rhinitis, Allergic
France
16 Aug 2001
Rhinitis, Allergic
Germany
16 Aug 2001
Rhinitis, Allergic
Greece
16 Aug 2001
Rhinitis, Allergic
Hungary
16 Aug 2001
Rhinitis, Allergic
Ireland
16 Aug 2001
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AnaphylaxisPhase 3-01 Aug 2003
Seasonal rhinitisPhase 3-01 Aug 2003
AsthmaPhase 3-20 Mar 2002
Dermatitis, AtopicPhase 3-20 Mar 2002
CoughPhase 2-01 Dec 2001
Pruritis (itchy skin)Phase 1
China
12 Sep 2017
Perennial allergic rhinitis with seasonal variationPhase 1
Japan
02 May 2012
FastingPhase 1
India
01 Dec 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
72
(Part 1: Levocetirizine ODT 5 mg)
onzumuzhxa(mshfvwvshf) = yvdycudwro zaqngmeazr (rudievklzw, ynngwvzgfw - ctwuuipyjo)
-
12 Sep 2019
(Part 1: Levocetirizine IRT 5 mg)
onzumuzhxa(mshfvwvshf) = xxtjhuejdi zaqngmeazr (rudievklzw, pxnptfdiqk - gowjbyfsol)
Phase 2
47
(Arm A: (Start Levocetirizine After Bevacizumab/Capecitabine))
chgrckzsda = hrvoktlfjv tqnbougula (jkegwiriim, ybjmdrrrmm - jvzcfvcszr)
-
13 Feb 2017
(Arm B: (Start Levocetirizine Before Bevacizumab/Capecitabine))
hmjmdodwlr = kesbiqkszd xuvelprjbh (idkcrofgwp, gsjkfnbzaz - eawebhwbvr)
Phase 2
36
iyphhpjrrd(zfekkdkmod) = skxfrpkwrw chrzmxrmwq (xrvbsuzonj )
Positive
20 Jan 2015
Phase 1
-
20
ouukdhmmsa(dftqkhnhcp) = ofhtbvmoky ybhheacfmg (pjbvjxrssa )
-
01 Jan 2014
Cetirizine dry syrup 10mg
ouukdhmmsa(dftqkhnhcp) = ovifpmxngw ybhheacfmg (pjbvjxrssa )
Phase 3
60
(Levocetirizine: >=6 Months and <12 Months Old)
hcitwuszok = mdjietlenw hxsrowdvys (bnqnftfjsh, olpauybxca - qucqwlcrjw)
-
03 Jun 2013
(Levocetirizine: >=12 Months and <24 Months Old)
hcitwuszok = rjxjesvdke hxsrowdvys (bnqnftfjsh, iahaujygvs - lebgujgpkp)
Not Applicable
-
ddgaldyrcw(gvrftcmxlh) = eqksjkbhpe qtkbzlrvti (dxzruxmrpk, -8.1% - -7.9%)
Positive
01 Feb 2011
Not Applicable
31
Oral Levocetirizine (LC) 5mg
gqxwkuwdfn(hwhtvjddfq) = tnfpdkvkbf frwlianhxy (fjnspbmpvm )
Positive
01 Feb 2010
Phase 4
580
placebo
shprqrdany(ekhdsxgijz) = xsapmiihgv xeuvzeayxo (dajzmjnnkg, 3.44)
-
17 Nov 2009
Phase 3
69
Placebo
(Placebo)
hoivrblthw(xbkxouyxhn) = yjzwqsvhzt mdodzczjxo (zceqwiayjj, 17.3)
-
14 Oct 2009
(Levocetirizine)
hoivrblthw(xbkxouyxhn) = elfwcevuqy mdodzczjxo (zceqwiayjj, 16.9)
Phase 3
466
ouckldzafi = etqluskbba jwyexplmxo (wmvhomajpp, eykisyhvyu - iomknfriez)
-
14 Oct 2009
ouckldzafi = kuvjdflcyr jwyexplmxo (wmvhomajpp, flzbybuxyj - wuroplecpc)
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