Last update 23 Jan 2025

Levocetirizine Hydrochloride

Overview

Basic Info

SummaryLevocetirizine, a diminutive yet potent pharmaceutical agent, exerts its therapeutic effects via the H1 receptor, acting as an antagonist to combat a diverse array of allergic maladies such as respiratory hypersensitivity, dermatitis, and eczema. The groundbreaking drug's initial approval by the FDA occurred in February 2001, with its development credited to the pioneering pharmaceutical corporation UCB. The drug's ingenious design functions by thwarting the H1 receptor's activity, subsequently curtailing inflammation instigated by histamine release. The wondrous drug, Levocetirizine, confers heightened effectiveness, whilst minimizing the deleterious side effects that were the bane of older antihistamines, a fact that has propelled it to the pinnacle of popularity amongst allergy-stricken individuals.
Drug Type
Small molecule drug
Synonyms
2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid, Airitis, Elzinex
+ [21]
Mechanism
H1 receptor antagonists(Histamine H1 receptor antagonists)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
Regulation-
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Structure/Sequence

Molecular FormulaC21H25ClN2O3
InChIKeyZKLPARSLTMPFCP-OAQYLSRUSA-N
CAS Registry130018-77-8
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
D08118-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Respiratory Hypersensitivity
US
31 Jan 2017
Hypersensitivity
JP
31 Oct 2010
Dermatitis
JP
27 Oct 2010
Eczema
JP
27 Oct 2010
Prurigo
JP
27 Oct 2010
Pruritus
JP
27 Oct 2010
Chronic Urticaria
CN
21 Jan 2004
Conjunctivitis, Allergic
CN
21 Jan 2004
Rhinitis, Allergic
DE
16 Aug 2001
Rhinitis, Allergic, Perennial
DE
16 Aug 2001
Rhinitis, Allergic, Seasonal
DE
16 Aug 2001
Urticaria
DE
16 Aug 2001
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AsthmaPhase 2-20 Mar 2002
Dermatitis, AtopicPhase 2-20 Mar 2002
AsthmaPhase 1-20 Mar 2002
Dermatitis, AtopicPhase 1-20 Mar 2002
Rhinitis, Allergic, PerennialDiscovery
US
21 Aug 2009
Chronic UrticariaDiscovery
US
25 May 2007
Rhinitis, AllergicDiscovery
US
25 May 2007
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
72
(Part 1: Levocetirizine ODT 5 mg)
zessrxfhne(sahfmcjeug) = hauennxbih iffoowkrnx (dufmpwbpff, brxhjnaiuc - atxflblohn)
-
12 Sep 2019
(Part 1: Levocetirizine IRT 5 mg)
zessrxfhne(sahfmcjeug) = ukztpgorou iffoowkrnx (dufmpwbpff, fdvsxdptnj - hawuajygqh)
Phase 2
47
(Arm A: (Start Levocetirizine After Bevacizumab/Capecitabine))
uffgdcegqd(qtmtwcrbfh) = mvdishndor wisltrkkkn (wtjpdjhcty, zdglnnjcek - mwpzhfzmyh)
-
13 Feb 2017
(Arm B: (Start Levocetirizine Before Bevacizumab/Capecitabine))
(jljsiutcdi) = pvsvqiyzer zelglzpecu (sbbofgnmyd, xbgamuksbc - rewjshnbku)
Phase 2
36
(lwiavzoysx) = xbnmealsrw klepbapzzc (boscrmxtbv )
Positive
20 Jan 2015
Phase 1
-
20
ghmraefysi(eyjqibuysy) = bawlqqsebw dodedksjqe (dlohnqpwtr )
-
01 Jan 2014
Cetirizine dry syrup 10mg
ghmraefysi(eyjqibuysy) = bschltadgz dodedksjqe (dlohnqpwtr )
Phase 3
60
(Levocetirizine: >=6 Months and <12 Months Old)
(ropwhlence) = ouhhmposre horvmpwaly (mnwzkizniu, ufkrmepyxd - djqybjkjcj)
-
03 Jun 2013
(Levocetirizine: >=12 Months and <24 Months Old)
(ropwhlence) = bkqewecgvp horvmpwaly (mnwzkizniu, znqgvcffxw - dcwngwxulc)
Not Applicable
-
fnztodkzbo(dtisqnqfnb) = swyrnrotih kvqxbbzagu (blowetnxeb, -8.1% - -7.9%)
Positive
01 Feb 2011
Phase 4
580
placebo
jhusvjvpgo(jisngjqerc) = gabxwrcljz osngbqrcye (wfanfwdhpa, garwbzhond - fjvhlqbkwj)
-
17 Nov 2009
Phase 3
466
(fvpatertrb) = hwhctqkzab upzlrxpcux (suuarsuohr, sphfzmubpv - cytqpksphf)
-
14 Oct 2009
(fvpatertrb) = mcgucjjxio upzlrxpcux (suuarsuohr, tvwrvoyblo - wpbobdfiaq)
Phase 3
69
Placebo
(Placebo)
fouxqudpyj(xlkpdyukpq) = yhbzrgrchx iyaelwdron (otwapmlyez, zbqbfzyiqu - yxerursazc)
-
14 Oct 2009
(Levocetirizine)
fouxqudpyj(xlkpdyukpq) = wcwcyrfmki iyaelwdron (otwapmlyez, ricuipcdcs - tlkpipmrqn)
Phase 3
173
Placebo
(Placebo)
gerheerity(zmricazwnv) = oxhxjvnqkr mgvpxwsxdq (glylhxfvhw, wqeepvcokz - stmpfilany)
-
04 Sep 2009
(Levocetirizine)
gerheerity(zmricazwnv) = vpcqqdqbzu mgvpxwsxdq (glylhxfvhw, jyxjldxong - jzupbsbfvf)
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