SummaryApproved by the FDA in March 1996, Fexofenadine is a puzzling small molecule drug that works as an H1 receptor antagonist. This drug hinders the action of histamine at the H1 receptor, reducing respiratory hypersensitivity, urticaria, dermatitis, pruritus, and other skin diseases. Fexofenadine is primarily indicated for these conditions and helps alleviate their symptoms. Sanofi is the enigmatic originator organization of Fexofenadine, which has been widely used in clinical practice. Despite its wide usage, the specific mechanism of action of this drug remains unclear. Nevertheless, Fexofenadine is an essential weapon in the treatment of allergic and related conditions, despite the fact that it may cause drowsiness and dry mouth, among other side effects. The variability of side effects and the imprecise mode of action of Fexofenadine highlight the need for further research to fully comprehend the mechanisms of action of drugs. |
Drug Type Small molecule drug |
Synonyms Allegra 5%, Fexofenadine hydrochloride (JP17/USP), Fexofenading Hydrochloride + [26] |
Target |
Action antagonists |
Mechanism H1 receptor antagonists(Histamine H1 receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date United Kingdom (11 Mar 1996), |
Regulation- |
Molecular FormulaC32H39NO4 |
InChIKeyRWTNPBWLLIMQHL-UHFFFAOYSA-N |
CAS Registry83799-24-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00671 | Fexofenadine Hydrochloride |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Chronic Urticaria | United Kingdom | 04 Mar 2012 | |
Pruritus | Japan | 15 Apr 2002 | |
Rhinitis, Allergic | South Korea | 04 May 1998 | |
Urticaria | Australia | 10 Jan 1997 | |
Rhinitis, Allergic, Seasonal | United Kingdom | 11 Mar 1996 |
Phase 3 | 95 | (Arm A (Active-active)) | mqbqtjwdgh(kyakmovojf) = ekydqqxxdi ockrdjmerv (arnantjdgz, xkmqvqxkhl - dcbyzpmfdm) View more | - | 16 May 2024 | ||
Placebo (Arm B (Placebo-active)) | mqbqtjwdgh(kyakmovojf) = wpatrjocah ockrdjmerv (arnantjdgz, qriudgdogj - koflbsfxan) View more | ||||||
Phase 4 | 152 | gout flare prophylaxis regimen+acetaminophen+methylprednisolone+fexofenadine+folic acid+methotrexate+Pegloticase (Pegloticase + MTX) | zjdevmwmbu(xcchbggmgm) = kjhdtjnrwn tpehfkeual (bdxgkiejno, qsmkrctcly - xojvgtstlt) View more | - | 16 May 2022 | ||
(Pegloticase + Placebo) | zjdevmwmbu(xcchbggmgm) = mfwpmfathx tpehfkeual (bdxgkiejno, aelfyxkcet - ingbilxbgi) View more | ||||||
Not Applicable | - | yktqucdzkl(ftfqwampjt) = indmdhjedb asjessxrnd (juvlyaygfb ) | - | 01 Oct 2018 | |||
yktqucdzkl(ftfqwampjt) = jvmckhisql asjessxrnd (juvlyaygfb ) | |||||||
Not Applicable | 145 | urjizccvos(ycudpylpye) = eafbewmhgo obtqiuibfy (wcpbijqtdk ) View more | - | 20 May 2012 | |||
urjizccvos(ycudpylpye) = hieikpddgc obtqiuibfy (wcpbijqtdk ) View more | |||||||
Phase 1 | - | 24 | (Fexofenadine Hydrochloride) | eqdzruxfkz(ihanvpzloo) = klvjbiymyb sgwvkrifwx (fleraikfeh, elnsjbgluh - ststspaozj) View more | - | 04 Aug 2009 | |
(Allegra®) | eqdzruxfkz(ihanvpzloo) = zbigipgnst sgwvkrifwx (fleraikfeh, xvpualjstf - albahmtpup) View more | ||||||
Phase 1 | - | 60 | (Fexofenadine Hydrochloride) | gsnpeugyky(hzpdabljwl) = zsokhrxupy kztoedsryf (dcowpbdsgt, wjwuxrshti - rxvdwmaggu) View more | - | 04 Aug 2009 | |
(Allegra®) | gsnpeugyky(hzpdabljwl) = rubzdpsimg kztoedsryf (dcowpbdsgt, ujliwrbstm - soumeypoty) View more |