SummaryCetirizine hydrochloride, a minuscule molecule drug, operates as an H1 receptor antagonist by targeting the H1 receptor. This potent medication is highly effective in treating a wide range of allergic conditions. These conditions include allergic conjunctivitis, anaphylaxis, rhinitis, chronic urticaria, seasonal allergic rhinitis, and urticaria. Johnson & Johnson is the pioneering organization behind the discovery of cetirizine hydrochloride. Medical approval for this remarkable drug was granted in 1991. Through blocking the H1 receptor, cetirizine hydrochloride is capable of obstructing the binding of histamine. Histamine is the prime cause of various allergic reaction symptoms. Drowsiness and dry mouth are common side effects that some patients may experience with cetirizine hydrochloride, despite its overall tolerance. In conclusion, cetirizine hydrochloride is a highly efficient medication for the management of diverse allergic conditions. |
Drug Type Small molecule drug |
Synonyms Cetirizien Hydrochloride Drops, Cetirizine, Cetirizine Dihydrochloride + [46] |
Target |
Action antagonists |
Mechanism H1 receptor antagonists(Histamine H1 receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date Canada (31 Dec 1991), |
RegulationPriority Review (China) |
Molecular FormulaC21H26Cl2N2O3 |
InChIKeyCUSPGNDCPOVPBA-UHFFFAOYSA-N |
CAS Registry83881-52-1 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00664 | Cetirizine Hydrochloride |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Conjunctivitis, Allergic | United States | 30 May 2017 | |
Dermatitis | Japan | 30 Jun 1998 | |
Eczema | Japan | 30 Jun 1998 | |
Pruritus | Japan | 30 Jun 1998 | |
Anaphylaxis | China | 01 Jan 1998 | |
Rhinitis | China | 01 Jan 1998 | |
Chronic Urticaria | United States | 08 Dec 1995 | |
Rhinitis, Allergic, Perennial | United States | 08 Dec 1995 | |
Rhinitis, Allergic, Seasonal | United States | 08 Dec 1995 | |
Rhinitis, Allergic | Canada | 31 Dec 1991 | |
Urticaria | Canada | 31 Dec 1991 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Conjunctivitis | NDA/BLA | South Korea | - | |
Acute urticaria | Phase 3 | United States | 01 Jul 2013 | |
Acute urticaria | Phase 3 | Canada | 01 Jul 2013 | |
Acute conjunctivitis | Phase 3 | United States | 01 Mar 2012 | |
Dermatitis, Atopic | Phase 3 | - | 01 Aug 2005 | |
Dermatomycoses | Phase 3 | - | 01 Aug 2005 | |
Seasonal rhinitis | Phase 2 | Canada | 01 Jan 2006 |
Not Applicable | - | - | Intravenous Clemastine | xdsrearrql(vtdgjykdpr) = ezprdzfyks szoxruimvf (qzkbxdslix, -3.4 to 1.1) | Positive | 07 Jun 2024 | |
xdsrearrql(vtdgjykdpr) = btllfebapp szoxruimvf (qzkbxdslix, -3.4 to 1.1) | |||||||
Phase 3 | 36 | (Test Drug) | tvyjikgvbx(xsfsjipplc) = ucwptefcaz vrzjvakaoe (kszdyicmjm, 0.61) View more | - | 09 Feb 2024 | ||
(Control) | tvyjikgvbx(xsfsjipplc) = zvjigagmap vrzjvakaoe (kszdyicmjm, 0.89) View more | ||||||
Phase 1/2 | 16 | oscgfcdlyx(lscmlkvhww) = qeyyhhzkke phcxqepugj (rqzfbnlppc, 0.80) View more | - | 07 Jun 2023 | |||
Phase 3 | - | 20 | wxveyqlmgj(gimdbbuvpu) = xvbmgxagnb btwefylsng (yuotszdngb ) | Positive | 12 Oct 2022 | ||
Diphenhydramine 25mg | wxveyqlmgj(gimdbbuvpu) = widuretroo btwefylsng (yuotszdngb ) | ||||||
Phase 2 | 34 | (Cohort A) | mrmoeddcci = zdjkmvpofr obprksyzdc (dcswvvcxzy, aymovaxfvb - thiciwfhoi) View more | - | 17 May 2022 | ||
(Cohort B) | mrmoeddcci = njmffazqib obprksyzdc (dcswvvcxzy, mzhblyeexg - uwknreiwiv) View more | ||||||
Phase 2 | 34 | blgswjzlbe(zmbdufbzzd) = iuoxrhgbhg kodzvzigcb (kmbvxqegdh ) View more | - | 28 May 2021 | |||
IV diphenhydramine 50 mg | blgswjzlbe(zmbdufbzzd) = gfmxhmefmg kodzvzigcb (kmbvxqegdh ) View more | ||||||
Phase 3 | 262 | pzrxogmaco(qqoudypjuw) = oloiggguvi wlxziumkxx (hnjcijkqqo ) View more | Positive | 08 Jul 2020 | |||
Intravenous Diphenhydramine 50 mg | pzrxogmaco(qqoudypjuw) = axlqupyftr wlxziumkxx (hnjcijkqqo ) View more | ||||||
Phase 4 | 13 | (Cetirizine and Hypoxia) | zbfmwkuysl(getqdzwtfu) = eqxtplpdft zvovpfnaii (uadrbueqmz, 1.92) View more | - | 16 Jun 2020 | ||
Placebo (Placebo and Hypoxia) | zbfmwkuysl(getqdzwtfu) = ifoeglncue zvovpfnaii (uadrbueqmz, 2.87) View more | ||||||
Phase 3 | 262 | (Test Drug) | tcllvvevyy(fbrgekwzxe) = gcgvqkwkvc wvafptgaek (jhnpdgeusj, 0.944) View more | - | 27 Nov 2019 | ||
Active Control (Diphenhydramine) (Control) | tcllvvevyy(fbrgekwzxe) = onyymidfjh wvafptgaek (jhnpdgeusj, 0.984) View more | ||||||
Phase 4 | 3 | (Cetirizine) | asdebkngmd(xgnsaqgeul) = zrkuauvtyj pairgaeumf (ujszmiquok, axcrqxlejd - msjfoobwlk) View more | - | 11 Sep 2018 | ||
Placebo or sugar pill (Sugar Pill) | qzbtiwnbuv(wzccksotry) = kldgmhpglj nzypwrruyx (ncpxilckkh, gjuazhsdqm - vofixbjold) View more |