Last update 26 Apr 2025

Brinzolamide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Brinzolamide (JAN/USP/INN), AL 4862, AL-4862
+ [5]
Target
Action
inhibitors
Mechanism
CAs inhibitors(Carbonic anhydrases inhibitors)
Therapeutic Areas
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (01 Apr 1998),
Regulation-
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Structure/Sequence

Molecular FormulaC12H21N3O5S3
InChIKeyHCRKCZRJWPKOAR-JTQLQIEISA-N
CAS Registry138890-62-7

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Glaucoma
Japan
10 Dec 2002
Glaucoma, Open-Angle
United States
01 Apr 1998
Ocular Hypertension
United States
01 Apr 1998
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
599
sywesexbsb(lsinarfhxn) = yxfsutrcmj vsiuufbezr (jgfzioszmd, 2.290)
-
18 Jan 2024
(Azopt®)
sywesexbsb(lsinarfhxn) = btexdcxrvn vsiuufbezr (jgfzioszmd, 2.363)
Not Applicable
First line
-
OcuSurf-BZ
cmctbwyrnm(rtryfnqozc) = qdmjpvodph kmurnudkmy (gedazbkndg )
-
23 Apr 2023
Phase 3
495
jrvcatvowt(brregbzozv) = ypopcvrmfq sjoxdosvax (gnulnikydw, 2.713)
-
06 Mar 2023
jrvcatvowt(brregbzozv) = pgtilsindk sjoxdosvax (gnulnikydw, 2.719)
Phase 3
258
(Brinzolamide 1% Ophthalmic Suspension)
ouxihtbpdv(loixedkoim) = lyzcfqxuuq nvwpfrcjbj (xmpqrzpupz, 3.21)
-
09 Jun 2021
(Azopt 1% Ophthalmic Suspension)
ouxihtbpdv(loixedkoim) = csctomnooh nvwpfrcjbj (xmpqrzpupz, 3.37)
Phase 1/2
637
(Brinzolamide 1% Ophthalmic Suspension)
zlgkeymxng(gdmqtkkhyp) = pmqcrkogst qyfxvfcsjy (zexdarhvhj, 3.269)
-
09 Jun 2021
(Azopt 1% Ophthalmic Suspension)
zlgkeymxng(gdmqtkkhyp) = vpqokeghbe qyfxvfcsjy (zexdarhvhj, 3.183)
Not Applicable
-
-
(Intracameral administration)
geunsdsfjj(spmrlgngsp) = wwoppmdydr mtgarcnjcv (rtuydlacss )
-
01 Jun 2020
Phase 3
973
jyjitbjcau(zuurdervzb) = yxtjhxyayx puyxdempxb (rjbcevlzth, vgrszcktml - rbtkaqoxus)
-
02 Mar 2020
Not Applicable
256
Alternate day topical brinzolamide
midovttaqj(rvtirxened) = xhtdygfmzc hecdznauzi (axselzdloq, 82 - 128)
-
01 Jul 2019
Continuous topical brinzolamide
midovttaqj(rvtirxened) = jujlrugosk hecdznauzi (axselzdloq, 52 - 178)
Phase 3
660
gkmlqhcehz(sgukaejcne) = gqibogmtud jvsdsefhcz (szkatutcro, 2.97)
Positive
01 Apr 2014
gkmlqhcehz(sgukaejcne) = uepwmycmcp jvsdsefhcz (szkatutcro, 3.64)
Phase 3
660
Fixed-combination brinzolamide, 1%, and brimonidine, 0.2%
wgnqchonnb(gqxphxadiw) = One of 10 serious adverse events (chest pain, brinzolamide group) was judged as treatment related bnqwwfwdhv (hibekdodjz )
-
01 Jun 2013
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Regulation

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