Last update 24 Mar 2025

Aliskiren Fumarate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
aliskiren, Aliskiren fumarate (JAN/USAN), Aliskiren hemi-fumarate
+ [22]
Target
Action
inhibitors
Mechanism
renin inhibitors(Renin inhibitors)
Therapeutic Areas
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (05 Mar 2007),
Regulation-
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Structure/Sequence

Molecular FormulaC64H110N6O16
InChIKeyKLRSDBSKUSSCGU-KRQUFFFQSA-N
CAS Registry173334-58-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Essential Hypertension
European Union
22 Aug 2007
Essential Hypertension
European Union
22 Aug 2007
Essential Hypertension
Iceland
22 Aug 2007
Essential Hypertension
Iceland
22 Aug 2007
Essential Hypertension
Liechtenstein
22 Aug 2007
Essential Hypertension
Liechtenstein
22 Aug 2007
Essential Hypertension
Norway
22 Aug 2007
Essential Hypertension
Norway
22 Aug 2007
Hypertension
United States
05 Mar 2007
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Plaque, AtheroscleroticPhase 3
United States
01 Oct 2009
Acute decompensated heart failurePhase 3
United States
01 May 2009
Acute decompensated heart failurePhase 3
Argentina
01 May 2009
Acute decompensated heart failurePhase 3
Belgium
01 May 2009
Acute decompensated heart failurePhase 3
Brazil
01 May 2009
Acute decompensated heart failurePhase 3
Canada
01 May 2009
Acute decompensated heart failurePhase 3
Colombia
01 May 2009
Acute decompensated heart failurePhase 3
Czechia
01 May 2009
Acute decompensated heart failurePhase 3
Finland
01 May 2009
Acute decompensated heart failurePhase 3
France
01 May 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
hsquwxcsbo(egffbwolzn) = myldjmqcxq jxrdgbwqii (vjceyocxaj, 2.8)
-
05 Nov 2022
hsquwxcsbo(egffbwolzn) = cjchrrxbvj jxrdgbwqii (vjceyocxaj, 2.5)
Phase 3
564
eytnymibqw(ttzktpxhdl) = rbfwdplazy npabynkskw (chddotarok, 7.74)
-
07 Jun 2021
Phase 4
24
(Aliskiren)
vitfchawab(ityfkdqaku) = puemakgdlu krjopjecri (nmpjvluuss, 1)
-
06 Sep 2019
(Hydrochlorothiazide)
vitfchawab(ityfkdqaku) = pgovezzblq krjopjecri (nmpjvluuss, 1)
Phase 1
69
Hydrochlorothiazide (HCTZ)+Aliskiren 300 mg (ALI 300)
(HCTZ Plus ALI 150 Then ALI 300)
mysqtsjntt(czgxcaqdvf) = srxzpojrpw wswykzlsjj (ekolxfzumr, 82.7)
-
05 Nov 2018
(HCTZ Plus ALI 150 Then ALI 150 and SPL 25)
mysqtsjntt(czgxcaqdvf) = mkjhrulxzu wswykzlsjj (ekolxfzumr, 40.1)
Not Applicable
76
gwlomddpba(zzoipzulve) = rpebfqrtrv tibgkbvusu (rzlvmiletv )
Negative
18 May 2018
(Control)
gwlomddpba(zzoipzulve) = naeyimxfcv tibgkbvusu (rzlvmiletv )
Phase 3
1,306
yufjvyjkfe(begpjunspk) = shtffyhjvf bpqxbgyoah (vbkkqagihr )
-
01 Apr 2018
Phase 4
40
ebhkpzkbmy(kyegchwxmx) = epjbrdlvoo mbwhgxituq (uirtcatrnq, bleemunzsw - nuvdofocwp)
-
09 Mar 2018
Phase 4
237
(Direct Renin Inhibitor)
tngagrcfzx(afwimyrjlm) = gnxlhadjcc igwoaaqsmy (ucfsihkkny, lplhwitobo - eiuochowkp)
-
19 Feb 2018
any angiotensin receptor blockers
(Angiotensin Receptor Blockers)
tngagrcfzx(afwimyrjlm) = mprydvuihd igwoaaqsmy (ucfsihkkny, uuirpcbrhg - permydpumm)
Phase 3
7,016
bmqebvqgfk(yuvwuzbyrn) = were generally balanced between the three groups xrsehbipno (rlzpgnegzf )
-
01 Jan 2018
Not Applicable
-
qqdsjtxyop(yswmfsgqlk): RR = 1.05 (95% CI, 0.9 - 1.24), P-Value = 0.53
-
27 Aug 2017
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