Long - Term Effect of Quinapril or Losartan or Their Combination on Diabetic Autonomic Neuropathy and Left Ventricular Function Over a Period of 4 Years. A Radionuclide Ventriculography Study.

Purpose: To investigate the effect of Quinapril (Q) or Losartan (L) or their combination on definite Diabetic Autonomic Neuropathy (DAN) and left ventricular systolic and diastolic function (LVF) over a period of 4 years.
Patients-methods: Fifty-nine patients with definite DAN [2 or more of the 4 Cardiovascular Reflex Tests (CRTs) were abnormal] were studied for 4 years. Patients were randomly allocated in 3 groups receiving A, 20 mg Q, B, 100 mg L and C, 20 mg Q +100 mg L respectively. CRTs analyzed with Mean Circular Resultant (MCR), Valsalva index, 30:15 ratio and postural hypotension. LV function was investigated with radionuclide ventriculography (RNV) at rest. Ejection fraction was used to assess LV systolic function, while peak filling rate, first third filling fraction, and atrial contribution to ventricular filling were used to investigate LV diastolic function. CRTs and RNV were performed at baseline and after 4 years.

Start Date01 Jan 2017

Sponsor / Collaborator

University Hospital AHEPA

NCT01669434

/ CompletedPhase 4IIT

Chronic Angiotensin Converting Enzyme Inhibitors in Intermediate Risk Surgery: A Randomized, Single-Blinded Study

Primary research hypothesis: Patients who continue their chronic ACEI therapy up to and including the morning of a non-cardiac, non-vascular surgery will experience more intraoperative hypotension than those who transiently hold their chronic ACEI preoperatively.
Secondary research hypothesis #1: Patients who continue their chronic ACEI up to and including the morning of a non-cardiac, non-vascular surgery will experience better postoperative control of hypertension than those who transiently hold their chronic ACEI preoperatively.
Secondary research hypothesis #2: Patients who continue their chronic ACEI up to and including the morning of a non-cardiac, non-vascular surgery will experience less acute renal failure than those who transiently hold their chronic ACEI preoperatively.
Secondary research hypothesis #3: In the subgroup of patients with a preoperative systolic blood pressure less than 110 mmHg, those who continue their chronic ACEI therapy up to and including the morning of a non-cardiac, non-vascular surgery will experience more intraoperative hypotension than those who transiently hold their chronic ACEI preoperatively.
Secondary research hypothesis #4: In the subgroup of patients above the age of 64, those who continue their chronic ACEI therapy up to and including the morning of a non-cardiac, non-vascular surgery will experience more intraoperative hypotension than those who transiently hold their chronic ACEI preoperatively.

Start Date01 Jun 2015

Sponsor / Collaborator

University of Nebraska

CTR20132627

/ Active, not recruitingNot Applicable

盐酸喹那普利片在健康男性受试者中的单次剂量、随机、开放生物等效性研究

[Translation] A single-dose, randomized, open-label bioequivalence study of quinapril hydrochloride tablets in healthy male subjects

研究健康男性受试者单次口服由武汉启瑞药业有限公司研制的盐酸喹那普利片和哈药集团制药总厂生产的盐酸喹那普利片（益恒）的相对生物利用度，评价两制剂间的生物等效性。

[Translation]

To study the relative bioavailability of a single oral dose of quinapril hydrochloride tablets developed by Wuhan Qirui Pharmaceutical Co., Ltd. and quinapril hydrochloride tablets (Yiheng) produced by Harbin Pharmaceutical Group Pharmaceutical Factory in healthy male subjects and to evaluate the bioequivalence of the two preparations.

Start Date14 Jul 2014

Sponsor / Collaborator

Wuhan Qirui Pharmaceutical Co., Ltd.

100 Clinical Results associated with Quinapril Hydrochloride

100 Translational Medicine associated with Quinapril Hydrochloride

100 Patents (Medical) associated with Quinapril Hydrochloride

1,384

Literatures (Medical) associated with Quinapril Hydrochloride

31 Dec 2024·Animal Cells and Systems

Tortoise-shell glue ameliorates male infertility through the hypothalamic-pituitary-gonadal axis in obese rats

Author: Sun, Tiansong ; He, Qinghu ; Li, Yingqiu ; Sheng, Wen ; Li, Bonan ; Zhu, Congxu ; Liu, Lumei

BackgroundMale infertility is a worldwide population health concern, but its etiol. remains poorly understood.Tortoise-shell glue (TSG) is widely utilized as a pharmaceutical or dietary supplement for various health ailments.This study aimed to evaluate the effects of TSG on male infertility in obese rats.MethodsA male infertility with obesity rat model was established after a high-fat diet (HFD) and cyclophosphamide (CTX) treatment.The body weight, testis weight, and weight of adipose tissues around the epididymis were detected.We then evaluated spermatozoon motility and concentration and testis pathol. changes.Next, we assessed the hypothalamic-pituitary-gonadal (HPG) axis.Moreover, serum metabolomics was used to identify differential metabolites.The Spearman correlation anal. was employed to assess the correlation between differential metabolites and sex hormone levels.ResultsHere, we demonstrated that TSG alleviated obesity and male infertility.Meanwhile, TSG restored the function of the HPG axis in obese infertility rats, including mRNA levels of GnRH, GnRHR, RFRP-3, and kisspeptin in the hypothalamus and pituitary and sex hormone levels in the serum.In addition, 16 potentially significant metabolites, such as Quinapril and Malabaricone C, were identified as significant in the therapeutic effects of TSG on male infertility.The majority of these differential metabolites exhibited recovery following TSG treatment.The further Spearman anal. demonstrated the close correlation between differential metabolites and sex hormones, especially Kamahine C.ConclusionTSG attenuated obesity and male infertility in rats through the HPG axis by regulating serum metabolites.It shows potential as a viable treatment option for male infertility.

01 Dec 2024·Microchemical Journal

A generic novel HPLC method for the determination of nitrite ion by direct derivatization

Author: Murugan, Manivannan ; Ilayaraja, Palaniappan ; Parthiban, Paramasivam

This research introduces a novel, simplified method to quantify carcinogenicity generating nitrite in Key Starting Materials (KSMs) and specific drugs.Since no straightforward approach exists in the literature, this method aimed to fill the lacunae and fulfill safety assessments in pharmaceutical applications.The developed method employs a direct and simple derivatization procedure using High-Performance Liquid Chromatog. (HPLC).The conditions include Zorbax SB C8 column (stationary phase), trifluoroacetic acid (TFA): water: acetonitrile at 0.05:55:45 % volume/volume as mobile phase A, and TFA: acetonitrile at 0.05:100 % volume/volume as mobile phase B in a gradient elution at 0.8 mL/min flow rate.The gradient program is time/%A, 0/100, 10/100, 15/0, 19/0, 20/100, 25/100.A simple method was established to regulate the nitrite ion levels in KSMs and certain medications.By making a fine-tuning to chromatog. conditions, this method can quantify nitrite content in any pharmaceutical materials, thus, demonstrating its generic applicability.The developed method was validated according to the International Council for Harmonization of Tech. Requirements for Pharmaceuticals for Human Use (ICH) guidelines.It is linear and accurate from the limit of quantitation (LOQ) to 150 % (i.e., 0.5 to 1.5 ppm) of the specified limit (1.0 ppm).The LOQ and limit of detection (LOD) for this method are 0.5 and 0.1 ppm, resp.

01 Dec 2024·Bioorganic Chemistry

Sodium cromoglycate exerts anti-pulmonary fibrosis effects by targeting the Keap1 protein to activate Nrf2 signaling

Article

Author: Huang, Yuwei ; Yuan, Lei ; Li, Yanchun ; Ma, Chao ; Wang, Chuncheng ; Liu, Xiaofeng ; Ma, Enlong ; Zhao, Xianchen ; Guan, Yingjun

Oxidative stress has been confirmed to be closely related to the occurrence and development of pulmonary fibrosis (PF). The Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid-2 related factor 2 (Nrf2) pathway plays a key role in maintaining cellular redox homeostasis. Targeting the Keap1 protein to activate Nrf2 could be a promising strategy for treating PF. Virtual screening via a pharmacophore model was used to screen candidate compounds with potential Keap1 binding ability from the U.S. Food and Drug Administration (FDA) database. The results revealed that sodium cromoglycate (Cro) has the highest fit value and absolute docking score and could improve the thermal stability of the Keap1 protein in a CETSA, confirming that Cro could bind to the Keap1 protein directly. Further studies revealed that Cro promoted Nrf2 translocation into the nucleus, relieved oxidative stress, prevented the epithelial-mesenchymal transition (EMT) process and upregulated fibrosis markers in TGF-β1-induced A549 cells, indicating that Cro has anti-pulmonary fibrosis activity in an in vitro lung fibrosis model. Moreover, in a mouse model of bleomycin (BLM)-induced pulmonary fibrosis, Cro administration improved pulmonary fibrosis, activated Nrf2 signaling, and blocked the EMT process. In summary, these results demonstrated that Cro could activate Nrf2 signaling to clear reactive oxygen species (ROS) by directly binding to Keap1 and alleviate pulmonary fibrosis by blocking the progression of EMT both in vitro and in vivo.

News (Medical) associated with Quinapril Hydrochloride

14 May 2024

·www.prnewswire.com

CardioPharma Announces Issuance of Global Patent to Mitigate the World's Top Killer

WILMINGTON, N.C., May 14, 2024 /PRNewswire/ -- CardioPharma Inc. (the "Company"), a specialty pharmaceutical company focused on drug development for cardiovascular diseases, announced that on August 29, 2023, the United States Patent and Trademark Office ("USPTO") issued US Patent 11,737,988 B2 entitled "Anti-Hypertensive and Cholesterol-Lowering Fixed-Dose Combination and Method of Manufacture." Additional patents covering the subject matter of the '988 Patent have been granted in South Africa in 2022 and Australia, Armenia, Belarus, and the Russian Federation in 2024. Three further patents have been accepted in Canada, New Zealand, and Israel and will issue in the near future. In addition to the foregoing, CardioPharma is pursuing additional patents in major markets throughout the world, all of which together will bolster CardioPharma's global presence for the products covered by the patent grants. The 20-year term for all of the patents runs through April 17, 2039. CardioPharma Pipeline CardioPharma's pipeline products contain some of the world's most consumed, individually dispensed medications for the prevention and treatment of cardiovascular disease. The lead product, CardiaPill® is a unique formulation combining a cholesterol modifying agent ("statin"), an Angiotensin-converting-enzyme inhibitor (ACE Inhibitor) and anti-platelet agent. Statins moderate cholesterol levels and include products such as Lipitor®, Zocor®, Pravachol®; and Crestor®. ACE inhibitors reduce blood pressure and include products such as Altace®, Lotensin®, Capoten® and Accupril®. Pipeline products also include combinations using Angiotensin II Receptor Blockers (ARBs) as well as different statins and other anti-platelet agents. Simplicity of dosing, improved adherence and significant cost benefits for patients, providers and payors around the world are among the many compelling and well-documented benefits that make these inexpensive products so anticipated. About CardioPharma CardioPharma (), Inc. is a specialty pharmaceutical company focused on patent-protected combinatorial cardiovascular medications. CardioPharma's goal is to create drugs that make it easier and more cost-effective for doctors and their patients to reduce the morbidity and mortality of the world's number one killer – cardiovascular disease. The products are unique to the global pharmaceutical industry – highly cost-effective with proven efficacy; providing both patient and provider convenience; promoting adherence, while delivering superior clinical outcomes and economic benefits to all stakeholders. For more information, visit . Forward looking statements The information in this press release contains forward-looking statements including the prospective development, commercialization and regulatory approval in the U.S. and international markets. Words such as "expects," "plans," "believe," "may," "will," "anticipated," "intended" and variations of these words or similar expressions are intended to identify forward-looking statements. In addition, any statements that refer to expectations, projections or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking statements. These statements are not guarantees of future performance and are subject to risks, uncertainties and assumptions that are difficult to predict. Therefore, our actual results could differ materially and adversely from those expressed in any forward-looking statements as a result of various factors including the Company's ability to raise sufficient funds to bring new products to the global market. Contact: [email protected] SOURCE CardioPharma, Inc.

Patent Expiration

28 Feb 2024

·www.biospace.com

FDA Ramps Up Manufacturing Inspections in India: Reuters

Pictured: Facade of the FDA building in Maryland/iStock, Grandbrothers The FDA is planning to increase its inspection of drug manufacturing facilities in India this year amid growing quality and supply concerns, Reuters reported Tuesday citing an agency executive. “We are putting every effort into increasing the number of inspections,” Sarah McMullen, FDA Country Director for India, told Reuters, adding that the regulator is also “requesting more drug investigators to be stationed here.” The decision to tighten regulatory scrutiny over Indian manufacturing facilities comes as the FDA grapples with two interconnected crises: The deteriorating quality of medicines and persistent drug shortages. The FDA in its annual Report on the State of Pharmaceutical Quality, published in June 2023, documented a record number of drug recalls, which reached its highest level in five years. The report covered the agency’s fiscal year 2022, which ran from October 1, 2021 to September 30, 2022. During that timeframe, the FDA issued 912 recalls across 166 manufacturing sites, most of which were due to violations of current good manufacturing practices (CGMP). Inspections of manufacturing sites also spiked to 328 in FY2022, which was “nearly triple the amount” of such visits in the year prior. The regulator also issued a high number of import alerts and warning letters, mostly affecting facilities in China, South Korea and India. In July 2023, the House Committee on Energy and Commerce wrote to the FDA requesting detailed information regarding its inspections of foreign drug manufacturing facilities—particularly those in China and India. Committee Chair Rep. Cathy Rodgers (R-WA), along with Subcommittee Chairs Reps. Brett Guthrie (R-KY) and Morgan Griffith (R-VA), expressed their concern that the U.S. might be becoming too reliant on “foreign manufacturers with a demonstrated pattern of repeatedly violating FDA safety regulations.” The FDA is also struggling to keep up with significant shortages of hundreds of life-saving drugs. Currently, the regulator has listed over 300 medicines in short supply, the highest number since 2014. Medicines affected by the shortages include amoxicillin, quinapril, cisplatin, carboplatin and the wildly popular weight-loss therapy semaglutide. Earlier this month, the House Ways and Means Committee held a hearing to investigate these shortages, noting that most of the treatments on the FDA’s list have seen limited availability for at least two years. The growing manufacturing problems in overseas facilities has made the drug shortages worse. India-based Intas Pharmaceuticals has received a warning letter from the FDA over several quality control lapses and poor data integrity. Intas, which manufactures several generic drugs, is on the FDA’s import alert list. Tristan Manalac is an independent science writer based in Metro Manila, Philippines. Reach out to him on LinkedIn or email him at tristan@tristanmanalac.com or tristan.manalac@biospace.com.

28 Feb 2024

·www.biospace.com

FDA Ramps Up Manufacturing Inspections in India: Reuters

F acade of the FDA’s office in Maryland iStock, Grandbrothers Amid the dual crises of worsening medicine quality and growing drug shortages, the FDA plans to increase inspections of Indian manufacturing facilities this year, Reuters reported Tuesday. Pictured: Facade of the FDA building in Maryland/iStock, Grandbrothers The FDA is planning to increase its inspection of drug manufacturing facilities in India this year amid growing quality and supply concerns, Reuters reported Tuesday citing an agency executive. “We are putting every effort into increasing the number of inspections,” Sarah McMullen, FDA Country Director for India, told Reuters , adding that the regulator is also “requesting more drug investigators to be stationed here.” The decision to tighten regulatory scrutiny over Indian manufacturing facilities comes as the FDA grapples with two interconnected crises: The deteriorating quality of medicines and persistent drug shortages. The FDA in its annual Report on the State of Pharmaceutical Quality, published in June 2023, documented a record number of drug recalls , which reached its highest level in five years. The report covered the agency’s fiscal year 2022, which ran from October 1, 2021 to September 30, 2022. During that timeframe, the FDA issued 912 recalls across 166 manufacturing sites, most of which were due to violations of current good manufacturing practices (CGMP). Inspections of manufacturing sites also spiked to 328 in FY2022, which was “nearly triple the amount” of such visits in the year prior. The regulator also issued a high number of import alerts and warning letters, mostly affecting facilities in China, South Korea and India. In July 2023, the House Committee on Energy and Commerce wrote to the FDA requesting detailed information regarding its inspections of foreign drug manufacturing facilities—particularly those in China and India. Committee Chair Rep. Cathy Rodgers (R-WA), along with Subcommittee Chairs Reps. Brett Guthrie (R-KY) and Morgan Griffith (R-VA), expressed their concern that the U.S. might be becoming too reliant on “foreign manufacturers with a demonstrated pattern of repeatedly violating FDA safety regulations.” The FDA is also struggling to keep up with significant shortages of hundreds of life-saving drugs. Currently, the regulator has listed over 300 medicines in short supply, the highest number since 2014. Medicines affected by the shortages include amoxicillin, quinapril, cisplatin, carboplatin and the wildly popular weight-loss therapy semaglutide. Earlier this month, the House Ways and Means Committee held a hearing to investigate these shortages, noting that most of the treatments on the FDA’s list have seen limited availability for at least two years. The growing manufacturing problems in overseas facilities has made the drug shortages worse. India-based Intas Pharmaceuticals has received a warning letter from the FDA over several quality control lapses and poor data integrity. Intas, which manufactures several generic drugs, is on the FDA’s import alert list . Tristan Manalac is an independent science writer based in Metro Manila, Philippines. Reach out to him on LinkedIn or email him at tristan@tristanmanalac.com or tristan.manalac@biospace.com .

100 Deals associated with Quinapril Hydrochloride

External Link

KEGG	Wiki	ATC	Drug Bank
D00459	Quinapril Hydrochloride	C09AA06	DB00881

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Hypertension	Japan	Mitsubishi Tanabe Pharma Corp.	30 Jun 1995

Clinical Result

Indication

Phase

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ESH2021	Not Applicable	EGR1 \| STAT3 \| PRR ... View more	12	Quinapril (Control (CTL))	(uilvnqdaqg) = ixkyxinnis ebwofrehvs (idpoqagxxy )	Positive	01 Apr 2021
				Quinapril (Diabetic (DM))	(uilvnqdaqg) = rdqndwubxv ebwofrehvs (idpoqagxxy )
NCT01669434 (CTgov)	Phase 4	Hypotension	291	LISINOPRIL+Captopril+ENALAPRILAT+BENAZEPRIL HYDROCHLORIDE+PERINDOPRIL ERBUMINE+RAMIPRIL+QUINAPRIL HYDROCHLORIDE+Enalapril Maleate+Perindopril Arginine+FOSINOPRIL SODIUM+TRANDOLAPRIL+MOEXIPRIL HYDROCHLORIDE (ACEI Omission)	rhjjwtbcdn(bqsqwkukyx) = xbhyndicge lcgjvzyooi (qdopanjomj, uekdnmaglf - cneihyvsgv) View more	-	11 Dec 2017
				ACEI continuation (ACEI Continuation)	rhjjwtbcdn(bqsqwkukyx) = jrqfcfmpzc lcgjvzyooi (qdopanjomj, kdjxhrbusl - dlpwaeehqt) View more
EASD2013	Not Applicable	Ventricular Dysfunction, Left \| Diabetic Neuropathies	-	Quinapril 20 mg	mxdptofmkt(ghjkjoswjc) = vfozorurov fapxcpmqjz (qvldatnhxd )	Positive	25 Sep 2013
PP.24.466 (ESH2010)	Not Applicable	Essential Hypertension Add-on serum creatinine levels	66	Quinapril+Valsartan 80 mg	apedbievre(qouqxewrzp) = lijtyximoz trxecxvbmr (zfvksahxgt ) View more	Positive	01 Jun 2010
				Valsartan 160 mg	apedbievre(qouqxewrzp) = gowkfznbie trxecxvbmr (zfvksahxgt ) View more

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