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Last update 20 Mar 2025

Lisinopril

Last update 20 Mar 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

SummaryLisinopril is a type of medication known as an angiotensin-converting enzyme (ACE) inhibitor that is frequently prescribed for the management of hypertension, heart failure, and other cardiovascular conditions. By preventing the conversion of angiotensin I to angiotensin II, a hormone that causes blood vessels to constrict, lisinopril helps to reduce blood pressure. The medication is available in oral formulations and generally well-tolerated by patients. Nonetheless, side effects, such as cough, dizziness, and hypotension, may occur. As a researcher, it is noteworthy that ongoing investigations into the potential benefits of lisinopril for the treatment of conditions like diabetic nephropathy and migraines have shown encouraging results in preclinical and clinical studies.

Drug Type

Small molecule drug

Synonyms

(S)-1-(N(2)-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline, [N2-[(S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline, Lisinopril (INN)

+ [26]

Target

ACE

Action

inhibitors

Mechanism

ACE inhibitors(Angiotensin-converting enzyme inhibitors)

Therapeutic Areas

Cardiovascular DiseasesEndocrinology and Metabolic DiseaseUrogenital Diseases

Active Indication

Diabetic NephropathiesChronic heart failureEssential Hypertension+ [4]

Inactive Indication

Polycystic Kidney, Autosomal Dominant

Originator Organization

Merck Sharp & Dohme Corp.

AstraZeneca PLC

Active Organization

Ratiopharm GmbH

TWi Pharmaceuticals, Inc.

Atnahs Pharma UK Ltd.

+ [6]

Inactive Organization

Alvogen, Inc.

Merck Research Laboratories Massachusetts LLC

Drug Highest PhaseApproved

First Approval Date

United States (29 Dec 1987),

Acute myocardial infarctionHeart FailureHypertension

Regulation-

Structure/Sequence

Molecular FormulaC21H35N3O7

InChIKeyCZRQXSDBMCMPNJ-ZUIPZQNBSA-N

CAS Registry83915-83-7

117

Clinical Trials associated with Lisinopril

NCT06745726

/ Not yet recruitingNot Applicable

Optimising Hypertension Management: Real-World Effectiveness of Zestril Personalised Dosing With the OptiZ Software as a Medical Device Companion App

Hypertension, or high blood pressure, is a major cause of preventable illness and premature death, affecting millions in the UK. Despite effective treatments, many patients struggle to achieve adequate blood pressure control. This study evaluates the effectiveness of the OptiZ. OptiZ is a mobile phone application ("app") intended to be installed on a mobile device as part of a treatment for hypertension for use by patients prescribed Zestril (lisinopril). The OptiZ app helps patients record blood pressure, dose-related side effects, and medication adherence, send reports to healthcare professionals for dose adjustments, set reminders to log their medication and blood pressure readings, and access information about high blood pressure and health tips.
This is a real-world observational study involving adults diagnosed with essential hypertension who are eligible for Zestril treatment. Recruitment will occur at selected GP practices across England over six months, with participants followed for 12 months. The study aims to enrol 113 participants. Using the OptiZ app, participants will record daily blood pressure readings, track medication adherence, record dose-related side effects, and access educational content on hypertension management. Healthcare professionals will use reports generated by the app to personalise Zestril dosing.
The main objective is to evaluate the OptiZ app's impact on reducing systolic blood pressure during the dose adjustment phase. Secondary objectives include adherence to Zestril, how often patients log blood pressure readings onto the OptiZ app and other patient-reported outcomes. Participants will also complete electronic questionnaires to provide feedback on their experience using the OptiZ app and their perceptions of hypertension treatment.
This study is funded by Closed Loop Medicine Ltd and Atnahs Pharma UK Ltd. The findings aim to improve hypertension care by using digital tools to enhance adherence, optimise dosing, and potentially reduce cardiovascular risks while guiding future digital solutions for chronic conditions.

Start Date01 Mar 2025

Sponsor / Collaborator

Closed Loop Medicine Ltd.Startup

NCT03201939

/ SuspendedPhase 2IIT

Optimal Management of HIV Infected Adults At Risk for Kidney Complications in Nigeria

In this study, the Investigators plan to determine the optimal means to prevent or slow the progression of kidney disease among genetically at-risk northern Nigerian HIV-infected adults. Based on data from studies of diabetic kidney disease that used medications that block the renin angiotensin aldosterone system (RAAS), we plan to evaluate whether or not RAAS inhibition (using a widely available medication that blocks RAAS) in HIV-infected adults produces similarly promising results.

Start Date01 Jan 2025

Sponsor / Collaborator

Vanderbilt University Medical Center

[+3]

NCT06372470

/ CompletedNot Applicable

Personalised Dose Optimisation of Zestril Supported by the Digital Blood Pressure Diary in a Primary Care Environment in England: Pragmatic Observational Pilot Study for Remote Hypertension Treatment

A pragmatic observational proof-of-concept study which aims to determine the feasibility of a remote titration clinic, assisted by home blood pressure monitoring and digital solutions, and assess its impact on real-world outcomes. By incorporating home blood pressure monitoring, the study seeks to offer a promising solution for personalised drug titration and self-management, potentially enhancing patient outcomes while optimising Zestril utilisation

Start Date15 Apr 2024

Sponsor / Collaborator

Closed Loop Medicine Ltd.Startup

[+1]

100 Clinical Results associated with Lisinopril

100 Translational Medicine associated with Lisinopril

100 Patents (Medical) associated with Lisinopril

4,971

Literatures (Medical) associated with Lisinopril

01 Dec 2025·Current Cardiology Reports

Blood Pressure Control and Incident Left-Ventricular Conduction Disease

Review

Author: Frimodt-Møller, Emilie K ; Marcus, Gregory M

PURPOSE OF REVIEW:

Cardiac conduction disease, a harbinger of pacemaker implantation, heart failure, and death, is commonly regarded as immutable. However, emerging research suggests it may be a target for upstream prevention strategies such as blood pressure management. This review summarizes recent evidence regarding blood pressure control and the development of conduction disease.

RECENT FINDINGS:

Recent observational studies link hypertension to both prevalent and incident conduction disease. In randomized trials, intensive blood pressure control among hypertensive individuals reduced the incidence of left-ventricular conduction abnormalities in the form of fascicular- and left bundle branch blocks, while treatment with lisinopril independent of blood pressure control appeared to reduce conduction disease risk. Understanding factors that influence conduction system disease development may help inform novel primary prevention strategies. Recent evidence suggests that treatment of hypertension may play a key role in the prevention of conduction disease.

01 Mar 2025·PEDIATRIC NEPHROLOGY

Real-world evidence of lisinopril in pediatric hypertension and nephroprotective management: a 10-year cohort study

Article

Author: Degraeuwe, Eva ; Raes, Ann ; Gasthuys, Elke ; Dehoorne, Joke ; Prytula, Agnieszka ; Dossche, Lien ; Walle, Johan Vande ; Snauwaert, Evelien ; Vermeulen, An

BACKGROUND:

Over the last 20 years, pediatric hypertension (pHTN) prevalence in Western society has risen from 3.5 to 9% due to childhood overweight, obesity, and secondary kidney and cardiological conditions. Few studies have assessed commonly used antihypertensive medication lisinopril's (ACE-inhibitor) long-term efficacy and the long-term value of renin-angiotensin-aldosterone system (RAAS) biomarkers.

METHODS:

This is a retrospective cohort study at Ghent University Hospital, Belgium, with 106 young patients (1-18 years) treated with lisinopril due to hypertension (HTN) and chronic kidney disease (CKD) assessed for treatment outcomes against clinical benchmarks over 10 years.

RESULTS:

Lisinopril was mainly initiated for secondary hypertension or nephroprotection (89%) due to kidney causes. A starting dose across groups was lower than 0.07 mg/kg for 48% (n = 50). HTN patients without CKD achieved systolic blood pressure below the 95th percentile within 2 years, but efficacy declined after 2.5 years. CKD patients maintained a steady response, reaching systolic targets by 40 months and showing improved diastolic control over 70 months. Proteinuria reduction had a median urine protein creatinine ratio (UPCR) to 0.57 g/g at 6 months, with a reappearance of UPCR 2 g/g creatinine after 40 months. Aldosterone breakthrough occurred from 6 months onward in all groups. Over 70 months, aldosterone and aldosterone-renin-ratio (ARR) progression significantly differ between children with and without normal kidney function.

CONCLUSIONS:

Treatment efficacy for systolic blood pressure in hypertensive patients with abnormal kidney function diminishes after 2.5 years and for proteinuria in children after 3 years, highlighting the need for dosage recalibration according to guidelines and/or the need for alternative treatments.

01 Feb 2025·INTERNATIONAL JOURNAL OF PHARMACEUTICS

Spatial separation of different drug substances in one microneedle array patch by combining inkjet printing and micromolding technology

Article

Author: Braun, Sebastian ; Lammerding, Lukas C ; Arora, Awadhi ; Breitkreutz, Jörg

Transdermal drug delivery using microneedle array patches has been investigated using a wide range of drug substances. Inkjet printing and micromolding are established methods for the production of microneedle array patches and both were used to combine lisinopril embedded in povidone and ibuprofen in Eudragit® RS / RL in a single patch. Dissolution studies, visual inspection, mechanical strength and insertion into an artificial skin membrane model were investigated. A clear spatial separation of the polymers / drugs was observed. Microneedle array patches containing povidone and Eudragit® RS / RL showed a height reduction below 10 %. 97.14 ± 3.76 % of the microneedles made of povidone and Eudragit® RS and 97.50 ± 2.13 % made of povidone and Eudragit® RL pierced the second layer of Parafilm® M. This indicated a sufficient insertion into the membrane model. 132.14 ± 47.47 µg (Eudragit® RS) and 135.02 ± 3.34 µg (Eudragit® RL) lisinopril has been dissolved after 9 min. It was possible to vary the dissolution of ibuprofen using both types of Eudragit®. 211.80 ± 22.98 µg ibuprofen were dissolved after 24 h (Eudragit® RS) and 445.16 ± 9.98 µg after 6 h (Eudragit® RL). The microneedles successfully pierced human skin and both drug substances permeated across it. This could lead to an interesting approach to combining incompatible drugs in one patch.

News (Medical) associated with Lisinopril

14 Jun 2024

·www.globenewswire.com

Chiesi Global Rare Diseases Showcases Ongoing Commitment to Multiple Rare Diseases Communities at ENDO 2024 Meeting Debut

• Results presented from a large, pooled database from three Phase 3 clinical trials evaluating MYCAPSSA (octreotide) for the treatment of people living with acromegaly • Additional presentations provide insights into the validation of the Lipodystrophy Severity Scoring tool and the Chiesi Management of Acromegaly (MACRO) registry BOSTON, June 14, 2024 (GLOBE NEWSWIRE) -- Chiesi Global Rare Diseases, a business unit of the Chiesi Group established to deliver innovative therapies and solutions for people living with rare diseases, announced updates from their rare endocrine disease portfolio with two late-breaking poster presentations and one oral presentation during the Endocrine Society’s ENDO 2024 Meeting that was held June 1-4, 2024, in Boston, Massachusetts. Presentations included a post hoc analysis of three Phase 3 clinical trials (CH-ACM-01, OPTIMAL, MPOWERED) studying MYCAPSSA (octreotide) as well as real-world MYCAPSSA use data from the Chiesi Management of Acromegaly (MACRO) registry and presentation of the Lipodystrophy Severity Scoring tool designed to assess the disease burden of lipodystrophy. "We're thrilled to support this community of people living with burdensome rare endocrine diseases through the innovation of new resources and validated medicines to aid in disease management," said Giacomo Chiesi, Head of Chiesi Global Rare Diseases. "As we approach the four-year anniversary of MYCAPSSA being on the market later this month, our commitment remains steadfast to commercializing solutions for the acromegaly and lipodystrophy patient communities.” Oral PresentationTitle: Biochemical Response, Symptom Control, and Safety of Oral Octreotide Capsules Treatment in Acromegaly: A Post Hoc Analysis of a Large Pooled Database from Three Phase 3 Clinical Trials2Key Highlights: MYCAPSSA demonstrated a 72% response rate in patients entering the studies with IGF-I values of ≤ 1x the upper limit of normal. A patient’s prior dose level of injectable medication did not significantly impact response rates.In this post-hoc analysis, symptom improvement was notable with significant reductions in joint pain (36% to 22%) and swelling (15% to 10%) in patients responding to MYCAPSSA. Median decrease of one symptom per patient and a mean decrease of 0.8 in Acromegaly Index of Severity (AIS) further underscored symptom improvement.Safety analysis revealed gastrointestinal issues as the most common adverse events with a median duration and time to onset of roughly two weeks for the first occurrence and a low rate of discontinuation. Late-Breaker Poster PresentationsTitle: Real-world Biochemical And Symptoms Outcomes With Oral Octreotide: Management Of Acromegaly (MACRO) Registry Experience3Key Highlights: Of the 230 patients participating in Chiesi Management of Acromegaly (MACRO) registry, 32 (14%) received MYCAPSSA at baseline, with an additional 26 (11%) initiating post-baseline. Common reasons for initiation included patient preference and lack of symptom or biochemical control.The mean time on OOC was 19.7 months, with the majority receiving treatment for at least 6 months. Most patients remained well-controlled biochemically and symptomatically, with 87% biochemically controlled and 71% symptomatically controlled at the last follow-up.The discontinuation rate was 33% and in cases attributed to a lack of biochemical or symptom control, dose titration to 80mg/day was not implemented in many cases.Overall, OOC demonstrated efficacy in maintaining or achieving biochemical control with the majority of newly-initiated patients reporting well-controlled symptoms. Title: Lipodystrophy Severity Score: Validation Of A Tool To Assess Disease Burden In Lipodystrophy4Key Highlights: The lipodystrophy severity score (LDS) is a validated tool that captures severity in patients with diverse manifestations of lipodystrophy. The LDS allows comparisons among patient groups and changes within patients over time.The LDS is a tool designed to quantify the diverse complications of lipodystrophy, a group of rare, potentially life-threatening disorders that affect how the body accumulates and stores fat.The LDSs showed high reliability and strong correlation with the Clinical Global Impression (CGI) of severity, effectively capturing the severity of lipodystrophy and changes over time. This tool is intended to compare patient groups, and monitor individual progress with future analysis involving in real-world data sets.Development into an online platform enhances functionality – a versatile and valuable resource for the lipodystrophy community.Future work will assess the LDS using real-world datasets. MYCAPSSA IMPORTANT SAFETY INFORAMATION INDICATION AND USAGE MYCAPSSA (octreotide) delayed-release capsules, for oral use, is a somatostatin analog indicated for long-term maintenance treatment in acromegaly patients who have responded to and tolerated treatment with octreotide or lanreotide. CONTRAINDICATIONS Hypersensitivity to octreotide or any of the components of MYCAPSSA. Anaphylactoid reactions, including anaphylactic shock, have been reported in patients receiving octreotide. IMPORTANT SAFETY INFORMATION WARNINGS AND PRECAUTIONS MYCAPSSA can cause problems with the gallbladder. Monitor patients periodically. Discontinue if complications of cholelithiasis are suspected. Blood sugar, thyroid levels, and vitamin B12 levels should be monitored and treated accordingly. Bradycardia, arrhythmia, or conduction abnormalities may occur. Treatment with drugs that have bradycardia effects may need to be adjusted. ADVERSE REACTIONS The most common adverse reactions (incidence >10%) are nausea, diarrhea, headache, arthralgia, asthenia, hyperhidrosis, peripheral swelling, blood glucose increased, vomiting, abdominal discomfort, dyspepsia, sinusitis, and osteoarthritis. DRUG INTERACTIONS The following drugs require monitoring and possible dose adjustment when used with MYCAPSSA: cyclosporine, insulin, antidiabetic drugs, calcium channel blockers, beta blockers, lisinopril, digoxin, bromocriptine, and drugs mainly metabolized by CYP3A4. Counsel women taking an oral contraceptive to use an alternative non-hormonal method of contraception or a back-up method when taking MYCAPSSA. Patients taking proton pump inhibitors, H2-receptor antagonists, or antacids concomitantly with MYCAPSSA may require increased dosages of MYCAPSSA. PREGNANCY Advise premenopausal females of the potential for an unintended pregnancy. Please contact Chiesi Farmaceutici S.p.A. at 1-888-661-9260 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. About AcromegalyAcromegaly typically develops when a benign tumor of the pituitary gland produces too much growth hormone, ultimately leading to significant health problems. Common features of acromegaly are facial changes, intense headaches, joint pain, impaired vision, and enlargement of the hands, feet, tongue, and internal organs. Serious health conditions associated with the progression of acromegaly include type 2 diabetes, hypertension, respiratory disorders, and cardiac and cerebrovascular disease. Acromegaly affects over 25,000 people in the United States alone with roughly 8,000 being treated with injectable somatostatin receptor ligands (iSRLs). A significant percentage of these people experience burdens associated with receiving iSRLs including prolonged injection-related pain and poorly-controlled symptoms. About LipodystrophyLipodystrophy syndromes are a heterogeneous group of rare, potentially life-threatening disorders that affect how the body accumulates and stores fat. These syndromes are categorized into two main forms: generalized lipodystrophy, characterized by the near-complete absence or progressive loss of fat (adipose) tissue, and partial lipodystrophy, where the tissue loss is more limited, typically impacting areas like limbs or upper body. Lipodystrophy is also categorized by etiology with inherited and acquired forms1. About Chiesi Global Rare DiseasesChiesi Global Rare Diseases is a business unit of the Chiesi Group established to deliver innovative therapies and solutions for people affected by rare diseases. As a family business, Chiesi Group strives to create a world where it is common to have a therapy for all diseases and acts as a force for good, for society and the planet. The goal of the Global Rare Diseases unit is to ensure equal access so as many people as possible can experience their most fulfilling life. The unit collaborates with the rare disease community around the globe to bring voice to underserved people in the health care system. For more information visit www.chiesirarediseases.com. About Chiesi GroupChiesi is an international, research-focused biopharmaceuticals group that develops and markets innovative therapeutic solutions in respiratory health, rare diseases, and specialty care. The company’s mission is to improve people’s quality of life and act responsibly towards both the community and the environment. By changing its legal status to a Benefit Corporation in Italy, the US, and France, Chiesi’s commitment to create shared value for society as a whole is legally binding and central to company-wide decision-making. As a certified B Corp since 2019, we’re part of a global community of businesses that meet high standards of social and environmental impact. The company aims to reach Net-Zero greenhouse gases (GHG) emissions by 2035. With over 85 years of experience, Chiesi is headquartered in Parma (Italy), operates in 31 countries, and counts more than 6,500 employees. The Group’s research and development centre in Parma works alongside 6 other important R&D hubs in France, the US, Canada, China, the UK, and Sweden. For further information please visit www.chiesi.com Garg A. Acquired and inherited lipodystrophies. N Engl J Med. 2004 Mar 18;350(12):1220-34. Doi: 10.1056/NEJMra025261. PMID: 15028826.Fleseriu M, et al. Biochemical Response, Symptom Control, and Safety of Oral Octreotide Capsules Treatment in Acromegaly: A Post Hoc Analysis of a Large Pooled Database from Three Phase 3 Clinical Trials. Presented at: Endocrine Society’s ENDO 2024 Meeting; June 1-4, 2024; Boston, Massachusetts.Yuen K, et al. Real-world Biochemical And Symptoms Outcomes With Oral Octreotide: Management Of Acromegaly (MACRO) Registry Experience. Presented at: Endocrine Society’s ENDO 2024 Meeting; June 1-4, 2024; Boston, Massachusetts.Brown R, et al. Lipodystrophy Severity Score: Validation Of A Tool To Assess Disease Burden In Lipodystrophy. Presented at: Endocrine Society’s ENDO 2024 Meeting; June 1-4, 2024; Boston, Massachusetts. Chiesi Group Media ContactChiara TravaginRare Communication ManagerTel: +39 348 8818985Email c.travagin@chiesi.com Sky Striar LifeSci CommunicationsTel: 617-797-6672Email sstriar@lifescicomms.com

Clinical ResultPhase 3

06 Jun 2024

·www.drugs.com

Several Drugs Linked to Risk for Aneurysmal Subarachnoid Hemorrhage

THURSDAY, June 6, 2024 -- Several commonly prescribed drugs are associated with aneurysmal subarachnoid hemorrhage (aSAH), according to a study published online June 5 in Neurology . Jos P. Kanning, from the University Medical Center Utrecht in the Netherlands, and colleagues conducted a drug-wide association study to examine the association between commonly prescribed drugs and aSAH incidence. Use of commonly prescribed drugs was examined across exposure windows (current, within three months; recent, three to 12 months; and past, >12 months). Exposure to 205 commonly prescribed drugs was investigated among 4,879 aSAH cases and 43,911 matched controls. The researchers found similar trends for lisinopril and amlodipine, with a decreased risk for aSAH in association with current use, while the risk for aSAH was increased with recent use. The risk for aSAH was reduced with current use of simvastatin, metformin, and tamsulosin. Increased aSAH risk was seen in association with current use of warfarin, venlafaxine, prochlorperazine, and co-codamol. "Future research should use a more hypothesis-driven approach to further investigate these associations and differentiate between drug class and specific drug substance effects," the authors write. "In addition, this research may help identify additional risk factors for aSAH, potentially leading to new pharmacologic therapy options for aneurysmal management." Abstract/Full Text Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

Clinical ResultClinical Study

05 Jun 2024

·www.sciencedaily.com

Could taking certain drugs reduce risk of ruptured brain aneurysm?

A new study suggests that people who take a few common drugs may have a decreased risk of having a bleeding stroke due to a ruptured brain aneurysm. The results do not prove that these drugs reduce the risk of this type of aneurysm; they only show an association. A new study suggests that people who take a few common drugs may have a decreased risk of having a bleeding stroke due to a ruptured brain aneurysm. The study is published in the June 5, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology. The results do not prove that these drugs reduce the risk of this type of aneurysm; they only show an association. "We urgently need new ways to prevent this type of stroke, which occurs at younger ages and with a higher death rate than other types of stroke," said study author Jos Peter Kanning, MSc, of University Medical Center Utrecht in the Netherlands. "Our current surgical treatments for brain aneurysms have a risk of permanent disability and death that often outweighs the potential benefits, so preventing rupture with a non-invasive drug would be very beneficial." For the study, researchers looked at 4,879 people who had ruptured brain aneurysms, called aneurysmal subarachnoid hemorrhages. Those people were each compared to nine people of the same age and sex, for a total of 43,911 people who did not have ruptured brain aneurysms. Then researchers looked at electronic health records to see what prescription drugs people took. They found that four drugs were associated with a decreased risk of having a ruptured brain aneurysm: the high blood pressure drug lisinopril; the cholesterol drug simvastatin; the diabetes drug metformin; and the drug tamsulosin, prescribed for enlarged prostate. After adjusting for other factors that could affect the risk of stroke, such as high blood pressure, smoking, alcohol abuse and total number of other health conditions, researchers found that people currently taking lisinopril were 37% less likely to have a ruptured brain aneurysm than those not taking the drug. People taking simvastatin were 22% less likely to have a stroke. Those taking metformin were 42% less likely to have a stroke and those taking tamsulosin were 45% less likely. Researchers also found an increased risk of having a ruptured brain aneurysm for people taking four drugs: the blood thinner warfarin; the antidepressant venlafaxine; the antipsychotic and antiemetic drug prochlorperazine; and the painkiller co-codamol. "Future research is needed to investigate these associations and determine whether these drugs are effective in reducing the risk of hemorrhagic stroke," Kanning said. "This work could also help us identify additional risk factors for subarachnoid hemorrhage, potentially leading to new therapies to manage aneurysms." A limitation of the study was that researchers looked at drug prescriptions. It is possible that people may not take their drugs or may take them incorrectly. The study was supported by the European Research Council.

Clinical Result

100 Deals associated with Lisinopril

External Link

KEGG	Wiki	ATC	Drug Bank
D08131	Lisinopril	C09AA03	DB00722

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Diabetic Nephropathies	Germany	Ratiopharm GmbH	18 Feb 2001
Chronic heart failure	Japan	Kyowa Pharmaceutical Industry Co., Ltd.	30 Jun 1995
Essential Hypertension	Switzerland	Atnahs Pharma UK Ltd.	08 May 1989
Hypertension, Renovascular	Switzerland	Atnahs Pharma UK Ltd.	08 May 1989
Acute myocardial infarction	United States	Merck Research Laboratories Massachusetts LLC	29 Dec 1987
Heart Failure	United States	Merck Research Laboratories Massachusetts LLC	29 Dec 1987
Hypertension	United States	Merck Research Laboratories Massachusetts LLC	29 Dec 1987

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Polycystic Kidney, Autosomal Dominant	Phase 3	United States	Alvogen, Inc.	09 Jan 2015

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00430040 (CTgov)	Phase 4	Diabetes Mellitus, Type 2 \| Inflammation \| Hypertension ... View more	14	lisinopril+Carvedilol Controlled Release (CR) (Carvedilol)	flohkcdqso(fkdoxuchvr) = jwpnhryhbs ebvzacaooe (ytchnlkvvw, 20) View more	-	16 Apr 2024
				lisinopril (Lisinopril)	flohkcdqso(fkdoxuchvr) = qwntxtcvpw ebvzacaooe (ytchnlkvvw, 17) View more
NCT03461003 (NICHE, CTgov)	Phase 4	Hypertension	49	Lisinopril+Hydrochlorothiazide+Amlodipine+Losartan (NICHE Method)	qtqucaypax(shspdyjzmk) = thsxtvrfla haymusukgm (nqqljcpwrg, 9.301) View more	-	09 Sep 2022
				Usual care (Usual Care)	qtqucaypax(shspdyjzmk) = nlqmgmyzuw haymusukgm (nqqljcpwrg, 9.586) View more
ECWAMER (ESH2022)	Not Applicable	COVID-19 C-reactive protein - \| ferritin \| fibrinogen ... View more	30	Lisinopril + Amlodipine + Rosuvastatin (ECWAMER)	jewplxpgat(ahpbxqatgo) = gxdfegsbkx tajxhjqxmk (wsnxymsnrf ) View more	Positive	01 Jun 2022
ESH2021	Not Applicable	Prediabetic State \| Hypertension	64	Lisinopril 5 mg + Metformin 2x500 mg	duzglxmnih(hwgrjjpxip) = tanxnzrgbk ocbnrwmpkk (ddrshwvdpe, 2.2)	Positive	01 Apr 2021
NCT01009918 (Lisinopril or Coreg CR in Reducing Side Effects in Women With Breast Cancer Receiving Trastuzumab, CTgov)	Phase 2	Cardiotoxicity \| Breast Cancer	468	lisinopril (Arm I Lisinopril)	hewxoznmma = mbukrczepo nckcfblrbg (hsocabfxlw, ddntshdefr - ppogffgsaz) View more	-	30 Mar 2021
				Coreg CR® (Arm II Coreg CR®)	hewxoznmma = nicykxgsru nckcfblrbg (hsocabfxlw, cpoauzjoap - ymelvxowxk) View more
NCT01984164 (CALIBREX, CTgov)	Phase 2	Mild cognitive disorder \| Hypertension	176	Candesartan (Candesartan)	zvqkofzmya(idmevfyhwz) = jmempvqjmu wzwejqutqi (dpxltyhpfi, 5.46) View more	-	21 Feb 2021
				Lisinopril (Lisinopril)	zvqkofzmya(idmevfyhwz) = crywtznrts wzwejqutqi (dpxltyhpfi, 5.89) View more
ASN2020	Not Applicable	Hypertension	-	Lisinopril 20 mg	wgkgheaswb(dkutittbpj) = buzejuzvnl wsidqckxug (pjudgejmwe )	Positive	19 Oct 2020
				Ca channel blocker	wgkgheaswb(dkutittbpj) = tufolbzxpy wsidqckxug (pjudgejmwe )
NCT00874432 (CTgov)	Phase 2	Cardiovascular Diseases \| Stiffness \| Chronic Kidney Diseases	43	angiotensin converting enzyme inhibitor (Chronic Kidney Disease)	uaryozmysb(hddpffqfoh) = bticzxokbb ggblphbzvh (lamvygjqkk, 1.12) View more	-	23 Sep 2020
				angiotensin converting enzyme inhibitor (Age Matched Control)	uaryozmysb(hddpffqfoh) = zbwialmhrk ggblphbzvh (lamvygjqkk, 2.52) View more
NCT00673790 (CTgov)	Phase 4	Glucose Intolerance \| Hypertension	537	lisinopril+Nebivolol+losartan (Nebivolol)	vpbumbvkbn(ggrfyvadot) = faxjjyivlq znrgcgbdna (mntuqjlmpb, 8.9) View more	-	26 Feb 2020
				lisinopril+losartan (Placebo)	vpbumbvkbn(ggrfyvadot) = ataffvkokg znrgcgbdna (mntuqjlmpb, 9.5) View more
NCT01880528 (CTgov)	Phase 2	Dyspnea \| Small Cell Lung Cancer \| Non-Small Cell Lung Cancer	23	lisinopril (Arm I (Lisinopril))	oiuyodqvzy = evzpgqpylv hgnzjmarqu (nblameolac, xunelwmiha - hosuhqlaiu) View more	-	17 Sep 2019
				placebo (Arm II (Placebo))	oiuyodqvzy = wsgsdlrlcu hgnzjmarqu (nblameolac, rgoupzglqs - majxwokmjf) View more

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