Methylene blue

SHENZHEN, CHINA, June 18, 2024 (GLOBE NEWSWIRE) -- Innovative drug Methylthioninium Chloride Enteric-coated Sustained-release Tablets (Lumeblue®) is an oral diagnostic drug, approved by China’s NMPA for enhancing visualisation of colorectal lesions in adult patients undergoing screening or surveillance colonoscopy. The results of the Phase III clinical trial in China show that the Product can significantly improve the detection rate of non-polypoid colorectal lesions (the primary endpoint of the study), leading to an improved detection rate of dangerous lesions such as non-polypoid adenomas (the secondary endpoint). The Product can be taken during the bowel preparation step, ensuring that colorectal staining is completed by the time colonoscopy is conducted. This not only enhances the detection rate of colorectal lesions but also potentially simplifies the colonoscopy procedure, making the examination more efficient and improving the screening benefits. As of now, CMS's newly launched innovative portfolio has been expanded to 5 products, continuously generating driving force to the Group’s sustainable and healthy development. China Medical System Holdings Limited (the “Company”, together with its subsidiaries, the “Group” or “CMS”) is pleased to announce that on 11 June 2024, the New Drug Application (NDA) of the Group’s innovative drug methylthioninium chloride enteric-coated sustained-release tablets (Lumeblue®) (the “Product”) has been approved by the National Medical Products Administration of China (NMPA). The drug registration certificate was obtained on 18 June 2024. The Product is indicated to enhancing visualisation of colorectal lesions in adult patients undergoing screening or surveillance colonoscopy, and it is the first oral methylthioninium chloride enteric-coated sustained-release tablets in China. The Group will synergize with existing gastroenterology products and resources to advance the commercialization and academic promotion related works of the Product in an orderly manner, aiming to achieve nationwide large-scale clinical application as soon as possible so as to benefit patients with colorectal disease. Lumeblue® is an oral diagnostic drug that uses patented multi-matrix (MMX) technology to deliver active substances directly to the colon and release them locally in a controlled manner. As an enhancer dye, the Product increases the contrast between colorectal lesions and healthy mucosa. The results of the Phase III clinical trial in China show that the Product can significantly improve the detection rate of non-polypoid colorectal lesions (the primary endpoint of the study), leading to an improved detection rate of dangerous lesions such as non-polypoid adenomas (the secondary endpoint)[1]. In addition, the Product can be taken during the bowel preparation step, ensuring that colorectal staining is completed by the time colonoscopy is conducted. This not only enhances the detection rate of colorectal lesions but also potentially simplifies the colonoscopy procedure, making the examination more efficient and improving the screening benefits. According to the diagnosis and treatment data of the Digestive Endoscopy Branch of the Chinese Medical Association, approximately a total of 28 million gastroenteroscopies were completed nationwide in 2012, including 5.83 million colonoscopies. In 2019, approximately 38.73 million gastroenteroscopies were completed nationwide, an increase of 34.62% compared with 2012[2]. The Chinese consensus of early colorectal cancer screening recommends that people aged 50 to 75 years old should be screened for colorectal cancer regardless of whether they have alarm symptoms[3]. There are approximately 400 million people aged 50 to 75 in China in 2020[4]. With the popularity of early screening for colorectal cancer in China, it is expected to witness a considerable growth of the number of colonoscopies in China in the future. The Product has been approved by the European Medicines Agency (EMA) to be commercialized in the European Union under the trade name Lumeblue™ in August 2020. The Group obtained an exclusive license for the Product from Cosmo Technologies Ltd, a fully owned subsidiary of Cosmo Pharmaceuticals NV, on 3 December 2020. Driven by the twin-wheel of "Collaborative R&D and Independent R&D", CMS has continuously deployed global first-in-class (FIC) and best-in-class (BIC) innovative products guided by patient and clinical demands. With enhancing R&D capabilities in developing differentiated innovative products, CMS has empowered the continuous transformation of scientific research outcomes into clinical application, continuously releasing the value of innovation. As of now, CMS's newly launched innovative portfolio has been expanded to 5 products, continuously generating driving force to the Group’s sustainable and healthy development. Desidustat Tablets and Methotrexate Injection (rheumatoid arthritis), CMS’s innovative pipeline products, are currently under NDA review in China. Meanwhile, over 10 innovative pipeline products are undergoing clinical trials in China, mainly randomized controlled trials (RCT). CMS is expected to launch differentiated innovative products every year in the future with higher efficiency and more controllable costs, continuing to optimize its product portfolio and build fresh driving forces for the mid- to long-term development of the Company. About CMS CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs. CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients. CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development of its advantageous specialty fields and expand business boundaries. While strengthening the competitiveness of the cardio-cerebrovascular/gastroenterology business, CMS independently operates its dermatology and medical aesthetics business, and ophthalmology business, aiming to gain leading positions in specialty therapeutic fields, whilst enhancing the scale and efficiency. At the same time, CMS has expanded its business territory to the Southeast Asian market, striving to become a "bridgehead" for global pharmaceutical companies to enter the Southeast Asian market, further escorting the sustainable and healthy development of the Group. Reference: The results of the Phase III clinical trial in China was published and can be found at: The diagnosis and treatment data of the Digestive Endoscopy Branch of the Chinese Medical Association Chinese consensus of early colorectal cancer screening (2019, Shanghai)，Chinese Journal of Internal Medicine，DOI： 10.3760/cma.j.issn.0578-1426.2019.10.004 CHINA POPULATION CENSUS YEARBOOK 2020, can be found at： CMS Disclaimer and Forward-Looking Statements This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert. This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections. Media Contact Brand: China Medical System Holdings Ltd. Contact: CMS Investor Relations Email: ir@cms.net.cn Website: Source: China Medical System Holdings Ltd.

Two research groups design a plasma (an ionized gas) reactor maintained by microwaves that makes it possible to decontaminate waters with high concentrations of dye. Plasma is an ionized gas -- that is, a gas containing electrons, ions, atoms, molecules, radicals, and photons. It is often called the fourth state of matter and, surprisingly, it permeates everything. Plasmas, which are artificially generated by transmitting energy to a gas, are found in the fluorescent tubes that light kitchens, but they have also allowed mobiles to become smaller and smaller. Plasma has been a veritable revolution in the world of technology. Before, to engrave the circuits on the silicon plates used in electronic devices like mobile phones, it was necessary to use polluting chemical products. Now, the use of plasma has made it possible to do this more cleanly and precisely, it being possible to make the slits smaller and smaller, and, with them, the devices. But plasma has other applications too, such as water treatment. The FQM-136 Physics of Plasmas and FQM-346 Organic Catalysis and Nanostructured Materials groups at the University of Cordoba collaborated on a research study whose purpose was the elimination of contaminants present in water by applying plasma to promote chemical processes. With the aim of tackling the problem of the increasing presence of organic pollutants in waters, such as dyes and other compounds from agricultural and industrial activity in waters that destabilize ecosystems, these researchers opted for the application of plasma. In 2017 they demonstrated, for the first time, that the argon plasmas induced by microwaves open to the air, when acting on water, generated in it reactive species containing oxygen and nitrogen (such as hydroxyl radicals, hydronous peroxide, nitrogen radicals) capable of decontaminating it. Now the researchers Juan Amaro Gahete, Francisco J. Romero Salguero and María C. García have managed to design a reactor of this type of plasma and to significantly increase the amounts of these active species generated in water, thus making possible the destruction of high concentrations of dyes (in this case, methylene blue) in just minutes. This was achieved by altering the design of the surfatron, the metal device that mixes the energy from a microwave generator with the plasma to maintain it. "What we've done is to place a small piece of silicon in the quartz discharge tube, allowing a different plasma to be generated, one that is not filamentary and is more efficient at creating active species when interacting with water," explained Professor María C. García. The aforementioned plasma components, when interacting with water, generate oxidizing species capable of degrading organic compounds and killing microorganisms, which allows this plasma reactor to be used in applications related to water remediation. This new configuration, therefore, expands the applicability of this type of plasmas. "The design completely changes the configuration of the electromagnetic field generated by the surfatron to create the plasma, resulting in plasma with different and more efficient properties, also eliminating the problem of filamentation (the division of the plasma column into many filaments), which destabilizes it," explained Professor García. And then...decontamination. "Those oxidizing species generated due to the action of plasma are very reactive and make it possible to destroy the organic matter inside the water," continued Professor Francisco J. Romero. For this to happen, the plasma is not introduced into the water. Rather it is made to act remotely, so that between the water and the plasma there is a zone of air where numerous reactions occur due to collisions between the excited species and the molecules of oxygen, nitrogen and water vapor, and "reactive species that diffuse into the liquid and end up with the contaminants" are generated. The decontaminating potential of this type of plasma, generated with this new design "has been tested to reduce high concentrations of methylene blue dye in water, with very efficient results in terms of energy, achieving the complete elimination of the dye at reduced treatment times," said researcher Juan Amaro. Thus, with this work progress is made on one of the applications of plasma, that "fourth state of matter" created by providing a stable gas with energy and converting it into an ionized gas, with this being applicable to almost everything: manufacturing microchips, disinfecting surfaces, healing wounds, depositing anti-reflective coatings on glasses, improving seed germination, recovering waste, activating the surface of plastics to achieve better paint adhesion, and countless other applications.