Delving into the Latest Updates on Articaine Hydrochloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Articaine, Articaine hydrochloride (JAN/USP)

+ [6]

Target

SCNA

Mechanism

SCNA blockers(Sodium channel alpha subunit blockers), Central nervous system modulators

Therapeutic Areas

Other Diseases

Active Indication

Anesthesia

Inactive Indication-

Originator Organization-

Active Organization

American Genomics, LLC

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure

Molecular FormulaC13H21ClN2O3S

InChIKeyGDWDBGSWGNEMGJ-UHFFFAOYSA-N

CAS Registry23964-57-0

View All Structures (2)

Adipose-derived stem cells (ADSCs) are characterized by their low immunogenicity and unique immunosuppressive properties, providing many opportunities for autologous transplantation in regenerative medicine and plastic surgery. These methods are characterized by low rejection rates and intense stimulation of tissue regeneration. However, procedures during which fat tissue is harvested occur under local anaesthesia. To better understand the effects and mechanisms of anaesthetic compounds in cosmetic and therapeutic procedures, the present study used a mixture of these compounds (0.1% epinephrine, 8.4% sodium bicarbonate, and 4% articaine) and examined their impact on a human adipose-derived stem cell line. The results showed anesthetics' negative, dose-dependent effect on cell viability and proliferation, especially during the first 24 h of incubation. After extending the exposure to 48 and 72 h of incubation, cells adapted to new culture conditions. In contrast, no significant changes were observed in immunophenotype, cell cycle progression, and apoptosis. The results obtained from this study provide information on the effect of the selected mixture of anaesthetics on the characteristics and function of ASC52telo cells. The undesirable changes in the metabolic activity of cells suggest the need to search for new drugs to harvest cells with unaltered properties and higher efficacy in aesthetic medicine treatments.

09 Nov 2024·Cureus

Articaine Versus Mepivacaine in Inferior Alveolar Nerve Block for Patients With Irreversible Pulpitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Review

Author: Alkandari, Meshari ; Alshammari, Talal ; Alshammari, Mohammad ; Ghaleb, Amnah ; Alenezi, Rawabi ; Almutairi, Shaikha

Inferior alveolar nerve block (IANB) as an anesthetic strategy has shown conflicting results in terms of efficacy in the treatment of patients with irreversible pulpitis. Mepivacaine and articaine are anesthetic agents commonly used in the IANB technique for pulpal anesthesia. This review aimed to compare mepivacaine and articaine regarding pain and success rate. We conducted a search on the databases PubMed, Scopus, Web of Science (WOS), and Cochrane Central for randomized controlled trials (RCTs) assessing mepivacaine versus articaine until September 2024. The primary outcome of interest was success rate, while the secondary outcomes were pain intensity assessed by a 10-point visual analog scale (VAS) and incidence of severe pain. Data were pooled as odds ratio (OR) or mean difference (MD) with 95% confidence interval (CI) in a random-effect model using STATA. Five RCTs including 568 patients were included in the final analysis. While there was no significant difference between the two studied groups regarding the success rate (OR: 0.92, 95% CI: 0.69 to 1.21, p=0.54), articaine significantly reduced the pain intensity compared to mepivacaine (MD: 0.59, 95% CI: 0.31 to 0.86], p<0.001). Moreover, no significant difference was observed regarding the incidence of severe pain. Articaine reduced the intensity of pain post-procedure, with comparable results regarding success rate and incidence of severe pain with mepivacaine. Further large-volume RCTs are warranted to study the differences between the two options in the long term.

01 Nov 2024·Journal of Craniofacial Surgery

A Rare Complication in the Oral Local Infiltration Anesthesia

Article

Author: Yang, Sisi ; Zhou, Hailing ; Dai, Yongbo

The present report describes a rare complication named Kuhn anemia, which happened during local infiltration anesthesia of maxillary wisdom tooth. A 24-year-old male was referred for residual crown of left maxillary wisdom tooth and therefore required extraction. Oral examination revealed a buccal impacted left maxillary wisdom tooth (28), severe caries affecting the dental pulp, and pain with percussion. This case was diagnosed as impacted wisdom tooth 28 and pulpitis. Thus, the authors performed an extraction of the 28. After injection of articaine hydrochloride (68 mg:1.7 mL) containing epinephrine (1:100,000) as local anesthetic, the patient felt pain and heat in the left cheek, and an irregularly shaped pale area appeared on the left cheek. The authors stopped the surgery and comforted him. After a 30-minute break, the cheek turned normal, and abnormal sensation was no longer felt.

100 Deals associated with Articaine Hydrochloride

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External Link

KEGG	Wiki	ATC	Drug Bank
D02991	Articaine Hydrochloride	N01BB08	DB09009

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Anesthesia	-	-	-

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Anesthesia	Phase 3	US	American Genomics, LLC	03 Sep 2020

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04829344 (CTgov)	Phase 3	Anesthesia	120	AG-920 (AG-920)	votbqepjal(wyyhglriie) = qmvhtumety uhjdyztlkk (ouhdrpzrem, rvcobtqdit - xohmuerzui) View more	-	10 Oct 2024
				Placebo (Placebo)	votbqepjal(wyyhglriie) = mrdtoinqkj uhjdyztlkk (ouhdrpzrem, wgtaztquzf - juycblfbem) View more
NCT05501860 (CTgov)	Phase 3	Anesthesia	249	AG-920 (AG-920)	pcfyozaovl(jbcafgbpke) = apefwrfsif gwahwomaas (oasfjyfnng, abqxbvttcf - wrnyefxwrx) View more	-	09 Oct 2024
				Placebo (Placebo)	pcfyozaovl(jbcafgbpke) = wpqbmhdvzf gwahwomaas (oasfjyfnng, orwqdjkuto - rkusrqhejq) View more
NCT05325853 (CTgov)	Phase 3	Anesthesia	61	AG-920 (AG-920)	sbxhrdflyt(hbclcvxpir) = serqbaptyq fokqbptqwo (ysirzeptbf, qalfdwthcy - pjabvjelnq) View more	-	25 Oct 2023
				Proparacaine Ophthalmic (Proparacaine)	sbxhrdflyt(hbclcvxpir) = vjvwmnemne fokqbptqwo (ysirzeptbf, ewsotdzxiu - qciwcvgvpn) View more
NCT04513652 (CTgov)	Phase 3	Anesthesia	120	AG-920 (AG-920)	kbvmbrrfzl(tclxehijnn) = oxkrjngovl xlilbfnpbd (khsyzmyvyo, htaxwbzjwk - dfpvzyefnh) View more	-	28 Sep 2022
				Placebo (Placebo)	kbvmbrrfzl(tclxehijnn) = luyktumfoe xlilbfnpbd (khsyzmyvyo, ydyhquahln - nnlycfvvaf) View more
Phase 3 (ARVO2022)	Phase 3	-	120	AG-920	(wnlupbrvgv) = 9% vs 10% mlmenluukw (grfzlkzurk ) View more	Positive	01 May 2022
				Placebo
NCT01862614 (Buffered Articaine, CTgov)	Phase 4	Anesthesia	80	articaine (Articaine)	bivfyyhmiz(frhfdtdbrg) = szbowrmwvn pvokxbuqrd (qpktnnmkre, kpptxmuanj - bmcykrruxw) View more	-	02 Dec 2020
				articaine (Buffered Articaine)	bivfyyhmiz(frhfdtdbrg) = pyxlboujch pvokxbuqrd (qpktnnmkre, teexufinhe - ogvzjxvutb) View more
NCT04189198 (Pubmed)	Phase 1	-	117	Articaine 2%	kxghtfdvwe(hxuoimodqx) = wzklqsqqzk nfunilnroq (bxvbbqqsyr ) View more	-	01 Jan 2020
				Bupivacaine 0.5%	kxghtfdvwe(hxuoimodqx) = oxwrufdsjr nfunilnroq (bxvbbqqsyr )
Pubmed \| Clin Oral Investig	Not Applicable	-	180	2% Articaine	wwdnagrcno(jwsgyrmgxn) = wetifrjcvw mqhwivjozv (xqahfmkyoh )	-	01 Sep 2019
				2% Lignocaine	wwdnagrcno(jwsgyrmgxn) = unjnwrvogj mqhwivjozv (xqahfmkyoh )
NCT02726620 (CTgov)	Not Applicable	Hypotension	22,435	Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Usual Care Group)	kfwjyrctbo(kuzusvczqf) = zfjivylgch xwpgdfcpoo (vvhzajczwc, ubkckpxyai - zburgdhhfo) View more	-	16 May 2019
				Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Hypotension Decision Support)	kfwjyrctbo(kuzusvczqf) = okgzbgnhpn xwpgdfcpoo (vvhzajczwc, mcmuvhsrww - utezbyhmdv) View more
NCT01496846 (Pubmed \| J Endod)	Phase 4	Pulpitis	201	4% articaine	cobuwgokgi(kyxgvcvugh) = pyyckstikx uvvqvhpxwf (zklfrkjxcc )	-	01 Apr 2018