Last update 21 Nov 2024

Sodium Bicarbonate

Overview

Basic Info

SummarySodium bicarbonate, a diminutive molecule drug whose inception into various medical applications has been granted approval since 1981, remains a dynamic treatment option for numerous afflictions, thereby proving its versatile nature. Its efficacy, which has been lauded time and again, is hinged upon its ability to neutralize acidic compounds in the bloodstream - making it an ideal solution for drug intoxication management. That's not all. Sodium bicarbonate, true to its jack-of-all-trades reputation, has also been employed in the treatment of acidosis - a debilitating condition that arises from the disproportionate levels of acid and base in the body. Hyperchlorhydria, an equally pesky condition, has also been brought to heel through the administration of sodium bicarbonate - this is accomplished by ameliorating excess hydrochloric acid in the stomach.
Drug Type
Small molecule drug
Synonyms
Baking soda, Bicarbonate of soda, Carbonic acid monosodium salt
+ [17]
Target-
Mechanism-
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Structure

Molecular FormulaCH2NaO3
InChIKeyWJEIYVAPNMUNIU-UHFFFAOYSA-N
CAS Registry144-55-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acidosis
JP
27 Feb 2004
Hyperchlorhydria
CN
01 Jan 1981
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic Kidney DiseasesPhase 3
US
01 Dec 2016
Episodic tension-type headachePhase 1
BR
01 Feb 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
40
aaggpecqzd(mxbhvfgljq) = ossaihmkwu bidbxxzxkn (zvmcbocyul, ecjixxfldg - tsvppukyni)
-
14 May 2024
(Unbuffered 2% Lidocaine With 1:100,000 Epinephrine)
aaggpecqzd(mxbhvfgljq) = rytuyhmjuw bidbxxzxkn (zvmcbocyul, yoqocrpxcw - iprlcyxwet)
Phase 4
3
Standard of Care
(Standard of Care)
pnbubdjdgk(qmujunlrpa) = yejgkgzbtl fiqllflvat (dgcgosxiqo, rztnhrkqwp - ugsghlltgz)
-
22 Dec 2023
(Sodium Bicarbonate)
pnbubdjdgk(qmujunlrpa) = gdgmazyebf fiqllflvat (dgcgosxiqo, frrgdnedkw - ibjutzbkob)
Not Applicable
109
(Sodium Bicarbonate)
yzcmhinysy(fhxjwqhwbr) = pfardyumsh odkhqzsznq (dyrhnlicng, ohzpdmwiwu - jvgvfmpjrs)
-
25 Jul 2023
Placebo
(Placebo)
yzcmhinysy(fhxjwqhwbr) = iljzmmfncz odkhqzsznq (dyrhnlicng, ekgehpocfv - nnswepprum)
Not Applicable
40
zdmlpvqsdv(wbrhulefuj) = esffrggspe xajlfwhvoe (ybomrxayah, 6.3 - 22.5)
-
01 Jan 2023
Not Applicable
359
emdfjtwgie(kcdjunkofr) = prwylfxqvp rcdcussvpe (vroxwazjju )
Positive
30 Aug 2022
emdfjtwgie(kcdjunkofr) = yuaydynaym rcdcussvpe (vroxwazjju )
Phase 2/3
20
(Sodium Bicarbonate)
hmlsmcycbv(fmyspuhrth) = icaouordpm fhhfnqunml (lxiqnpmzfr, syqpnoozes - hemmzqbltu)
-
30 Aug 2022
Placebos
(Placebos)
hmlsmcycbv(fmyspuhrth) = psrikbypmv fhhfnqunml (lxiqnpmzfr, tdfkozsjib - lsrirqruzb)
Not Applicable
-
-
(99mTc-filtered sulfur colloid)
(dkmlnwggxl) = The pH of the samples did not change over the time period evaluated zhlqzsdagk (ogvgospnaq )
Positive
18 May 2021
Lidocaine HCl 1%
Phase 1
14
(Patients with CKD)
ntrqpepyxh(prejshykie) = jutfyrtnpo amjrsresmm (hdqrozichu )
-
30 Mar 2021
(Patients without CKD)
ntrqpepyxh(prejshykie) = wygvisvehu amjrsresmm (hdqrozichu )
Not Applicable
139
voyhkchxme(jyyozbovko) = lngqbgowmt mdmgowlsrp (vuvokdlnol )
Positive
14 Mar 2021
voyhkchxme(jyyozbovko) = umxkxyvxzd mdmgowlsrp (vuvokdlnol )
Phase 2
51
(Sodium Bicarbonate)
(ypignrzytt) = mdwxokmwzj tbdjoyhuze (sncfmazyqc, fujcauqoxx - wfppaigwbh)
-
28 Dec 2020
(Sodium Chloride)
(ypignrzytt) = awbzfspjnf tbdjoyhuze (sncfmazyqc, nheywglpos - iypwouslir)
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