Drug Type Small molecule drug |
Synonyms 4-amino-4-deoxypteroylglutamate, 4-amino-PGA, 4-aminofolic acid + [13] |
Target |
Mechanism DHFR inhibitors(Dihydrofolate reductase inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC19H20N8O5 |
InChIKeyTVZGACDUOSZQKY-LBPRGKRZSA-N |
CAS Registry54-62-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D02527 | Aminopterin | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Psoriasis | Phase 2 | US | 01 Nov 2018 | |
Rheumatoid Arthritis | Phase 2 | UA | 01 Feb 2013 | |
Recurrent Endometrial Cancer | Phase 2 | US | 01 Jan 1998 | |
Refractory Acute Leukemia | Phase 2 | US | 01 Jul 1997 | |
Refractory Leukemia | Phase 2 | US | 01 Jul 1997 |
Phase 2 | 19 | (LD-Aminopterin Oral Capsule) | lqrjebmdlm(kbcpdbhnvn) = cshazchhgj dafwlrsrqt (celyhvhxao, yoeinsnesc - axhmrnjryv) View more | - | 14 Apr 2023 | ||
Placebo oral capsule (Placebo Oral Capsule) | lqrjebmdlm(kbcpdbhnvn) = qusyxyayxe dafwlrsrqt (celyhvhxao, gwligfsrej - hyiuljhpuw) View more | ||||||
Phase 2 | 60 | Daunomycin+Cyclophosphamide+leucovorin+Hydrocortisone+6-thioguanine+aminopterin+6-mercaptopurine+dexamethasone+Vincristine+Methotrexate+Cytarabine+L-Asparaginase (Arm 2 High Risk) | uzxsswtpww(awwudjodzo) = mhphddzqzc cxfpadojjl (ojhmeobeyj, atdfzpuawu - elfwspexee) View more | - | 09 Jun 2014 | ||
Daunomycin+leucovorin+Hydrocortisone+6-mercaptopurine+dexamethasone+Methotrexate+Vincristine+Cytarabine+L-Asparaginase (Arm 1 Standard Risk) | xpsuekdbak(ffghltmrhf) = bezemhhzxp wqsjywlpgz (tvbmpcgrnj, tkrekoafuf - mqjgvzoltk) View more |