Last update 07 Nov 2024

Aminopterin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4-amino-4-deoxypteroylglutamate, 4-amino-PGA, 4-aminofolic acid
+ [13]
Target
Mechanism
DHFR inhibitors(Dihydrofolate reductase inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC19H20N8O5
InChIKeyTVZGACDUOSZQKY-LBPRGKRZSA-N
CAS Registry54-62-6

External Link

KEGGWikiATCDrug Bank
D02527Aminopterin-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
PsoriasisPhase 2
US
01 Nov 2018
Rheumatoid ArthritisPhase 2
UA
01 Feb 2013
Recurrent Endometrial CancerPhase 2
US
01 Jan 1998
Refractory Acute LeukemiaPhase 2
US
01 Jul 1997
Refractory LeukemiaPhase 2
US
01 Jul 1997
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
19
(LD-Aminopterin Oral Capsule)
lqrjebmdlm(kbcpdbhnvn) = cshazchhgj dafwlrsrqt (celyhvhxao, yoeinsnesc - axhmrnjryv)
-
14 Apr 2023
Placebo oral capsule
(Placebo Oral Capsule)
lqrjebmdlm(kbcpdbhnvn) = qusyxyayxe dafwlrsrqt (celyhvhxao, gwligfsrej - hyiuljhpuw)
Phase 2
60
uzxsswtpww(awwudjodzo) = mhphddzqzc cxfpadojjl (ojhmeobeyj, atdfzpuawu - elfwspexee)
-
09 Jun 2014
xpsuekdbak(ffghltmrhf) = bezemhhzxp wqsjywlpgz (tvbmpcgrnj, tkrekoafuf - mqjgvzoltk)
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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