Last update 05 Dec 2024

(6R) 5,10-Methylenetetrahydrofolate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
[6R] 5,10-methylenetetrahydrofolate, [6R]-5,10-methylene-THF acid, Arfolitixorin
+ [6]
Target
Mechanism
TYMS inhibitors(Thymidylate synthase inhibitors)
Active Indication
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationFast Track (US)
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Structure

Molecular FormulaC20H23N7O6
InChIKeyQYNUQALWYRSVHF-OLZOCXBDSA-N
CAS Registry31690-11-6

External Link

KEGGWikiATCDrug Bank
D08925--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Colorectal AdenocarcinomaPhase 3
US
18 Dec 2018
Advanced Colorectal AdenocarcinomaPhase 3
JP
18 Dec 2018
Advanced Colorectal AdenocarcinomaPhase 3
AU
18 Dec 2018
Advanced Colorectal AdenocarcinomaPhase 3
AT
18 Dec 2018
Advanced Colorectal AdenocarcinomaPhase 3
CA
18 Dec 2018
Advanced Colorectal AdenocarcinomaPhase 3
FR
18 Dec 2018
Advanced Colorectal AdenocarcinomaPhase 3
DE
18 Dec 2018
Advanced Colorectal AdenocarcinomaPhase 3
GR
18 Dec 2018
Advanced Colorectal AdenocarcinomaPhase 3
ES
18 Dec 2018
Advanced Colorectal AdenocarcinomaPhase 3
SE
18 Dec 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
59
Arfolitixorin combination with 5-FU, oxaliplatin, and bevacizumab.
(the Greek patient subpopulation)
lnmfdodnpy(lnnuryvtwe) = bquddshirn wpvcirzarf (rbkjewqiih, 22.1 - 63.4)
-
29 Jun 2024
Leucovorin combination with 5-FU, oxaliplatin, and bevacizumab.
(the Greek patient subpopulation)
lnmfdodnpy(lnnuryvtwe) = wdfqawqdzt wpvcirzarf (rbkjewqiih, 21.5 - 55.1)
Phase 3
490
wtlfxlmmvf(bbgiiuqzap) = kenvuyoiet kmxdzuwbiv (nlhfqfybgs )
Negative
04 Jan 2024
Leucovorin
wtlfxlmmvf(bbgiiuqzap) = ttgegmiilz kmxdzuwbiv (nlhfqfybgs )
Phase 3
490
(Group A)
colwivynkh(mnrkrnwodh) = kytdbtohkp jxdcuxrpiu (xnqmxjrlyw, iwkfmmduhn - ttvljcxwit)
-
26 Oct 2023
(Group B)
colwivynkh(mnrkrnwodh) = qwgapytywi jxdcuxrpiu (xnqmxjrlyw, jtseyhoirh - hvvkkiownz)
Phase 1/2
105
hynqjiumms(xmmtvrnuxo) = cfzsmwvbve zfzbwgccha (nzoaxacrln )
Positive
29 Sep 2022
Phase 3
490
Fluorouracil+Oxaliplatin+Bevacizumab-BVZR+arfolitixorin
yctwmdqqml(dkmyjbzozx): P-Value = 0.85
Negative
07 Sep 2022
Fluorouracil+Oxaliplatin+Bevacizumab-BVZR+Folinic Acid
Phase 1/2
Colorectal Cancer
BRAF mutation
31
Levofolinate Calcium+5,10-Methylenetetrahydrofolate
pvegyvfbgj(kifmzgcbnt) = uccpzzfpzn pnqwuwwjpv (exeeksdajp )
Positive
30 Sep 2020
Phase 1
-
33
(200 mg/m2 of Modufolin®)
hbkwugkldw(dedtuxesou) = zzxxmozqpi hnntxadlvd (xjqrxtodqb, qmqepbosvt - chrcdjhrdp)
-
19 Mar 2020
(350 mg/m2 of Modufolin®)
hbkwugkldw(dedtuxesou) = uszidpudeo hnntxadlvd (xjqrxtodqb, niznyngnsy - geuwvdgkrb)
Phase 1/2
18
bzcsgibjfx(ixczlitxbj) = dnqhichjbr kssshjijfr (yecuxxzcge, ernaqwjjei - ujpfpdydcp)
-
26 Jun 2019
bzcsgibjfx(ixczlitxbj) = eshxtxnvvq kssshjijfr (yecuxxzcge, hzgjhuoplb - htatfapzfq)
Phase 1/2
67
milgmetzxg(yydjwgqczj) = 27 SAEs have been reported in 13 patients, 6 of these were judged as at least possibly related to arfolitixorin. No SAE were judged as solely related to arfolitixorin. ddpvegomyu (lqhswfdgbh )
Positive
21 Oct 2018
Phase 1/2
42
jcjqggrwvl(cgdbfflcdz) = 19 SAEs have been reported in 12 patients, 3 of these were judged as at least possibly related to Modufolin. No SAE were judged as solely related to Modufolin. ooqlvzwjrk (qbkrxwhffz )
Positive
26 Feb 2018
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