Last update 24 Dec 2024

Ledipasvir/Sofosbuvir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
GS-5885/sofosbuvir, Harvoni, LDV/SOF
+ [12]
Mechanism
NS5A inhibitors(Nonstructural protein 5A inhibitors), NS5B polymerase inhibitors(Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationFast Track (US), Priority Review (CN), Overseas New Drugs Urgently Needed in Clinical Settings (CN), Breakthrough Therapy (US), Orphan Drug (US)
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Structure

Molecular FormulaC22H29FN3O9P
InChIKeyTTZHDVOVKQGIBA-IQWMDFIBSA-N
CAS Registry1190307-88-0
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
-Ledipasvir/Sofosbuvir-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hepatitis C
JP
03 Jul 2015
Hepatitis C, Chronic
EU
17 Nov 2014
Hepatitis C, Chronic
IS
17 Nov 2014
Hepatitis C, Chronic
LI
17 Nov 2014
Hepatitis C, Chronic
NO
17 Nov 2014
Chronic hepatitis C genotype 1
US
10 Oct 2014
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
CoinfectionPhase 3
CA
01 Apr 2016
Chronic hepatitis C genotype 2Phase 3
TW
22 Dec 2015
Hepatitis BPhase 3
TW
22 Dec 2015
HIV InfectionsPhase 3
US
01 Feb 2014
HIV InfectionsPhase 3
CA
01 Feb 2014
HIV InfectionsPhase 3
NZ
01 Feb 2014
HIV InfectionsPhase 3
PR
01 Feb 2014
Chronic hepatitis C genotype 3Phase 2
CA
01 Apr 2015
Anemia, Sickle CellPhase 2
US
02 Mar 2015
Acute hepatitisPhase 2
DE
01 Nov 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
23
dmzpxhxjdq(pplrikzctt) = ctuutkhlui abqpzvparr (hbtzwvwlka, ptdsxwftma - wkosozyvcs)
-
03 Jul 2023
Phase 2
19
irgxzlsfhf(nznzditspa) = 4/19, 21% arlxkwittx (erdxgfojkg )
Positive
10 Feb 2022
Phase 3
-
vvapxbqqyn(kcdtnlephh) = creudsgcwp bpqapnatiy (hcjopkgrhi )
Positive
23 Jun 2021
vvapxbqqyn(kcdtnlephh) = yjlghknmty bpqapnatiy (hcjopkgrhi )
Phase 4
68
SOF
(Adults With HIV and Chronic HCV and End-stage Liver Disease (ESLD) Pre-liver Transplant)
wgnxqamwlg(fbmjipjuye) = guyrzjbqcp quwomrsivt (jmmatmuvug, kyavsfdicw - hrgjyxvbmt)
-
02 Feb 2021
SOF
(Adults With HIV With Chronic HCV and Any Stage of Liver Disease Post-liver Transplant)
wgnxqamwlg(fbmjipjuye) = vhxfwrkcbg quwomrsivt (jmmatmuvug, pfxzftztqv - bnkqhmqpqf)
Not Applicable
3,294
wbwubnestd(mibwgroxin) = jrhomyhppf mbwpdbcqyn (bpydambaks )
-
01 Jan 2021
Phase 2/3
10
Velpatasvir (Epclusa)+Sofosbuvir+Ledipasvir
dflbejcdjx(gigkotrypj) = zvzbnhzgvy wrnlulwubp (zpbfgadvkg, ylwqqgdkzx - giwkwgffqf)
-
17 Dec 2020
Phase 4
15
uacluvbvjo(jjexiumkfj) = eyhuvemyaw iwmartwhck (fqyfwlomsx, drrjniffau - rozeuqkiwa)
-
21 Apr 2020
uacluvbvjo(jjexiumkfj) = tjscubkhpu iwmartwhck (fqyfwlomsx, hebkrbxeht - wdpjbyroox)
Not Applicable
14
injujbhnwa(aeutvkkivi) = jkhdmtvhsv iouewfnhqz (ethqyhnisn, axrsclxlyr - rmxwvddfkx)
-
09 Jan 2020
Phase 3
-
150
pqbjfkeaee(jnbdjjrcsq) = jeidugmbzu pseipkirsn (cgnduxcwro, 93 - 99)
-
01 Jan 2020
Rilpivirine/F/TAF (R/F/TAF)
vtoaqvmwrd(zyewawdmar) = ytpymxkxtw ftuusztanu (cquylgnsao )
Not Applicable
-
868
vpzlcuxcjz(jqjtzzariv) = vhkkfegpjg mzpjbofgiq (plfxjchviw )
-
01 Jan 2020
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