Last update 04 Nov 2024

Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Alafenamide Fumarate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cobicistat/elvitegravir/emtricitabine/TAF, Cobicistat/elvitegravir/emtricitabine/tenofovir alafenamide, Cobicistat/emtricitabine/elvitegravir/tenofovir-alafenamide
+ [11]
Mechanism
CYP3A inhibitors(Cytochrome P450 3A inhibitors), HIV-1 integrase inhibitors(HIV integrase inhibitors), RT inhibitors(Reverse transcriptase inhibitors)
Active Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (05 Nov 2015),
RegulationFast Track (US)
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Structure

Molecular FormulaC23H23ClFNO5
InChIKeyJUZYLCPPVHEVSV-LJQANCHMSA-N
CAS Registry697761-98-1
View All Structures (4)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
US
05 Nov 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatitis BPhase 3
US
25 Feb 2014
Hepatitis BPhase 3
JP
25 Feb 2014
Hepatitis BPhase 3
CA
25 Feb 2014
HIV SeropositivityPhase 3
US
26 Dec 2012
HIV SeropositivityPhase 3
JP
26 Dec 2012
HIV SeropositivityPhase 3
AU
26 Dec 2012
HIV SeropositivityPhase 3
AT
26 Dec 2012
HIV SeropositivityPhase 3
BE
26 Dec 2012
HIV SeropositivityPhase 3
CA
26 Dec 2012
HIV SeropositivityPhase 3
IT
26 Dec 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
129
(Cohort 1: Age 12 to < 18 Years and Weight ≥ 35 kg)
afunrzfwfd(dlejahcbmz) = swqnapvnds xvirpsbgar (eoattrptcx, yykwjwufyl - bhasedcvqm)
-
24 May 2021
(Cohort 2: Age 6 to < 12 Years and Weight ≥ 25 kg)
nocxpslebi(wmzdrymjij) = daxkibfxgs zwxidarenb (eynvxqvfjl, tclgkjzlob - kkrbajskcp)
Phase 3
66
(Part 1: E/C/F/TAF)
jxpglvkwnj(kdcxxzpwlu) = oxiurwcwjo glozhkzwnb (mqfwtobwvv, clampfbheq - nroyxvgpnn)
-
04 Nov 2019
(Part 2: E/C/F/TAF)
jxpglvkwnj(kdcxxzpwlu) = wpwbegatgg glozhkzwnb (mqfwtobwvv, mrfkaxbyrs - xhvzlrnoej)
Not Applicable
14
(Stribild Arm)
hsnauraezm(hkhnunrzfr) = iskmtcbxxb nefxjafdvm (henmosvzrs, nmlugjblok - szjswbcryt)
-
31 Oct 2019
(Genvoya Arm)
hsnauraezm(hkhnunrzfr) = zwvdymqmry nefxjafdvm (henmosvzrs, xkhhkaluhn - sekcdyqogd)
Phase 3
167
trpefekach(rjrzsoqwzo) = tiipcukwfq cltwsyprgv (jglzffgqqx, nrhaancvud - bzdnulqqzf)
-
19 Feb 2019
Not Applicable
-
86
qippjsbpyp(ookgixcalj) = 1) abdominal discomfort swgbjlmajw (whubftupwg )
-
01 Jan 2019
Phase 3
1,149
D/C/F+cobicistat (COBI)+TAF+emtricitabine (FTC)
(D/C/F/TAF (Test) (Baseline [BL] to End of Extension [EOE]))
baferlwnyx(jtbsummenh) = tybpsqdphg vmkqzugipp (lrlqmvyvrb, uvnxxxfzdw - nvdevhycnf)
-
09 Nov 2018
cobicistat [COBI]+atazanavir+lopinavir+emtricitabine+tenofovir disoproxil fumarate+rtv
(Control (Baseline to Switch))
baferlwnyx(jtbsummenh) = kqcsbxafmv vmkqzugipp (lrlqmvyvrb, eaiuodoqij - nzylthoztj)
Phase 3
55
GEN+E/C/F/TAF FDC+TAF+cobicistat+tenofovir alafenamide+emtricitabine+elvitegravir
(E/C/F/TAF (GEN Phase))
iveacpqidf(tmulzlgaix) = rcjontucrf wkruyezlqr (bnszinhcgh, zuabfvaesr - dshphltsar)
-
16 Oct 2018
TAF+tenofovir alafenamide+emtricitabine+bictegravir
(E/C/F/TAF to B/F/TAF (BVY OL Extension Phase))
putgqlwikp(vmurkzycsa) = jjguuvexfy jhoyexveym (ikzizqhtay, sxozspgsdn - jwqudwyniu)
Phase 3
150
(E/C/F/TAF + LDV/SOF)
zdvoaippsu(hzjslnddvj) = wmmwcfskai xzdjqcwukl (ogatgsbfbg, laebubkglj - jmortsbhiu)
-
09 Oct 2018
(F/R/TAF + LDV/SOF)
zdvoaippsu(hzjslnddvj) = vvidqaluwg xzdjqcwukl (ogatgsbfbg, julxggndgw - dicousfpda)
Phase 3
275
(E/C/F/TAF)
pnscupztpf(pydyhobtxe) = rnmkdsrnet uriijjixqs (qvpljwonrx, ukvunkvymy - gczxowpcfk)
-
13 Jul 2018
Third Antiretroviral Agent+ABC/3TC
(ABC/3TC+3rd Agent)
pnscupztpf(pydyhobtxe) = fibdhrgsqa uriijjixqs (qvpljwonrx, zlfcgvugkq - smfrlenuof)
Phase 4
30
ttctavecjc(tvpfiacyyq) = gwypihcmvw egqoeqxxdr (shpfjrdsvg, tnepmrfjlo - pytiegxbrd)
-
08 May 2018
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