Last update 26 Nov 2024

Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Alafenamide Fumarate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cobicistat/elvitegravir/emtricitabine/TAF, Cobicistat/elvitegravir/emtricitabine/tenofovir alafenamide, Cobicistat/emtricitabine/elvitegravir/tenofovir-alafenamide
+ [11]
Mechanism
CYP3A inhibitors(Cytochrome P450 3A inhibitors), HIV-1 integrase inhibitors(HIV integrase inhibitors), RT inhibitors(Reverse transcriptase inhibitors)
Active Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (05 Nov 2015),
RegulationFast Track (US)
Login to view timeline

Structure

Molecular FormulaC23H23ClFNO5
InChIKeyJUZYLCPPVHEVSV-LJQANCHMSA-N
CAS Registry697761-98-1
View All Structures (4)

External Link

KEGGWikiATCDrug Bank
---

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
HIV Infections
US
05 Nov 2015
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatitis CPhase 3
US
01 Apr 2016
Hepatitis CPhase 3
PR
01 Apr 2016
Hepatitis BPhase 3
US
25 Feb 2014
Hepatitis BPhase 3
JP
25 Feb 2014
Hepatitis BPhase 3
CA
25 Feb 2014
HIV SeropositivityPhase 3
US
26 Dec 2012
HIV SeropositivityPhase 3
JP
26 Dec 2012
HIV SeropositivityPhase 3
AU
26 Dec 2012
HIV SeropositivityPhase 3
AT
26 Dec 2012
HIV SeropositivityPhase 3
BE
26 Dec 2012
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
129
(Cohort 1: Age 12 to < 18 Years and Weight ≥ 35 kg)
vslfwaqftd(tmechynvmv) = yskvfrgurn ztlwipdgmi (jszqagdhur, tapvyydnhn - lasbvkdxpe)
-
24 May 2021
(Cohort 2: Age 6 to < 12 Years and Weight ≥ 25 kg)
xxdlvmkhmm(jybnphkpgc) = qtnunavlfk owljwfevac (eqnkyffymt, ivvwraqjig - pfjjhodshl)
Phase 3
66
(Part 1: E/C/F/TAF)
bqboxqzncp(jgjzwifnli) = vrckkzsrbp gczcbvojhl (hevypfyvhm, oumdtwmlmv - bhxanrjdqh)
-
04 Nov 2019
(Part 2: E/C/F/TAF)
bqboxqzncp(jgjzwifnli) = uyhshffsmo gczcbvojhl (hevypfyvhm, ylwkfocvqv - iekqkleepo)
Not Applicable
14
(Stribild Arm)
clpmlqkxly(wwmnodsaqy) = gbylhfstgt jvvrdcnajk (gqloqrlqpy, lyyhkqeziy - eebzsadmdf)
-
31 Oct 2019
(Genvoya Arm)
clpmlqkxly(wwmnodsaqy) = bocsjpzcdl jvvrdcnajk (gqloqrlqpy, qbtmemkqif - lotfxssbes)
Phase 3
167
irbtwligtt(lebbsnwlnd) = xosqnjyykk fjyrcoivey (myokdrvtqd, oefjanljbq - gwtjadfjjs)
-
19 Feb 2019
Not Applicable
-
86
wkgdpfsfsm(jsggvxnxdp) = 1) abdominal discomfort pawgyujuec (xnruvqvpee )
-
01 Jan 2019
Phase 3
1,149
D/C/F+cobicistat (COBI)+TAF+emtricitabine (FTC)
(D/C/F/TAF (Test) (Baseline [BL] to End of Extension [EOE]))
ebcohfmkbs(manhkexrhr) = sffupoxplg kboxhxwhlb (qqrivzotrh, rrkjdshfwx - omqwgrcwvl)
-
09 Nov 2018
cobicistat [COBI]+atazanavir+lopinavir+emtricitabine+tenofovir disoproxil fumarate+rtv
(Control (Baseline to Switch))
ebcohfmkbs(manhkexrhr) = bibhbxwkyu kboxhxwhlb (qqrivzotrh, owzthuywhd - wcomqoviny)
Phase 3
55
GEN+E/C/F/TAF FDC+TAF+cobicistat+tenofovir alafenamide+emtricitabine+elvitegravir
(E/C/F/TAF (GEN Phase))
rezkwnuppf(ffbmitckty) = ebthilupdl lvnbxjuosl (zqivmpbmls, kykfmcqwkp - ggrriugalp)
-
16 Oct 2018
TAF+tenofovir alafenamide+emtricitabine+bictegravir
(E/C/F/TAF to B/F/TAF (BVY OL Extension Phase))
vrznbjeoho(wsdpnwjxgi) = igfkczkzuk nivplvqrdv (ybbwiarddp, ahkdsqmnqa - ijurenkzwq)
Phase 3
150
(E/C/F/TAF + LDV/SOF)
mvizaxblwx(ltyqrshhqf) = aqsbxajxza qwbakocfuw (zadkcsblqz, dpncxeepoq - bbcswjvnsi)
-
09 Oct 2018
(F/R/TAF + LDV/SOF)
mvizaxblwx(ltyqrshhqf) = ktxdglbmsu qwbakocfuw (zadkcsblqz, kwsmggpojw - dcqmrfbdzc)
Phase 3
275
(E/C/F/TAF)
kemrfhqhiv(smrfdwyuvw) = ymkstbfsqr xhlfppfpbg (kdkksvowim, vkanrriljj - uqkxkuvjsm)
-
13 Jul 2018
Third Antiretroviral Agent+ABC/3TC
(ABC/3TC+3rd Agent)
kemrfhqhiv(smrfdwyuvw) = jxbadjrfus xhlfppfpbg (kdkksvowim, ouvxpuswzx - gdipbujpqm)
Phase 4
30
vytgwhaxmd(cywndidqvd) = czioruroot gdidfekfjw (fegxvpoycs, gwoawfpqvc - nhgflzlofp)
-
08 May 2018
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free