The aim for this pilot study is to test the hypothesis that pre-dosing with gel-forming dietary fibres (methylcellulose or psyllium) will alter the colonic fermentation of a model fermentable dietary fibre (Inulin) when delivered separately, in contrast to our previous trials where gel-forming and fermentable dietary fibres were co-administered. Performance of each gel-forming dietary fibre will be compared to placebo (water) to assess treatment effectiveness.

Start Date01 Oct 2024

Sponsor / Collaborator

The University of Nottingham

[+1]

NCT06738329

/ RecruitingNot Applicable

Investigating the Impact of the Seaweed Derived Food Additive, Carrageenan, on the Human Gut Microbiome

The goal of this study is to investigate whether a seaweed derived food additive, carrageenan, has an impact on the human gut microbiome in vivo. The primary purpose is to assess whether consumption of a carrageenan containing product for 4 weeks can alter the bacterial composition of the gut microbiome in healthy individuals and whether the addition of a prebiotic fibre, inulin, to the product has an enhanced beneficial impact of the gut composition. The main questions to answer are:
Does the consumption of a confectionary item containing carrageenan and inulin lead to a positive impact on the faecal microbial community when compared to the confectionary item containing no carrageenan and no inulin (placebo)? Participants will be asked to consume 2 gummy sweets for 4 week period and provide stool and urine samples on 3 occasions over a 9 week period.
Does the consumption of a confectionary item containing carrageenan and inulin improve gastrointestinal comfort measured using overall SHS-GI score when compared to baseline measurements recorded during run in period?

Start Date01 Oct 2024

Sponsor / Collaborator

The University of Reading

NCT06528041

/ RecruitingNot ApplicableIIT

Effect of Native Chicory Inulin Supplementation on Rates of Microbial Change Between Individuals

The main aim of this study is to investigate differences in rate, extent of change and persistence of the gut microbiota in healthy adult volunteers in response to native chicory inulin. Along with investigating the impact of native chicory on bowl habits, mood and appetite. The two main questions this study aims to answer:
* To what extent do differences exist in rate of change over time between individuals in gut microbiota response (Bifidobacterium growth) to native chicory inulin supplementation.
* To what extent do differences exist between individuals in persistence of the gut microbiota upon stopping supplementation.
The effects of native chicory inulin on gut microbiota response will be compared to a maltodextrin placebo to sure changes in gut microbiota result directly from chicory inulin supplementation.
Participants will firstly complete a one-week run-in phase to establish baseline data and will then be allocated to either native chicory inulin or maltodextrin supplementation for 6 weeks. Inulin will be delivered at 12 g/day split into 2 x 6g portions. Maltodextrin will be calorie matched at 6 g/day split into 2 x 3g portions. This will then be followed by a 6 week post-supplementation phase. Fecal and blood samples will be collected regularly throughout all phases for analysis of gut microbiota and compounds of interest. Participants will also record any changes in gastrointestinal sensation, bowel habits and mood in a diary. Changes in appetite sensation will also measured.

Start Date01 Aug 2024

Sponsor / Collaborator

Purdue University

100 Clinical Results associated with Inulin

100 Translational Medicine associated with Inulin

100 Patents (Medical) associated with Inulin

3,500

Literatures (Medical) associated with Inulin

01 Apr 2025·Food Microbiology

Assessment of the ability of Lactococcus lactis 537 to bind aflatoxin M1 in the presence of inulin and Terminalia ferdinandiana (Kakadu plum)

Article

Author: Almutairi, Batlah ; Fletcher, Mary T ; Dong, Anran ; Turner, Mark S ; Sultanbawa, Yasmina ; Hong, Hung Trieu

One promising method for the detoxification of Aflatoxin M1 (AFM1) involves the use of probiotic bacteria combined with prebiotics. This approach is both safe and cost-effective, while also offering additional health benefits. The objective of this study was to investigate the capacity of Lactococcus lactis 537 (Lc. Lactis 537) to bind AFM1 in milk and phosphate-buffered saline (PBS), either in the presence or absence of inulin or Kakadu plum fruit powder (KP), which are prebiotic substances. Lc. Lactis 537 was incubated for 0, 1, 2, and 24 h at 30 °C, with or without inulin or KP, to assess its ability to bind and reduce AFM1 levels. The concentration of AFM1 was determined using liquid chromatography-mass spectrometry (LC-MS9) during the different incubation periods. The results demonstrated that Lc. Lactis 537 significantly reduced the initial concentration of AFM1 in both milk and PBS after 24 h of incubation. Moreover, the presence of inulin or KP enhanced the binding and reduction capacity of Lc. Lactis 537. This suggests that the synbiotic effect where probiotic bacteria like Lc. Lactis work in synergy with prebiotics such as inulin or KP could play a critical role in the removal of AFM1 from contaminated substances. In conclusion, the synbiotic of Lc. Lactis 537 with inulin or KP represents a promising biological approach for AFM1 detoxification, and further research is warranted to explore its potential applications in food safety.

01 Mar 2025·International Journal of Biological Macromolecules

Oral colon-retentive inulin gels protect against radiation-induced hematopoietic and gastrointestinal injury by improving gut homeostasis

Article

Author: Xie, Hua ; Fang, Yubao ; Yuan, Bochuan ; Zhuang, Bo ; Yuan, Tianyu ; Sun, Yingbao ; Jin, Yiguang ; Yan, Wenrui ; Wei, Meng ; Liu, Dongdong

Ionizing radiation-induced injury often occurs in nuclear accidents or large-dose radiotherapy, leading to acute radiation syndromes characterized by hematopoietic and gastrointestinal injuries even to death. However, current radioprotective drugs are only used in hospitals with unavoidable side effects. Here, we heated the aqueous solution of inulin, a polysaccharide dietary fiber, forming colon-retentive gel as a radiation protector in radiotherapy. Mouse models were established after ⁶⁰Co γ-ray irradiation of the total body or abdomen. Inulin gels were orally administered to the mice every day from 3 days pre-radiation to 3 days post-radiation. The hematopoietic system was well protected with good blood cell recovery and cell proliferation in the femur and spleen. Oral inulin gels increased the relative abundances of key commensal microorganisms including f_Lachnospiraceae, Akkermansia, Blautia, and short-chain fatty acid metabolites. The secretion of the anti-inflammation cytokines IL-22 and IL-10 in the intestinal cells also increased. Similarly, the expression of the tight junction proteins claudin-1 and occludin in the gut mucosa was affected. In an orthotopic murine colorectal cancer model, oral inulin gels followed by 10-Gy abdomen radiation improved the radiotherapy efficiency with low attenuated radiation injury. Taken the data together, these results suggest that oral inulin gels are a bioactive material against ionizing radiation-induced injury.

01 Mar 2025·Nutrition

Mucin gene expression in the large intestine of young pigs: The effect of dietary level of two types of chicory inulin

Article

Author: Tuśnio, Anna ; Konopka, Adrianna ; Skomiał, Jacek ; Gawin, Kamil ; Święch, Ewa ; Barszcz, Marcin ; Taciak, Marcin

OBJECTIVESInulin is a plant polysaccharide that may affect the gut barrier depending on its degree of polymerization (DP). Therefore, this study aimed to determine the effect of dietary level of two inulin types differing in DP on mucin content and MUC gene expression in the colon mucosa of pigs.METHODSThe 40-d experiment involved 56 piglets divided into seven groups fed a diet with 0%, 1%, 2%, or 3% inulin with DP of 10 or 23. Mucin content was measured fluorometrically, gene expression was determined by quantitative polymerase chain reaction, and data were analyzed by one-way analysis of variance and three-way analysis of variance.RESULTSIn the proximal colon, mucin content was decreased by the diet with 1% inulin with DP of 23 (IN23), whereas in the middle colon mucin content was decreased by the other IN23 diets. The diet with 3% inulin with DP of 10 upregulated MUC2 and MUC12 in the proximal colon and MUC2 and MUC13 in the middle colon. In the proximal colon, all IN23 diets increased MUC2 expression, whereas the 2% and 3% IN23 diets upregulated MUC1 and MUC12. In the middle colon, MUC2 was increased by the 1% and 2% IN23 diets, MUC4 by the 1% diet, and MUC13 by the 3% diet. In the distal colon, the 3% IN23 diet upregulated MUC1, whereas all IN23 diets downregulated MUC2, MUC4, and MUC12. With the exception of MU13 and MUC20, the expression of MUC genes was the highest in the proximal colon.CONCLUSIONSInulin, particularly with higher DP, may exert a beneficial effect on the colon mucosa by modulation of MUC gene expression.

News (Medical) associated with Inulin

28 May 2024

·www.sciencedaily.com

Weight gain is kicked to the curb in antipsychotic drug breakthrough

Thousands of Australians struggle with serious mental health conditions. But when the recommended treatment involves antipsychotic medications, the side effects are excess kilos, which only adds weight to an already complex diagnosis. Now, new research shows that antipsychotics can be reformulated with a strategically engineered coating that not only mitigates unwanted weight gain but also boosts serotonin levels by more than 250%. Thousands of Australians struggle with serious mental health conditions. But when the recommended treatment involves antipsychotic medications, the side effects are excess kilos, which only adds weight to an already complex diagnosis. Now, world first research from the University of South Australia shows that antipsychotics can be reformulated with a strategically engineered coating that not only mitigates unwanted weight gain but also boosts serotonin levels by more than 250%. Funded by the Hospital Research Foundation (THRF) Group, researchers specifically tested Lurasidone, a drug used in the treatment of schizophrenia and bipolar depression, finding that the new coatings target the gut microbiome to improve drug absorption by 8-fold, while concurrently overcoming common side effects such as weight gain. The coatings are created from tiny core-shell particles made from the dietary fibre, inulin, and bioactive medium chain triglycerides. The inulin shell boosts the gut microbiome by providing an energy source for gut bacteria, while the medium chain triglycerides facilitate drug absorption into the bloodstream. It's a breakthrough discovery that has the potential to change the lives of millions of people worldwide. Lead researcher UniSA's Dr Paul Joyce says microbiota-targeting microcapsules have the potential to improve treatment outcomes of mental health medications. "Most patients suffering from schizophrenia or bipolar disorder are prescribed a range of antipsychotic medications, which trigger significant adverse effects by disrupting the gut microbiome -- the microbial ecosystem that naturally colonises the gut," Dr Joyce says. "The most notable side effect is weight gain, with many patients often seeing increases of between 10-15% of their body weight after just three months of treatment. "Because the gut microbiome plays a major role in regulating overall health, especially mood and cognition, the detrimental impact of these medications on the microbiome often makes them counterproductive. "Instead of improving mood and cognition, the medication leads to a cascading cycle of poor mental and metabolic health as patients now struggle with excess weight and mental health issues. "To make matters worse, most antipsychotics need to be consumed with food to maximise their effect. Yet for a very vulnerable patient population, ensuring this happens is challenging, with most patients gaining suboptimal drug levels. "Clearly, new strategies are needed to eliminate side effects and the need for these medications to be taken with food -- and that's exactly what we've achieved with the drug Lurasidone. "This research shows that when antipsychotic drugs are formulated with our new smart core-shell microparticles, drug absorption increases, mitigating the need for the medication to be consumed with food, while also boosting the diversity and abundance of the gut microbiome to overcome common side effects, such as weight gain. "Importantly, because we are not developing new drugs, rather reformulating them, the new therapies can be fast-tracked for clinical use, so we could expect them within the next few years rather than the 10-15 years needed for new drug molecules to be approved by regulatory bodies." Next steps are to test the efficacy of these re-formulated therapies within human patients, with longer term goals being to extend these technologies across all mental health therapies, including anti-depressants, to mitigate any adverse effects.

Microbial therapy

08 Apr 2024

·www.prnewswire.com

Premium Jane Introduces Innovative Keto Product Line to Enhance Ketogenic Diet Experience

SCOTTSDALE, Ariz., April 8, 2024 /PRNewswire/ -- Premium Jane, a household name in the health supplements industry for nearly a decade, has unveiled a line of new products that are designed to complement and accelerate the benefits of a ketogenic diet. The "keto" diet, known for its emphasis on low-carb/high-fat calorie intake, has surged in popularity recently for its ability to help rapidly shed pounds, increase energy levels, and sharpen mental focus and acuity. After years of researching how to optimize this diet, Premium Jane has developed a range of products that are engineered to speed up the results of keto, as well as maintain the effects of the ketogenic state. The cornerstone of Premium Jane's new Keto line is a once-a-day fiber supplement formulated with inulin and chicory root - two crucial (but often overlooked) components of the ketogenic diet. Inulin is a type of soluble plant fiber that bypasses much of the digestive system until it reaches the colon. There, it serves as a prebiotic fiber and nourishes beneficial bacteria (such as Bifidobacteria and Lactobacilli) in the gut. By stimulating the growth of beneficial bacteria, inulin helps maintain a healthy balance of gut microflora. This is essential for balanced digestion, immune function, mental sharpness, and a whole lot more. Another key function of the product is its potential to help slow down emptying of the stomach, thereby enhancing feelings of fullness and boosting weight loss efforts. "We are beyond thrilled to unveil our new Keto product line," says Premium Jane CEO Jeff Yauck. "The ketogenic state isn't just a trend; we, along with research experts across the world, believe it really is the future of health and weight loss." In addition to the inulin fiber supplement, Premium Jane has also released a line of dietary capsules containing 7-keto DHEA - a naturally occurring metabolite of dehydroepiandrosterone (DHEA). 7-keto DHEA has been studied for its potential to enhance metabolic rate and support fat loss, making it an ideal complement to a ketogenic lifestyle. Additionally, Premium Jane is offering Keto BHB gummies, which contain a unique blend of calcium, magnesium, and sodium beta-hydroxybutyrate (BHB). Research is showing BHB to have profound effects on mental clarity, sustained energy, and accelerated fat burning. To place an order or to learn more about the new Keto product range from Premium Jane, visit the company's official website at . Contact: Premium Jane [email protected] SOURCE Premium Jane

08 Mar 2024

·www.prnewswire.com

Burt's Bees® Showcases Clinical Efficacy of Aloe and Prebiotic Containing Products in Addressing Common Skin Concerns

Clinical studies presented at the 2024 American Academy of Dermatology Annual Meeting demonstrate how nature-based products support the microbiome in compromised skin, while improving barrier function and hydration DURHAM, N.C., March 8, 2024 /PRNewswire/ -- Burt's Bees, the #1 dermatologist recommended natural skin care brand* and a pioneer in naturally-derived lip and skin care solutions, announced its latest research findings on the benefits of nature-based products to maintain and protect skin health and hydration. The studies will be presented at the American Academy of Dermatology (AAD) Annual Meeting from March 8-12, 2024. The latest research findings from Burt's Bees highlight: The efficacy of an aloe-containing moisturizer in improving skin barrier function and hydration in sensitive skin populations The impact of a moisturizer containing aloe and rice milk in supporting the skin microbiome for those with atopic dermatitis and rosacea The tolerability of a topical formulation in populations with mild to moderate acne "Whether our aim is to improve barrier function, boost hydration or support the microbiome, we focus on bringing the best solutions nature has to offer to consumers as we have done for more than 40 years," said Hemali Gunt, Ph.D., head of clinical and scientific affairs at Burt's Bees. "Burt's Bees has a deep understanding of both facial and lip skin, which is at the foundation of our research and development efforts as we continue to pioneer the use of new ingredients and innovations in the natural skin care space." New Burt's Bees data that will be presented at AAD 2024 includes: The effectiveness of aloe vera and rice extract-containing moisturizing cream in improving and maintaining barrier function and hydration in xerotic skin; Gunt H., Levy S.; Online Poster About the Research: A nature-based moisturizing cream containing aloe and rice extract was studied in 32 female participants with moderately dry skin The study evaluated the effectiveness of the moisturizing cream in improving skin hydration and barrier function/transepidermal water loss When compared to baseline, results demonstrated a significant improvement in moisturization and skin barrier function in individuals with dry and sensitive skin A multi-functional moisturizer containing aloe vera and rice extract maintains a diverse and balanced facial skin microbiome in sensitive skin; Gunt H., Ahmad N. and Sivamani R.; Online Poster About the Research: A baseline-controlled study evaluating the effectiveness of a moisturizing cream containing aloe vera and rice extract was conducted in 42 female participants over six weeks Participants had either atopic dermatitis or rosacea with visible redness Results showed that the nature-based moisturizer significantly increased skin hydration while supporting the skin microbiome without disrupting the skin barrier Daily use of prebiotic-containing topical formulation balances and restores skin microbiome in subjects with mild to moderate acne; Gunt H., Levy S., and Sivamani R.; March 8, 2024, poster presentation from 2:20-2:25 p.m. PST in the Sails Pavilion, Poster Center 1 About the Research: A six-week baseline-controlled study evaluated the efficacy and tolerability of a topical formulation containing prebiotics in participants with mild to moderate acne Investigator and participant-assessed tolerability demonstrated that the product was well tolerated while changes in the appearance of acne and skin microbiome were consistent with improvement in overall skin condition of those with mild to moderate acne "The skin microbiome is fundamental to supporting a healthy skin barrier. Barrier dysfunction in individuals with acne-prone skin results in alterations and imbalances in the microbiome, leading to inflammation and breakouts," said Stanley Levy, M.D., a board-certified dermatologist in Chapel Hill, North Carolina and study consultant. "This research demonstrates that a topical nature-based gel cream containing inulin, an effective prebiotic, can assist in supporting a balanced microbiome in patients with mild to moderate acne and replenish moisture content without provoking breakouts." Burt's Bees will also highlight naturally-derived products containing aloe, shea and coconut on-site at AAD, booth location #3217, where attendees can learn more about the brand's nature-based product research and core product offerings, including forthcoming research in the lip health space. To learn more about the proven power of Burt' Bees nature-based products, visit for our clinical data and resources. About Burt's Bees | is the #1 dermatologist recommended natural skin care brand, born in the woods of Maine, and known for its original Beeswax Lip Balm. Burt's Bees products are consciously made with ingredients from nature to nourish skin from head to toe. From responsible sourcing to mindful packaging and landfill-free operations, Burt's Bees is made with care by nature, for nature, for all—since 1984. NYSE: CLX-B. *Based on a November 2023 NielsenIQ national survey of U.S. Dermatologists SOURCE Burt's Bees

Clinical Result

100 Deals associated with Inulin

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KEGG	Wiki	ATC	Drug Bank
D00171	Inulin	V04CH01	DB00638

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Diagnostic agents	JP	Fuji Yakuhin Co., Ltd.	11 Oct 2005

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04118010 (CTgov)	Phase 4	Cystic Fibrosis	40	Vitamin D3+inulin (Vitamin D3 and Inulin)	hwgvddbwlx(zgragubtzd) = pdwffxbqei vyuyvzcdnt (kdpekugcot, eewaecngab - tszllmkkwk) View more	-	07 Feb 2024
				Placebo Inulin+Vitamin D3 (Vitamin D3 and Placebo Inulin)	hwgvddbwlx(zgragubtzd) = oqcdtbrqmi vyuyvzcdnt (kdpekugcot, covxlnlecz - ojyagirxsp) View more
UEGW2023	Not Applicable	-	-	Inulin	ssnofyrazv(wvkrumpher) = gioxoaczed nqfnwwbkax (dbmvigtkol ) View more	-	15 Oct 2023
				INULIN (Placebo)	ssnofyrazv(wvkrumpher) = sbxswnqzsa nqfnwwbkax (dbmvigtkol ) View more
DDW2023	Not Applicable	-	-	inulin (LPS)	gydhciscad(ootzqmvkik) = omhfbawwsm bkxitppfvz (womqetcqfm )	-	07 May 2023
				Inulin	gydhciscad(ootzqmvkik) = evavjqdyfp bkxitppfvz (womqetcqfm )
NCT02794766 (CTgov)	Phase 2	Tongue Diseases \| Stomatodysodia	45	Placebo	ggpeeiqtlk(lfnhuztror) = ajgbskntry qcpfnvnsce (dhewnpkemu, ufvnxubwlp - bhkrudwsxd) View more	-	19 Aug 2020
ASN2015	Not Applicable	Hypomagnesemia Maintenance TRPM6 (rs3750425 and rs2274924)	133	Inulin supplementation	yvfosifflm(qebgijzkbt) = tbyygdmgbq xewzdnvwxo (yxbunawmgy ) View more	Positive	03 Nov 2015
				Inulin (Healthy non-PPI users)	xgbswmewwg(pmqcrdzjgc) = wvqjxvahsi zqnraeklrz (huezckriqo )
UEGW2015	Not Applicable	Irritable bowel syndrome with constipation	-	Functional food jelly containing inulin, curcumin and pyridoxine	(edazpkvagq) = jqjatnfury eqolaxcesg (fzfrtptpbx ) View more	-	01 Oct 2015
				functional food product containing inulin and curcumin (Standard diet)	(edazpkvagq) = leorcxnqgw eqolaxcesg (fzfrtptpbx ) View more
NCT00335504 (CTgov)	Phase 2	Rectal Cancer \| Colonic Cancer \| Precancerous Conditions	85	laboratory biomarker analysis+atorvastatin calcium (Arm I (Atorvastatin Calcium))	xhbitvoicf(dkpregdzvc) = gfizhjldbx fiuitqbrlz (gpzodprcjr, mimwynxvkx - gesqcohbrt) View more	-	08 Feb 2013
				laboratory biomarker analysis+sulindac (Arm II (Sulindac))	xhbitvoicf(dkpregdzvc) = arsntegvhl fiuitqbrlz (gpzodprcjr, bpkhuoabrv - dtvbsqbeob) View more

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