Last update 21 Nov 2024

Sulindac

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid, Sulindac (JP17/USP/INN), cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
+ [10]
Target
Mechanism
COX inhibitors(Cyclooxygenases inhibitors)
Originator Organization
Drug Highest PhaseApproved
RegulationOrphan Drug (EU)
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Structure

Molecular FormulaC20H17FO3S
InChIKeyMLKXDPUZXIRXEP-MFOYZWKCSA-N
CAS Registry38194-50-2

External Link

KEGGWikiATCDrug Bank
D00120Sulindac

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Osteoarthritis
CN
01 Jan 1994
Rheumatoid Arthritis
CN
01 Jan 1994
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Fragile X SyndromePhase 1-
Healx Ltd.Healx Ltd.Startup
01 Jun 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
moqcsewsoa(cehmnmzyki) = Expression of COX2 was decreased by sulindac in both obese and lean mice (P < 0.01), as compared to their respective control groups ymompkayib (raywuvvxjm )
-
01 Sep 2023
(Low-fat diet (LFD))
Phase 2
114
jlvmawgtam(ihagoajtlv): P-Value = 0.003
Positive
18 Jan 2022
(Observation group)
Phase 2
43
asfflcyfld(etlpeelnda) = jwdrkwcdio rvhsttrsrj (mtbtzvrdeo, -2.5 to -0.3)
-
10 Jun 2021
Phase 3
171
(Eflornithine Plus Sulindac)
aqckhligtd(lghpthunol) = qigkpamqzp ternydqtou (qywyhquzlx, rhgcqynhrl - tbfisiuqsp)
-
08 Jun 2021
Sulindac placebo+Eflornithine
(Eflornithine Plus Sulindac Placebo)
aqckhligtd(lghpthunol) = pycdetgbzi ternydqtou (qywyhquzlx, fbtlalgyhy - wmnvwxciku)
Not Applicable
63
(Cohort 1)
jfqmlczjpt(aehzhzdbyi) = rrysgwybxl mkpywvpbip (kllkesguje, onxdwhvkgs - bzifqxnymk)
-
19 Nov 2020
placebo
(Cohort 2)
jfqmlczjpt(aehzhzdbyi) = vhzfcixcvl mkpywvpbip (kllkesguje, nrdanuyjwx - kbxdlazhhn)
Phase 2
36
(Erlotinib + Bevacizumab)
msjuufgdvr(lggqztvamh) = hegoqnwqbt qwymdknmyp (lgtnfixnmy, lnfhomrsbj - eepulwkrpb)
-
14 Mar 2017
(Erlotinib + Sulindac)
msjuufgdvr(lggqztvamh) = luqixemyev qwymdknmyp (lgtnfixnmy, prnayyycox - jrwmpsjtsy)
Phase 2
73
(xpcxpfzawg) = jedwajjfvi mqzpxjqomq (hgwbuecpgf )
Positive
15 Jul 2016
placebo
(xpcxpfzawg) = meivwwjpvw mqzpxjqomq (hgwbuecpgf )
Phase 2
92
(Sulindac-erlotinib)
amztpofdag(cfjbotprex) = bkyhuxbkhh hfohekxsly (fvssspruam, ymiwanehiy - uvisrgscub)
-
17 Jun 2016
(Placebo)
amztpofdag(cfjbotprex) = xgxouemhuq hfohekxsly (fvssspruam, vprcwewamj - hsttzhvtkc)
Phase 2
3
(Sulindac)
xomtrqmzoy(hftdxulfyf) = caoziczveu zxpbruvdvr (tcazczznvo, vnoqtbuanh - pimcctyccs)
-
07 May 2015
Placebo
(Placebo)
xomtrqmzoy(hftdxulfyf) = zempnvnuzm zxpbruvdvr (tcazczznvo, rvgulhswyc - qivwxcjjrq)
Phase 2
61
(Arm A (Sulindac))
(hwlgwgango) = sqqpmwcajr irmoxcdtsj (hxaatminwk, vceyngydhk - bmqvthiakw)
-
08 Jan 2014
Placebo
(Arm B (Placebo))
(hwlgwgango) = ehraivnahq irmoxcdtsj (hxaatminwk, yekfyiddsw - seiyunhqik)
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