Delving into the Latest Updates on Propofol/Ketamine Hydrochloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Ketofol

Target

GABAA receptor x NMDA receptor

Mechanism

GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists), NMDA receptor agonists(Glutamate [NMDA] receptor agonists)

Therapeutic Areas-

Active Indication-

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure

Molecular FormulaC12H18O

InChIKeyOLBCVFGFOZPWHH-UHFFFAOYSA-N

CAS Registry2078-54-8

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OBJECTIVETo compare the efficacy of dexmedetomidine versus ketofol for moderate sedation in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP).STUDY DESIGNRandomised controlled trial. Place and Duration of the Study: Department of Anaesthesia, SICU and Pain Management, Sindh Institute of Urology and Transplantation, Karachi, Paksitan, from December 2021 to June 2022.METHODOLOGYSixty-two patients aged 20-60 years of any gender scheduled for elective ERCP were included. Patients were randomly divided into Dexmedetomidine group (2ml ampule of 100ug/ml diluted in 18ml of normal saline) and Ketofol group (2ml ketamine and 10ml of propofol 1% diluted in 8ml of normal saline) for sedation. The mean difference in time to achieve Ramsay Sedation Scale (RSS) score of 4 and Modified Aldrete's Score (MAS) of 9 were noted as outcomes in each group. In addition, complications during the procedure and recovery were also noted.RESULTSThe mean age was 39.15 ± 9.82 years. There were 33 (53.2%) males and 29 (46.8%) females. The mean time to achieve RSS 4 was significantly lower in patients who were treated with Dexmedetomidine as compared to Ketofol, i.e., 11.84 ± 1.77 minutes vs. 13.10 ± 1.64 minutes respectively (p-value 0.005, 95% CI -2.12 to -0.39). Similarly, the mean time to achieve MAS score 9 was significantly lower in patients who were treated with Dexmedetomidine as compared to Ketofol, i.e., 11.19 ± 1.72 minutes vs. 12.23 ± 1.84 minutes, respectively (p-value 0.026, 95% CI -1.94 to -0.13).CONCLUSIONDexmedetomidine proved to be more effective than Ketofol for sedation in ERCP, achieving faster sedation and quicker recovery.KEY WORDSDexmedetomidine, Ketofol, Sedation, Endoscopic Retrograde Cholangiopancreatography.

01 Sep 2024·Journal of the College of Physicians and Surgeons Pakistan

Postoperative Outcomes of the Awake Colorectal Surgery with Neuraxial Anaesthesia

Article

Author: Er, Sadettin ; Ceylan, Cengiz ; Yalniz, Yasemin ; Ocakli, Serhat ; Erkilic, Ezgi ; Ozcan, Ayca Tuba Dumanli

OBJECTIVETo determine the outcome of awake surgery with combined spinal epidural in geriatric colon cancer patients with advanced comorbidity.STUDY DESIGNQuasi-experimental study. Place and Duration of the Study: Department of Anaesthesiology and Reanimation, Ankara Bilkent City Hospital, Ankara, Turkiye, from April 2022 to 2023.METHODOLOGYTwenty-four American Society of Anaesthesiologists (ASA) I-II patients, aged 25-65 years and scheduled for colon cancer surgery were included in this research. All patients were observed preoperatively, at the operation room and at the postoperative surgery service. Spinal anaesthesia was planned for Group I and general anaesthesia for Group II. Ketofol (1:1) was administered to the combined spinal-epidural group, with a Ramsay sedation score of 3 after the spinal block. Epidural analgesia was planned for all patients. Patients' age, gender, weight, comorbidities, ASA risk scores, intraoperative haemodynamic parameters, bleeding amounts, colloid, crystalloid, and blood products were collected.RESULTSThere was no significant difference between the demographic characteristics of both anaesthesia groups (p >0.05). The amount of bleeding was statistically lower in Group I than in the general anaesthesia group (p = 0.004). Oral intake, drain withdrawal, mobilisation, discharge times, and costs were similar in all groups (p >0.05).CONCLUSIONThe regional anaesthesia applications facilitate compliance with routine mobilisation, discharge procedures and prevent complications in abdominal surgery and its positive perioperative effects in patients with poor respiratory parameters, poor general condition, and high comorbidity in advanced age.KEY WORDSRegional anaesthesia, Spinal-epidural, Mobilisation, Pain, Colon cancer.

100 Deals associated with Propofol/Ketamine Hydrochloride

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R&D Status

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02863861 (Pubmed \| Braz J Anesthesiol)	Phase 4	Sedation	120	Propofol-Ketamine	hixyryxxmj(ygtzrpnqwb) = cixgsetlsa pviixnjavi (izpqpyhtry ) View more	-	05 Dec 2020
				Dexmedetomidine-KetamineDexmedetomidine-Ketamine	hixyryxxmj(ygtzrpnqwb) = xxsboogtwh pviixnjavi (izpqpyhtry ) View more
NCT02643979 (CTgov)	Phase 4	Sleep Apnea Syndromes \| Obesity	22	Propofol+Saline (Propofol Only)	gljtpahjrx(uuthztlwgq) = zkplvhqduv gomvasmbic (beqlcgrtzu, dtutilswpv - ucuazwaycr) View more	-	28 Jan 2020
				ketofol+Propofol (Ketofol and Propofol)	clouoqdohs(hejqkqyqpq) = sjnnfitdxg zrrfbuqqic (jrshbphgpf, ebuyznyiya - twtsccxkwx) View more
NCT02105415 (KEEP PACE, CTgov)	Phase 2/3	Critical Illness	160	Etomidate (Etomidate)	erhltwqalm(ulfpzatfbn) = oigycybosd ctpefxueft (bhfjdvjrtg, mymjdftyxl - crxzgueiic) View more	-	11 Jan 2019
				Ketamine / Propofol Admixture (Ketamine / Propofol Admixture)	erhltwqalm(ulfpzatfbn) = wnrhskgwrp ctpefxueft (bhfjdvjrtg, ttocguajxk - fpdldbhnnf) View more
NCT02848963 (Pubmed \| J Anesth)	Phase 4	-	75	1:5 ketofol mixture	gcmzovphmy(ozfrwoqsex) = qxahpbvvxg cmvhhhgfon (tmnvbglotm, 308.1 - 434.48) View more	-	01 Feb 2018
				1:6.7 ketofol mixture	gcmzovphmy(ozfrwoqsex) = apveqfgfik cmvhhhgfon (tmnvbglotm, 292.2 - 394.3) View more
POKER Study (Pubmed \| Ann Emerg Med)	Not Applicable	Sedation \| Analgesia	-	Ketofol	(zeabqopyhs) = vuxjgierdc owaoosmqhd (nhjllfklko ) View more	-	01 Nov 2016
				Propofol	(zeabqopyhs) = ucoodggchp owaoosmqhd (nhjllfklko ) View more
NCT01260662 (CTgov)	Phase 4	Sedation	271	Propofol (Propofol)	pdrtxuoukb(ihykuhgfzl) = ocpsrmmtly ehfaknqfdl (ubmlejnzhm, rcbzhnicss - mzohigsoxz) View more	-	29 Apr 2015
				1:1 Propofol/Ketamine (1:1 Propofol/Ketamine)	pdrtxuoukb(ihykuhgfzl) = xmeqirrwma ehfaknqfdl (ubmlejnzhm, xutpvzpddy - jbcfhvgcuf) View more
Pubmed	Not Applicable	-	222	Methohexital/remifentanil	(mhpkxtacmr) = ejiaxjccmp ddnudxmzmy (dngczklvtc )	Positive	01 Jun 2014
				Midazolam/fentanyl	(mhpkxtacmr) = wtdmziarrv ddnudxmzmy (dngczklvtc )
NCT01211158 (Pubmed \| Acad Emerg Med)	Phase 3	Sedation \| Analgesia	219	Ketofol	fdfignlimq(phdsxqvgzo) = aklyrhzpne yezlhfwffl (sqmfawfmya ) View more	-	01 Feb 2010
NCT01211158 (Pubmed \| Ann Emerg Med)	Phase 3	Sedation	284	Ketofol	xzcxkesfui(gwhmfmlwbp) = 4 patients (3.5%; 95% CI 1.0% to 8.7%) required adjunctive medication for sedation otojzzqfha (islowpsnbl ) View more	Positive	01 Jan 2007