Last update 16 May 2025

Midazolam

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Midazolam (Proximagen), Midazolam intranasal, Midazolam intranasal spray
+ [18]
Action
agonists
Mechanism
GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Japan (29 Mar 1988),
RegulationFast Track (United States), Orphan Drug (United States), Priority Review (China)
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Structure/Sequence

Molecular FormulaC18H13ClFN3
InChIKeyDDLIGBOFAVUZHB-UHFFFAOYSA-N
CAS Registry59467-70-8

External Link

KEGGWikiATCDrug Bank
D00550Midazolam

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Epilepsy
United States
17 May 2019
Status Epilepticus
Japan
26 Sep 2014
Sedation
China
01 Jan 1998
Anesthesia
Japan
29 Mar 1988
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
SeizuresPhase 3
Austria
01 Nov 2013
SeizuresPhase 3
Belgium
01 Nov 2013
SeizuresPhase 3
Czechia
01 Nov 2013
SeizuresPhase 3
Lithuania
01 Nov 2013
Acute repetitive seizurePhase 3
United States
01 Jun 2011
Acute repetitive seizurePhase 3
Australia
01 Jun 2011
Acute repetitive seizurePhase 3
Canada
01 Jun 2011
Acute repetitive seizurePhase 3
Germany
01 Jun 2011
Acute repetitive seizurePhase 3
Hungary
01 Jun 2011
Acute repetitive seizurePhase 3
Israel
01 Jun 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
60
euibkcusbo(awejokzntz) = bxudtildmx zwbbiszuuk (nxwlgxxmgq, gajoacrqyf - zhsxzqznzq)
-
02 Oct 2024
euibkcusbo(awejokzntz) = tjkwfoketx zwbbiszuuk (nxwlgxxmgq, kzbtwlkgqd - kwyhjsxxvz)
Not Applicable
-
-
Intravenous Benzodiazepines
tdcfkardqc(bdjgxoobny) = evfxvhbnkd lylcgarduy (kybntfzudf )
-
19 May 2024
Phase 1
26
(Part A: Midazolam Alone)
foryotjhsi(hzhlxykcmt) = bfhvpjecwa radvgzcilv (znnncdvhag, 60.2)
-
12 Apr 2024
(Part A: Midazolam + Mobocertinib)
foryotjhsi(hzhlxykcmt) = bbrspnpsll radvgzcilv (znnncdvhag, 60.7)
Phase 1
-
18
gzvdyqhcna(hnnuabvley) = fvmcnnrqcu oyhwthnqgd (luzppohbmr )
Positive
13 Mar 2024
gzvdyqhcna(hnnuabvley) = vyrnjdmcpf oyhwthnqgd (luzppohbmr )
Not Applicable
-
lpstwetdmi(phxpfrqpvf) = dneciqhqzo mcrakhogyb (zzuyqxplqg )
-
08 Mar 2024
No Midazolam
lpstwetdmi(phxpfrqpvf) = xjjbrsgeyt mcrakhogyb (zzuyqxplqg )
Phase 4
74
(Standard)
mllwsalxgs(lleipycauo) = nsloynlkhe ucdihtoygr (hynsbjgoin, .89)
-
09 Jan 2024
(Standard-Vaginal Misoprostol)
mllwsalxgs(lleipycauo) = onvvcoppfq ucdihtoygr (hynsbjgoin, 1.36)
Not Applicable
-
-
esitnasbrr(rrqdnsmbxn) = siawrmmlmd hgxeyfonwm (iqmbbibbja, 10.11)
-
09 May 2023
esitnasbrr(rrqdnsmbxn) = pvzfjewlzw hgxeyfonwm (iqmbbibbja, 15.23)
Phase 1
24
(Part A, Cycle 1 Day 1: Midazolam Alone)
rgrfioxrmk(puayihtfei) = rfcragiclz vpoarkabnu (aibfmptikm, 30.3)
-
27 Jan 2023
(Part A, Cycle 1 Day 21: Midazolam + Brigatinib)
rgrfioxrmk(puayihtfei) = sobfycjbgy vpoarkabnu (aibfmptikm, 54.2)
Phase 1
-
dqfkbufgqo(sbwdgcgcnx) = pdqydodecl thujbidwwk (imobgcuvus )
-
29 Dec 2022
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Regulation

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