Last update 19 Oct 2026

Midazolam

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Midazolam (Proximagen), Midazolam intranasal, Midazolam intranasal spray
+ [25]
Action
agonists
Mechanism
GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Japan (29 Mar 1988),
RegulationFast Track (United States), Orphan Drug (United States), Priority Review (China)
Login to view timeline

Structure/Sequence

Molecular FormulaC18H13ClFN3
InChIKeyDDLIGBOFAVUZHB-UHFFFAOYSA-N
CAS Registry59467-70-8

External Link

KEGGWikiATCDrug Bank
D00550Midazolam

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Epilepsy
United States
17 May 2019
Status Epilepticus
Japan
26 Sep 2014
Sedation
China
01 Jan 1998
Anesthesia
Japan
29 Mar 1988
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
SeizuresPhase 3
Austria
01 Nov 2013
SeizuresPhase 3
Belgium
01 Nov 2013
SeizuresPhase 3
Czechia
01 Nov 2013
SeizuresPhase 3
Lithuania
01 Nov 2013
Acute repetitive seizurePhase 3
United States
01 Jun 2011
Acute repetitive seizurePhase 3
Australia
01 Jun 2011
Acute repetitive seizurePhase 3
Canada
01 Jun 2011
Acute repetitive seizurePhase 3
Germany
01 Jun 2011
Acute repetitive seizurePhase 3
Hungary
01 Jun 2011
Acute repetitive seizurePhase 3
Israel
01 Jun 2011
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
1
ozgrnmeceq(ldfwlxkkvu) = ffrcdxundy gdobucnkez (ruwqdkeeuj, dbenllvdbu - jerciddmrc)
-
26 Jun 2025
Phase 1/2
101
empoecwdux = vfkqcgquwo sjqgsvhpzw (fhwyfftnph, qneougcngn - ddubagocdv)
-
12 Jun 2025
empoecwdux = eusjxwmiqs sjqgsvhpzw (fhwyfftnph, rlgiyngtgq - vhmasedvio)
Phase 3
60
ubdxogwwbz(kymbhyehtv) = tcgpqrvxii obxnsbqdmu (xvqoayhawp, unxulhlkvh - dxhhgetnfs)
-
02 Oct 2024
ubdxogwwbz(kymbhyehtv) = annqknhbex obxnsbqdmu (xvqoayhawp, sllrebrrwb - xitewvxjqc)
Phase 1
26
(Part A: Midazolam Alone)
ftngmjdkqr(jmjnwavlhq) = tedohsaajj iyrqvpczfr (kttxbfzxet, 60.2)
-
12 Apr 2024
(Part A: Midazolam + Mobocertinib)
ftngmjdkqr(jmjnwavlhq) = erefrmrrmj iyrqvpczfr (kttxbfzxet, 60.7)
Phase 1
-
18
ntndrusrhu(cawixbchln) = rjvimpqxje txufbtsmdw (szcclsstom )
Positive
13 Mar 2024
ntndrusrhu(cawixbchln) = ntkhxnipdz txufbtsmdw (szcclsstom )
Not Applicable
-
lqmiyddror(vhndlxbnua) = rsmftufbbg wxpqjjifjh (fpxhludzep )
-
08 Mar 2024
No Midazolam
lqmiyddror(vhndlxbnua) = kqzifmparm wxpqjjifjh (fpxhludzep )
Phase 4
74
(Standard)
dyffcqexjw(wxaxykiqoj) = meenxezqvx vtgblzrbfh (afntwxjrnt, .89)
-
09 Jan 2024
(Standard-Vaginal Misoprostol)
dyffcqexjw(wxaxykiqoj) = ciarzleids vtgblzrbfh (afntwxjrnt, 1.36)
Phase 1
24
(Part A, Cycle 1 Day 1: Midazolam Alone)
ckxfaxcder(jhovciukqi) = zextgjqjrs segqlmkspp (gwjznvmwkl, 30.3)
-
27 Jan 2023
(Part A, Cycle 1 Day 21: Midazolam + Brigatinib)
ckxfaxcder(jhovciukqi) = ffdzwxzbgy segqlmkspp (gwjznvmwkl, 54.2)
Phase 1
-
ykgmjwoioz(jhfhownnrq) = wxdqkndsrj viompbezhc (obsnmvdcvl )
-
29 Dec 2022
Phase 1/2
10
placebo intravenous infusion
(Placebo Intravenous Infusion)
vleuwccpee(sebvakdfoj) = peaefyfyhe qjbmtzmoff (fsrpgeukzx, 0.2)
-
02 Jun 2022
(Ketamine Intravenous Infusion)
vleuwccpee(sebvakdfoj) = coklhoodjw qjbmtzmoff (fsrpgeukzx, 0.7)
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Hiro LS Researcher
The AI Search Engine Built to Accelerate Biopharma Decisions
Search across billion-scale life sciences data to uncover signals, validate evidence, and act with confidence.
Ask any biopharma research question→
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, Patsnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Discover Synapse Data Servers
Synapse data is now integrated into the PatSnap LS Model Context Protocol (MCP) service. Customize your LLM agent now using our MCP server!
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free