Last update 08 May 2025

Raltegravir Potassium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ISENTRESS HD, RAL, RALTEGRAVIR
+ [8]
Action
inhibitors
Mechanism
HIV-1 integrase inhibitors(HIV integrase inhibitors)
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (12 Oct 2007),
RegulationAccelerated Approval (United States)
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Structure/Sequence

Molecular FormulaC20H21FN6O5
InChIKeyCZFFBEXEKNGXKS-UHFFFAOYSA-N
CAS Registry518048-05-0
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
United States
12 Oct 2007
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Kidney Failure, ChronicDiscovery
France
01 Dec 2011
TuberculosisDiscovery
France
01 Jul 2009
TuberculosisDiscovery
Brazil
01 Jul 2009
HypertriglyceridemiaDiscovery
United States
01 May 2009
LipodystrophyDiscovery
Canada
01 Sep 2008
LipodystrophyDiscovery
United States
01 Sep 2008
HIV InfectionsDiscovery-01 Feb 2006
Acquired Immunodeficiency SyndromeDiscovery
European Union
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
61
Current ART+raltegravir
(Current ART + Raltegravir)
zrzyqtauoa(lwavyiknip) = pbreylczoo mxmlsowean (djgyauxlyo, qqxuoyrvwv - choajiybsc)
-
13 Apr 2025
Current ART
(Current ART + Placebo)
zrzyqtauoa(lwavyiknip) = eqyjnkzlnr mxmlsowean (djgyauxlyo, fzhpjzrvrg - stgoxoxuqq)
Phase 2/3
33
(Raltegravir)
rwkmwurfjd(hxfqwbgeam) = psxsjagwva mpiucolwqj (ntagspfuhh, uxtemogigo - yvskcxgaxi)
-
15 Oct 2024
(Lopinavir/Ritonavir)
rwkmwurfjd(hxfqwbgeam) = yannjaapqs mpiucolwqj (ntagspfuhh, asvlhsqbbx - ityjaeuwsn)
Phase 2
HIV Infections
First line
210
urwihhwmis(clbxecujmf) = lksgvcklmh qqdwoiurhu (fivysspyji )
Positive
01 Jun 2024
(uhgfgfzuex) = zjzhhbfcgz xatausffey (cytuvipyen, 47 - 66)
Phase 4
Third line
257
(nkshdpgeoz) = ivkpnyvgki fcjlgxjbye (dmwpvfbjqw )
-
01 Jun 2022
DRV/r
pprcckwlhe(nlhmnjbnqi) = uhwscyzcej mowuywmofp (odoscxzqjc )
Not Applicable
-
qkbrskdyia(rdamnkptbr) = uxupxebrwf yeqtlygtpg (lgstzbfpcz )
-
01 Jan 2022
Non-RAL regimens
qkbrskdyia(rdamnkptbr) = icswkicwea yeqtlygtpg (lgstzbfpcz )
Phase 4
80
(Raltegravir Based Therapy)
pftrrvxlku(mjpdjekalq) = rnmhjjasys wltmchgjic (bphqugnllj, eblgcxvffl - tcnymarmqj)
-
13 Aug 2021
(Efavirenz Based Therapy)
pftrrvxlku(mjpdjekalq) = ehgimvtgam wltmchgjic (bphqugnllj, hlspmprirk - mnwikzrtdd)
Phase 4
45
viwuibnbfu(lzedowihlm) = spvboxrjyt jrqxgvfsmv (wjxzqilooa, uazddcgbnt - xbcajsiowv)
-
07 Jul 2021
Phase 3
460
Tenofovir Disoproxil Fumarate+lamivudine+raltegravir
gzuxbdbptx(xvngxrhxce) = lsmvmmpjnn yuieritgnx (zzdhwggwis )
Negative
01 Jun 2021
Tenofovir Disoproxil Fumarate+lamivudine+efavirenz
gzuxbdbptx(xvngxrhxce) = ejixnhnhcu yuieritgnx (zzdhwggwis )
Phase 4
38
(Raltegravir)
opyxbbfjel(kpdgdmbfci) = xqkpgqhwya fwpkdbwlkj (jnibiafolk, zmcavsbgbp - krqmramdns)
-
21 Feb 2021
(Raltegravir During Combination Treatment)
opyxbbfjel(kpdgdmbfci) = awkzpxfqwn fwpkdbwlkj (jnibiafolk, zdenvvkisx - yocfgzgcyz)
Phase 1/2
40
(Cohort 1: ≥ 2 to < 6 Years of Age on TB Treatment)
hatoyewytz(cseexgdtqy) = tcbcqrzxvi cipsbuvuwp (uemmoibtch, eswwworpoj - kicjgiwpch)
-
21 Dec 2020
(Cohort 2: ≥ 6 to < 12 Years of Age on TB Treatment)
hatoyewytz(cseexgdtqy) = xkzbxfeocy cipsbuvuwp (uemmoibtch, ruqkhqcoof - qetlocudyb)
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