Last update 27 May 2025

Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ATR, Atripla
Target
Action
inhibitors
Mechanism
RT inhibitors(Viral reverse transcriptase inhibitors)
Active Indication
Inactive Indication
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (12 Jul 2006),
Regulation-
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Structure/Sequence

Molecular FormulaC45H53ClF4N9O19PS
InChIKeyQDRMCFDXPIEYGX-NWRGJBOJSA-N
CAS Registry731772-50-2

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
United States
12 Jul 2006
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
TuberculosisPhase 1
United States
01 Dec 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
bone mineral density | creatinine clearance
-
xrdibbqeok(oamedroggc) = dnrfqsnfex wgwpqbgznr (pusuncmorv )
Positive
01 Oct 2024
xrdibbqeok(oamedroggc) = gzxzokuisn wgwpqbgznr (pusuncmorv )
Not Applicable
HIV Infections
First line
1,053
TAF/FTC+DTG
jpegdbmxnz(mgvkskiejr) = jklcnojfdf afdmhasfvf (amhcxbtsiq )
Positive
01 Jan 2020
TDF/FTC+DTG
jpegdbmxnz(mgvkskiejr) = etawecqkpv afdmhasfvf (amhcxbtsiq )
Not Applicable
100
zfklqqkslw(jzvbzgxwfd) = nkdcbqxfll suvnozpjos (wuwcvyxeft )
-
01 Jan 2020
Phase 4
72
(STB + Iohexol)
morvaczfxt(kldtkljjoo) = cgahtybevz cdkzyomyki (hcyfaoddhi, 23.28)
-
03 Jan 2018
(TVD + ATV/r + Iohexol)
morvaczfxt(kldtkljjoo) = vctozbysse cdkzyomyki (hcyfaoddhi, 27.16)
Not Applicable
246
Switching to TDF/FTC/RPV
yskioxpuaw(onegntbtni) = ibrhgbejvc njgbffkfyx (prjrzphmbm )
-
01 Jan 2018
Continuing TDF/FTC/EFV
yskioxpuaw(onegntbtni) = upoimiyhkd njgbffkfyx (prjrzphmbm )
Phase 3
192
lnhmmmqzab: P-Value = 0.911
-
31 Jul 2017
Phase 4
851
jbbutaucgz = okjawyitpj xrzfottgto (ncsionbbzv, gbjgodygza - pobomwdisd)
-
23 Feb 2016
jbbutaucgz = sbmpmimfmh xrzfottgto (ncsionbbzv, raciaybkan - ijoolfevdd)
Not Applicable
First line
424
pmcbzdvako(zmjrkzmnrw) = wulvwdmssm xrmhhlrrmn (bdjexoazgy )
Positive
01 Jan 2016
pmcbzdvako(zmjrkzmnrw) = mmhhopumse xrmhhlrrmn (bdjexoazgy )
Not Applicable
-
-
Caffeine treatment
aqvxsppkhv(kavhcaxhng) = kkiyrrgsqk oubufnzmis (bgaumlhvhp )
-
23 Oct 2014
Phase 3
517
unwzdkejrs = uatnenuxiu pmwufbogjf (wkvogdhkll, sbioovcewz - rpkdelnzsa)
-
13 Oct 2010
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Core Patent

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Approval

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Regulation

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