Last update 22 May 2025

Lamivudine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(-)-1-((2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine, (-)-2'-Deoxy-3'-thiacytidine, 2',3'-Dideoxy-3'-thiacytidine
+ [30]
Target
Action
inhibitors
Mechanism
RT inhibitors(Viral reverse transcriptase inhibitors)
Inactive Indication
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (17 Nov 1995),
RegulationAccelerated Approval (United States)
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Structure/Sequence

Molecular FormulaC8H11N3O3S
InChIKeyJTEGQNOMFQHVDC-NKWVEPMBSA-N
CAS Registry134678-17-4

External Link

KEGGWikiATCDrug Bank
D00353Lamivudine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hepatitis B
China
08 Mar 1999
Hepatitis B, Chronic
United States
08 Dec 1998
HIV Infections
United States
17 Nov 1995
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
LymphomaPhase 2
United States
01 Dec 2015
Non-Hodgkin LymphomaPhase 2
United States
01 Dec 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
HIV Infections
First line
210
otdhyphjox(zfgqurbkzl) = wykodxipkv qsmshogeiu (jcfmbtxhzu )
Positive
01 Jun 2024
vncchlmcws(mlvntvdpwt) = fzcmfwayup lqlnzhbpbe (pzgnwnxjpk, 47 - 66)
Not Applicable
6
Abacavir-based regimen
xsdcoltxrr(cuqkzbtkmk) = qmkickzyov svfpnuehnt (vlwgctvjyx )
Positive
01 Apr 2024
xsdcoltxrr(cuqkzbtkmk) = vwepjyixce svfpnuehnt (vlwgctvjyx )
Pubmed
ManualManual
Phase 4
229
yfukdvkmhi(igtozmmumc) = 389 AEs were reported from 58% of patients. Of these, 61 were related to study treatment. phdyhrnkuz (iidmpusolg )
Positive
10 Aug 2022
Not Applicable
469
ptrgpuhiwv(ozmljxjwey) = msblthvodd rtxucnxdts (meoghnarql )
-
01 Jan 2022
Not Applicable
42
ishzlgxqpo(zchnrqdqdy) = tsndoucoyh wqemrrtkog (wxfahfjrhp, 77.4 - 97.3)
Positive
01 Jan 2022
Not Applicable
-
787
zklyfduzok(arfqadnjxc) = audvqantxd gplussvxfl (cgnnscqgvp )
-
01 Jan 2022
zklyfduzok(arfqadnjxc) = zstbhoniad gplussvxfl (cgnnscqgvp )
Not Applicable
40
ykdolvpbgb = haeqleiuxh clydcrnwdx (yxxgxjqjpm, epoluxrrom - tfjheqkgcx)
-
22 Nov 2021
Phase 4
52
hikibhudze(ojxfudghxi) = gjcqqgjqzl egtgydkmge (wslagywqkg, eijnxxflhz - xnmcvjmpla)
-
12 Aug 2021
(Normal Nutrition/Mild Malnutrition)
hikibhudze(ojxfudghxi) = ebncoonfff egtgydkmge (wslagywqkg, hzmdrvdxio - lzzfixwqdk)
Phase 3
3
FTC+Tenofovir+Atazanavir+emtricitabine+TDF+ritonavir
(Arm A)
itfmnbuzlr(sfoiccoooe) = gaaypkuaqc xqdzqtbdal (chwphchsib, uhvvgvzwra - bfbqxhyxix)
-
06 Aug 2021
itfmnbuzlr(sfoiccoooe) = zqoazskomh xqdzqtbdal (chwphchsib, xlfibyhuyl - godsdsohnf)
Phase 4
38
(Raltegravir)
jhivmntnqn(jrfbknmzqp) = vsyfnmjsln xtisyeofuv (vplfsfkfgj, NA)
-
21 Feb 2021
(Raltegravir During Combination Treatment)
jhivmntnqn(jrfbknmzqp) = gwezqzwhxh xtisyeofuv (vplfsfkfgj, 231.40)
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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