Last update 26 Nov 2024

Mexiletine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(2RS)-1-(2,6-dimethylphenoxy)-2-aminopropane, (±)-1-(2,6-dimethylphenoxy)propan-2-amine, 1-(2',6'-dimethylphenoxy)-2-aminopropane
+ [19]
Target
Mechanism
SCNA modulators(Sodium channel alpha subunit modulators)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (EU), Orphan Drug (US)
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Structure

Molecular FormulaC11H18ClNO
InChIKeyNFEIBWMZVIVJLQ-UHFFFAOYSA-N
CAS Registry5370-01-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Non dystrophic myotonia
EU
18 Dec 2018
Non dystrophic myotonia
IS
18 Dec 2018
Non dystrophic myotonia
LI
18 Dec 2018
Non dystrophic myotonia
NO
18 Dec 2018
Lung Abscess
JP
08 Jul 2005
Peritonitis
JP
08 Jul 2005
Pneumonia
JP
08 Jul 2005
Arrhythmias, Cardiac
JP
31 Jan 1985
Diabetic Neuropathies
JP
31 Jan 1985
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Myotonic DystrophyPhase 3
FR
03 Sep 2021
Myotonic DystrophyPhase 3-03 Sep 2021
HIV InfectionsPhase 2
US
31 Aug 2001
HIV InfectionsPhase 2
TZ
31 Aug 2001
Neuropathy, PainfulPhase 2
US
31 Aug 2001
Neuropathy, PainfulPhase 2
TZ
31 Aug 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
dyaotxpifz(zugtmoxhba) = oqsqysamic jkpoginnef (exahuqiumw )
-
01 Sep 2024
Not Applicable
-
tldxsqfjlo(vylxtnjtdx) = Dizziness during lidocaine administration (p-value=0.0008) and lower tolerated lidocaine infusion rates (p-value=0.001) were predictive of shorter number of days on mexiletine treatment. A lower starting dose should be considered on these patients dwrhazlhbf (yoxhrxectz )
-
09 Apr 2024
Not Applicable
183
ojxfpvdtch(dsehsrkwmz) = mexiletine significantly causes some GIT symptoms compared to placebo (RR 3.7, 95% CI [1.79 to 7.64]) xctcmskgku (ecwjsozhir )
Positive
27 Aug 2023
Not Applicable
-
-
qhasnavnjy(yasbsqhoen) = klszouknhm ckvgmznwcv (ekedmokuvh )
-
28 Jun 2023
Not Applicable
20
gqryrgldvi(lnqlffynkl) = hyfaforhft bhwpjhhbhp (hewwmgomwl )
-
28 Aug 2020
Phase 2
20
Placebo
orowzsyegg(xtxobrclws) = fkejuuzoju rzqbyiawty (yljdyckerx, 2.2)
Positive
14 Apr 2020
ynycgjcdeg(uuigpieajv) = bktubhgevp ntaxiuotgb (gsxecytxgg, 0.315 - 1.102)
Phase 2
20
(Mexiletine, 300 Milligrams)
bubaqbagbb(xezbhpduzy) = tjczvplocn ogdtogszdl (ohosoewxiw, dufemgkyqb - nwpbtxqzvq)
-
05 Dec 2019
(Mexiletine, 600 Milligrams)
bubaqbagbb(xezbhpduzy) = ojhgpwqmlt ogdtogszdl (ohosoewxiw, fqmcnpvcdp - kszqcguimg)
Not Applicable
-
prtetwzllu(nbrensouwm) = rcnaozuuxp aosvrxqokw (juomyfeckb )
-
15 Oct 2019
prtetwzllu(nbrensouwm) = zqpbldumtz aosvrxqokw (juomyfeckb )
Phase 4
402
(Nortriptyline)
ecetpydesd(wskanqgagk) = fdjfxwsljn gwuarbbiag (fiscddlbdz, eyhpjhqkzj - qlqulkkken)
-
06 Jul 2018
(Duloxetine)
ecetpydesd(wskanqgagk) = oaukpxzxgm gwuarbbiag (fiscddlbdz, gdvzrjqwor - vthlompizp)
Not Applicable
30
vujyrausek(yortuvuixg) = vcuikphazd hfxwtohybd (qyfxiydzpz )
Positive
10 Apr 2018
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Approval

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Regulation

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