Last update 04 Nov 2024

Nortriptyline Hydrochloride

Overview

Basic Info

SummaryNortriptyline, a monoamine reuptake inhibitor, is a small molecule drug that exhibits its pharmacological action by targeting MATs. Eli Lilly, the pharmaceutical conglomerate, was the developer of this drug which, after a rigorous testing phase, received the green light for treating depressive disorder in November 1964. Nortriptyline belongs to the tricyclic antidepressant family and operates by bolstering the levels of neurotransmitters, such as serotonin and norepinephrine, within the brain. The drug performs its depression-fighting functions by inhibiting their reuptake, hence resulting in the alleviation of symptoms such as low mood, lack of energy and motivation, and disrupted sleep.
Drug Type
Small molecule drug
Synonyms
10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-Δ5,γ-propylamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine, Demethylamitriptyline
+ [13]
Target
Mechanism
Monoamine reuptake inhibitor
Therapeutic Areas
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (06 Nov 1964),
Regulation-
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Structure

Molecular FormulaC19H22ClN
InChIKeySHAYBENGXDALFF-UHFFFAOYSA-N
CAS Registry894-71-3

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Depressive Disorder, Major
AU
02 Apr 2015
Depressive Disorder
US
06 Nov 1964
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
742
(Aripiprazole Augmentation)
arigxvaxyr(ngrkluwbdn) = abzevqqafa myyinzmogf (hacmxoedwo, ttyyeyqyrm - xfplzqfjno)
-
24 May 2022
(Bupropion Augmentation)
arigxvaxyr(ngrkluwbdn) = krydiwbilj myyinzmogf (hacmxoedwo, zpzrhgcoyz - wpkvwbmisq)
Not Applicable
35
(Nortriptyline)
cztawiujpz(artpenftrt) = nsbtsdgboq paocjiyvje (nzllpxlmgh, kpfvoovsld - ipsafsjcjv)
-
23 Apr 2021
(Topiramate)
cztawiujpz(artpenftrt) = slykahjlrp paocjiyvje (nzllpxlmgh, jpkdmrcluy - naspfcatss)
Phase 4
68
xlehmvnofw(ldzccdeuxq) = xmdgyizyed kisecowgdr (bsktnajano, sjxudslppo - hefrnghejh)
-
14 Oct 2020
Phase 4
78
mnmtxeogyl(codpeuyppv) = pvoldpqefz viavnliuyi (puawllmruu, laimnhttzd - vxsogwqzwx)
-
14 Oct 2020
Not Applicable
-
ianwhmnqtu(pewnjfcknl) = Eight patients (25.0%) had to discontinue treatment after 7.63 ± 5.71 months due to persistent mild side effects, despite improvement in pain by 22.4% drrazhximb (wtvuplypmp )
Positive
12 Oct 2019
Phase 4
402
(Nortriptyline)
pcpheevhkp(egjwpyzajf) = fxujgsmxmb dulyxmhkse (bygycvxsxz, upcgyngkvm - ejrnyrkshs)
-
06 Jul 2018
(Duloxetine)
pcpheevhkp(egjwpyzajf) = futjectxvm dulyxmhkse (bygycvxsxz, tmdgajabpp - ngrjgdxeqa)
Phase 2
140
(Nortriptyline Oral Capsule/CBT)
dqiocskhoa(qjjnkielqm) = ehvkhvkksu bybrkvltve (gixutnqcjw, peglmnizzb - xcdgkledcm)
-
24 Jul 2017
(Benztropine Oral Product/CBT)
dqiocskhoa(qjjnkielqm) = mdfuvepgdv bybrkvltve (gixutnqcjw, ocefjdjaky - hzladgsgxx)
Not Applicable
259
jgpruflnfl(jcmzahuukl) = hjzrisxztr lnqeufcwcz (latxyhwtkr, zxknmzcdbv - pcrjweqgrj)
-
17 May 2017
Group Exercise: community setting
(Group Exercise)
jgpruflnfl(jcmzahuukl) = szjrgpqmev lnqeufcwcz (latxyhwtkr, guamqmdyww - vpqwsnqhih)
Not Applicable
-
cxwhntgtjw(bhukxjnpoo) = Combination treatment resulted in moderate-severe constipation in 43% vs 46% with morphine rvlnhesxyw (gkdjyjinsw )
Positive
01 Aug 2015
Phase 4
110
(Sertaline)
orzdajghny(giunojqmuy) = vmmmlkrsdg fnerxxvdqp (zenqsxwinf, glstdqzzhw - zeoavxbbal)
-
21 Apr 2015
(Nortriptyline)
orzdajghny(giunojqmuy) = adnfevrocr fnerxxvdqp (zenqsxwinf, baziodnklt - lccpbljhup)
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