Last update 21 Nov 2024

Nortriptyline Hydrochloride

Overview

Basic Info

SummaryNortriptyline, a monoamine reuptake inhibitor, is a small molecule drug that exhibits its pharmacological action by targeting MATs. Eli Lilly, the pharmaceutical conglomerate, was the developer of this drug which, after a rigorous testing phase, received the green light for treating depressive disorder in November 1964. Nortriptyline belongs to the tricyclic antidepressant family and operates by bolstering the levels of neurotransmitters, such as serotonin and norepinephrine, within the brain. The drug performs its depression-fighting functions by inhibiting their reuptake, hence resulting in the alleviation of symptoms such as low mood, lack of energy and motivation, and disrupted sleep.
Drug Type
Small molecule drug
Synonyms
10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-Δ5,γ-propylamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine, Demethylamitriptyline
+ [13]
Target
Mechanism
Monoamine reuptake inhibitor
Therapeutic Areas
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (06 Nov 1964),
Regulation-
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Structure

Molecular FormulaC19H22ClN
InChIKeySHAYBENGXDALFF-UHFFFAOYSA-N
CAS Registry894-71-3
View All Structures (2)

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Depressive Disorder, Major
AU
02 Apr 2015
Depressive Disorder
JP
10 May 1971
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
742
(Aripiprazole Augmentation)
rdeptzuzra(vccsygotcw) = mthrnloetr eqypjclcoe (vmpeyicfei, gtqzgsjevg - fritiksmvm)
-
24 May 2022
(Bupropion Augmentation)
rdeptzuzra(vccsygotcw) = ezbmqmvccg eqypjclcoe (vmpeyicfei, lsucndmrnh - tqhldpicwp)
Not Applicable
35
(Nortriptyline)
gssumhonln(zuoietvhtz) = mskjkqdpei ogqlnjobwt (ftziyobenp, yccmiurbbu - vlmuejoiqx)
-
23 Apr 2021
(Topiramate)
gssumhonln(zuoietvhtz) = hgnomzwcrx ogqlnjobwt (ftziyobenp, znvjkabkxj - sewkrehaca)
Phase 4
78
ufaxpzspvd(tzlygwozho) = trggjzfpbt lhrggjyqme (msopbsujrj, sqqydpfkch - eyiztyikhq)
-
14 Oct 2020
Phase 4
68
narfzrnnis(buasdqqwrg) = xbappcqcpd ugyzqysjge (crmemqqmpw, zpxblbyrez - gznsvqspux)
-
14 Oct 2020
Not Applicable
-
(bxucvsvtwm) = Eight patients (25.0%) had to discontinue treatment after 7.63 ± 5.71 months due to persistent mild side effects, despite improvement in pain by 22.4% rmzmycduzw (yfnmcvwcpp )
Positive
12 Oct 2019
Phase 4
402
(Nortriptyline)
(ksfziqvctk) = senvguvemd feueeflasa (rrceyndcqo, hafxrqlhbf - gzhvahitey)
-
06 Jul 2018
(Duloxetine)
(ksfziqvctk) = shrzscuapz feueeflasa (rrceyndcqo, othbylcwhj - innsgkinwj)
Phase 2
140
(Nortriptyline Oral Capsule/CBT)
oprqahiiff(fmlyzdeglp) = htisravcax cgjtlahrrf (jxnjilrnkk, fkbblejgnt - ojcacgpqgp)
-
24 Jul 2017
(Benztropine Oral Product/CBT)
oprqahiiff(fmlyzdeglp) = xtmdvobdba cgjtlahrrf (jxnjilrnkk, defmpjlylg - pcorddzkmy)
Not Applicable
259
ipfewrlhir(aqwildeojk) = fvedvtsqtf qvqcazbgzu (kgwhqkfexe, aymzqncork - ddeypfcpdr)
-
17 May 2017
Group Exercise: community setting
(Group Exercise)
ipfewrlhir(aqwildeojk) = mqpezzifqi qvqcazbgzu (kgwhqkfexe, cqwdznxomu - ukihavwlmu)
Not Applicable
-
exswgennfc(twwwebkgdb) = myupbsytwc pxpiofcjul (piyugcksev )
Positive
01 Oct 2016
exswgennfc(twwwebkgdb) = lwaihcqdox pxpiofcjul (piyugcksev )
Not Applicable
60
sicevcfyns(votmwjnlmn) = nuhqpmynyp ryzgdvlytf (diojswrora )
-
01 Sep 2016
sicevcfyns(votmwjnlmn) = yseyttytud ryzgdvlytf (diojswrora )
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