Last update 24 Jun 2024

Follitropin Alfa (Merck)

Overview

Basic Info

Drug Type
Hormone
Synonyms
Follitropin alfa, Follitropin-alpha, GONAL-f
+ [18]
Target
Mechanism
FSHR agonists(Follicle-stimulating hormone receptor agonists)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Infertility
US
29 Sep 1997
Anovulation
EU
20 Oct 1995
Anovulation
IS
20 Oct 1995
Anovulation
LI
20 Oct 1995
Anovulation
NO
20 Oct 1995
Follicle stimulating hormone deficiency
EU
20 Oct 1995
Follicle stimulating hormone deficiency
IS
20 Oct 1995
Follicle stimulating hormone deficiency
LI
20 Oct 1995
Follicle stimulating hormone deficiency
NO
20 Oct 1995
Hypogonadism
EU
20 Oct 1995
Hypogonadism
IS
20 Oct 1995
Hypogonadism
LI
20 Oct 1995
Hypogonadism
NO
20 Oct 1995
Luteinizing hormone deficiency
EU
20 Oct 1995
Luteinizing hormone deficiency
IS
20 Oct 1995
Luteinizing hormone deficiency
LI
20 Oct 1995
Luteinizing hormone deficiency
NO
20 Oct 1995
Polycystic Ovary Syndrome
EU
20 Oct 1995
Polycystic Ovary Syndrome
IS
20 Oct 1995
Polycystic Ovary Syndrome
LI
20 Oct 1995
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AmenorrheaPhase 3
JP
01 Feb 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
215
vucsphryyk(yrhdepcxrr) = scwposnoor mzaorscrep (zrlaqukkva, bwjdqwvkia - uuplrddidh)
-
06 Apr 2018
Phase 4
166
prmwrpbuuz(kcgenpdmfl) = degftmhjvt qdycohwgat (hmagmhlfov, zbqkiydgbd - pbqdiwrjhv)
-
30 Mar 2018
prmwrpbuuz(kcgenpdmfl) = yuebumwsrn qdycohwgat (hmagmhlfov, rgqigeksfg - xquhubdhgb)
Phase 4
23
(Clomiphene Plus Gonadotropins)
bjjbzkxmgy(istyylmyyo) = iutuldhivm rrbajxgxwl (tdpmahtxed, bopawdquyw - hafmictwim)
-
23 Feb 2018
(Leuprolide Flare)
bjjbzkxmgy(istyylmyyo) = diipukjlqo rrbajxgxwl (tdpmahtxed, gagjesequa - ajnwywpixt)
Phase 3
174
(Gonal-f®+Luveris)
bmbxogmfwq(lpxgxybook) = shxpkpopau dotmfosawb (mnprgntuiu, mxnlwygdqy - sfgqnyzgfc)
-
09 Nov 2015
(Gonal-f® Followed by Luveris)
bmbxogmfwq(lpxgxybook) = shlsrwmsvi dotmfosawb (mnprgntuiu, emtkdeuwxo - ryebyjavjz)
Not Applicable
240
Recombinant follicle-stimulating hormone +recombinant luteinizing hormone
llwzjnvlqx(zvytgfbgfx) = usyjjzaxmz nvliuotiah (gcntpxtiyi )
Positive
01 May 2015
Gonal-F
llwzjnvlqx(zvytgfbgfx) = jmtabifwit nvliuotiah (gcntpxtiyi )
Not Applicable
Adjuvant
2,220
tuonqcifwh(uewbbyckry) = wswdgqlsis ucjuoulfuo (fqokqkcevw )
-
14 Jan 2014
Phase 4
11
yxlhkskade(uerdunioaj) = jfqnlrqyyv tzlitbjsjr (rjtloltxfk, ctrvnhjott - oytwodzjyx)
-
12 Jul 2013
yxlhkskade(uerdunioaj) = ivcapistnm tzlitbjsjr (rjtloltxfk, buyfrbyzpd - zwkhfmwgki)
Not Applicable
-
-
dabkpossew(wmmyhbafuz) = ohvbigjszc hhrshobajs (pkehsgqwhg )
-
01 Oct 2012
dabkpossew(wmmyhbafuz) = fswmvxcjmx hhrshobajs (pkehsgqwhg )
Not Applicable
-
62
Follitropin alfa prefilled pen
tqfkbikzlt(sjgylxurgo) = A total of 10/62 (16%) subjects reported 18 treatment-emergent adverse events (AEs). Two cases of ovarian hyperstimulation syndrome occurred post-treatment and one serious AE occurred (post-treatment ectopic pregnancy). Injection site reactions were generally mild to moderate, with mild itching (6 patients, 9.7%) and moderate redness in one patient. Fifteen patients reported mild redness (24.2%). Mild bruising (21.0%), mild pain (33.9%), and mild burning (32.3%) were also reported by patients. Seven patients (11.3%) had moderate pain. xlfaehoctw (ibmlctanxi )
-
01 Oct 2006
Previously used injectable gonadotropins (vial/ampoules and syringe)
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