Delving into the Latest Updates on Urofollitropin (Serono) with Synapse

Overview

Basic Info

Drug Type

Hormone

Synonyms

Fertinex, Fertinorm HP, Follitropin human

+ [7]

Target

FSHR

Mechanism

FSHR agonists(Follicle-stimulating hormone receptor agonists)

Therapeutic Areas

Urogenital Diseases

Active Indication

Female infertility associated with anovulation

Inactive Indication-

Originator Organization

Merck Serono SA

Active Organization

Hong Kong Ferring Pharmaceutical Co., Ltd. Beijing Representative OfficeFerring GmbHFerring Holding SA

+ [1]

Inactive Organization

Ferring Pharmaceuticals SA

IBSA Institut Biochimique SA

EMD Serono, Inc.

Drug Highest PhasePhase 3

First Approval Date

US (18 Sep 1986),

Infertility

RegulationOrphan Drug (US)

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Structure/Sequence

Sequence Code 3246α

Sequence Code 3253α

The aim of this study will be to compare between 4 different induction protocols in women who:
Failed to achieve ovulation after clomiphene citrate treatment at a dose of 150mg daily (if the patient can tolerate this dose) for 5 days for 3 cycles or only 100 mg daily for the same duration (if she can't tolerate higher dose)
Failed to achieve pregnancy after 3 cycles of ultrasound indicated ovulation with clomiphene citrate treatment at a dose of 100mg or 150mg daily.
All induction protocols will be carried out in non-IVF cycles, and continued for 3 cycles or until pregnancy whichever will be earlier.

Start Date01 Jun 2022

Sponsor / Collaborator

Menoufia University

EUCTR2016-004034-14-IT

/ Unknown statusPhase 2/3IIT

Randomized controlled phase IIb-III clinical trial to assess the effectiveness of different regimens with u-FSH in the infertile male - UFO – UROFOLLITROPIN IN OLIGOZOOSPERMIA

Start Date11 Oct 2018

Sponsor / Collaborator-

NCT02544191

/ Unknown statusPhase 2IIT

GnRHa Combined With hCG and hMG for Treatment of Patients With Non-obstructive Azoospermia: A Single-center Prospective Study in China

Preliminary reports showed that hormonal treatment may improve the chance of retrieving viable testicular sperm from men with NOA. It was generally believed that gonadotrophin treatment would be ineffective in the presence of high plasma levels of endogenous gonadotrophin.The purpose of this study is to determine whether GnRHa(gonadotropin-releasing hormone agonist) combined with hCG(human chorionic gonadotropin) and hMG(human menopausal gonadotropin) are effective in the treatment of non-obstructive azoospermia.

Start Date01 Dec 2015

Sponsor / Collaborator

Affiliated Jinling Hospital, Medical School of Nanjing University

100 Clinical Results associated with Urofollitropin (Serono)

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100 Translational Medicine associated with Urofollitropin (Serono)

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100 Patents (Medical) associated with Urofollitropin (Serono)

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158

Literatures (Medical) associated with Urofollitropin (Serono)

01 Sep 2023·Zhonghua nan ke xue = National journal of andrology

[Clinical efficacy of Xuanju compound capsule combined with urofollitropin in the treatment of patients with idiopathic oligoasthenozoospermia].

Article

Author: Chen, Li-Sha ; Yu, Yue-Xin ; Shi, Sheng-Jia ; Zhao, Ying-Ying ; Wei, Wei

OBJECTIVETo evaluate the therapeutic effects of Xuanju compound capsule combined with urofollitropin (uFSH) in the treatment of idiopathic oligoasthenozoospermia.METHODSFrom June 2022 to June 2023, patients with idiopathic oligoastheospermia were enrolled in this study, and divided into trail group (Xuanju compound capsule combined with urofollitropin tablets, n=53) and control group (urofollitropin tablets, n=61) according to the difference in treatment. Treatment methods: Xuanju compound capsule, 3 pills, three times a day; Urofollitropin, 75IU, one times three day. The curses of treatments for control group and trail group is 12 weeks. In order to evaluate the therapeutic effects of control group and trial group, semen volume, sperm concentration, progressive sperm ratio (PR), peripheral serum sex hormone, liver functions were analyzed before and after treatment for two times.RESULTSCompared with the baseline, the semen volume and liver function were not significantly changed after the treatment in control group and trial group. However, sperm concentration, PR, testosterone (T) levels, follicle stimulating hormone (FSH) levels, and luteinizing hormone (LH) levels were significantly unregulated after the treatment in control group and trial group. More importantly, compared to control group, sperm concentration, PR, T leves, FSH levels, LH levels, and T/E2 ratio of trial group were further enhanced after the treatment, which were statistically significant (P < 0.05).CONCLUSIONSXuanju compound capsule combined with urofollitropin tablets could significantly improve the semen quality, up-regulate the testosterone levels and T/E2 ratio in patients with idiopathic oligoasthenozoospermia.

01 Jan 2023·Gynecologic and Obstetric Investigation

Dosing Characteristics of Recombinant Human Luteinizing Hormone or Human Menopausal Gonadotrophin-Derived LH Activity in Patients Undergoing Ovarian Stimulation: A German Fertility Database Study

Article

Author: Allignol, Arthur ; Bühler, Klaus ; Schertz, Joan ; Longobardi, Salvatore ; Hubbard, Julie ; Verpillat, Patrice ; Fischer, Robert ; Strezsak, Valerie ; Lispi, Monica

Objectives: The aim of the study was to evaluate dosing of recombinant human luteinizing hormone (r-hLH) or human menopausal gonadotrophin (hMG)-derived medications with LH activity in ovarian stimulation (OS) cycles for in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). Design: A non-interventional study was performed to analyse data from the German RecDate database (January 2007–December 2011). Participants/Materials, Setting, Methods: Starting/total r-hLH/hMG dose, OS duration/cycle number, r-hLH/hMG initiation day (first day of administration), and population/cycle characteristics were assessed in women (≥18 years) undergoing OS for IVF/ICSI using r-hLH or hMG-derived medications (excluding corifollitropin alfa, clomiphene citrate, letrozole, mini/micro-dose human chorionic gonadotrophin, and urofollitropin alone). Data were summarized descriptively. Results: 67,858 identified cycles utilized medications containing r-hLH (10,749), hMG (56,432), or both (677). Mean (standard deviation) OS duration with r-hLH and hMG was 10.1 (4.43) and 9.8 (6.16) days, respectively. Median (25th–75th percentile) r-hLH starting dose (75.0 [75.0–150.0] IU) was consistent across patients regardless of age, infertility diagnosis, or gonadotrophin-releasing hormone (GnRH) protocol. Median (25th–75th percentile) hMG-derived LH activity starting dose was 225.0 (150.0–300.0) IU, regardless of GnRH protocol, but was lower in women aged <35 years and those with ovulation disorders/polycystic ovary syndrome. Median (25th–75th percentile) total dose for r-hLH (750.0 [337.5–1,125.0] IU) and hMG-derived LH activity (1,575.0 [750.0–2,625.0] IU) varied according to patients’ age, infertility diagnosis, cycle number, and r-hLH/hMG initiation day. GnRH antagonist use resulted in a numerically higher median total hMG-derived LH activity dose than GnRH agonist use. Limitations: The data used in this study were taken from electronic medical records relating to a specific timeframe (2007–2011) and therefore may not accurately reflect current clinical practice; however, it is likely that the differences between the two compounds would be maintained. Additionally, secondary data sources may suffer from uniformity and quality issues. Conclusions: The standard of care for OS cycles is described with respect to IVF/ICSI treatment including an LH component in Germany during the specified timeframe.

01 Oct 2021·Carbohydrate PolymersQ1 · CHEMISTRY

Dry cultivation and cultivar affect starch synthesis and traits to define rice grain quality in various panicle parts

Q1 · CHEMISTRY

Article

Author: Jiang, Yang ; Chen, Zongkui ; Cai, Mingli ; Du, Yunfeng ; Li, Ping ; Cao, Cougui

A pot experiment was conducted to explore the effects of high-quality (Huanghuazhan, HH), drought-resistant (IR, IRAT109) and drought-susceptible cultivars (ZS, Zhenshan97) under flooding irrigation and dry cultivation (D) on the starch accumulation and synthesis, physicochemical traits of starch granules and rice grain quality at the upper (U) and lower panicle. Under D treatment, IR and ZS had lower rice quality, especially the appearance and cooking quality. DHH-U had the highest appearance, nutritional and cooking quality among all cultivars under D treatment, which could be ascribed to the synthesis of more short-branch chain amylopectin and correspondingly higher starch granule tightness. DHH-U also maintained ordered carbohydrate structure, crystalline regions, and many hydrophilic and hydrophobic functional groups in starch granules before pasting. It could prevent the polymerization of small molecules to avoid the formation of macromolecules after pasting. Overall, these findings may facilitate the improvement of grain quality in rice dry cultivation.

100 Deals associated with Urofollitropin (Serono)

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External Link

KEGG	Wiki	ATC	Drug Bank
D06269	Urofollitropin (Serono)	G03GA04	DB00094

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Female infertility associated with anovulation	Phase 3	CN	Ferring GmbH	17 Oct 2013
Female infertility associated with anovulation	Phase 3	CN	Ferring Holding SA	17 Oct 2013
Female infertility associated with anovulation	Phase 3	CN	Hong Kong Ferring Pharmaceutical Co., Ltd. Beijing Representative Office	17 Oct 2013
Female infertility associated with anovulation	Phase 3	CN	Ferring Arzneimittel Gmbh	17 Oct 2013
Infertility, Female	Phase 1	CN	Ferring Pharmaceuticals SA	20 Jun 2014
Infertility	Preclinical	US	EMD Serono, Inc.	18 Sep 1986

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01969201 (FAST, CTgov)	Phase 4	Infertility	710	Urofollitrophin (Fostimon®)	wvndjkddxd(vgpqmprqte) = vrgmdnamyr tyclwargfc (shqhyhjhkd, dsiasccdsa - miikkczwpn) View more	-	09 Oct 2019
				Follitrophin alpha (Gonal-F®)	wvndjkddxd(vgpqmprqte) = clpdmuxjqo tyclwargfc (shqhyhjhkd, hqpwttrgoa - wiqhhsrmfj) View more
NCT01921166 (Diminished Ovarian Reserve, CTgov)	Phase 4	Infertility	23	Menopur+Clomid+Bravelle+Follistim+Gonal f (Clomiphene Plus Gonadotropins)	jozrqvevrk(kesszlxrhn) = gnxbjvwasd nfmmogavpe (dkknhfmuya, cfmiycthdh - sycxwangcl) View more	-	23 Feb 2018
				Leuprolide flare (Leuprolide Flare)	jozrqvevrk(kesszlxrhn) = jrnlhpooan nfmmogavpe (dkknhfmuya, alcjcxczwq - qaivandgua) View more
NCT01417195 (COMBINE, CTgov)	Phase 4	Infertility	122	Menopur+Bravelle (Menopur and Bravelle Combination)	(zsscmxeany) = ftspecutif qrxvztliui (savyawsiim, kjbvctaexb - klypwlcenv) View more	-	24 Apr 2014
				Menopur (Menopur Alone)	(zsscmxeany) = ctdbudravy qrxvztliui (savyawsiim, wkgukzvwmh - nydquxzvoj) View more