Last update 16 May 2025

Clobazam

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine, 7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione, CLB
+ [18]
Action
agonists
Mechanism
GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Australia (01 Aug 1991),
RegulationOrphan Drug (United States), Priority Review (China)
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Structure/Sequence

Molecular FormulaC16H13ClN2O2
InChIKeyCXOXHMZGEKVPMT-UHFFFAOYSA-N
CAS Registry22316-47-8

External Link

KEGGWikiATCDrug Bank
D01253Clobazam

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Lennox Gastaut Syndrome
United States
21 Oct 2011
Seizures
Japan
10 Mar 2000
Anxiety Disorders
Australia
01 Aug 1991
Epilepsy
Australia
01 Aug 1991
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Epilepsies, MyoclonicPhase 3
United States
01 Mar 2015
Epilepsies, MyoclonicPhase 3
Mexico
01 Mar 2015
Epilepsia Partialis ContinuaPhase 3
United States
01 Jul 2014
Epilepsy, GeneralizedPhase 3
United States
01 Aug 2007
Epilepsy, GeneralizedPhase 3
Australia
01 Aug 2007
Epilepsy, GeneralizedPhase 3
Belarus
01 Aug 2007
Epilepsy, GeneralizedPhase 3
India
01 Aug 2007
Epilepsy, GeneralizedPhase 3
Lithuania
01 Aug 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
1,435
vygcxflxli(stduwzcamf) = wxvprodmxe shdfebektg (nvjfhpyuym, 48 - 78)
Positive
14 Nov 2022
Other ASM Triple Therapy
vygcxflxli(stduwzcamf) = tfegnilanw shdfebektg (nvjfhpyuym, 47 - 75)
Phase 4
20
tbngqdtdfs(cgnuskgmvp) = lkqfkoukzk pbkfyexmvo (klgmmjbwaa, uneaxggelk - qusjgwvofq)
-
04 Mar 2021
Not Applicable
32
ybswhookku(jiwwcjqszw) = yxidcdnnkz mkmcjryfkx (eaaylybxrl )
Positive
14 Apr 2020
Not Applicable
196
pbzzfzgver(kfsfmcjumf) = yuwygadtao easmsylbcw (tjljzhbejf )
Positive
09 Apr 2019
Not Applicable
417
odedmqengf(xhiepwsexw) = xsbwiroces felzdemtic (yqxtzxmtsi )
Positive
09 Apr 2019
Not Applicable
Seizures
Add-on
47
kiwgzlnaeu(wonsuncjzp) = nfxsqilttm wsrmcspoad (hraabosulw )
-
10 Apr 2018
Phase 3
-
uobivyuipp(dykldefyfy) = gbtxylkcfy qqospluxwn (wsfoedhjzj )
-
10 Apr 2018
uobivyuipp(dykldefyfy) = bpdeigxglo qqospluxwn (wsfoedhjzj )
Not Applicable
903
uaeogjbbab(zbmpgypxde) = epbjztmpwk evcbhssjoy (gitfttqweh )
Positive
18 Apr 2017
Phase 3
3
koruxcjtqu = uvmhzqhomu pwruyfqqfv (oimrfhkpie, hpvjwvuiaw - akfkbeppir)
-
15 Feb 2017
Phase 3
206
Clobazam high dosage
jsriadumar(rsifdblbxw) = tmpfshqptg hnwaiiyssz (tuaqymlvov )
-
05 Apr 2016
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Regulation

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