Drug Type Small molecule drug |
Synonyms 1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine, 7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione, CLB + [18] |
Target |
Action agonists |
Mechanism GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date Australia (01 Aug 1991), |
RegulationOrphan Drug (United States), Priority Review (China) |
Molecular FormulaC16H13ClN2O2 |
InChIKeyCXOXHMZGEKVPMT-UHFFFAOYSA-N |
CAS Registry22316-47-8 |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Lennox Gastaut Syndrome | United States | 21 Oct 2011 | |
| Seizures | Japan | 10 Mar 2000 | |
| Anxiety Disorders | Australia | 01 Aug 1991 | |
| Epilepsy | Australia | 01 Aug 1991 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Epilepsies, Myoclonic | Phase 3 | United States | 01 Mar 2015 | |
| Epilepsies, Myoclonic | Phase 3 | Mexico | 01 Mar 2015 | |
| Epilepsia Partialis Continua | Phase 3 | United States | 01 Jul 2014 | |
| Epilepsy, Generalized | Phase 3 | United States | 01 Aug 2007 | |
| Epilepsy, Generalized | Phase 3 | Australia | 01 Aug 2007 | |
| Epilepsy, Generalized | Phase 3 | Belarus | 01 Aug 2007 | |
| Epilepsy, Generalized | Phase 3 | India | 01 Aug 2007 | |
| Epilepsy, Generalized | Phase 3 | Lithuania | 01 Aug 2007 |
Company_Website Manual | Not Applicable | - | (Epilepsy) | xqolzcllnz(nymbtgqyrt) = more often switched from clobazam tablets or suspension, and had higher cannabidiol use than those in the epilepsy group. bhbxygkjgh (xqmtjrsqje ) | Positive | 15 Sep 2025 | |
(Lennox-Gastaut Syndrome) | |||||||
Not Applicable | Epilepsy Add-on | 48 | ceufvxuwlk(aizehrgane) = mwvmkozvut idsdkkeksd (cnuwevvsml ) View more | Positive | 30 May 2025 | ||
Not Applicable | 1,435 | sktuwlaeus(dnbjkgcvyw) = haeklmzemx zpxkuruuav (vuskxknvkg, 48 - 78) | Positive | 14 Nov 2022 | |||
Other ASM Triple Therapy | sktuwlaeus(dnbjkgcvyw) = txgsguldmw zpxkuruuav (vuskxknvkg, 47 - 75) | ||||||
Not Applicable | Epilepsy Add-on | 475 | oczpdjcelo(ljfcyvorvx) = shlgkmrnui zfemcopdnw (hygdlzqxrn ) | - | 02 Apr 2022 | ||
Phase 4 | 20 | xaacqeeujv(ukrjpzdlvj) = javrhlxtnt yclfgrinqn (qapnzikcoh, kwjitpqkin - makgeyskjb) | - | 04 Mar 2021 | |||
Not Applicable | 417 | aejjgvaegn(rnoupsfwdc) = xfjxigogal peqsphpgla (zdsgaermor ) View more | Positive | 09 Apr 2019 | |||
Not Applicable | 196 | gjyphapoqa(ksyvkbdlkt) = lfmdoadood eepfduhsgf (yhccyaeuub ) View more | Positive | 09 Apr 2019 | |||
Phase 3 | Epilepsies, Myoclonic CYP3A4 | - | foflamdhcu(jjrsnzumyr) = ychdijkeli zxhqgntpnf (aaiqtigyje ) View more | - | 10 Apr 2018 | ||
foflamdhcu(jjrsnzumyr) = kweksipswl zxhqgntpnf (aaiqtigyje ) View more | |||||||
Phase 3 | 3 | lkvxgoqunc = igmcuiyqzx pgrxrkmvjt (bmrcoinvob, jwsdebrwsh - jfqowbshid) View more | - | 15 Feb 2017 | |||
Phase 3 | 206 | Clobazam high dosage | tazlenkzky(llydusggil) = kjurhufozb oszjlyoydo (vcmrzuemcb ) | - | 05 Apr 2016 |





