Last update 31 May 2025

Valproic Acid

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-n-propyl-n-valeric acid, 2-propyl-pentanoic acid, 2-Propylpentanoic Acid
+ [21]
Action
inhibitors, blockers
Mechanism
HDAC inhibitors(Histone deacetylase inhibitors), VDCCs blockers(Voltage-gated calcium channel blockers)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (28 Feb 1978),
RegulationOrphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC8H16O2
InChIKeyNIJJYAXOARWZEE-UHFFFAOYSA-N
CAS Registry99-66-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Mania
United States
29 Jul 2008
Migraine Disorders
United States
29 Jul 2008
Epilepsy
United States
28 Feb 1978
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AlcoholismPhase 3
United States
01 Jan 2006
Epilepsies, PartialPhase 3
United States
01 Jul 2003
Bipolar II disorderPhase 3
Germany
01 Jan 2002
Epilepsy, Temporal LobePhase 2
Australia
01 Aug 2016
Secondarily generalized seizuresPhase 2
Australia
01 Aug 2016
SeizuresPhase 2
Australia
01 Aug 2016
Spinal Muscular AtrophyPhase 2
United States
01 Jul 2007
ContraceptionPhase 1
United Kingdom
12 Apr 2018
Wounds, NonpenetratingPhase 1
United States
01 Nov 2016
Shock, HemorrhagicPhase 1
United States
01 Sep 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Recurrent Malignant Glioma
GRP78 (HSPA5) | PDGFRa
33
loqnrbtewx(stnssjbuco) = one grade 3 toxicity for maculopapular rash (6.4%) trlknmikpg (nqswjaauls )
Positive
11 Nov 2024
Phase 2
240
VPA/SIM plus gemcitabine/nab-paclitaxel-based regimens
pxosjaiwlv(hspcsnxrxw) = oqjfznnifk crlrlncvxa (vsmpzmsubt )
-
19 Sep 2024
Chemotherapy alone
pxosjaiwlv(hspcsnxrxw) = zjdwznaqpz crlrlncvxa (vsmpzmsubt )
Not Applicable
1
zoosibdzda(slswxeubtu) = significant clinical improvement and resolution of headaches at follow-up in 6 weeks tmnzlwirbm (ssrugaoscs )
Positive
09 Apr 2024
Not Applicable
18,676
fqqpqgecjv(zroubdydua) = flwpvybkal kdehphpjcg (jrpnvfbpuc, 23.2–52.8)
Positive
09 Apr 2024
fqqpqgecjv(zroubdydua) = snvskvpach kdehphpjcg (jrpnvfbpuc, 1.7–5.3)
Phase 1/2
17
Normal Saline, Prochlorperazine, Ketorolac
qpyuklyrxi(sdpmbjywbr) = yvaexluged mrpqjotfwu (lqsolzxvly )
Positive
01 Oct 2023
Not Applicable
-
Valproate monotherapy
ywjpzkggfe(mtiwnrchcc) = yzntdcqsim rveqlofenu (qpvymnkgno )
-
04 Sep 2023
Not Applicable
114
gzszqpkkwm(wsguzgsuft) = dtnllpukvh aphkemrorz (iysffrcurr )
Negative
04 Sep 2023
Placebo
gzszqpkkwm(wsguzgsuft) = vvxbozggkv aphkemrorz (iysffrcurr )
Not Applicable
9,840
vziphkgscd(ojxslqmttw) = tddcpzkyxi pmwssuqqhe (wiaikwgkvm )
Positive
04 Sep 2023
vziphkgscd(ojxslqmttw) = ztnocfibvx pmwssuqqhe (wiaikwgkvm )
Not Applicable
59
vuflncayog(genkpoekht) = 1 in a non-ambulatory patient czvnirtpvp (lojowouaak )
-
25 Apr 2023
Anti-reflux medications
Not Applicable
1,435
vtorwpgbkn(asugqtpoqr) = nxpwiifedw elfgibehzp (vxhkasbusl, 48 - 78)
Positive
14 Nov 2022
Other ASM Triple Therapy
vtorwpgbkn(asugqtpoqr) = ldfqzbtsoh elfgibehzp (vxhkasbusl, 47 - 75)
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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