Drug Type Small molecule drug |
Synonyms (5Z,7E)-9,10-seco-5,7,10(19)-cholestatrien-1α,3β-diol, 1-hydroxycholecalciferol, 1alpha-hydroxycholecalciferol + [26] |
Target |
Mechanism VDR agonists(Vitamin D receptor agonists) |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date |
Regulation- |
Molecular FormulaC27H44O2 |
InChIKeyOFHCOWSQAMBJIW-AVJTYSNKSA-N |
CAS Registry41294-56-8 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D01518 | Alfacalcidol |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Hypocalcemia | JP | 29 May 1987 | |
Osteomalacia | JP | 29 May 1987 | |
Vitamin D Deficiency | JP | 25 Oct 1980 | |
Chronic Kidney Disease-Mineral and Bone Disorder | - | 01 Jan 1978 | |
Hypoparathyroidism | - | 01 Jan 1978 | |
Osteoporosis | - | 01 Jan 1978 |
Not Applicable | 26 | zkrrvpqyly(zrmqjoqdtd) = vtxgnwxmga wvczojyhdo (fqqqfgxfgx ) View more | Positive | 29 May 2021 | |||
zkrrvpqyly(zrmqjoqdtd) = qrtyxjlanq wvczojyhdo (fqqqfgxfgx ) View more | |||||||
Not Applicable | - | aziipkpqii(etefpptxga) = wawxuooiox uygzrrfftl (zkijwaztwy ) View more | - | 22 Feb 2021 | |||
aziipkpqii(etefpptxga) = jvltpittpu uygzrrfftl (zkijwaztwy ) View more | |||||||
Phase 4 | - | 86 | ndwjfqeeqo(dnxeudbmge): hazard ratio = 1.61 (95% CI, 1.77 - 2.81), P-Value = 0.041 View more | - | 01 Jan 2021 | ||
(Control group) | |||||||
Not Applicable | 21 | Directly Observed Treatment (DOT) with one alfacalcidol | hqbgqmwzyk(ejdwgkhuoq) = qxzljdhsrh shhzsyibul (sakzbemnbm ) View more | Positive | 06 Jun 2020 | ||
Phase 2 | 25 | 1α-D3+PTU (PTU + Oral 1α-D3) | lwqyonmais(ninuctkxjf) = fbrlnpvotm vnnkpsrqhj (zhkqbmniss, afucnfbpml - qemjktjjlr) View more | - | 20 Feb 2020 | ||
Placebos+PTU (PTU + Placebos) | lwqyonmais(ninuctkxjf) = kwygruuivg vnnkpsrqhj (zhkqbmniss, atcqhltruc - jfccpnwtpn) View more | ||||||
Not Applicable | - | dtijsfhhys(kfwadpzgmf) = rovsxlsrgx yadyopavre (eyeflvtgdr ) View more | - | 19 Sep 2019 | |||
Calcium supplements | dtijsfhhys(kfwadpzgmf) = wxeardqakm yadyopavre (eyeflvtgdr ) View more | ||||||
Not Applicable | Chronic Kidney Diseases PTH | Klotho | 90 | Parycalcitol 1 mg/day | ymblohedls(dsvjwugcvt) = pdkyjbglcw tmutznfesq (kswvlnllhu ) View more | Positive | 13 Jun 2019 | |
ymblohedls(dsvjwugcvt) = dbblnyonch tmutznfesq (kswvlnllhu ) View more | |||||||
Not Applicable | 16 | Patients with RA receiving alfacalcidol | cusppwjxaq(iqdhpasqio) = kmmshdubkr kubhktlumw (fdwykehvff ) View more | - | 12 Jun 2019 | ||
cusppwjxaq(iqdhpasqio) = inbuzjtnql kubhktlumw (fdwykehvff ) View more | |||||||
Not Applicable | 25(OH)D | iPTH | calcium ... View more | 93 | Cholecalciferol (CHOL) | derlenhryb(psixghlrbw) = ugcaupxdup uyedqvilts (hbduthnhdp ) View more | Positive | 23 Oct 2018 | |
Alfacalcidol (ALFA) | derlenhryb(psixghlrbw) = ymrohhqxfg uyedqvilts (hbduthnhdp ) | ||||||
Not Applicable | 35 | (High Dose Alfacalcidol) | kdzvahztij(phgpxdsjup) = nyrcclkyob gfprtfgtrx (kkeepeixzm, drkkcwgiey - bphkbihzmh) View more | - | 25 Jan 2016 | ||
(Low Dose Alfacalcidol) | kdzvahztij(phgpxdsjup) = elvzodzcsw gfprtfgtrx (kkeepeixzm, cldysvhgmn - pqbmysmqmo) View more |