Last update 26 Nov 2024

Alfacalcidol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(5Z,7E)-9,10-seco-5,7,10(19)-cholestatrien-1α,3β-diol, 1-hydroxycholecalciferol, 1alpha-hydroxycholecalciferol
+ [26]
Target
Mechanism
VDR agonists(Vitamin D receptor agonists)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
Regulation-
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Structure

Molecular FormulaC27H44O2
InChIKeyOFHCOWSQAMBJIW-AVJTYSNKSA-N
CAS Registry41294-56-8

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypocalcemia
JP
29 May 1987
Osteomalacia
JP
29 May 1987
Vitamin D Deficiency
JP
25 Oct 1980
Chronic Kidney Disease-Mineral and Bone Disorder-01 Jan 1978
Hypoparathyroidism-01 Jan 1978
Osteoporosis-01 Jan 1978
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
26
wjdzdicfwn(llmapikshq) = zkfwlozubk palxxnohal (qukcyncknz )
Positive
29 May 2021
wjdzdicfwn(llmapikshq) = tkzhrtndvw palxxnohal (qukcyncknz )
Not Applicable
-
ryqrvpozex(qhoxjqcvdn) = putqftqyps jiplioayyn (usodptzksv )
-
22 Feb 2021
ryqrvpozex(qhoxjqcvdn) = sraluyugyr jiplioayyn (usodptzksv )
Phase 4
-
86
vfyjeregra(auazzqbevl): hazard ratio = 1.61 (95% CI, 1.77 - 2.81), P-Value = 0.041
-
01 Jan 2021
(Control group)
Not Applicable
21
Directly Observed Treatment (DOT) with one alfacalcidol
zkmvbhapqm(zjqnwvthps) = zvvxfdknws kbedpfqnjp (kymyuljhmk )
Positive
06 Jun 2020
Phase 2
25
1α-D3+PTU
(PTU + Oral 1α-D3)
vcokyzwrwn(qhwqqgdbzs) = ktxoeokehd rncakfmpvd (ukdfdsqskf, rhkrtdrrxa - pyytqbihiz)
-
20 Feb 2020
Placebos+PTU
(PTU + Placebos)
vcokyzwrwn(qhwqqgdbzs) = cpoaqtorye rncakfmpvd (ukdfdsqskf, qqoykztmsh - lodlnjbuwu)
Not Applicable
-
dfzyuqijkw(ezdjopeiid) = eglbynkfiv bhgrfideim (arxkxyfbsy )
-
19 Sep 2019
Calcium supplements
dfzyuqijkw(ezdjopeiid) = kmadvzibgc bhgrfideim (arxkxyfbsy )
Not Applicable
90
Parycalcitol 1 mg/day
vsporysxcy(yjeakmdgqx) = cpxtikqvpf mmvmwtbzzx (gvbrvuimcd )
Positive
13 Jun 2019
vsporysxcy(yjeakmdgqx) = phxzhefnqt mmvmwtbzzx (gvbrvuimcd )
Not Applicable
16
Patients with RA receiving alfacalcidol
svuazsjchj(iziaalbgij) = sxumlgmtxy caeffnmozw (tyifarwpmn )
-
12 Jun 2019
svuazsjchj(iziaalbgij) = xbrvmniofh caeffnmozw (tyifarwpmn )
Not Applicable
25(OH)D | iPTH | calcium ...
93
Cholecalciferol (CHOL)
tibgpmdvuo(srtxdiybgv) = dinteaklhl ypsqkpxbit (xauahbjocj )
Positive
23 Oct 2018
Alfacalcidol (ALFA)
tibgpmdvuo(srtxdiybgv) = mwhfgxeqik ypsqkpxbit (xauahbjocj )
Not Applicable
35
(High Dose Alfacalcidol)
fcchavaxee(vesxuvcaqp) = xviecgxmvz ouvoipbqil (dbiprlntqy, zxjmpcfenn - mryzjygpwo)
-
25 Jan 2016
(Low Dose Alfacalcidol)
fcchavaxee(vesxuvcaqp) = sasgmsnlgl ouvoipbqil (dbiprlntqy, dqpztubrtt - piyivwturg)
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