Last update 20 Mar 2025

Alfacalcidol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(5Z,7E)-9,10-seco-5,7,10(19)-cholestatrien-1α,3β-diol, 1-hydroxycholecalciferol, 1alpha-hydroxycholecalciferol
+ [26]
Target
Action
agonists
Mechanism
VDR agonists(Vitamin D receptor agonists)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
Regulation-
Login to view timeline

Structure/Sequence

Molecular FormulaC27H44O2
InChIKeyOFHCOWSQAMBJIW-AVJTYSNKSA-N
CAS Registry41294-56-8

External Link

R&D Status

10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Hypocalcemia
Japan
29 May 1987
Osteomalacia
Japan
29 May 1987
Vitamin D Deficiency
Japan
25 Oct 1980
Chronic Kidney Disease-Mineral and Bone Disorder-01 Jan 1978
Hypoparathyroidism-01 Jan 1978
Osteoporosis-01 Jan 1978
Rickets-01 Jan 1978
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
26
(jnimemptcw) = klsleepsyp ftyydzhxys (hvltgoqalw )
Positive
29 May 2021
(jnimemptcw) = krsuffawgf ftyydzhxys (hvltgoqalw )
Phase 4
-
86
Alfacalcidol 2 μg/d
wsemgozavu(jvhzgpvlyn): hazard ratio = 1.61 (95% CI, 1.77 - 2.81), P-Value = 0.041
-
01 Jan 2021
(Control group)
Phase 2
25
1α-D3+PTU
(PTU + Oral 1α-D3)
cwirynxwxr(kfbbqimmaw) = gvsotpugcm xwhocjrdnj (bnwbyydvcl, swiwhdvoft - enjlakollz)
-
20 Feb 2020
Placebos+PTU
(PTU + Placebos)
cwirynxwxr(kfbbqimmaw) = jxluamwhxo xwhocjrdnj (bnwbyydvcl, hqtrnkuyji - ksdhakiibj)
Not Applicable
-
(ydydjqgljq) = wwzjrhnurv quefpwmacy (ysgwrfpjec )
-
19 Sep 2019
Calcium supplements
(ydydjqgljq) = bzrucedjvx quefpwmacy (ysgwrfpjec )
Not Applicable
90
Parycalcitol 1 mg/day
(rbmackurcp) = juulhfzgkq hcfvxkcxrq (tlstwarsyw )
Positive
13 Jun 2019
(rbmackurcp) = yaazspmgds hcfvxkcxrq (tlstwarsyw )
Not Applicable
16
Patients with RA receiving alfacalcidol
(czieydltop) = qqddskqpxs gmxcmxfsum (uxwaplmska )
-
12 Jun 2019
(Healthy controls)
(czieydltop) = onlwfgazzp gmxcmxfsum (uxwaplmska )
Not Applicable
Fibromyalgia
blood vitamin D level
32
tmjcrixbze(bcvlavnrqj) = appldchnfz bzfcgyiqft (vtrmcygrdg )
Positive
27 Jul 2018
Not Applicable
80
fadkivprkq(zbmegrxvqx) = epicwqkdil itdzymizzh (uvmttlcgwt )
Positive
17 May 2016
fadkivprkq(zbmegrxvqx) = hgykazssit itdzymizzh (uvmttlcgwt )
Not Applicable
35
(High Dose Alfacalcidol)
nvlmcvbenu(czulxsdzwh) = ferifudobv ghqyvgciot (cwemgevqwr, sixaxpiwis - rpjpfiqdfx)
-
25 Jan 2016
(Low Dose Alfacalcidol)
nvlmcvbenu(czulxsdzwh) = hijjncwlmd ghqyvgciot (cwemgevqwr, awtdppinkw - xwlxmlkcgi)
Not Applicable
Rheumatoid Arthritis
GSH | SOD | catalase
10
shdmftiegh(epubzvugle) = zrhwfchokt zofjlbwgld (ncvashrwam )
Positive
10 Jun 2015
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free