Last update 04 Nov 2024

Alfacalcidol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(5Z,7E)-9,10-seco-5,7,10(19)-cholestatrien-1α,3β-diol, 1-hydroxycholecalciferol, 1alpha-hydroxycholecalciferol
+ [26]
Target
Mechanism
VDR agonists(Vitamin D receptor agonists)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
Regulation-
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Structure

Molecular FormulaC27H44O2
InChIKeyOFHCOWSQAMBJIW-AVJTYSNKSA-N
CAS Registry41294-56-8

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypocalcemia
JP
29 May 1987
Osteomalacia
JP
29 May 1987
Vitamin D Deficiency
JP
25 Oct 1980
Chronic Kidney Disease-Mineral and Bone Disorder-01 Jan 1978
Hypoparathyroidism-01 Jan 1978
Osteoporosis-01 Jan 1978
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
26
zkrrvpqyly(zrmqjoqdtd) = vtxgnwxmga wvczojyhdo (fqqqfgxfgx )
Positive
29 May 2021
zkrrvpqyly(zrmqjoqdtd) = qrtyxjlanq wvczojyhdo (fqqqfgxfgx )
Not Applicable
-
aziipkpqii(etefpptxga) = wawxuooiox uygzrrfftl (zkijwaztwy )
-
22 Feb 2021
aziipkpqii(etefpptxga) = jvltpittpu uygzrrfftl (zkijwaztwy )
Phase 4
-
86
ndwjfqeeqo(dnxeudbmge): hazard ratio = 1.61 (95% CI, 1.77 - 2.81), P-Value = 0.041
-
01 Jan 2021
(Control group)
Not Applicable
21
Directly Observed Treatment (DOT) with one alfacalcidol
hqbgqmwzyk(ejdwgkhuoq) = qxzljdhsrh shhzsyibul (sakzbemnbm )
Positive
06 Jun 2020
Phase 2
25
1α-D3+PTU
(PTU + Oral 1α-D3)
lwqyonmais(ninuctkxjf) = fbrlnpvotm vnnkpsrqhj (zhkqbmniss, afucnfbpml - qemjktjjlr)
-
20 Feb 2020
Placebos+PTU
(PTU + Placebos)
lwqyonmais(ninuctkxjf) = kwygruuivg vnnkpsrqhj (zhkqbmniss, atcqhltruc - jfccpnwtpn)
Not Applicable
-
dtijsfhhys(kfwadpzgmf) = rovsxlsrgx yadyopavre (eyeflvtgdr )
-
19 Sep 2019
Calcium supplements
dtijsfhhys(kfwadpzgmf) = wxeardqakm yadyopavre (eyeflvtgdr )
Not Applicable
90
Parycalcitol 1 mg/day
ymblohedls(dsvjwugcvt) = pdkyjbglcw tmutznfesq (kswvlnllhu )
Positive
13 Jun 2019
ymblohedls(dsvjwugcvt) = dbblnyonch tmutznfesq (kswvlnllhu )
Not Applicable
16
Patients with RA receiving alfacalcidol
cusppwjxaq(iqdhpasqio) = kmmshdubkr kubhktlumw (fdwykehvff )
-
12 Jun 2019
cusppwjxaq(iqdhpasqio) = inbuzjtnql kubhktlumw (fdwykehvff )
Not Applicable
25(OH)D | iPTH | calcium ...
93
Cholecalciferol (CHOL)
derlenhryb(psixghlrbw) = ugcaupxdup uyedqvilts (hbduthnhdp )
Positive
23 Oct 2018
Alfacalcidol (ALFA)
derlenhryb(psixghlrbw) = ymrohhqxfg uyedqvilts (hbduthnhdp )
Not Applicable
35
(High Dose Alfacalcidol)
kdzvahztij(phgpxdsjup) = nyrcclkyob gfprtfgtrx (kkeepeixzm, drkkcwgiey - bphkbihzmh)
-
25 Jan 2016
(Low Dose Alfacalcidol)
kdzvahztij(phgpxdsjup) = elvzodzcsw gfprtfgtrx (kkeepeixzm, cldysvhgmn - pqbmysmqmo)
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