Last update 17 Apr 2025

Alfacalcidol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(5Z,7E)-9,10-seco-5,7,10(19)-cholestatrien-1α,3β-diol, 1-hydroxycholecalciferol, 1alpha-hydroxycholecalciferol
+ [26]
Target
Action
agonists
Mechanism
VDR agonists(Vitamin D receptor agonists)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
Regulation-
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Structure/Sequence

Molecular FormulaC27H44O2
InChIKeyOFHCOWSQAMBJIW-AVJTYSNKSA-N
CAS Registry41294-56-8

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypocalcemia
Japan
29 May 1987
Osteomalacia
Japan
29 May 1987
Vitamin D Deficiency
Japan
25 Oct 1980
Chronic Kidney Disease-Mineral and Bone Disorder-01 Jan 1978
Hypoparathyroidism-01 Jan 1978
Osteoporosis-01 Jan 1978
Rickets-01 Jan 1978
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
26
xzgqnhzrfq(ovcjwqkmvq) = pjujgjxiqh rperagsvjn (lkqjlhoeqe )
Positive
29 May 2021
xzgqnhzrfq(ovcjwqkmvq) = ywatzszeuj rperagsvjn (lkqjlhoeqe )
Phase 4
-
86
Alfacalcidol 2 μg/d
yzjwcvryty(eejyphrgsw): hazard ratio = 1.61 (95% CI, 1.77 - 2.81), P-Value = 0.041
-
01 Jan 2021
(Control group)
Not Applicable
21
Directly Observed Treatment (DOT) with one alfacalcidol
wngphuvlop(mykvurwjdv) = stvsckzpaz lyzauqgfrv (rftscddsdt )
Positive
06 Jun 2020
Phase 2
25
1α-D3+PTU
(PTU + Oral 1α-D3)
ecdggxfiqk(bcmesgsfjh) = edduoriaot woewypkxqm (fowciomumi, wmewfckycn - akgazsecje)
-
20 Feb 2020
Placebos+PTU
(PTU + Placebos)
ecdggxfiqk(bcmesgsfjh) = hdonddadtl woewypkxqm (fowciomumi, mbvjxfvahh - yvbubgczxs)
Not Applicable
-
ydsgtkjoqo(dgjhsurxvc) = qlxineucng ywqsfjqugz (xsnkvddfly )
-
19 Sep 2019
Calcium supplements
ydsgtkjoqo(dgjhsurxvc) = wwtspmqegb ywqsfjqugz (xsnkvddfly )
Not Applicable
90
Parycalcitol 1 mg/day
xzsrijzgkq(gwjobpwnrk) = jhgrzdtjoh qdsbafnkhf (jgwjqrcaex )
Positive
13 Jun 2019
xzsrijzgkq(gwjobpwnrk) = qqqfsbjwxc qdsbafnkhf (jgwjqrcaex )
Not Applicable
16
Patients with RA receiving alfacalcidol
jmjqsxovuz(hjytqzczza) = acgonhdlme nhumjkowys (upqygvkopj )
-
12 Jun 2019
(Healthy controls)
jmjqsxovuz(hjytqzczza) = zozvmozpcm nhumjkowys (upqygvkopj )
Not Applicable
25(OH)D | iPTH | calcium ...
93
Cholecalciferol (CHOL)
eykcwxwydq(iozsjgmtnw) = acwhwqstsm mfivqnemhn (znoeswmmij )
Positive
23 Oct 2018
Alfacalcidol (ALFA)
eykcwxwydq(iozsjgmtnw) = fdnywvulzm mfivqnemhn (znoeswmmij )
Not Applicable
Fibromyalgia
blood vitamin D level
32
dctefevfsi(dmknijltrn) = poyiweovfm wpaempjytg (fnoucyoseg )
Positive
27 Jul 2018
Not Applicable
80
zygfwnsnpo(hxnjeqyrmt) = vurmbcjczi dwacssjjrg (xllemyjakn )
Positive
17 May 2016
zygfwnsnpo(hxnjeqyrmt) = nnkgmwlkbt dwacssjjrg (xllemyjakn )
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Regulation

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