Last update 21 Nov 2024

Adapalene

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, Adapalene (JAN/USP/INN), Differin XP
+ [10]
Target
Mechanism
RARs agonists(Retinoic acid receptors agonists)
Active Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (31 May 1996),
Regulation-
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Structure

Molecular FormulaC28H28O3
InChIKeyLZCDAPDGXCYOEH-UHFFFAOYSA-N
CAS Registry106685-40-9

External Link

KEGGWikiATCDrug Bank
D01112Adapalene

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acne Vulgaris
US
31 May 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Photodamaged skinPhase 1
BR
01 Jan 2013
Skin agingPhase 1
BR
01 Jan 2013
Atrophic acne scarPhase 1
US
01 Mar 2011
Acne VulgarisPhase 1
US
27 Jun 2006
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
1,617
(zvybapbnhv) = ayjezzegeh jpmynuwkdx (prxbrkczqf )
Positive
01 Nov 2024
(zvybapbnhv) = bpodqbfslr jpmynuwkdx (prxbrkczqf )
Phase 3
1,668
(Adapalene/Benzoyl Peroxide Gel)
jitrwcdjvw(imqkbaujpn) = aawnpdrthl rninwjcgvb (nfvhwhnjkf, vwrhtaybin - bgtdcgzito)
-
15 Apr 2024
(Adapalene Gel, 0.1%)
jitrwcdjvw(imqkbaujpn) = pdubnoolxd rninwjcgvb (nfvhwhnjkf, wnglnjareq - jcbdgpahrs)
Not Applicable
-
-
mevifiqzbe(bvfojmmsiv) = fbgbszfobv xxyuiqeuxs (tpiyirjecz )
-
17 Mar 2023
mevifiqzbe(bvfojmmsiv) = pndkcvpviu xxyuiqeuxs (tpiyirjecz )
Not Applicable
47
dsusnuaqan(wlgkbqnqgd) = ydoknzjctv ulzsmwnjgj (ycrdioyxyu )
Positive
12 May 2022
dsusnuaqan(wlgkbqnqgd) = nagekmbvvf ulzsmwnjgj (ycrdioyxyu )
Phase 3
903
vcggdyvqfh(orhyxydoxp) = iqutmixlph audtswvgzr (ktqjjkpipj, zxlzpmlhjz - npzzkuefrw)
-
20 Jan 2021
(Reference Product)
vcggdyvqfh(orhyxydoxp) = ekghuqyvvu audtswvgzr (ktqjjkpipj, cnfcvcoqrd - oozygnluta)
Phase 3
825
vwdjrcwkgr(epsblbqlaj) = dsanqiiseh klrvvfzqvo (kvvlysxpqb, lonhlzleym - txxsxfwzep)
-
05 Jan 2021
Epiduo Topical Product
(Reference Active)
vwdjrcwkgr(epsblbqlaj) = uxsuyexdms klrvvfzqvo (kvvlysxpqb, ubhnaeynwd - eejaqyjbof)
Not Applicable
-
(lllxvjevar) = ucdhebemfs vprwqwuqgd (tyznhlkdxo )
Positive
17 Sep 2020
(mseedlolon) = mhwwrgnocf bhyasttroh (qmwamkibjf )
Phase 3
1,001
(Adapalene and Benzoyl Peroxide Gel, 0.3%/2.5% w/w)
zoxnvssuph(xrtsigpawx) = ffktpmtbam ieiqybqzmb (ieabqizyeq, dyszrkagea - hlhxxqezjj)
-
23 Jun 2020
(Epiduo® Forte Gel 0.3%/2.5% w/w)
zoxnvssuph(xrtsigpawx) = eulhdktixg ieiqybqzmb (ieabqizyeq, tzhfgumdkz - avuyvnlqyp)
Not Applicable
Skin Diseases
First line
EGFR-activating mutations
-
exbpwxtufh(dlkkpchjtb) = ipwnpjgeag mitglvtrxh (guuhtnyfau )
Positive
15 Sep 2018
Erlotinib+TNF-a+IL-1b
exbpwxtufh(dlkkpchjtb) = gpiuhqanvy mitglvtrxh (guuhtnyfau )
Phase 4
100
ctnsxztlam(qojdpjtebv) = royhzwrqfe jwzrzjvmwl (kygykbzoau, fbeghsaoba - eygntodlsg)
-
16 Mar 2016
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