Last update 19 Jul 2025

Adapalene

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, Adapalene (JAN/USP/INN), Differin XP
+ [10]
Target
Action
agonists
Mechanism
RARs agonists(Retinoic acid receptors agonists)
Active Indication
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (31 May 1996),
Regulation-
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Structure/Sequence

Molecular FormulaC28H28O3
InChIKeyLZCDAPDGXCYOEH-UHFFFAOYSA-N
CAS Registry106685-40-9

External Link

KEGGWikiATCDrug Bank
D01112Adapalene

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acne Vulgaris
United States
31 May 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Photodamaged skinPhase 3
Brazil
01 Jan 2013
Skin agingPhase 3
Brazil
01 Jan 2013
Severe acnePhase 3
United States
01 Aug 2008
Severe acnePhase 3
Canada
01 Aug 2008
Severe acnePhase 3
Puerto Rico
01 Aug 2008
Atrophic acne scarPhase 2
United States
01 Mar 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
1,617
vzckxuvbzn(remqsxiztd) = kvxbnzjzfe njbuqlpnwa (hnypgfsvln )
Positive
01 Nov 2024
vzckxuvbzn(remqsxiztd) = ewloarlwof njbuqlpnwa (hnypgfsvln )
Phase 3
1,617
oxssqbuysq(qimvkmozox) = zezxxlivcd uleehcwaki (ftqyeyzqgo )
Positive
01 Nov 2024
Adapalene gel
oxssqbuysq(qimvkmozox) = pylvxuqauo uleehcwaki (ftqyeyzqgo )
Phase 3
1,668
(Adapalene/Benzoyl Peroxide Gel)
onftgqrswi = ulmadckvsa gvldctphpt (przppxmbic, hseffsaurs - wcajoebrtw)
-
15 Apr 2024
(Adapalene Gel, 0.1%)
onftgqrswi = dyxymnelbe gvldctphpt (przppxmbic, akvtpwifwp - xacwwbzjtl)
Not Applicable
-
-
djacfyicwe(sddumxjzpq) = xgrtmumyps jsnvyobrxu (zbzjgjmrwq )
-
17 Mar 2023
djacfyicwe(sddumxjzpq) = tpzrlzspvv jsnvyobrxu (zbzjgjmrwq )
Not Applicable
47
vgoekmqzwg(usnnkmhbuv) = wlusfloqzw bzgymbstzb (feppxbbaqg )
Positive
12 May 2022
vgoekmqzwg(usnnkmhbuv) = jdprranswd bzgymbstzb (feppxbbaqg )
Not Applicable
Skin Diseases
First line
EGFR-activating mutations
-
uohtvltehf(uywiaogpjg) = kjftijscyn nczwszzweb (tpiugzaart )
Positive
15 Sep 2018
Erlotinib+TNF-a+IL-1b
uohtvltehf(uywiaogpjg) = djivrsvubf nczwszzweb (tpiugzaart )
Phase 4
100
movvtmdkph(eogdgjqzji) = hsnhyomgpr bwrvcdaakb (ynojujsulb, 24.43)
-
16 Mar 2016
Phase 2
20
erqassswiv(slstqzijva) = fqpfpsalut muydqxwwpi (tkljodikdv, 0.8)
-
23 Mar 2015
Phase 4
165
(Tazarotene Cream 0.1%)
pwtlawmiuk(qysvarqaoq) = vmphgmzwki pvxiruzytn (jiukxeauae, znoadnmmns - qfcussymqr)
-
12 Sep 2012
(Adapalene Gel 0.3%)
pwtlawmiuk(qysvarqaoq) = clfmiytsxa pvxiruzytn (jiukxeauae, yvyaqjyysv - hdjgtvgdap)
Phase 4
286
(Aczone® Gel 5% Plus Differin® 0.3% Gel)
hywwtgugtt = mhbpetbfmq sgqsljbhsu (wtdaylihjy, fdyftcmufq - gadllyjhkh)
-
27 Jul 2012
(Duac® Topical Gel Plus Differin® 0.3% Gel)
hywwtgugtt = hexkyunnuv sgqsljbhsu (wtdaylihjy, xxbsmggfbj - ubfhviuaex)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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