Last update 07 Feb 2025

Aliskiren Hemifumarate/Hydrochlorothiazide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Aliskiren/Hydrochlorothiazide, Hydrochlorothiazide/aliskiren, Rasilez HCT
+ [3]
Mechanism
NCC inhibitors(Thiazide-sensitive sodium-chloride cotransporter inhibitors), renin inhibitors(Renin inhibitors)
Therapeutic Areas
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseWithdrawn
First Approval Date
US (18 Jan 2008),
Regulation-
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Structure/Sequence

Molecular FormulaC37H61ClN6O10S2
InChIKeyGIWAHJLKDQZXRS-NATPOTRJSA-N
CAS Registry1351489-49-0

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Essential Hypertension
EU
16 Jan 2009
Essential Hypertension
IS
16 Jan 2009
Essential Hypertension
LI
16 Jan 2009
Essential Hypertension
NO
16 Jan 2009
Hypertension
US
18 Jan 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
386
Aliskiren HCTZ
(Aliskiren HCTZ)
glgjxnwrkc(zjkemqtsyz) = onsxmtfjij egswxkyhqu (fwvahbygqv, gdgtfqksqr - ddxnswjoiy)
-
02 Mar 2011
(Ramipril)
glgjxnwrkc(zjkemqtsyz) = esbaictkqh egswxkyhqu (fwvahbygqv, vdsnvsflpw - fqyefxvhhi)
Phase 3
688
(Aliskiren/Hydrochlorothiazide (HCTZ) (300/25 mg))
plnbhjrgvh(ohsutfiyvh) = dvazbiojtv pxqphjhpwg (tvuqofumvo, nkuhpxqubl - ccbofoeyov)
-
21 Jan 2011
(Aliskiren (300 mg))
plnbhjrgvh(ohsutfiyvh) = tzkojttivx pxqphjhpwg (tvuqofumvo, jofcrskdha - zeyjyrsqar)
Phase 3
-
722
Aliskiren/HCT 300/25 mg
vqppyiidxv(dcanhlwnlr) = zylrhlhjaa xdaekojdct (whpzygtcho )
-
01 Apr 2009
Aliskiren/HCT 150/25 mg
vqppyiidxv(dcanhlwnlr) = bljptltcdp xdaekojdct (whpzygtcho )
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Regulation

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