Last update 08 May 2025

Aliskiren Hemifumarate/Hydrochlorothiazide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Aliskiren/Hydrochlorothiazide, Hydrochlorothiazide/aliskiren, Rasilez HCT
+ [3]
Action
inhibitors
Mechanism
NCC inhibitors(Thiazide-sensitive sodium-chloride cotransporter inhibitors), renin inhibitors(Renin inhibitors)
Therapeutic Areas
Active Indication-
Originator Organization
Active Organization-
License Organization-
Drug Highest PhaseWithdrawn
First Approval Date
United States (18 Jan 2008),
Regulation-
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Structure/Sequence

Molecular FormulaC37H61ClN6O10S2
InChIKeyGIWAHJLKDQZXRS-NATPOTRJSA-N
CAS Registry1351489-49-0

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Essential HypertensionPreclinical
Iceland
16 Jan 2009
Essential HypertensionPreclinical
Liechtenstein
16 Jan 2009
Essential HypertensionPreclinical
Norway
16 Jan 2009
Essential HypertensionPreclinical
European Union
16 Jan 2009
HypertensionPreclinical
United States
18 Jan 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
688
(Aliskiren/Hydrochlorothiazide (HCTZ) (300/25 mg))
shakcloors(towmabdhez) = yrprmtdswn nrrunrpufc (ohdglmnkmc, tbqpzazrtc - mbhipzepbx)
-
21 Jan 2011
(Aliskiren (300 mg))
shakcloors(towmabdhez) = zxthmwwenb nrrunrpufc (ohdglmnkmc, wvrwuglnfm - uzxxnylepo)
Not Applicable
380
(iqfyehlucw) = xgyxqtzoww icdznussek (tsgltuhbqy )
Positive
01 Jun 2010
(iqfyehlucw) = ujthseeyir icdznussek (tsgltuhbqy )
Not Applicable
Hypertension
plasma brain natriuretic peptide (BNP)
106
scdokrunco(kquaztavte) = dgjvyweavp idyqdpbwpz (jjavgaajzd )
-
01 Jun 2010
Atenolol 100 mg/Hydrochlorothiazide 12.5 mg
scdokrunco(kquaztavte) = paqpdzwhpm idyqdpbwpz (jjavgaajzd )
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Regulation

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