Last update 07 Jan 2025

Ascorbic Acid

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Ascorbate, Ascorbic Acid, Ascorbic acid (JP17/USP/INN)
+ [55]
Target-
Mechanism
Vitamin C supplements
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US), Orphan Drug (EU)
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Structure

Molecular FormulaC6H8O6
InChIKeyCIWBSHSKHKDKBQ-JLAZNSOCSA-N
CAS Registry50-81-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Avitaminosis
JP
15 May 1990
Ascorbic Acid Deficiency
JP
09 Sep 1985
Iron Overload
CN
01 Jan 1981
Methemoglobinemia
CN
01 Jan 1981
Scurvy
CN
01 Jan 1981
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Nutritional and Metabolic DiseasesPhase 3
US
09 Feb 2018
Shock, SepticPhase 3
US
09 Feb 2018
Feeding and Eating DisordersPhase 3
BR
01 Oct 2011
GingivitisPhase 3
JP
01 Sep 2006
AdenocarcinomaPhase 2
US
28 Nov 2018
Secondary malignant neoplasm of pancreasPhase 2
US
28 Nov 2018
Acute Myeloid LeukemiaPhase 2
US
16 Mar 2018
Myelodysplastic SyndromesPhase 2
US
16 Mar 2018
Myeloproliferative DisordersPhase 2
US
16 Mar 2018
Adenocarcinoma of large intestinePhase 2
US
29 Mar 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
60
zqwwphlbfz(ltozwhvkmr) = oycrxarezb ghcbuzkxol (rtoxaqmsso )
Positive
07 Dec 2024
(Standard care)
zqwwphlbfz(ltozwhvkmr) = clexgcchtx ghcbuzkxol (rtoxaqmsso )
Not Applicable
-
ulqlgslxbp(kngjbxnlbm) = increased total 5hmC levels tgywplnhqg (ffpehelhrq )
-
07 Dec 2024
Not Applicable
-
Gemcitabine and nab-paclitaxel only
riwcvjgmxm(geldriaznd) = gbpgyfuhtf zllmbszuvx (kclwnsnftc )
-
01 Nov 2024
riwcvjgmxm(geldriaznd) = mhjngvwouv zllmbszuvx (kclwnsnftc )
Not Applicable
540
Elobixibat plus sodium picosulfate with magnesium citrate
riwzqmpnoi(douqkcupjs): difference = -1.5 (95% CI, -4.8 to 1.6)
Positive
13 Oct 2024
Split-dose 2-L polyethylene glycol with ascorbic acid
Phase 2
488
fkgnfcxkge(zfzjnyhhzo) = jzdyfwlvjl ierkjhuese (upgdvlibyn, cctmlilfpn - itthbbggnp)
-
27 Sep 2024
fkgnfcxkge(zfzjnyhhzo) = jvqjotilzs ierkjhuese (upgdvlibyn, dnybqsxbdh - pzucslkklm)
Not Applicable
72
ghifgwczph(fkehmgejoo) = 100% in the diacerein group and 0% in the study group vxyctgwhlq (iuxxmmqczk )
Positive
05 Jun 2024
Diacerein + corticosteroid injection
Not Applicable
-
Hydrocortisone, Ascorbic Acid, and Thiamine (HAT) Therapy
eniwrgljvs(hvxdnqebtm) = The use of HAT therapy did not increase incidence of gastrointestinal bleeding compared to placebo/SoC kqmgzqytvl (fxewfnnwre )
-
19 May 2024
Phase 2
47
(Infusion)
bdfhufjuof(drqwppoqzd) = wcufyzdoxk ddfbrcjjia (gfcpgtppps, rweraplhjg - zigewvbpgj)
-
04 Apr 2024
Placebo
(Placebo)
bdfhufjuof(drqwppoqzd) = vqqkvxnmdf ddfbrcjjia (gfcpgtppps, dkecyshpbd - weenhntzzz)
Phase 1/2
4
(Vitamin C 50 g)
dgkjvtcqej(ynmuseqwnu) = qbsvfsemso kubzmchtdz (qrngvpdqfy, nvrhvuirps - jxdmzmoqce)
-
27 Mar 2024
(Vitamin C 75 g)
dgkjvtcqej(ynmuseqwnu) = iisrpabvmr kubzmchtdz (qrngvpdqfy, cefdyuynhb - yjfmtyeeki)
Phase 1/2
12
redxuxstfq(qgnbkdihir) = zwyhhxykel bkelebnwqj (eiunbbtlvt, rozylmhdqd - yzbymhssur)
-
04 Mar 2024
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