Radiation therapy improves cancer cure rates by killing cancer cells but it also contributes to long-term side effects in cancer survivors by unintentionally damaging normal organs such as the intestine. This research will what side effects patients with cancer experience, if high dose vitamin C helps reduce these side effects, and if high dose vitamin C increases the survival of patients with pancreatic cancer. We will meet with patients during the study to better understand their experience during their cancer treatment. In the long term, our research could provide a new way help cancer survivors avoid many permanent side effects of cancer treatments.

Start Date31 Dec 2025

Sponsor / Collaborator

The Holden Comprehensive Cancer Center

NCT06710899

/ Not yet recruitingEarly Phase 1

Does Vitamin C Improve the Efficacy of Methenamine Hippurate (Hiprex®) in Prophylaxis of Recurrent Urinary Tract Infections? A Proof of Concept Study

A single centre proof of concept study to assess whether Vitamin C improves the efficacy of Methenamine Hippurate (Hiprex®) in the prophylaxis of recurrent urinary tract infections (rUTIs) in women

Start Date01 Sep 2025

Sponsor / Collaborator

University Hospitals of North Midlands NHS Trust

NCT04756063

/ RecruitingPhase 4IIT

Parenteral Ascorbic Acid Repletion in TransplantatIon (PARTI): A Randomized, Double-Blinded, Placebo-Controlled Trial

A single-center, randomized, double-blinded placebo-controlled trial is proposed to investigate administration of supraphysiologic doses of ascorbic acid (vitamin C, AA) to patients undergoing liver transplantation. Participants randomized to the intervention group will receive intravenous (IV) AA 1500 mg every 6 hours for 48 hours. Participants randomized to the control group will receive a saline placebo. The primary study outcome will be a change in the Sequential Organ Failure Assessment (SOFA) score from baseline to three days after the first dose of drug (dSOFA3). Secondary outcomes will include total vasopressor dose in norepinephrine equivalents, 30-day and 1-year mortality, and serum AA levels.

Start Date01 Sep 2025

Sponsor / Collaborator

University of Wisconsin Madison

100 Clinical Results associated with Ascorbic Acid

100 Translational Medicine associated with Ascorbic Acid

100 Patents (Medical) associated with Ascorbic Acid

130,382

Literatures (Medical) associated with Ascorbic Acid

01 Feb 2026·BIOMATERIALS

Directed differentiation of human mesenchymal stromal cells into functional endothelial cells having IKAROS-mediated immune tolerance properties

Article

Author: Oh, HanJun ; Han, Jung-Kyu ; Shin, Dasom ; Kim, Ju-Hee ; Chung, Seok ; Kim, Minseop ; Kim, Hyo-Soo ; Lee, Seyoon ; Shin, Youngchul ; Kwon, Seong Keun ; Lee, Haena ; Kim, Jong-Il

We report an efficient method for the directed differentiation of mesenchymal stromal cells derived from embryonic stem cells (EMSCs) into functional endothelial cells (EC), addressing the challenges of direct conversion, such as cellular senescence. We found that transduction of one transcription factor, ER71, was required for the efficient derivation of induced endothelial cells from EMSCs (MiECs). Addition of transforming growth factor-β inhibitor (SB431542), vascular endothelial growth factor, and ascorbic acid to the culture media enhanced the differentiation efficiency. After one week of the induction protocol, 75.4 ± 4.5 % of EMSCs were directly differentiated into ECs as defined by double-positivity for VE-cadherin/PECAM1. MiECs demonstrated endothelial characteristics and functions. Interestingly, the immune tolerance of MSCs was potentiated in MiECs, and were mediated by IKAROS, a direct transcriptional target of ER71. We established an efficient protocol for direct differentiation of MSCs into functional ECs with immune tolerance properties based on ER71 transduction. This technology provides the allogenic cell source for ready-to-use cell therapies for diseases or conditions requiring vascularization.

01 Jan 2026·BIOMATERIALS

Epidermal and dermal cell-composed organospheres to assess microplastic-induced skin toxicity

Article

Author: Hu, Yunxia ; Cai, Yongde ; Nicolas, George Michael ; Dai, Xiaoyong ; Ma, Shaohua

The alarming prevalence of microplastics (MPs) in personal care products and their inherent presence in animals and humans necessitate the development of alternative experimental approaches to evaluate their cytotoxicity, mechanisms, and long-term effects. Microfluidic bead-jet printed skin organospheres, comprising epidermal and dermal cells, present significant promise in addressing MP research, creating high-throughput and reproducible screening systems. Medium-density bioprinted E18 pregnant mouse fetus epidermal and dermal cell (Epi-Dc) organospheres exhibited fast self-aggregation, migration, and cellular differentiation. Co-culture revealed a size-dependent MP uptake rate, with smaller MPs having higher internalization ratios. The 100 nm MP penetrated the epidermal layer and migrated toward the central region, while the 500 nm MP remained in the peripheral area. Ultraviolet A (UVA)-irradiated MPs also significantly increased oxidative stress, cell apoptosis, and ROS levels via upregulation of oxidative stress-associated genes (SOD, p53, and Bax). Furthermore, vitamin C treatment following MP-UVA irradiation decreased reactive oxygen species levels, while cell viability assay using conventional skin-associated drugs indicate dose- and time-dependent induced cytotoxicity. These results demonstrate the broad applications of Epi-Dc organospheres in skin toxicity evaluation and rapid drug testing.

01 Jan 2026·TALANTA

Microfluidic paper-based analytical devices for antioxidant vitamins C and E in foods

Article

Author: Kaneta, Takashi ; Kawahara, Mana ; Danchana, Kaewta

In this study, we developed microfluidic paper-based analytical devices (μPADs) for the determination of antioxidant vitamins. The proposed μPADs utilize the reduction of metal ions by hydrophilic and hydrophobic antioxidant vitamins, which is followed by colorimetric reactions with chelating reagents. Hydrophilic vitamin C reduces Fe(III) to Fe(II) and forms a stable Fe(II)-bathophenanthroline complex in an aqueous solution. By contrast, this complex is unstable in organic solvents, and hydrophobic vitamin E requires Fe(III) and bathophenanthroline to be replaced with Cu(II) and bathocuproine. In these results, the relationship between the logarithm of a vitamin's concentration and its color intensity was linear and ranged from 4.4 to 35 mg L^-1 for ascorbic acid and 50-200 mg L^-1 for α-tocopherol. The limits of detection, estimated from the standard deviation of blank samples, were 3.1 mg L^-1 for ascorbic acid and either 27 mg L^-1 (in hexane) or 48 mg L^-1 (in ethanol) for α-tocopherol. The proposed method was used to quantify vitamin C in bell peppers, mandarin oranges, kiwifruit, and lemons, as well as vitamin E in almonds, almond milk, and dietary supplements. The results demonstrate the effectiveness of these μPADs for the practical analysis of antioxidant vitamins in food samples.

100

News (Medical) associated with Ascorbic Acid

04 Aug 2025

·www.einpresswire.com

Patients from the USA, Canada and EU Are Traveling to Louisville KY [Kentuckiana] for Dr. Cruz’s Brain Trauma Therapy

LOUISVILLE, KY, UNITED STATES, August 4, 2025 / EINPresswire.com / -- Patients with traumatic brain injuries (TBI) and stroke symptoms are finding new hope in Louisville, Kentucky, where Dr. Rafael F. Cruz MD and his team at Kentuckiana Integrative Medicine offer Perispinal Etanercept therapy—an innovative procedure that’s drawing patients from across the United States, Canada and Europe seeking relief from debilitating symptoms often unaddressed by conventional medicine. Traumatic brain injuries and strokes can leave patients with life-altering challenges, including memory loss, chronic pain, speech difficulties, and mobility issues. While conventional therapy focuses on managing symptoms, Dr. Cruz’s approach in using Perispinal Etanercept, has shown rapid and dramatic results. “Perispinal Etanercept is a game-changer for patients who have been told there’s no hope for improvement,” says Dr. Cruz, a nationally recognized leader in integrative medicine. “We’ve seen patients regain speech, mobility, and cognitive function within hours of therapy. It’s truly life-changing.” What Is Perispinal Etanercept Therapy? Perispinal Etanercept is an anti-TNF (tumor necrosis factor) biologic that targets chronic inflammation in the brain—a key driver of ongoing neurological dysfunction after TBI or stroke. Administered via a specialized injection technique, the therapy allows the medication to reach the brain and cerebrospinal fluid quickly, often resulting in noticeable improvements in speech, mobility, and pain within hours. Dr. Cruz and his team at Kentuckiana Integrative Medicine are among the few clinics in the U.S. offering this advanced therapy, making Louisville a destination for patients worldwide. Real Stories of Recovery from Kentuckiana Integrative Medicine: Patients from all over the country have shared inspiring stories of recovery after being seen at Kentuckiana Integrative Medicine. > Eduard Wilks., a stroke survivor, went from using a walker to taking independent steps after therapy. > Louis Meier, Parkinson's shuffling gate and history of falls corrected in hours > Mike Bonin., an IT engineer, has made significant strides in overcoming paralysis and balance issues following his therapy. The Potential for Stroke Recovery: While not a patient at the clinic, Linda's story is a powerful example of the remarkable recovery that is possible. Linda, a teacher from Connecticut, regained her speech and improved her ability to walk three years after a massive stroke. Watch these patient video testimonials and many more on our website . Kentuckiana Integrative Medicine Specializes in Advanced Therapies for Complex Conditions: 1. Neurological and Brain Injury Therapies: TBI, stroke, Parkinson’s, ALS, and Long Haulers Syndrome with innovative solutions like Perispinal Etanercept and regenerative therapies. 2. Regenerative Medicine Injections: Offering regenerative messenger signaling “stem “ cellular injection therapy, hyper-concentrated PRP (enhanced with procaine, photobiomodulation, and B vitamins), Prolozone Therapy and Prolozone Therapy for pain and tissue repair. 3. Ketamine Therapy: For mental health challenges like PTSD, depression, and chronic pain. 4. Wellness Therapies: Using advanced PRP and regenerative messenger signaling “stem “ cellular injection therapy for enhanced results. 5. Heart Disease Reversal Therapies: IV EDTA Chelation and IV Phospholipids for cardiovascular health. 6. Cancer Support Therapies: IV Ozone, IV DMSO, IV Alpha Lipoic Acid, IV Vitamin C Therapy, Low Dose Naltrexone and other Repurposed Medications to boost immunity and support overall well-being. Take the Next Step! If you or a loved one is living with the effects of TBI or stroke, Kentuckiana Integrative Medicine invites you to explore the possibilities of Perispinal Etanercept therapy. > Request FREE information at www.ReGenMedKy.com — takes just 30 seconds. > Schedule a consultation by calling 812-913-4416. Consultations are $400, but the fee is credited back if you invest $2,500 or more in your plan. Don’t let brain trauma define your future. Join the growing number of patients from across the U.S. who are finding hope and healing in Louisville with Dr. Cruz’s innovative therapies. About Kentuckiana Integrative Medicine Kentuckiana Integrative Medicine, led by Dr. Rafael F. Cruz MD, is a leading clinic specializing in regenerative and integrative medicine. Located in Louisville, KY, the clinic serves patients from the Kentuckiana region and beyond, offering cutting-edge therapies for TBI, stroke, Parkinson’s, and other neurological conditions. Read our disclaimer here: regenmedky.com/fda-disclaimer Kentuckiana Integrative Medicine Kentuckiana Integrative Medicine +1 812-913-4416 email us here Stroke, Parkinsons, & Traumatic Brain Injury Therapies Legal Disclaimer: EIN Presswire provides this news content "as is" without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.

Cell Therapy

30 Jul 2025

·www.einpresswire.com

TOP PURE ALPHA LIPOIC ACID 99% FACTORY Appearance in CPhI China

XIAN, SHANXI, CHINA, July 30, 2025 / EINPresswire.com / -- In the dynamic world of pharmaceuticals, nutraceuticals, and cosmetics, the demand for highly pure and effective active ingredients is soaring. Consumers and industries alike are increasingly seeking compounds that offer proven health benefits and deliver tangible results. Among these crucial ingredients, Alpha Lipoic Acid (ALA) stands out for its remarkable versatility and potent properties. Shaanxi Ruiwo Phytochem Co., Ltd., a high-tech manufacturing enterprise, has emerged as a leading force in this specialized domain, consistently providing exceptional quality active ingredients, including pure Alpha Lipoic Acid 99% , to a global clientele. Their prominent presence and recognition at CPhI China underscore their pivotal role in advancing the supply chain for these vital compounds. The Expanding Market for Active Ingredients and CPhI China's Central Role The global market for active ingredients is experiencing robust growth, fueled by several key trends. An aging global population, coupled with increasing health consciousness, drives demand for dietary supplements, functional foods, and targeted therapeutic solutions. Advancements in scientific research continue to uncover new applications and benefits for existing compounds, while a persistent focus on product purity, bioavailability, and ethical sourcing further shapes industry dynamics. Companies are under increasing pressure to ensure the highest quality standards, traceability, and compliance with stringent international regulations. Alpha Lipoic Acid (ALA): A Star Active Ingredient Within this flourishing landscape, Alpha Lipoic Acid (ALA) shines as a particularly significant active ingredient. ALA is an organic compound found in every cell of the human body, playing a crucial role in energy metabolism. It is unique in its ability to function as both a water-soluble and fat-soluble antioxidant, allowing it to work throughout the body to neutralize harmful free radicals. This dual solubility sets it apart from other antioxidants like Vitamin C (water-soluble) and Vitamin E (fat-soluble). The diverse applications of ALA contribute to its escalating demand across multiple sectors: Pharmaceuticals: ALA is widely studied and used, particularly for its role in managing conditions like diabetic neuropathy, where it helps improve nerve function and reduce symptoms. Its anti-inflammatory properties also make it a subject of research for various neurodegenerative conditions. Nutraceuticals and Health Care: As a powerful antioxidant, ALA is a popular ingredient in dietary supplements aimed at supporting cellular health, enhancing antioxidant defenses, promoting healthy metabolism, and aiding in glucose utilization. It's often included in formulas for weight management, energy enhancement, and cardiovascular health. Cosmetics and Personal Care: Due to its potent antioxidant and anti-inflammatory properties, ALA is increasingly incorporated into topical skincare products. It helps protect the skin from environmental damage, reduce the appearance of fine lines and wrinkles, improve skin texture, and promote a youthful complexion. The market for high-purity ALA , particularly 99% pure, is driven by the need for maximum efficacy and safety in end products. Manufacturers require ingredients that meet rigorous specifications to ensure the therapeutic or cosmetic benefits are fully realized. This growing demand for premium, highly concentrated active ingredients underscores the need for reliable and quality-focused suppliers. CPhI China: A Global Gateway for Active Ingredients CPhI China stands as the most comprehensive and influential pharmaceutical industry event in Asia, serving as a critical platform for the entire pharmaceutical supply chain, from raw materials to finished formulations. For manufacturers and suppliers of active ingredients like Shaanxi Ruiwo Phytochem, CPhI China is more than just an exhibition; it's a strategic hub for global business. Each year, CPhI China brings together tens of thousands of industry professionals from around the world, including pharmaceutical manufacturers, research institutions, distributors, and buyers of APIs (Active Pharmaceutical Ingredients), excipients, and fine chemicals. The event provides unparalleled opportunities for: Showcasing Innovation: Companies like Ruiwo Phytochem can present their latest advancements in ingredient purity, synthesis techniques, and application solutions. Facilitating Sourcing and Procurement: It serves as a vital marketplace where global buyers can source high-quality active ingredients, establish new supply relationships, and verify supplier credentials. The specific mention of "Best PURE ALPHA LIPOIC ACID 99% FACTORY Appearance in CPhI China" signifies a company's leadership and trustworthiness in a highly competitive segment. Networking and Collaboration: The event fosters invaluable connections, allowing for discussions on market trends, regulatory changes, and potential partnerships. Market Insight: Through dedicated forums, conferences, and expert presentations, attendees gain critical insights into the latest market dynamics, technological breakthroughs, and future regulatory landscapes influencing the active ingredients sector. CPhI China's sheer scale and international reach make it an indispensable event for any company aiming to solidify its position in the global pharmaceutical, nutraceutical, and cosmetic ingredients markets. For Shaanxi Ruiwo Phytochem, being recognized as a leading factory for pure Alpha Lipoic Acid 99% at this prestigious event affirms their commitment to excellence and their capacity to meet stringent global demands. Shaanxi Ruiwo Phytochem: A Leader in High-Purity Active Ingredients Shaanxi Ruiwo Phytochem Co., Ltd. embodies the pinnacle of innovation and precision in the realm of active ingredients and natural plant extracts. As a high-tech manufacturing enterprise, the company is meticulously dedicated to the research and development, production, and sales of a wide array of active monosour ingredients, alongside its foundational expertise in natural plant extracts. Their steadfast commitment to providing a steady supply of top-tier products and innovative services has cemented their reputation as a trusted partner across the global pharmaceutical, health care, and cosmetics industries. Company's Core Advantages – Purity and Precision: Ruiwo Phytochem's distinguished position is built upon several foundational strengths: Advanced Research and Development (R&D): The company’s robust R&D capabilities are central to its success. They continuously invest in cutting-edge research to develop novel extraction and synthesis methods, ensuring the highest purity and bioavailability of their active ingredients. This includes meticulous process optimization for compounds like Alpha Lipoic Acid to achieve a guaranteed 99% purity, a critical benchmark for efficacy and safety in sensitive applications. High-Tech Manufacturing Excellence: Ruiwo Phytochem operates state-of-the-art manufacturing facilities that adhere to rigorous international quality management systems. This advanced infrastructure enables precise control over every stage of production, from raw material sourcing and purification to final product analysis and packaging. Their commitment to manufacturing excellence ensures consistent quality, batch after batch, which is indispensable for pharmaceutical and high-end cosmetic formulations. Unwavering Quality Assurance: Quality is not just a buzzword but a core principle at Ruiwo Phytochem. They implement comprehensive quality control protocols, including stringent testing for purity, heavy metals, microbial contaminants, and other impurities. This meticulous approach guarantees that their products, including their flagship pure Alpha Lipoic Acid 99%, meet or exceed the most demanding industry standards and regulatory requirements worldwide. Reliable and Steady Supply: In today's volatile supply chain environment, reliability is paramount. Ruiwo Phytochem is dedicated to maintaining a steady and secure supply chain, ensuring that their global customers receive their critical ingredients on time and in full. This operational reliability helps clients maintain their production schedules and meet market demands without interruption. Main Product Applications – Alpha Lipoic Acid in Focus: Shaanxi Ruiwo Phytochem’s portfolio of active ingredients and natural plant extracts finds broad utility across its target sectors, with high-purity Alpha Lipoic Acid being a standout offering: Pharmaceutical Applications: Their pure Alpha Lipoic Acid 99% serves as a vital active pharmaceutical ingredient (API) in the manufacturing of drugs, particularly those targeting metabolic disorders and neurological conditions. Its high purity is essential for formulation integrity, dosage consistency, and therapeutic efficacy, meeting the strict requirements of pharmaceutical regulatory bodies. Health Care and Nutraceutical Formulations: In the rapidly expanding health and wellness sector, Ruiwo Phytochem’s ALA is a preferred choice for dietary supplement manufacturers. It's incorporated into products designed to provide antioxidant support, enhance energy metabolism, support nerve health, and assist in glucose management. The consistent quality ensures that these health products deliver their promised benefits to consumers. Cosmetic and Personal Care Innovations: The beauty industry is increasingly leveraging science-backed active ingredients. Ruiwo Phytochem’s Alpha Lipoic Acid is a prized component in advanced skincare products, including anti-aging serums, creams, and lotions. Its antioxidant properties help protect the skin from oxidative stress, reduce visible signs of aging, and promote a healthier, more radiant complexion. Customer-Centric Approach and Key Client Partnerships: Ruiwo Phytochem's success is deeply intertwined with its strong, collaborative relationships with its global customer base. The company prides itself on offering innovative services that go beyond mere product supply. They act as strategic partners, providing: Technical Support: Assisting clients with formulation development, application guidance, and technical troubleshooting to optimize product performance. Customized Solutions: Working closely with customers to develop tailor-made ingredients or specific purity profiles to meet unique product requirements. Market Insights: Sharing their deep understanding of industry trends and regulatory changes to help clients navigate complex markets and identify new opportunities. Their clientele typically includes leading pharmaceutical companies, prominent nutraceutical brands, and innovative cosmetic manufacturers worldwide. While specific customer names remain confidential, Ruiwo Phytochem’s ability to consistently deliver high-quality, high-purity ingredients like Alpha Lipoic Acid 99% has made them a trusted and preferred supplier for businesses that demand excellence and reliability in their supply chains. Their long-standing partnerships are a testament to their unwavering commitment to client success and mutual growth. Looking Ahead: A Future Defined by Purity and Progress The future of the active ingredients market is bright, driven by continuous scientific discovery and an ever-increasing global emphasis on health and well-being. Shaanxi Ruiwo Phytochem Co., Ltd. is exceptionally well-positioned to lead this charge. By combining their profound expertise in R&D and high-tech manufacturing with an unyielding commitment to quality and customer service, they are not just responding to market demands; they are actively shaping the future of high-purity active ingredients. Their recognition as a "Best PURE ALPHA LIPOIC ACID 99% FACTORY" at an influential platform like CPhI China further solidifies their status as a global leader dedicated to delivering excellence and contributing to healthier lives worldwide. For more information on Shaanxi Ruiwo Phytochem Co., Ltd. and their comprehensive range of high-purity active ingredients and natural plant extracts, please visit their official website: https://www.ruiwophytochem.com/ Shaanxi Ruiwo Phytochem Co., Ltd. +86 158 9170 2900 info@ruiwophytochem.com Shaanxi Ruiwo Phytochem Co., Ltd. Visit us on social media: LinkedIn Facebook Legal Disclaimer: EIN Presswire provides this news content "as is" without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.

05 Jun 2025

·www.prnewswire.com

FutureCeuticals, Inc. Announces Peer-Reviewed Publication Highlighting Cellular Health and Immune Support Benefits of vitAlign®

MOMENCE, Ill., June 5, 2025 /PRNewswire/ -- New research published in the International Journal of Molecular Sciences shows that vitAlign®, a proprietary and comprehensive healthy aging innovation from FutureCeuticals, delivers significant benefits for restoring cellular health and supporting a healthy immune response. The study highlights vitAlign's effectiveness in regulating cellular function and metabolic imbalances associated with immune stressors—from the seasonal cold and flu to more complex environmental and immune-related challenges. Researchers evaluated the impact of a low, 50 mg dose of vitAlign in medically stable adults aged 40–55 recovering from a moderate course of COVID-19, as defined by CDC guidelines. The study compared vitAlign to a 1000 mg dose of Vitamin C, focusing on key markers and processes that directly impact immune and cellular health. Results showed that vitAlign significantly reduced excessive reactive oxygen species (ROS) production in mitochondria and through the NOX2 and iNOS pathways—key mechanisms that influence immune and cellular function. Additionally, researchers observed increased levels of circulating, bioavailable nitric oxide, suggesting support for endothelial function and cardiovascular health. The authors noted that the increase in nitric oxide is likely attributable to vitAlign's ability to regulate multiple pathways of ROS production. Notably, vitAlign delivered measurable effects within 30 minutes, lasting up to three hours. In contrast, Vitamin C, which was used as a positive control, was administered at twenty times the dose and did not demonstrate comparable broad-spectrum activity. "These findings build on over a decade of published clinical research establishing vitAlign as a significant cellular health innovation, now extended directly to immune function," said J. Randal Wexler, FutureCeuticals' General Counsel and Vice President of R&D. "Previously, we've shown that vitAlign improves cellular energy efficiency and helps restore metabolic balance, both acutely and over time." Wexler added, "These new results, which compare favorably to a well-known antioxidant like Vitamin C, reinforce vitAlign's potential as a multi-faceted phytonutrient formula, providing broad support for healthy aging, cardiovascular health, and immune function. Our partners are excited about what this means for product innovation and their customers looking for daily cellular health support." About FutureCeuticals: FutureCeuticals, Inc. is the developer of vitAlign and a leader in the research, development, and manufacture of plant-based powders and extracts for the functional food, beverage, and dietary supplement markets. SOURCE FutureCeuticals, Inc. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Clinical Result

100 Deals associated with Ascorbic Acid

External Link

KEGG	Wiki	ATC	Drug Bank
D00018	Ascorbic Acid	G01AD03 S01XA15	DB00126

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Iron Overload	China	Yichang Humanwell Pharmaceuticals Co., Ltd.	01 Jan 1981
Methemoglobinemia	China	Yichang Humanwell Pharmaceuticals Co., Ltd.	01 Jan 1981
Scurvy	China	Yichang Humanwell Pharmaceuticals Co., Ltd.	01 Jan 1981
Ascorbic Acid Deficiency	Japan	T’s Pharma Co., Ltd.	31 Jan 1978

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Nutritional and Metabolic Diseases	Phase 3	United States	Beth Israel Deaconess Medical Center, Inc.	09 Feb 2018
Shock, Septic	Phase 3	United States	Beth Israel Deaconess Medical Center, Inc.	09 Feb 2018
Colorectal Cancer	Phase 3	Belgium	Norgine Ltd.	01 Oct 2014
Colorectal Cancer	Phase 3	France	Norgine Ltd.	01 Oct 2014
Colorectal Cancer	Phase 3	Germany	Norgine Ltd.	01 Oct 2014
Colorectal Cancer	Phase 3	Italy	Norgine Ltd.	01 Oct 2014
Colorectal Cancer	Phase 3	Poland	Norgine Ltd.	01 Oct 2014
Colorectal Cancer	Phase 3	Spain	Norgine Ltd.	01 Oct 2014
Colorectal Cancer	Phase 3	United Kingdom	Norgine Ltd.	01 Oct 2014
Feeding and Eating Disorders	Phase 3	Brazil	EMS SA (Brazil)	01 Oct 2011

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ALFEO (ESMO_GI2025)	Not Applicable	Mismatch repair-deficient Colonic Cancer Neoadjuvant pMMR	24	High-dose vitamin C (HDVC)	aclpapooro(nruuvftzge) = vukbpojkbq fdmaouezlh (ajrmjtutbx )	Positive	03 Jul 2025
ASCO2025	Not Applicable	Colorectal Cancer	262	High-dose Vitamin C + FOLFOX	ihlchenwsl(bxsslzustb) = Severe euurkxnkvt (ewtiikkgow ) View more	Positive	30 May 2025
				FOLFOX
ASCO2025	Phase 1/2	Pancreatic Ductal Adenocarcinoma	62	Intravenous Vitamin C	hvltjovqgh(lguejniofa) = Most grade ≥3 adverse effects were related to chemotherapy or disease progression, including cytopenia, transaminitis, electrolyte imbalances, fever, and pulmonary embolism pkrnwavxgd (uteqjtocfw ) View more	Positive	30 May 2025
PB2761 (EHA2025)	Phase 2/3	Chronic Myelomonocytic Leukemia	54	High dose ascorbate (TET2 knockout)	eoaoqnkfrw(romvttkhxr) = qbyqmnuuwx zgejxqntrc (mqiwydnnvg ) View more	Positive	14 May 2025
EHA2025	Not Applicable	Glucosephosphate Dehydrogenase Deficiency \| Pyruvate Kinase Deficiency	3	Vitamin C (PKD patients)	khhgqggrsq(mbwyyncmji) = mtslyaxsyk pyncvtenxb (fbgidrgyut )	Positive	14 May 2025
				Vitamin C (G6PD deficiency patients)	khhgqggrsq(mbwyyncmji) = gxxcpkgqda pyncvtenxb (fbgidrgyut )
NCT05555576 (Pubmed \| PLoS One)	Not Applicable	Musculoskeletal Pain	55	Vitamin C 1g twice a day	acwhtxvzix(tgskuflzjr) = ejdrpfvzft lmbgrzaxrz (rpncgjrslk, 3.3 - 19.5)	Positive	31 Dec 2024
				Vitamin C (Placebo)	acwhtxvzix(tgskuflzjr) = qiaezzgzfi lmbgrzaxrz (rpncgjrslk, 1.5 - 16.0)
NCT02905578 (Pubmed \| Redox Biol)	Phase 2	Metastatic Pancreatic Cancer	-	Gemcitabine and nab-paclitaxel only	cmldqbqcgn(lkecrnetkh) = uepbevoycb qgvlvakjlt (mzmkjilrea ) View more	-	01 Nov 2024
				Gemcitabine and nab-paclitaxel + Pharmacological ascorbate (P-AscH<sup>-</sup>)	cmldqbqcgn(lkecrnetkh) = fcahlqvtsh qgvlvakjlt (mzmkjilrea ) View more
UEGW2024	Not Applicable	-	540	Elobixibat plus sodium picosulfate with magnesium citrate	vhpaadypls(ipvzuchsmm): difference = -1.5 (95% CI, -4.8 to 1.6) View more	Positive	13 Oct 2024
				Split-dose 2-L polyethylene glycol with ascorbic acid
NCT04291508 (ASTER, CTgov)	Phase 2	Respiratory Failure \| Critical Illness \| Sepsis ... View more	488	Acetaminophen (IV Acetaminophen-Active)	smpfgleksv(egmxcrprxq) = rqoapxjuko gzbjqmrqns (kkvtwscnxu, 10.6) View more	-	27 Sep 2024
				Intravenous Vitamin C (refrigerated) (IV Vitamin C-Active)	smpfgleksv(egmxcrprxq) = ithzhdvogy gzbjqmrqns (kkvtwscnxu, 9.5) View more
NCT01905150 (CTgov)	Phase 2	Pancreatic Cancer	34	VitaminC+G-FLIP-DM (G-FLIP Alone for 4 Weeks, Then G-FLIP+VitaminC. When DP Occurred, Then G-FLIP-DM+VitaminC)	ioffyucbxl(uvfvszomrr) = arqhhkmtxy sieqxozprs (rmnnbohmnc, aedrzpxwfq - vsydlccupt) View more	-	14 Aug 2024
				VitaminC+G-FLIP-DM+G-FLIP (G-FLIP+VitaminC. When DP Occurred, Then G-FLIP-DM+Vitamin C.)	ioffyucbxl(uvfvszomrr) = tppxrswucz sieqxozprs (rmnnbohmnc, lqoyftnzos - ghgmbkagvc) View more

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