Last update 24 May 2025

Flutamide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4'-nitro-3'-trifluoromethylisobutyranilide, Flutamide (JP17/USP/INN), FTA
+ [16]
Target
Action
antagonists
Mechanism
AR antagonists(Androgen Receptor antagonists)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (27 Jan 1989),
Regulation-
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Structure/Sequence

Molecular FormulaC11H11F3N2O3
InChIKeyMKXKFYHWDHIYRV-UHFFFAOYSA-N
CAS Registry13311-84-7

External Link

KEGGWikiATCDrug Bank
D00586Flutamide

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Prostatic Cancer
United States
27 Jan 1989
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
206
Androgen deprivation therapy+Enzalutamide+Flutamide
(Enzalutamide 160 mg 1st Line AAT/Flutamide 375 mg 2nd Line AAT)
bvrxidxafd(gupuragaat) = bwcrxhhjou cfdzjslzmf (cdhgymeehz, tgtrayhkxj - wqryilroff)
-
21 May 2021
Androgen deprivation therapy+Enzalutamide+Flutamide
(Flutamide 375 mg 1st Line AAT/Enzaltumide 160 mg 2nd Line AAT)
bvrxidxafd(gupuragaat) = alxgvzbitz cfdzjslzmf (cdhgymeehz, dhqdwlelmh - dtmodqywlu)
Phase 4
115
lactose
(Placebo)
feuftfbnqb(hywurdolki) = mxlajopmql rknijtyevi (ngpmcvqqnh, 2.3)
-
19 Nov 2019
(Flutamide)
feuftfbnqb(hywurdolki) = gnycxsidkc rknijtyevi (ngpmcvqqnh, 2.1)
Not Applicable
-
kzdootbukk(liaaacpies) = sdhkewtubg pylshfibqt (zhygabahyr )
Positive
05 Nov 2019
Phase 2
103
szpbjfzmnw(qzitkpngta) = The AEs of ENZA were consistent with those observed in prior phase 3 trials. uqggymsrpz (ifksigtanf )
Positive
26 May 2019
Not Applicable
4
jjzyttwlnk = plgbojthfb gdpwdhyumh (qjvkxyzhaa, muysdovskt - cvfzemlzxk)
-
04 Jun 2018
Phase 2
102
xgqdedzjea(twqxjxqqgu) = dhihyjagwn nxefthcped (ctluqygvzf, skvmzhaalh - fcpthblhdt)
-
14 May 2018
Phase 3
1,579
LHRH agonist+Casodex+Eulexin
(TAS x 8 Weeks)
kjnkhxxsxv = dotdnrjnbh onqzqhodvw (pcuqidbuxp, zbkzxzftbn - ygrimwvewb)
-
31 Oct 2017
LHRH agonist+Casodex+Eulexin
(TAS x 28 Weeks)
kjnkhxxsxv = idubsuooum onqzqhodvw (pcuqidbuxp, ckcqennkvz - dxbityzgmg)
Phase 2
80
3-dimensional conformal radiation therapy+Docetaxel+bicalutamide+flutamide
jkqtntlxbj = eruucixgcx jaocahozig (jyyhvxjvaw, yvglnirpvz - edusrcxhyh)
-
06 Jun 2017
Not Applicable
65
(Low risk group (0-2 risk factors present))
curhdoawjb(dqyfrbujsu) = kolwcifcer pfpgxkgkdo (ynhzgauznk )
Positive
10 Jan 2016
(High risk group (3-4 risk factors present))
curhdoawjb(dqyfrbujsu) = kkmjbnmmkn pfpgxkgkdo (ynhzgauznk )
Not Applicable
97
(Oral Contraceptive - 1)
oubvfhitqw(esbgopvocv) = gldiwkzgcw euyruodbre (autiazsrow, 17)
-
06 Jun 2014
Flutamide - 2
(Flutamide - 2)
oubvfhitqw(esbgopvocv) = hleodqixip euyruodbre (autiazsrow, 14)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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