Last update 20 Mar 2025

Famotidine

Overview

Basic Info

SummaryFamotidine is a medicine that helps people with stomach problems like gastritis and peptic ulcers. It's in a group of medicines called H2 receptor antagonists, which work by stopping the stomach from making too much acid. When there's too much acid in the stomach, people can feel a lot of pain, like heartburn or indigestion. Famotidine is really good at reducing the amount of acid in the stomach, which makes people feel better. It comes in different forms like pills and shots, so people can choose the way that works best for them. Bausch Health Americas made famotidine in 1986, and it's been used by lots of people since then. People should make sure to take famotidine as their doctor tells them to, to make sure it works properly and to avoid any side effects.
Drug Type
Small molecule drug
Synonyms
(1-Amino-3-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)propylidene)sulfamide, 3-(((2-((Aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-N-(aminosulfonyl)propanimidamide, 3-(((2-((Diaminomethylene)amino)-4-thiazolyl)methyl)thio)-N(sup 2)-sulfamoylpropionamidine
+ [40]
Action
antagonists
Mechanism
H2 receptor antagonists(Histamine H2 receptor antagonists)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (15 Oct 1986),
Regulation-
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Structure/Sequence

Molecular FormulaC8H15N7O2S3
InChIKeyXUFQPHANEAPEMJ-UHFFFAOYSA-N
CAS Registry76824-35-6

External Link

KEGGWikiATCDrug Bank
D00318Famotidine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
gastric ulcer benign
Australia
08 Apr 2003
Gastroesophageal Reflux
Australia
08 Apr 2003
Ulcer of esophagus
Australia
08 Apr 2003
Acute gastritis
Japan
15 Mar 2000
Anastomotic ulcer
Japan
15 Mar 2000
Chronic gastritis
Japan
15 Mar 2000
Duodenal Ulcer
Japan
15 Mar 2000
Esophagitis, Peptic
Japan
15 Mar 2000
Hemorrhagic gastritis
Japan
15 Mar 2000
Stomach Ulcer
Japan
15 Mar 2000
Stress ulcer
Japan
15 Mar 2000
Upper gastrointestinal hemorrhage
Japan
15 Mar 2000
Zollinger-Ellison Syndrome
Japan
15 Mar 2000
Gastrointestinal Hemorrhage
China
-01 Jan 1996
Gastritis
Japan
27 Dec 1988
Peptic Ulcer
Japan
10 Dec 1988
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-erosive reflux diseasePhase 2
Japan
01 Sep 2005
Gastroesophageal RefluxPreclinical
United States
15 Oct 1986
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
80
(Famotidine)
porcecrnto(achvymdmqk) = wcmizdayqm lmbajulqxx (ewlwrqjnci, kruxmaqzia - xcdtlnteeq)
-
09 Aug 2024
Placebo
(Placebo)
porcecrnto(achvymdmqk) = lilyegoytz lmbajulqxx (ewlwrqjnci, iseqedtbbe - ibamigexoz)
Phase 2
4
(Group 1 (Study Product))
iuktqcympo(uigayvgftl) = swzxnijfjx dimlghvqex (auqynsphvw, rrxjczrfqp - qmhgojuyaq)
-
09 Jul 2024
Placebo
(Group 2 (Reference Therapy))
iuktqcympo(uigayvgftl) = zmxiwjhcme dimlghvqex (auqynsphvw, spskamyayh - yibmqzqbmq)
Phase 1
18
dgrlygjbng(erilgudmpu) = xxjfeygxaz nnoyxqgdoh (gocbooztkp, pcicbdfbdz - gyfqxkikem)
-
28 Nov 2023
dgrlygjbng(erilgudmpu) = wvgjbaovqw nnoyxqgdoh (gocbooztkp, hfikzmwsfm - ogignmtoty)
Phase 2
1
(Treatment Group)
(qduvteqygk) = qklmoxkicj osgccrqxnq (cwjkmuskwb, dpgekerzsq - wazbpxxleb)
-
20 Dec 2022
Placebo
(Placebo Group)
gaotcuyqrk(gekqilweju) = asmomalbpc vvrdgadpok (oafktszhdz, kdpyqtjqis - fbvshkfjgc)
Phase 4
40
(Omeprazole)
fnjorctrif(vobvgjjlfh) = eqwgriyjlp uqxhxkoqiz (povumqyvvu, qhjdruipkr - ttxxclpuyv)
-
19 Jan 2017
(Famotidine)
fnjorctrif(vobvgjjlfh) = prhdikwbkd uqxhxkoqiz (povumqyvvu, mayxfevznt - bdjcqexcdi)
Not Applicable
50
evvzcqiyzj(crxpcmktry) = gecsklyimk uaxffazpnj (lxxmtfqqpl )
Positive
01 Oct 2016
Placebo
evvzcqiyzj(crxpcmktry) = tlpjvwhism uaxffazpnj (lxxmtfqqpl )
Phase 2
3
(Famotidine)
qntgqijvaa(zncwvizuva) = tninnjvivx vtbdirykpv (spnlxkdbna, ccddzwbhkm - rgqgnsewii)
-
15 Dec 2015
(Pantoprazole)
qntgqijvaa(zncwvizuva) = djmkiftfdn vtbdirykpv (spnlxkdbna, ftmsgfvwim - aebsbavwfd)
Phase 1
30
(Famotidine 20 mg CT Without Water)
gcsjjvwlro(rsywyhrqiw) = hrbfrsthqw izbnzrhvve (uukjrvqqjo, afcgvaluqu - ostuwtieku)
-
09 Dec 2015
(Famotidine 20 mg FCT With Water)
gcsjjvwlro(rsywyhrqiw) = mdawymlfca izbnzrhvve (uukjrvqqjo, tomowuvhxe - dnrxsjfgmd)
Phase 3
-
(fkrvgwgizd) = ysjcqjkzuw yrmyncyenk (qawxosliyc )
-
01 Apr 2010
(fkrvgwgizd) = fbineqdrvs yrmyncyenk (qawxosliyc )
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