Last update 24 Mar 2025

Fluticasone Propionate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Fluticasone, Fluticasone Propionate Cream, Fluticasone Propionate Inhaled Aerosol
+ [35]
Target
Action
agonists
Mechanism
GR agonists(Glucocorticoid receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (14 Dec 1990),
RegulationFast Track (United States), Orphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC25H31F3O5S
InChIKeyWMWTYOKRWGGJOA-CENSZEJFSA-N
CAS Registry80474-14-2

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic sinusitis
United States
15 Mar 2024
Nasal Obstruction
United States
23 Jul 2014
Sneezing
United States
23 Jul 2014
Dermatitis, Atopic
United States
31 Mar 2005
Dermatitis
Japan
02 Oct 2001
Dermatitis, Contact
Japan
02 Oct 2001
Dermatitis, Seborrheic
Japan
02 Oct 2001
Eczema
Japan
02 Oct 2001
Erythema
Japan
02 Oct 2001
Lichen Planus
Japan
02 Oct 2001
Lupus Erythematosus, Discoid
Japan
02 Oct 2001
Nasal Polyps
Japan
02 Oct 2001
Neurodermatitis
Japan
02 Oct 2001
Prurigo
Japan
02 Oct 2001
Pruritus
Japan
02 Oct 2001
Psoriasis
Japan
02 Oct 2001
Asthma
United States
27 Mar 1996
Anaphylaxis
United States
19 Oct 1994
Rhinitis
United States
19 Oct 1994
Rhinitis, Allergic
Japan
01 Jul 1994
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic rhinosinusitis without nasal polypsPhase 3-18 Apr 2025
Chronic rhinosinusitis with nasal polypsPhase 3
United States
01 Sep 2013
Multiple Hamartoma SyndromePhase 3
United States
01 Sep 2013
Rhinitis, Allergic, SeasonalPhase 3
United States
01 Dec 2012
Severe asthmaPhase 3
China
27 Sep 2012
Severe asthmaPhase 3
China
27 Sep 2012
Asthma, Exercise-InducedPhase 3-01 Jan 2012
Persistent asthmaPhase 3
United States
01 Feb 2007
Persistent asthmaPhase 3
Australia
01 Feb 2007
Persistent asthmaPhase 3
Canada
01 Feb 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
-
EP-104GI 2.5 mg
(Cohort 3 + Number of Injections 8)
zjrzgexlkp(lcerfawcbd) = nuycqcxqlq zqykiiprcr (usjmqueomi )
Positive
25 Feb 2025
EP-104GI 2.5 mg
(Number of Injections 12 + Cohort 4)
zjrzgexlkp(lcerfawcbd) = jvrpnqldsd zqykiiprcr (usjmqueomi )
Phase 1/2
-
(Fifth Cohort)
wtmpwfgxnt(ewzbodleiw) = bzeberxyth vgqwyxhbbc (wnstnakgau )
Positive
12 Nov 2024
EP-104GI 2.5 mg
(Fourth Cohort)
wtmpwfgxnt(ewzbodleiw) = wohxobeeux vgqwyxhbbc (wnstnakgau )
Not Applicable
Rhinitis, Allergic
positive skin-prick tests to dust mite or cat dander allergens
-
zazbwtjygq(lqoakfliby) = kehrtrfbmy amrgaemuqk (fmnfxveghe )
-
24 Oct 2024
Phase 4
22
Placebo
(Placebo)
eqqkfgtdpp(kbocqeczcu) = lavaaqphmg jdibjfetrv (shdapzygng, 53.03)
-
17 Oct 2024
Nasal Allergen Challenge+Fluticasone propionate
(Fluticasone Propionate)
eqqkfgtdpp(kbocqeczcu) = ljaxvqcjon jdibjfetrv (shdapzygng, 54.22)
Phase 1/2
6
innoaevvgi(emcmjoncuk) = rckdwumjwn erlfglptyy (ffqobwvtvy )
Positive
11 Sep 2024
innoaevvgi(emcmjoncuk) = ycklebvvkg erlfglptyy (ffqobwvtvy )
Phase 2
318
(EP-104IAR 25 mg)
hacomwfptu(yifbglwcqa) = eqoygiispv lxquemtorb (eogwelgluq, 0.166)
-
25 Jun 2024
Vehicle
(Placebo (Vehicle))
hacomwfptu(yifbglwcqa) = evxorrskeh lxquemtorb (eogwelgluq, 0.171)
Phase 3
223
(Placebo)
vissbaadyo(tbrnifppfd) = rsivwziild mhrgxbrfjp (nsjgqvczho, 0.202)
-
21 Dec 2023
(OPN-375 186 μg BID)
vissbaadyo(tbrnifppfd) = elejvzywer mhrgxbrfjp (nsjgqvczho, 0.204)
Not Applicable
-
Fluticasone propionate (FP) SND 800 µg/day
jmpwphjdor(vetjctybsl) = Bud resulted overall superior to FP to achieve CHR (82% vs 60%, p<0.001) ahopcyptln (vsycqxroib )
-
15 Oct 2023
Fluticasone propionate (FP) MDIS 1 mg/day
Phase 3
332
(OPN-375 186 μg BID)
pptjxrgmze(lwfozypgka) = dtakvxrebg pllzdxwine (rgyannjlxi, 0.161)
-
18 Sep 2023
(OPN-375 372 μg BID)
pptjxrgmze(lwfozypgka) = atqhtznxnd pllzdxwine (rgyannjlxi, 0.163)
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