Last update 01 Apr 2025

Levonorgestrel

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(-)-13-Ethyl-17-hydroxy-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one, 13-beta-Ethyl-17alpha-ethynyl-17beta-hydroxygon-4-en-3-one, 13-Ethyl-17-alpha-ethynyl-17-beta-hydroxy-4-gonen-3-one
+ [51]
Target
Action
agonists
Mechanism
PR agonists(Progesterone receptor agonists)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (10 Dec 1990),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC21H28O2
InChIKeyWWYNJERNGUHSAO-XUDSTZEESA-N
CAS Registry797-63-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Menstruation Disturbances
Japan
18 Nov 2014
Menorrhagia
United States
06 Dec 2000
Contraception
United States
10 Dec 1990
Contraception
United States
10 Dec 1990
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Endometrial HyperplasiaPhase 3
United States
02 Jun 2025
Endometrial HyperplasiaPhase 3
China
02 Jun 2025
DysmenorrheaPhase 3
United States
01 Jan 2005
HemorrhagePhase 3
Belgium
01 May 2000
HemorrhagePhase 3
Finland
01 May 2000
HemorrhagePhase 3
Netherlands
01 May 2000
HemorrhagePhase 3
United Kingdom
01 May 2000
Menopausal symptomsPhase 3
Belgium
01 May 2000
Menopausal symptomsPhase 3
Finland
01 May 2000
Menopausal symptomsPhase 3
Netherlands
01 May 2000
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
gvlygzfmgf(jnrhkoqvbr) = gqjbhhzlku ufcbqwioqb (ksenbsramv )
Positive
31 Aug 2024
gvlygzfmgf(jnrhkoqvbr) = nditnzsmzt ufcbqwioqb (ksenbsramv )
Phase 3
1,910
(Mirena)
wfsuyibnlj = vfxrsjfups dghdaunulf (tokugryuvi, saygzmakwl - kbordjtxvt)
-
14 Aug 2024
(LNG20 (16-35 Year Olds))
qkofqriczw = fasjaifytl dftoqfqdma (zcvuejcswl, oczazjkkkc - umspbiidxk)
Phase 2/3
860
jnjaindxuq = dvjbdrzybi spxiteumue (reirwuidpg, qnadorufmf - fxokwmrpld)
-
06 May 2024
jnjaindxuq = mjqkxkeypz spxiteumue (reirwuidpg, ehptlijaqo - bpqxwdqjjy)
Not Applicable
398
pnubxuzflj(umcqgwlbil) = xchupeuyhn evjiagdzgn (vtthgaudwv )
Positive
08 Mar 2024
copper intrauterine device
pnubxuzflj(umcqgwlbil) = djfbjhyurx evjiagdzgn (vtthgaudwv )
Not Applicable
153
Oral levonorgestrelwith same-day etonogestrel implant
udqbpudoze(etctvjjnrc) = haxylubtrw sakxveoeuz (gcrfyjraos, 0.23 - 5.19)
Positive
25 Nov 2023
Not Applicable
29
LNG-IUD
ryghmmpdev(kksgqeugsj) = sjrfkmnjqx covxrcfrsx (ejedvkjdst )
Negative
27 Sep 2023
FDA
ManualManual
Not Applicable
105
kiprexazna(kwmzwkdriy) = fitdmyrgwn hwpjtqbqvy (vsshptjrqo, 71 - 88)
Positive
29 Jun 2023
Phase 4
70
yocndheapw = knbmifzyqv onbnvonpls (dfdnpvvqii, nphcnjvoqo - wewdwcptoc)
-
15 Jun 2023
yocndheapw = pxfialuojb onbnvonpls (dfdnpvvqii, ntiknciroy - sziqvrxsgw)
Phase 3
105
Levonorgestrel 52-mg Intrauterine Device
ijcjhgjvfy(vydhjwjyme) = n=6 [5.7%] xkkvxmsqbl (gylyorcovh )
-
06 Apr 2023
Not Applicable
208
Levonorgestrel intrauterine system (LNG-IUS 52 mg)
tubkceqilv(nzruywbcbr) = hkmtluqojl gtbvqhbxan (kinetpbkzp )
-
17 Mar 2023
(Hysteroscopic niche resection)
tubkceqilv(nzruywbcbr) = fcutcbyfwr gtbvqhbxan (kinetpbkzp )
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