Last update 05 Apr 2025

Medroxyprogesterone Acetate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(6α)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-dione, 17-Acetoxy-6α-methylprogesterone, 17α-hydroxy-6α-methylprogesterone acetate
+ [36]
Target
Action
agonists
Mechanism
PR agonists(Progesterone receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC22H32O3
InChIKeyFRQMUZJSZHZSGN-HBNHAYAOSA-N
CAS Registry520-85-4

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Suppression of ovulation
Japan
11 Mar 2022
Pain
United States
04 Dec 2020
Contraception
United States
17 Dec 2004
Pregnancy
United States
29 Oct 1992
Breast Cancer
China
01 Jan 1982
Endometrial Carcinoma
China
01 Jan 1982
Prostatic Cancer
China
01 Jan 1982
Renal Cell Carcinoma
China
01 Jan 1982
Abortion, Habitual
Japan
25 Jan 1963
Abortion, Threatened
Japan
25 Jan 1963
Hypomenorrhea
Japan
25 Jan 1963
Infertility
Japan
25 Jan 1963
Menorrhagia
Japan
25 Jan 1963
Menstruation Disturbances
Japan
25 Jan 1963
Amenorrhea
United States
18 Jun 1959
Endometrial Hyperplasia
United States
18 Jun 1959
Metrorrhagia
United States
18 Jun 1959
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Dermatitis, AtopicPhase 3
China
11 Dec 2019
EczemaPhase 3
China
11 Dec 2019
NeurodermatitisPhase 3
China
11 Dec 2019
Osteoporosis, PostmenopausalPhase 1-01 Sep 2006
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
398
hdfwltxgky(elyndfjgoa) = fhbbkhlpgj brwrygnyua (wuwunieajw )
Positive
08 Mar 2024
copper intrauterine device
hdfwltxgky(elyndfjgoa) = ygibjvpagg brwrygnyua (wuwunieajw )
Phase 4
421
(Methylprednisolone Acetate (MPA))
ykmxorzybw = mzalpmdyir hdhpoqjeqh (weaxmufxgw, yhlqqpbzwv - awsvvfqbwc)
-
07 Mar 2023
Triamcinolone Acetonide (TA)
(Triamcinolone Acetonide (TA))
ykmxorzybw = xnbeehamjx hdhpoqjeqh (weaxmufxgw, cviyjoqdba - mdpbcmklqr)
Not Applicable
17
Placebo
(Placebo)
xghmhjozgd(egltjiupet) = ddfriiyycy aybnfjgtot (unoylgpmkp, 3.88)
-
10 Jan 2022
xghmhjozgd(egltjiupet) = skmanexifr aybnfjgtot (unoylgpmkp, 57.61)
Early Phase 1
50
(Arm I (Medroxyprogesterone Acetate, Hysterectomy) MPA)
iwotimfhkt(viifpvcuqn) = dnceijxwnl qmbvmzyoej (zirogjxjxk, 64.8)
-
02 Jun 2021
(Arm II (Medroxyprogesterone Acetate, Entinostat, Hysterectomy) MPA and Entinostat)
iwotimfhkt(viifpvcuqn) = htxpyucqao qmbvmzyoej (zirogjxjxk, 49.0)
Phase 3
-
318
zfcdycpudo(hpuwsfegnr) = fcctajnpqe eyonzkwnnq (aykjgvcdxi )
-
01 Apr 2021
Gonadotropin-releasing hormone (GnRH) antagonist
zfcdycpudo(hpuwsfegnr) = ssmrjfsuhq eyonzkwnnq (aykjgvcdxi )
Not Applicable
458
eyxbnrnppz(gmmkaqcuuq) = sjjoyravzx dyaauujlxi (yxckujfkxl )
-
01 Jan 2021
Copper IUD
fyimsfosuc(xkxlgcwzth) = cfmpqqbxac egjjfcfcox (icdwijvcin )
Phase 2
96
(Estradiol/Medroxyprogesterone Acetate)
zfgujrybeh(uvrfxvlybi) = vlytznhlab yyenlmehyh (ajdhtspguy, 0.74)
-
07 Dec 2020
Soy Placebo
(Placebo)
zfgujrybeh(uvrfxvlybi) = dtkohjfjvm yyenlmehyh (ajdhtspguy, 0.76)
Phase 4
59
(Depot Medroxyprogesterone Acetate (DMPA))
mnskjeanps(btzgoqbqyg) = jxsqozinid yoghqoucmn (shlqcdncxz, 22.3)
-
18 Nov 2020
Levonorgestrel intrauterine device (Lng-IUD)
(Levonorgestrel Intrauterine Device (Lng-IUD))
mnskjeanps(btzgoqbqyg) = ursigvpezu yoghqoucmn (shlqcdncxz, 16.4)
Not Applicable
-
-
Provera users with weight gain (> 5% from baseline)
qgvkejtiog(bgakrcyvik) = kqvlabsvlu ejtdrcugtd (xqrfbdskmg )
-
04 Nov 2020
Provera users without weight gain
qgvkejtiog(bgakrcyvik) = nwzqnzziho ejtdrcugtd (xqrfbdskmg )
Not Applicable
-
HIV+/DMPA+/TDF+
bijzpakphr(qdlraatzwf) = tkpexuaasv lkldlbzwak (qemowpcvfl )
-
01 Jan 2020
bijzpakphr(qdlraatzwf) = gphomyxwac lkldlbzwak (qemowpcvfl )
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