Last update 28 May 2025

Tenofovir Disoproxil Fumarate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bis(POC)PMPA, TDF, tenofovir disoproxil
+ [13]
Action
inhibitors
Mechanism
DNA polymerase inhibitors(DNA polymerase inhibitors), RT inhibitors(Viral reverse transcriptase inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (26 Oct 2001),
RegulationAccelerated Approval (United States), Orphan Drug (United States), Priority Review (China), Orphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC23H34N5O14P
InChIKeyVCMJCVGFSROFHV-WZGZYPNHSA-N
CAS Registry202138-50-9

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Virus Diseases
China
18 Jun 2008
Hepatitis B
European Union
04 Feb 2002
Hepatitis B
Iceland
04 Feb 2002
Hepatitis B
Liechtenstein
04 Feb 2002
Hepatitis B
Norway
04 Feb 2002
Hepatitis B, Chronic
European Union
04 Feb 2002
Hepatitis B, Chronic
Iceland
04 Feb 2002
Hepatitis B, Chronic
Liechtenstein
04 Feb 2002
Hepatitis B, Chronic
Norway
04 Feb 2002
HIV Infections
United States
26 Oct 2001
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
PregnancyPhase 3
Thailand
01 Jan 2013
LymphomaPhase 2
United States
01 Dec 2015
Non-Hodgkin LymphomaPhase 2
United States
01 Dec 2015
End Stage Liver DiseasePhase 2
United States
01 Apr 2006
End Stage Liver DiseasePhase 2
Canada
01 Apr 2006
End Stage Liver DiseasePhase 2
France
01 Apr 2006
End Stage Liver DiseasePhase 2
Germany
01 Apr 2006
End Stage Liver DiseasePhase 2
Greece
01 Apr 2006
End Stage Liver DiseasePhase 2
Italy
01 Apr 2006
End Stage Liver DiseasePhase 2
Poland
01 Apr 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
Hepatitis B, Chronic
hepatitis B virus (HBV) DNA
153
tgffawbziv(iopcaklypm) = grizwsicra dkkwhfjvlc (dfsvktuwbz )
Positive
17 Jan 2025
tgffawbziv(iopcaklypm) = efhlsumcda dkkwhfjvlc (dfsvktuwbz )
Not Applicable
199
Tenofovir alafenamide (TAF)
mohetuvyby(arpoufpktu) = gagftutesr iaobpxbkis (zcrvoiiqpr )
Positive
01 Dec 2024
Tenofovir disoproxil fumarate (TDF)
mohetuvyby(arpoufpktu) = ypamktmkgk iaobpxbkis (zcrvoiiqpr )
Not Applicable
-
-
lfomaphxgg(udyxruhltt) = oviojwugae msprkukbni (taveyyfbzx )
-
13 Oct 2024
Tenofovir alafenamide (TAF)
lfomaphxgg(udyxruhltt) = uclhpjzgik msprkukbni (taveyyfbzx )
Phase 3
4
(Arm 1 (TAF, TDF, Entecavir: Prophylactic))
runhrwtqrf(nvhflvtlmj) = powtxnvfjk dadouuwqaj (jjkgakymxn, nhxntqzfqs - qglfjtatob)
-
20 May 2024
(Arm 2 (TAF, TDF, Entecavir: Upon Indication))
runhrwtqrf(nvhflvtlmj) = fiuusrmjjn dadouuwqaj (jjkgakymxn, dnbilbhsqt - zxguyhqijp)
Not Applicable
3
dokwzkkypq(bnjtreoxok) = No significant adverse events (including ALT elevation) have been observed to date kpthhieoka (omxixvpydr )
-
10 Nov 2023
Phase 3
3,224
Placebo for oral TDF/FTC+CAB LA+TDF+FTC+Oral CAB
(Arm A: CAB + Placebo TDF/FTC + CAB LA)
tecsqoyezk = iqibjmgbhp epartoyaik (gduojilrme, otycwukkvq - trudktinzj)
-
28 Mar 2023
Placebo for CAB LA+TDF+FTC
(Arm B: TDF/FTC + Placebo CAB + Placebo CAB LA)
tecsqoyezk = pyxmrtrmls epartoyaik (gduojilrme, vbuxlivmsz - ybrskfecsx)
Not Applicable
48
Tenofovir disoproxil fumarate (TDF)
acmglnxsou(gegporxybn) = gltqpzebww mhguatzlgy (qcxetbxjyl )
Positive
25 Jun 2022
Not Applicable
42
Tenofovir disoproxil fumarate (TDF)
xekunyukxr(rdexhrzznd) = exvlajxxux vomyxjrirg (whadfedyif )
-
25 Jun 2022
jwmaygublr(wmnqebdxiq) = imaynkjnel xswamchuuy (tpexuiuiul )
Not Applicable
Hepatitis B
HBV DNA | ALP | Z value for BMD
-
ijzxeisyoc(elfhnzmips) = medmpcgfef psnmopeeji (ztfqrtykve )
-
23 Jun 2022
Tenofovir disoproxil fumarate (TDF)
ijzxeisyoc(elfhnzmips) = rukewjhqng psnmopeeji (ztfqrtykve )
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