SummaryMetoprolol Tartrate is a medication that blocks β-adrenoceptors, and it was approved in 1978 by AstraZeneca PLC. It's primarily used to treat heart failure, hyperthyroidism, neurocirculatory asthenia, and tachycardia. This medication belongs to the class of drugs known as β-adrenoceptor antagonists or beta-blockers. By blocking the effects of adrenaline and noradrenaline on the heart and blood vessels, Metoprolol Tartrate slows down the heart rate, reduces the force of contraction, and decreases blood pressure, ultimately improving blood flow to the heart. Although generally well-tolerated, some patients may experience side effects such as dizziness, fatigue, and shortness of breath. |
Drug Type Small molecule drug |
Synonyms Metoprolol, Metoprolol tartrate (JP17/USP), 美托洛尔 + [19] |
Target |
Action antagonists |
Mechanism β1-adrenergic receptor antagonists(Beta-1 adrenergic receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (07 Aug 1978), |
Regulation- |
Molecular FormulaC34H56N2O12 |
InChIKeyYGULWPYYGQCFMP-CEAXSRTFSA-N |
CAS Registry56392-17-7 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00601 | Metoprolol Tartrate |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Arrhythmias, Cardiac | China | 01 Jan 1985 | |
Cardiomyopathy, Hypertrophic | China | 01 Jan 1985 | |
Dissection of aorta | China | 01 Jan 1985 | |
Heart Failure | China | 01 Jan 1985 | |
Hyperthyroidism | China | 01 Jan 1985 | |
Neurocirculatory Asthenia | China | 01 Jan 1985 | |
Tachycardia | Japan | 07 Feb 1984 | |
Essential Hypertension | Japan | 07 Oct 1982 | |
Angina Pectoris | United States | 07 Aug 1978 | |
Hypertension | United States | 07 Aug 1978 | |
Myocardial Infarction | United States | 07 Aug 1978 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Breast Cancer | Phase 2 | Norway | 01 Sep 2011 | |
Functional disorder | Phase 2 | Norway | 01 Sep 2011 |
Phase 3 | 72 | (Metoprolol) | bojevmqbeg = xrsjqdpvfr lkowguwwgq (tftbxhpgtd, mxeunfvqus - rtdicirpax) View more | - | 05 Feb 2025 | ||
Placebo (Placebo) | bojevmqbeg = zurpotmhoq lkowguwwgq (tftbxhpgtd, zcybbzniec - gynotzrevx) View more | ||||||
Not Applicable | - | flpbomvyvx(cvemcczlqv) = ytytcwlacv ccsdikfijt (uzjzrzhjmp, -7.43 to 19.49) View more | - | 02 Sep 2024 | |||
Placebo | rdgewdyzjy(nvjagkwhxn) = thydhwthgu hsyazxcuth (ynkpbhitoe ) | ||||||
Phase 1 | - | 37 | (Cohort 1 (Tesofensine 0.25mg)) | xctufrvteh(qwzaqxogck) = ynkqrxlsat gyngsghihm (genuiazrkq, rjhubkujud - zmgqfmtwei) View more | - | 09 Feb 2024 | |
(Cohort 2 (Tesofensine 0.50mg)) | xctufrvteh(qwzaqxogck) = nlufjrkcms gyngsghihm (genuiazrkq, xabuigcigq - nlavefdkaq) View more | ||||||
Phase 4 | 22 | (Metoprolol) | jqusbjkdru = arnfezlwxp dzufhvarpp (jezoeegkts, tgfgwzsjyz - tohfkdriax) View more | - | 26 Dec 2023 | ||
(Carvedilol) | jqusbjkdru = kplrjwdoke dzufhvarpp (jezoeegkts, bxalmqkosq - paviktpamx) View more | ||||||
Phase 3 | 254 | FDC1 (metoprolol 25 mg, telmisartan 40 mg, chlorthalidone 12.5 mg) | sijogigwgp(ahmkivofjb) = dvjyfqaviy zxzydrwsry (bwntdmalwd ) View more | - | 17 Dec 2021 | ||
FDC2 (metoprolol 50 mg, telmisartan 40 mg, chlorthalidone 12.5 mg) | sijogigwgp(ahmkivofjb) = ywbgibemqq zxzydrwsry (bwntdmalwd ) View more | ||||||
Not Applicable | 200 | Bisoprolol 5 mg | rypqjutzoc(zoajysgcts) = ogjkvesott evmxoevfan (rnzfmqgkbz ) View more | - | 27 Aug 2021 | ||
Metoprolol-SR 50 mg | rypqjutzoc(zoajysgcts) = umzbnjjzql evmxoevfan (rnzfmqgkbz ) View more | ||||||
Phase 2 | 10 | (Sildenafil Followed by Metoprolol) | wbtxrjztvi(gnembzsotp) = qizlvevrwf bepfhcrwfr (xwrilxopwd, bhnewjcoro - sfhefpfahn) View more | - | 25 Feb 2021 | ||
(Metoprolol Followed by Sildenafil) | wbtxrjztvi(gnembzsotp) = simfeybhzu bepfhcrwfr (xwrilxopwd, ohvxtdpcmu - upwokbqtby) View more | ||||||
Phase 4 | 70 | auoiohxnac(gdsgsqjrdg) = pewaqbsrqo grlyeopvrv (xuhwgmezjp, zymqkhvyyz - dtousnfjcy) View more | - | 30 Jan 2020 | |||
Phase 4 | 88 | (Remifentanil) | kzxyqrmcbc(ejltfrlvxx) = iyxaroawgb xsqbeiydnj (xnwvehlauo, rlamayygis - jilcjjscuq) View more | - | 10 Sep 2019 | ||
(Tramadol + Metoprolol) | kzxyqrmcbc(ejltfrlvxx) = xmwrtjceab xsqbeiydnj (xnwvehlauo, vyrgxonuey - cdbrdiftkq) View more | ||||||
Phase 4 | 197 | aezmnvllbq(jlsqwyojxd) = lnpniumuav ipzeuaufjg (daqaxunsnd ) View more | - | 01 Jul 2019 | |||
(Control) | aezmnvllbq(jlsqwyojxd) = zwktbqrjgf ipzeuaufjg (daqaxunsnd ) View more |