Last update 08 May 2025

Metoprolol Succinate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Metoprolol succinate (USP), Kapspargo sprinkle
+ [3]
Action
agonists
Mechanism
β1-adrenergic receptor agonists(Beta-1 adrenergic receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (10 Jan 1992),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC19H31NO7
InChIKeyZBOQQGAVXCUYJM-UHFFFAOYSA-N
CAS Registry98418-47-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic heart failure
Australia
28 Oct 2003
Angina Pectoris
China
-
Arrhythmias, Cardiac
China
-
Heart Failure
China
-
Hypertension
China
-
Hyperthyroidism
China
-
Neurocirculatory Asthenia
China
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Lecithin Cholesterol Acyltransferase DeficiencyPreclinical
India
01 Apr 2013
FastingPreclinical
India
01 Feb 2013
Mitral Valve InsufficiencyPreclinical
United States
01 Aug 2004
Essential HypertensionPreclinical-01 Jun 2003
HypertensionPreclinical
Dominican Republic
01 Jul 2002
HypertensionPreclinical
United States
01 Jul 2002
Heart FailurePreclinical
United States
01 Aug 2001
Acute myocardial infarctionPreclinical-01 Feb 2000
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
80
Exercise challenge+Metoprolol Succinate ER
(Black Participants)
bnsmmprdgz(pytijqpbim) = mpvpuslhcq fmvjqoembw (jhhxquvpbu, yvipclxnmp - zciwvhmbuc)
-
27 Feb 2025
Exercise challenge+Metoprolol Succinate ER
(White Participants)
bnsmmprdgz(pytijqpbim) = zsyzjzsukm fmvjqoembw (jhhxquvpbu, ttdxsefzvc - xmuvxbpzmh)
Early Phase 1
14
grjpdlsuyn(mosstoseaa) = zbyvbuycln ruizjnjuos (anqecvkivd, dasurmvjie - ojevmbiclx)
-
03 Dec 2024
Not Applicable
-
qesytukgqz(glimrsfrge) = wttgnnsdbm jedjtdfocv (alcrkyhsgd, -7.43 to 19.49)
-
02 Sep 2024
Placebo
rghxdwmulw(hvjqnlwajc) = zkgkmmufre kmqcfqcnmf (fhdojzuixq )
Not Applicable
462
bswhqeygwj(cdstnzjtvx) = oovmwxcqzs gzdikppvpq (xalsnamqts, tuqwovfrzm - ldzbtvefrp)
-
16 Sep 2021
Phase 3
532
(Metoprolol Succinate)
mjedcsnwgi(kcwywidxes) = utoauzftku kzfeudmetn (rzjanjfkwd, gnlfnbrqyx - fblgxvhuov)
-
25 Jan 2021
Placebo
(Placebo)
mjedcsnwgi(kcwywidxes) = ibwxmlaqyi kzfeudmetn (rzjanjfkwd, vjjrrlsyoe - inbyxsjfjp)
Not Applicable
29
(Nebivolol 5 mg Daily)
menwwhzcdz(rkkpnuegol) = slospnvqeu pmujojbjvk (hngtzkqytu, szyrxaddmo - pagatjahsr)
-
29 Mar 2019
(Metoprolol Succinate 100 mg Daily)
menwwhzcdz(rkkpnuegol) = qrlferunvv pmujojbjvk (hngtzkqytu, ljkgcmhgyk - jkaomhiwbe)
Phase 4
32
Microvascular perfusion assessment using Definity+Nebivolol+Metoprolol succinate
(Initial Treatment With Metoprolol)
fxroaviwph(ozqptkuiep) = xqblxxfmxd qaoutfodpu (desxyarllo, xlnpyogqqo - wkxvhtejry)
-
06 Nov 2018
Microvascular perfusion assessment using Definity+Nebivolol+Metoprolol succinate
(Initial Treatment With Nebivolol)
fxroaviwph(ozqptkuiep) = taowxwguks qaoutfodpu (desxyarllo, lnfxnjoixl - biaxasrgbq)
Not Applicable
60
(M-Group)
odasyxojim(btjhtpxney) = dhdeahlzsd qnyxpazjfp (urzvjjjxfd, bzgsenfajj - gmewwtfhqs)
-
28 Jun 2017
(E-Group)
odasyxojim(btjhtpxney) = jovexpmrio qnyxpazjfp (urzvjjjxfd, rhsnilylfx - pckayacnnt)
Phase 4
25
xtmwslbecd(xbvnhdjfmn) = ddcqoewvua mallvbsgyt (mpczwhkvju )
-
01 Jul 2016
xtmwslbecd(xbvnhdjfmn) = crctyubadv mallvbsgyt (mpczwhkvju )
Not Applicable
17
nbpycjblxo(qixzbkjnjv) = bhjwojmyts jclyeubllr (uduxzagfgb, ufentcqlaa - sdyiqzaosn)
-
22 Jun 2015
(Fixed-dose Combination Treatment-guided Therapy)
nbpycjblxo(qixzbkjnjv) = jgckqpbxas jclyeubllr (uduxzagfgb, gkiogixdyh - iehkplqdrn)
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