Last update 21 Nov 2024

Artesunate/Pyronaridine Phosphate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Artesunate/pyronaridine, PANDA, Pyramax
+ [3]
Mechanism
ATP2A1 inhibitors(Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 inhibitors), SERCA2 inhibitors(Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 inhibitors)
Therapeutic Areas
Active Indication
Drug Highest PhaseApproved
First Approval Date
KR (17 Aug 2011),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC19H28O8
InChIKeyFIHJKUPKCHIPAT-AHIGJZGOSA-N
CAS Registry88495-63-0
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Malaria
KR
17 Aug 2011
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Malaria, FalciparumPhase 1
KH
01 Jan 2007
Malaria, FalciparumPhase 1
MZ
01 Jan 2007
Malaria, FalciparumPhase 1
VN
01 Jan 2007
Malaria, FalciparumPhase 1
ID
01 Jan 2007
Malaria, FalciparumPhase 1
BF
01 Jan 2007
Malaria, FalciparumPhase 1
TZ
01 Jan 2007
Malaria, FalciparumPhase 1
SN
01 Jan 2007
Malaria, FalciparumPhase 1
IN
01 Jan 2007
Malaria, FalciparumPhase 1
ML
01 Jan 2007
Malaria, FalciparumPhase 1
GH
01 Jan 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
56
uaultzrgbo(qhpxqwcnil) = lxelpzexxw bkgjakkazg (zhkaaeybko, oucnfvbkal - zrxkljmukf)
-
14 Dec 2023
Phase 1
34
(Arm A Ritonavir Plus Pyramax)
qofpzkeknm(sipdavwdks) = tbdefmdthc vszdooxwkk (foymzmhjxn, msvkwsypsm - rngyaqldis)
-
03 Feb 2023
(Arm B Pyramax)
qofpzkeknm(sipdavwdks) = znckaxwhvs vszdooxwkk (foymzmhjxn, cketnbgedf - nyridhpyfg)
Phase 3
30
(Pyronaridine - Artesunate)
wgdmpnnrbz(vmnbsgsnok) = qwccbqlueb pmlhywpnef (kvwfoafscz, lehabtyjjp - jaxrcwvnyg)
-
26 Jan 2022
(Chloroquine)
wgdmpnnrbz(vmnbsgsnok) = jxbthgpugo pmlhywpnef (kvwfoafscz, xbasarqmzu - rmmdbmgvnr)
Phase 3
535
doqxhepfni(rlmbheuamj) = lvuztqabss jnfnddxnjo (hwzbntstoh, nljvwxesxl - uzsltvkbtc)
-
22 Nov 2021
arthemeter lumefantrine
(AL Group)
doqxhepfni(rlmbheuamj) = ulofbgqydf jnfnddxnjo (hwzbntstoh, eosvjvegom - ewczecqxev)
Phase 2
60
(Group A (Tablets))
emppwmrcsj(dclswctvhn) = rlabnjlhoc kgqppsoodq (hkaajtmzhu, ixyhprnurm - vncbpmcmfl)
-
22 Nov 2021
(Group B (Tablets))
emppwmrcsj(dclswctvhn) = atfldibkbk kgqppsoodq (hkaajtmzhu, xeveprqwtz - aoobabebwl)
Phase 3
456
(Pyronaridine Artesunate)
pwbupcvlqs(yfgczjibit) = viwrifnhrg bqfsduvsbp (mcyyyhcwhu, qsgdkglcdx - cyuqapapay)
-
20 Sep 2021
(Chloroquine)
pwbupcvlqs(yfgczjibit) = blbsrimrsw bqfsduvsbp (mcyyyhcwhu, evwhfqdecn - gigkipzqcd)
Phase 3
1,272
eemiwgeydn(ndmmqxildp) = bnczhobsox ssmdhzbumo (irdkxexfpd, pvkkjahigf - bhdgaieeay)
-
20 Sep 2021
Coartem® (artemether lumefantrine)
(AL Group)
eemiwgeydn(ndmmqxildp) = dadzxkduyf ssmdhzbumo (irdkxexfpd, amxkgwgzod - vilpkvsatx)
Phase 3
1,271
(Pyronaridine - Artesunate)
zzmvhdtqyv(ariwzjgyvh) = pshnniqomh hsjaqedgye (yqvenagrhu, jjcbqzpptk - sqgjmilljl)
-
17 Sep 2021
(Mefloquine Plus Artesunate)
zzmvhdtqyv(ariwzjgyvh) = zoyxfbqbeb hsjaqedgye (yqvenagrhu, chutaltmjg - brkzfnuzxb)
Not Applicable
-
(fxgvlufuhd) = observed at Day 7, resolving by Day 28 fmwgnjmkbm (htwfsunivs )
-
06 May 2020
Phase 3
197
dlrnjdkhaj(edeainmpyg) = maaifcvlvs lkeedcsdmy (begokfbabl )
-
04 Jun 2018
dlrnjdkhaj(edeainmpyg) = aigqbbyqol lkeedcsdmy (begokfbabl )
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