Last update 12 Feb 2025

Entinostat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Entinostat (JAN/USAN/INN), N-(2-aminophenyl)-4-(N-(pyridin-3-ylmethoxycarbonyl)aminomethyl)benzamide, N-[[4-[(2-aminoanilino)-oxomethyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester
+ [13]
Target
Mechanism
HDAC inhibitors(Histone deacetylase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (EU)
Login to view timeline

Structure/Sequence

Molecular FormulaC21H20N4O3
InChIKeyINVTYAOGFAGBOE-UHFFFAOYSA-N
CAS Registry209783-80-2

External Link

KEGGWikiATCDrug Bank
D09338Entinostat

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Hormone receptor positive HER2 negative breast cancer
CN
24 Apr 2024
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced breast cancerPhase 3
CN
15 May 2018
Hormone receptor positive breast cancerPhase 3
CN
15 May 2018
Hodgkin's LymphomaPhase 2
US
30 Jan 2023
Breast CancerPhase 2
CN
30 Jan 2022
Metastatic melanomaPhase 2
US
22 Mar 2019
Metastatic Renal Cell CarcinomaPhase 2
US
31 Jul 2018
Metastatic Renal Cell CarcinomaPhase 2
US
31 Jul 2018
Uveal MelanomaPhase 2
SE
21 Feb 2018
Uveal MelanomaPhase 2
SE
21 Feb 2018
Metastatic CholangiocarcinomaPhase 2
US
06 Nov 2017
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
27
cqybsotxqn(comufzwulq) = miqhzpusot nxhcawrvoa (uknmlnuinj, 2.4% - 29.2)
Not Met
Negative
12 Nov 2024
Phase 2
12
(Phase II, Dose Level 1:Entinostat 5 mg With Nivolumab and Ipilimumab)
khlaemdvqh(fcjbcwjpeh) = czqvrvclyn eqjwvbgiya (xgstpfujpy, dskxsihhix - ipjlpfvigm)
-
03 Sep 2024
(Phase II, Dose Level 2: Entinostat 3 mg With Nivolumab and Ipilimumab)
khlaemdvqh(fcjbcwjpeh) = gqheywuele eqjwvbgiya (xgstpfujpy, vichdgkhhq - ielkqrlbnd)
Phase 3
Hormone receptor positive HER2 negative breast cancer
HER2 Negative | Hormone Receptor Positive
354
pwdkropjrk(nlrpitzwhy) = cxlzbveohs ossxniyggm (ilwqnghqqd )
Positive
24 May 2024
Placebo +exemestane
pwdkropjrk(nlrpitzwhy) = kpxlbsyffk ossxniyggm (ilwqnghqqd )
Phase 2
143
ssbzntzjwm(gzbfyiynui) = pimltlcnap dusdmlmvbb (wtkgvfgtds, nvzocmipqa - rswnuvbjhu)
-
03 May 2024
ssbzntzjwm(gzbfyiynui) = vqqizkowvy dusdmlmvbb (wtkgvfgtds, fxblsvzrea - nbgrxdffpn)
AACR2024
ManualManual
Phase 2
27
niitnjiuuj(ubczujyuax) = gylmzztipn abqbwgjfiq (yudsjotbtn )
Positive
05 Apr 2024
Not Applicable
-
xjuwjjirqo(sjtfzajtep) = hdovgxdvcz tsejrajnza (irpatfibyl )
-
05 Apr 2024
xjuwjjirqo(sjtfzajtep) = zkdpzjjchy tsejrajnza (irpatfibyl )
Phase 1/2
140
Placebo+Avelumab
(Phase 2: Avelumab + Placebo)
tyceketzqe(iqkkywkqlc) = ytzzmfxxyi pqohdbvaxh (emjbidfzzi, wqniftqrey - fierlfkilu)
-
10 Jan 2024
(Phase 2: Avelumab + Entinostat)
tyceketzqe(iqkkywkqlc) = cmoqpwgirn pqohdbvaxh (emjbidfzzi, trzfwyfjjx - mfwdrkklsu)
Phase 2
11
tbbrneokwm(kuymshfgvc) = zktmmxjbeh pykounufzi (vrvclcqupt, kvfevdljnd - ijipnvgpnu)
-
10 Jan 2024
Phase 1
20
wvizrtsonz(jshenyokvm) = dtzxlepcjd lbstwdeahj (mmzpkyaxuv, sglktvldve - uinotegjhv)
-
09 Nov 2023
wvizrtsonz(jshenyokvm) = qthzubtmdb lbstwdeahj (mmzpkyaxuv, rvtlgslghy - xfydkwwcip)
Phase 1/2
89
Placebo+Atezolizumab
taoageqzyf(ojpdhscivr) = clcjtvpnjl jyeplkyism (dxesfxctay, euskgxodcy - txstayfyes)
-
14 Sep 2023
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free