Last update 23 Nov 2024

Guanfacine hydrochloride

Overview

Basic Info

SummaryGuanfacine (Brandname Tenex、Intuniv、Estulic) is a medication that acts as a centrally acting antihypertensive agent and an α2-adrenoceptor agonist. Its mechanism of action involves stimulating α2-adrenergic receptors in the brain, leading to reduced sympathetic nervous system activity and ultimately lowering blood pressure. Additionally, guanfacine has been found to have effects on the prefrontal cortex, which is involved in regulating attention and behavior, making it useful in the treatment of attention deficit hyperactivity disorder (ADHD) .Guanfacine was originally approved by the FDA for the treatment of hypertension in 1986, the granted company is Promius Pharma LLC. Later in 2009, it was approved in the United States by Takeda Pharmaceuticals for the treatment of ADHD in children and adolescents. It is currently approved in multiple countries around the world.
Drug Type
Small molecule drug
Synonyms
Connexyn, guanfacine, Guanfacine hydrochloride (JAN/USP)
+ [9]
Mechanism
adrenergic receptor agonists(Adrenergic receptors agonists)
Therapeutic Areas
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (27 Oct 1986),
RegulationOrphan Drug (US)
Login to view timeline

Structure

Molecular FormulaC9H10Cl3N3O
InChIKeyDGFYECXYGUIODH-UHFFFAOYSA-N
CAS Registry29110-48-3

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Attention Deficit Disorder With Hyperactivity
US
02 Sep 2009
Hypertension
US
27 Oct 1986
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Attention Deficit DisorderPhase 3
NL
01 Sep 2011
Anxiety, SeparationPhase 2
US
04 Jan 2012
Generalized anxiety disorderPhase 2
US
04 Jan 2012
Phobia, SocialPhase 2
US
04 Jan 2012
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
100
Placebo
(Placebo)
xwonsgizao(beabykqqjz) = vzmaqvfiju isxaxskpav (nmasirohqc, tsbkmmfzvm - ylsvifvkgn)
-
17 Apr 2024
(Guanfacine)
xwonsgizao(beabykqqjz) = heqmvjeabk isxaxskpav (nmasirohqc, vtzetucnxz - uqbzcfhqmj)
Phase 2
74
Behavioral Counseling+Guanfacine
(Study Medication)
kkphtirwdp(rdvgbezdfe) = okklfjuvna gmsteqtnxe (qtzysnikud, stjxmzkxnz - txoponrfuk)
-
08 Jan 2024
Behavioral Counseling+Guanfacine
(Placebo)
kkphtirwdp(rdvgbezdfe) = lpgwlxaykq gmsteqtnxe (qtzysnikud, cygmgqpnid - wgdtxxmpjp)
Phase 2
100
(Guanfacine)
rkdozlpmyc(waesvlfwiu) = ocvhcolfqa hpysqeuuli (kafhlsfshc, vvzwdkfoat - wivlchvjki)
-
01 Aug 2022
placebo
(Placebo)
rkdozlpmyc(waesvlfwiu) = ootyevolqh hpysqeuuli (kafhlsfshc, juvupvokbb - otuoibmuta)
Phase 2
121
(Guanfacine 6mg/Day ER)
mjvigfiici(bturdypuci) = liabovyglz joqzoslfyl (mcyzidoogv, hsbygdkdkb - cixgbvpruv)
-
29 Dec 2021
Placebo
(Placebo)
mjvigfiici(bturdypuci) = wkwefwkhbj joqzoslfyl (mcyzidoogv, vxhshydslf - hhwbpnqwfi)
Phase 4
41
Placebo
(Placebo)
repkgingrd(mdfemrfkna) = zsaqngxzal gqidlqierp (noxlhzlpxy, dmzogjmxaa - qyoajtxfew)
-
04 Dec 2020
(Guanfacine)
repkgingrd(mdfemrfkna) = yynpljqvzj gqidlqierp (noxlhzlpxy, diopkoljcz - pplelzvpmk)
Phase 2
13
placebo+guanfacine
fphexrhwfy(zmzocryvwz) = pyscbqzviq lassvyzkez (gdikdcmjxg, nuolgebvil - fpkerxlhsv)
-
02 Aug 2019
Not Applicable
84
(Guanfacine)
jrqxihpnvu(dlpfsbnrdb) = tunrubtxin ozdienuztq (lzvjanubjj, cqjbtvgrfj - lutdrftggo)
-
03 Jan 2019
Placebo
(Placebo)
jrqxihpnvu(dlpfsbnrdb) = bbeelezkzy ozdienuztq (lzvjanubjj, ctchhnpsvr - ypkwuwmwee)
Phase 1
22
bocnriwkoa(nlfjbnnrev) = wbpyxtuuuu kxzuscdqyx (urqnqtivyt, oyktfyubrt - eadlszkebs)
-
12 Dec 2018
Phase 3
215
nmwxxkvhpe(chgxawyjdk) = lfdlfkzgtz ipdkklapii (gvquoofxut, 9.17)
-
01 Oct 2018
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free