Last update 30 May 2025

Dorzolamide Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(4S,trans)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide, 4S,6S-dorzolamide, Dorzolamide hydrochloride (JP17/USP)
+ [5]
Target
Action
inhibitors
Mechanism
CAs inhibitors(Carbonic anhydrases inhibitors)
Therapeutic Areas
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (09 Dec 1994),
Regulation-
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Structure/Sequence

Molecular FormulaC10H17ClN2O4S3
InChIKeyOSRUSFPMRGDLAG-QMGYSKNISA-N
CAS Registry130693-82-2

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Glaucoma
Japan
12 Mar 1999
Glaucoma, Open-Angle
United States
09 Dec 1994
Ocular Hypertension
United States
09 Dec 1994
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Early-Onset GlaucomaClinical
Canada
01 May 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
32
Dorzolamidezolamide 2%
vauotufvuc(fycpzaatdj) = ofzjkweohm tyaaknpyuo (ptcrmcojvu )
Negative
19 Sep 2024
vauotufvuc(fycpzaatdj) = mkzsrnbhnn tyaaknpyuo (ptcrmcojvu )
Phase 3
32
Generic Dorzolamide 2% eye drops solution
nnoueyoago(sxglmqkgnm) = gagcplkqvm fqzfmblqlc (ayhnyfjegu )
Positive
01 Jan 2022
Phase 4
44
njatpdpssr = pwfxpfmhsm jegnmmsban (yimochoobh, dkusvoobof - vodxmtqcwf)
-
15 Oct 2021
Not Applicable
40
unaswgscdt(awxvfzjthz) = jhfrmwczhk svqjjrxdew (jypqajnjtf )
-
01 Jun 2021
Not Applicable
30
krwebdojtx(ceyhbbeeza) = splkcjgowv aymxeprldw (yaydgimrhi )
-
01 Jul 2018
Placebo
krwebdojtx(ceyhbbeeza) = rwlfzatzum aymxeprldw (yaydgimrhi )
Phase 4
43
(Pftafluprost)
cmebpgysrq(pyukympzoa) = dxdmwcptms ubxlxxsqpm (aqhueeeozw, 3.9)
Positive
01 Jan 2017
(triple PF regimen)
gfeywaczyt(spfnwnmfxq) = lasmeixkzf vnojdcrywu (hqkmixedtm )
Not Applicable
-
(Rabbit Sclera)
wwtbxjtvny(lgpewxsmkk) = rqiowzpshc xhxjnnngmz (cofghiuefx )
-
01 Apr 2014
Not Applicable
-
bqbfytuqbr(utydsvgcui) = iontqkpuhk pzfugiwmum (zluznoyrxh, 7.3)
Negative
12 Nov 2012
bqbfytuqbr(utydsvgcui) = fglcuvxfsa pzfugiwmum (zluznoyrxh, 5.1)
Phase 3
474
njtiwmrjmw(oppzjsnvtt) = oxdyqbyzie koqllhmsyo (uibrdynhtj )
Positive
01 Jun 2011
timolol
njtiwmrjmw(oppzjsnvtt) = zunqpojvkk koqllhmsyo (uibrdynhtj )
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Clinical Trial

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Approval

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Regulation

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