[Translation] A randomized, open-label, single-dose, two-sequence, two-period, double-crossover bioequivalence study of alogliptin benzoate tablets (25 mg) in Chinese healthy subjects under fasting conditions

主要研究目的：按有关生物等效性试验的规定，选择Takeda Pharmaceutical Company Limited为持证商的苯甲酸阿格列汀片（商品名：尼欣那，规格：25mg）为参比制剂，对石家庄四药有限公司生产并提供的受试制剂苯甲酸阿格列汀片（规格：25mg）进行空腹给药人体生物等效性试验，比较受试制剂中药物的吸收速度和吸收程度与参比制剂的差异是否在可接受的范围内，评价两种制剂在空腹给药条件下的生物等效性。次要研究目的：观察健康受试者口服受试制剂苯甲酸阿格列汀片（规格：25mg）和参比制剂苯甲酸阿格列汀片（商品名：尼欣那，规格：25mg）的安全性。

[Translation]

Main purpose of study: According to the relevant provisions of bioequivalence test, Takeda Pharmaceutical Company Limited was selected as the reference preparation for alogliptin benzoate tablets (trade name: Nisina, specification: 25mg), and the test preparation alogliptin benzoate tablets (specification: 25mg) produced and provided by Shijiazhuang Siyao Co., Ltd. was used for fasting human bioequivalence test, to compare whether the absorption rate and degree of the drug in the test preparation were within the acceptable range with the reference preparation, and to evaluate the bioequivalence of the two preparations under fasting conditions. Secondary purpose of study: To observe the safety of oral administration of the test preparation alogliptin benzoate tablets (specification: 25mg) and the reference preparation alogliptin benzoate tablets (trade name: Nisina, specification: 25mg) in healthy subjects.

Start Date24 Mar 2025

Sponsor / Collaborator

Shijiazhuang No. 4 Pharmaceutical Co., Ltd.

CTR20250729

/ Active, not recruitingNot Applicable

苯甲酸阿格列汀片（25mg）在中国健康受试者中餐后给药条件下随机、开放、单剂量、两序列、两周期、双交叉生物等效性试验

主要研究目的：按有关生物等效性试验的规定，选择Takeda Pharmaceutical Company Limited为持证商的苯甲酸阿格列汀片（商品名：尼欣那，规格：25mg）为参比制剂，对石家庄四药有限公司生产并提供的受试制剂苯甲酸阿格列汀片（规格：25mg）进行餐后给药人体生物等效性试验，比较受试制剂中药物的吸收速度和吸收程度与参比制剂的差异是否在可接受的范围内，评价两种制剂在餐后给药条件下的生物等效性。次要研究目的：观察健康受试者口服受试制剂苯甲酸阿格列汀片（规格：25mg）和参比制剂苯甲酸阿格列汀片（商品名：尼欣那，规格：25mg）的安全性。

[Translation]

Main purpose of study: According to the relevant provisions of bioequivalence test, Takeda Pharmaceutical Company Limited was selected as the reference preparation for alogliptin benzoate tablets (trade name: Nisina, specification: 25mg), and the test preparation alogliptin benzoate tablets (specification: 25mg) produced and provided by Shijiazhuang Siyao Co., Ltd. was used for human bioequivalence test after meal administration. The difference between the absorption rate and absorption extent of the drug in the test preparation and the reference preparation was compared to see whether it was within an acceptable range, and to evaluate the bioequivalence of the two preparations under the condition of postprandial administration. Secondary purpose of study: To observe the safety of oral administration of the test preparation alogliptin benzoate tablets (specification: 25mg) and the reference preparation alogliptin benzoate tablets (trade name: Nisina, specification: 25mg) to healthy subjects.

Start Date23 Mar 2025

Sponsor / Collaborator

Shijiazhuang No. 4 Pharmaceutical Co., Ltd.

CTIS2025-520460-18-00

/ Not yet recruitingPhase 1

- BLCL-AE-EU-02

Start Date18 Feb 2025

Sponsor / Collaborator

Tecnimede Sociedade Tecnico Medicinal SA

100 Clinical Results associated with Alogliptin Benzoate

100 Translational Medicine associated with Alogliptin Benzoate

100 Patents (Medical) associated with Alogliptin Benzoate

1,053

Literatures (Medical) associated with Alogliptin Benzoate

01 May 2025·Diabetes Therapy

A Randomized Phase 3 Study Evaluating the Efficacy and Safety of Alogliptin in Pediatric Participants with Type 2 Diabetes Mellitus

Article

Author: Klingensmith, Georgeanna ; Peng, Xuejun Victor ; Xie, Yunlong ; Hsia, Daniel S ; Tamborlane, William V ; Shah, Amy S ; Czerniak, Richard

INTRODUCTION:

There is an unmet need for pharmacological therapies for children with type 2 diabetes mellitus (T2DM). We assessed the efficacy and safety of an oral dipeptidyl peptidase-4 inhibitor, alogliptin, 25 mg once daily (QD), as a potential treatment for pediatric patients with T2DM.

METHODS:

This phase 3, 52-week, multicenter, randomized, double-blind, placebo-controlled trial was conducted in children and adolescents (10-17 years old) with T2DM. Participants had glycosylated hemoglobin (HbA1c) ≥ 6.5% at baseline (≥ 6.5% to < 11% without treatment or on metformin alone; ≥ 7.0% to < 11% on insulin alone or in combination with metformin). Where required, participants underwent prerandomization stabilization of their background metformin and/or insulin therapy. All received diabetes education and home glucose-monitoring training (during screening, prerandomization stabilization, and specified visits through week 26). Participants were then stratified based on previous antihyperglycemic therapy for 12 weeks before screening into schedule A (antihyperglycemic treatment-naïve) or B (metformin and/or insulin). The primary efficacy endpoint was change in HbA1c levels from baseline at week 26. Safety was assessed as a secondary endpoint at week 52.

RESULTS:

Overall, 152 participants (median age, 14 years; 68.9% female) were randomized (1:1) to receive either alogliptin (n = 75) or placebo (n = 77). The majority were white (58.3%), had a body mass index of ≥ 30 kg/m² (60.3%), and had received previous antihyperglycemic therapy (82.1%). The difference in HbA1c levels from baseline to week 26 between the alogliptin and placebo groups (least squares mean change [95% confidence interval]) was 0.10 (- 0.63, 0.83; p = 0.78). There was no difference in efficacy endpoints between alogliptin and placebo across both subgroups. No new safety concerns were observed with alogliptin treatment.

CONCLUSION:

Alogliptin 25 mg QD did not significantly improve glycemic control versus placebo in pediatric patients with T2DM. Alogliptin treatment was safe and well tolerated, and no new safety concerns were observed in this study.

TRIAL REGISTRATION:

ClinicalTrials.gov: NCT02856113; EudraCT: 2015-000208-25.

01 Mar 2025·REPRODUCTIVE TOXICOLOGY

Alogliptin attenuates testicular damage induced by monosodium glutamate in both juvenile and adult male rats by activating autophagy: ROS dependent AMPK/mTOR

Article

Author: Farag, Azza I ; Hassan, Heba A ; Ramadan, Rania Saad ; Nafea, Ola Elsayed ; Morsy, Manal Mohammad ; Morsi, Reham M

Monosodium glutamate (MSG) is one of the most commonly used food additives, known for its adverse health effects. Alogliptin (ALO) is a highly selective dipeptidyl peptidase-4 inhibitor, but its role in male reproductive function remains debated. The study was designed to evaluate and compare the potential of ALO in mitigating MSG-induced testicular toxicity in juvenile and adult male rats. Juvenile and adult male rats were treated with either MSG or pretreated with ALO before MSG administration. The rats then received ALO and MSG concurrently for 28 days. Testicular tissues were isolated and subjected to histo-biochemical and molecular assessments. Our results demonstrated that ALO reversed MSG-induced testicular injury, as evidenced by the restoration of reproductive hormone balance (increased serum luteinizing hormone and testosterone concentrations), suppression of oxidative stress injury (decreased testicular malondialdehyde, increased superoxide dismutase activity, and minimal 8-hydroxy-2'-deoxyguanosine immunoreactivity), inflammation (reduced testicular tumor necrosis factor-alpha levels), and fibrosis (decreased testicular collagen fiber deposition). Additionally, ALO impeded apoptosis and activated autophagy by decreasing caspase-3 activity, stimulating the AMPK/mTOR pathway, downregulating Bax and SQSTM-1/p62 expression, upregulating Bcl2 and Beclin 1, promoting testicular proliferation (increased number of proliferating cell nuclear antigen-positive cells in the testis), restoring glycogen content in the testis (mild to moderate periodic acid-Schiff reaction), and preserving testicular architecture. MSG induced more severe adverse testicular effects in juvenile rats, while ALO pretreatment was more protective in adult rats. ALO's anti-inflammatory, antioxidant, antiapoptotic, pro-autophagic, antifibrotic, and proliferative actions in the testis suggest its promising potential for combating male reproductive dysfunction.

01 Mar 2025·SAUDI MEDICAL JOURNAL

Effects of antidiabetic drugs on the level of serum uric acid in patients who have type 2 diabetes

Review

Author: Wang, Guixia ; Wang, Gang

Hyperuricemia and type 2 diabetes mellitus (T2DM) are interconnected, in that each disorder increases risk for the other. Some antidiabetic drugs may decrease the level of serum uric acid (SUA). This narrative review describes the effects of multiple antidiabetic drugs on the SUA level and their possible mechanisms of action in patients with T2DM. The results showed that sodium glucose contransporter-2 inhibitors (SGLT2is), thiazolidinediones, metformin, and linagliptin decreased the SUA; insulin, sitagliptin, and alogliptin increased the SUA; and glucagon-like peptide-1 receptor agonists (GLP-1 RAs), sulfonylureas, and alpha-glucosidase inhibitors had little effect on the SUA. Sodium glucose contransporter-2 inhibitors appeared to have the greatest effect on lowering SUA, possibly because they reduce pentose phosphate pathway metabolism and increase the renal excretion of urate by altering renal tubular uric acid transporters. Among all antidiabetic drugs currently used, SGTL2is appeared to be the most promising therapeutic option for T2DM patients with hyperuricemia.

News (Medical) associated with Alogliptin Benzoate

14 Feb 2024

·endpts.com

Appeals court sides with AstraZeneca, BMS, McKesson in saxagliptin heart failure case

A Sixth Circuit appeals court this week upheld a decision in favor of AstraZeneca, Bristol Myers Squibb and McKesson in a case alleging that diabetes products containing saxagliptin can cause heart failure. Saxagliptin is the key ingredient in the discontinued type 2 diabetes treatments Onglyza and Kombiglyze. It’s a dipeptidyl peptidase-4 (DPP-4) inhibitor, designed to help lower blood sugar along with diet and exercise. But in 2016, an FDA safety review found that saxagliptin and another DPP-4 inhibitor called alogliptin may increase patients’ risk of heart failure. You’ll get access to free articles each month, plus you can customize what newsletters get delivered to your inbox each week, including breaking news.

Patent Infringement

24 Nov 2023

·synapse.patsnap.com

What are DPP-4 inhibitors and how do you quickly get the latest development progress?

Dipeptidyl peptidase-4 (DPP-4) is an enzyme found in the human body that plays a crucial role in regulating glucose metabolism. It is primarily expressed in the pancreas, intestines, and immune cells. DPP-4 is responsible for breaking down incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which are released after a meal to stimulate insulin secretion and reduce blood sugar levels. By inhibiting DPP-4 activity, pharmaceutical drugs can prolong the action of these incretin hormones, leading to increased insulin release, improved glycemic control, and potential therapeutic benefits for individuals with type 2 diabetes. Several dozens of DPP-4 inhibitors have been introduced to the market, with sitagliptin, vildagliptin, saxagliptin, alogliptin, and linagliptin being available in domestic markets. DPP-4 inhibitors can be combined with multiple antidiabetic drugs to form fixed-dose combinations, among which, the combinations with metformin are most common. The currently available DPP-4 inhibitor-metformin fixed-dose combinations in the domestic market include sitagliptin/metformin tablets, vildagliptin/metformin tablets, saxagliptin/metformin extended-release tablets, linagliptin/metformin tablets. DPP-4 inhibitors can be used as monotherapy for type 2 diabetes and can also be combined with other antidiabetic drugs for the treatment of type 2 diabetes. The most commonly combined antidiabetic drugs with DPP-4 inhibitors are metformin, followed by sulfonylureas, thiazolidinediones, and insulin. They can also be used in combination with two other antidiabetic drugs, forming a triple therapy commonly including combinations of DPP-4 inhibitors + metformin + sulfonylureas, DPP-4 inhibitors + metformin + thiazolidinediones, and DPP-4 inhibitors + metformin + insulin. The analysis of the target DPP-4 in the pharmaceutical industry reveals a competitive landscape with several companies focusing on the development of DPP-4 inhibitors. Merck & Co., Inc., Takeda Pharmaceutical Co., Ltd., C.H. Boehringer Sohn AG & Co. KG, LG Chem Ltd., and AstraZeneca PLC are among the companies growing fastest under this target. The primary indication for the approved drugs is diabetes mellitus, type 2. Small molecule drugs are progressing most rapidly, indicating intense competition around the innovative drug. The United States, European Union, Japan, and China are the countries/locations developing fastest under this target, with China showing significant progress. Overall, the target DPP-4 presents opportunities for further research and development in the treatment of diabetes and related indications. Unlocking Blood Sugar Control: The Role of DPP-4 Inhibitors in Type 2 Diabetes ManagementDPP-4 inhibitors, also known as dipeptidyl peptidase-4 inhibitors, are a type of medication used in the treatment of type 2 diabetes. From a biomedical perspective, DPP-4 inhibitors work by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4), which is responsible for breaking down incretin hormones in the body. Incretin hormones play a role in regulating blood sugar levels by stimulating the release of insulin and reducing the production of glucagon. By inhibiting DPP-4, these medications increase the levels of incretin hormones, leading to improved blood sugar control. DPP-4 inhibitors are typically taken orally and are often prescribed as an adjunct to diet and exercise in the management of type 2 diabetes. They can be used as monotherapy or in combination with other antidiabetic medications, such as metformin. Some common examples of DPP-4 inhibitors include sitagliptin, saxagliptin, linagliptin, and alogliptin. These medications have been shown to be effective in lowering blood sugar levels and have a favorable safety profile. It's important to note that DPP-4 inhibitors are not recommended for the treatment of type 1 diabetes or diabetic ketoacidosis. They are primarily used in the management of type 2 diabetes and can help improve glycemic control in individuals with this condition. As with any medication, DPP-4 inhibitors may have potential side effects, and it is essential to consult with a healthcare professional for proper evaluation and monitoring while taking these medications. Catalog of DPP-4 InhibitorsThe currently marketed DPP-4 inhibitors include: Sitagliptin/Metformin HydrochlorideSitagliptinRetagliptin PhosphateGemigliptin/DapagliflozinMetformin Hydrochloride/Sitagliptin HydrochlorideEmpagliflozin/Linagliptin/Metformin HydrochlorideAnagliptin/Metformin HydrochlorideErtugliflozin/Sitagliptin PhosphateGosogliptinEvogliptinFor more information, please click on the image below. What is the purpose of using DPP-4 inhibitors?DPP-4 inhibitors can be used as a mono-drug treatment for type 2 diabetes, or in combination with other glucose-lowering drugs for the treatment of type 2 diabetes. For more information, please click on the image below to log in and search. How can you get the most recent advancements in DPP-4 inhibitors?In the Synapse database, you can keep abreast of the latest research and development advances of DPP-4 inhibitors anywhere and anytime, daily or weekly, through the "Set Alert" function. Click on the image below to embark on a brand new journey of drug discovery!

01 Mar 2023

·www.biospace.com

Tachyon Announces Financing and Start of Clinical Study of First-in-Class KDM4 Inhibitor for Advanced Cancers

- First patient enrolled in Phase 1 clinical study of TACH101, a small molecule, KDM4 histone demethylase inhibitor, in patients with advanced or metastatic solid tumors - Tachyon also announces the appointment of Jeff Stafford, Ph.D., to the Company’s Board of Directors SAN FRANCISCO & HOUSTON--(BUSINESS WIRE)-- Tachyon Therapeutics, Inc. ("Tachyon" or "the Company"), a private, clinical-stage biotechnology company developing transformative cancer therapies against novel targets today announced the closing of a financing that brings the Company’s total equity financing raises to $11.6 million and, together with a recently announced CIRM grant of $7.1 million, brings total funding in the Company to $18.7 million since the Company started operations in 2020. The round includes new investors, Veblen Ventures, Khosla Ventures, and Red Tree Venture Capital, and existing investors, demonstrating their continued commitment to supporting Tachyon's potential. Proceeds from the financing are being used to run the Phase 1 clinical study in advanced solid tumors for TACH101, a first-in-class, small molecule, KDM4 histone demethylase inhibitor, as well as to advance the Company’s pipeline of emerging oncology drug candidates targeting previously unexplored mechanisms of tumorigenesis. “The Tachyon team are enabling new frontiers in targeted oncology by developing cancer therapies that address fundamental drivers of tumorigenesis,” commented Heath Lukatch, Ph.D., Managing Director of Red Tree Venture Capital. “We look forward to supporting the team as they work towards transforming the treatment paradigms for advanced and metastatic solid tumors.” “This new capital, from a committed and distinguished investor syndicate that includes new and existing investors as well as the grant from CIRM, highlights the progress we’ve made to bring our lead program into the clinic,” said Frank Perabo, M.D. Ph.D., Chief Executive Officer of Tachyon. Founded on the scientific work of Drs. Stephen Quake and Michael Clarke at Stanford University, Tachyon Therapeutics is developing novel, first-in-class therapeutics that target pathways to fight cancer at its core tumorigenic mechanisms. In November 2019, Tachyon received an exclusive license to research, develop, and commercialize products for small molecule inhibitors of KDM4 including TACH101 (formerly QC8222) from Celgene Quanticel Research, Inc, now Bristol Myers Squibb, Summit, NJ. The Company recently received clearance of the Company’s Investigational New Drug (IND) application for TACH101 and enrolled its first patient in a Phase 1 clinical study in patients with advanced or metastatic solid tumors (ClinicalTrials.gov Identifier NCT05076552). “The start of our first clinical trial for TACH101, our lead program, is a significant milestone for the company as we strive to bring promising new therapeutics to patients who are fighting advanced cancers,” continued Dr. Perabo. “We are also pleased to welcome to our Board of Directors, Dr. Jeff Stafford, who has decades of experience in developing innovative small molecule therapeutics against novel cancer targets and led the initial discovery and development of our novel KDM4-inhibitor, TACH101.” Dr. Stafford is the President and CEO of 858 Therapeutics. Prior to this, he was the founding CSO of Quanticel Pharmaceuticals (acquired by Celgene), where his team discovered TACH101 from a single cell genomics platform for precision targeting of cancer stem cells. Dr. Stafford has also held senior scientific and management positions at Takeda and GlaxoSmithKline and was the founding CEO of Jecure. Dr. Stafford’s discovery teams have been responsible for the discovery of three FDA-approved drugs – Votrient™ (pazopanib), Nesina™ (alogliptin), and Byfavo™ (remimazolam) – and several others currently in clinical trials. About Tachyon Therapeutics Inc. Tachyon Therapeutics, Inc. develops first-in-class therapeutics against novel targets from previously unexplored cancer dysregulation pathways to propel new options for the treatment of advanced cancers. Tachyon operates with a dedicated internal core development team and a virtual external network of expertise to achieve one goal – advance our programs with speed, innovation, quality and scientific integrity. For more information, please visit .

Phase 1Executive ChangeIND

100 Deals associated with Alogliptin Benzoate

External Link

KEGG	Wiki	ATC	Drug Bank
D06553	Alogliptin Benzoate	A10BH04	DB06203

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Diabetes Mellitus, Type 2	Japan	Takeda Pharmaceutical Co., Ltd.	06 Apr 2010
Diabetes Mellitus, Type 2	Japan	Teijin Pharma Ltd.	06 Apr 2010

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Diabetes Mellitus, Noninsulin-Dependent, 2	Phase 3	Japan	Takeda Pharmaceutical Co., Ltd.	01 Feb 2014
Acute Coronary Syndrome	Phase 3	United States	Takeda Pharmaceutical Co., Ltd.	01 Sep 2009
Acute Coronary Syndrome	Phase 3	Japan	Takeda Pharmaceutical Co., Ltd.	01 Sep 2009
Acute Coronary Syndrome	Phase 3	Argentina	Takeda Pharmaceutical Co., Ltd.	01 Sep 2009
Acute Coronary Syndrome	Phase 3	Australia	Takeda Pharmaceutical Co., Ltd.	01 Sep 2009
Acute Coronary Syndrome	Phase 3	Austria	Takeda Pharmaceutical Co., Ltd.	01 Sep 2009
Acute Coronary Syndrome	Phase 3	Belgium	Takeda Pharmaceutical Co., Ltd.	01 Sep 2009
Acute Coronary Syndrome	Phase 3	Brazil	Takeda Pharmaceutical Co., Ltd.	01 Sep 2009
Acute Coronary Syndrome	Phase 3	Bulgaria	Takeda Pharmaceutical Co., Ltd.	01 Sep 2009
Acute Coronary Syndrome	Phase 3	Canada	Takeda Pharmaceutical Co., Ltd.	01 Sep 2009

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02856113 (2015-000208-25, Pubmed \| Diabetes Ther)	Phase 3	Diabetes Mellitus, Type 2	152	Alogliptin 25 mg QD	sqtcaxpgjz(povbzvgyqs) = ravieqrzhb cgrukdhwzf (qxjrduhduw, -0.63 to 0.83)	Negative	04 Mar 2025
1340-P (ADA2024)	Not Applicable	Diabetes Mellitus	-	SGLT2i	ouigfjmdel(wdbemebama) = zxmilvwxml uaxivynkya (sgjrocezof, 16.6 - 19.7)	Positive	14 Jun 2024
				DPP4i	ouigfjmdel(wdbemebama) = fcldlymsdc uaxivynkya (sgjrocezof, 19.1 - 21.4)
NCT05782192 (Pubmed)	Phase 3	Diabetes Mellitus, Type 2	-	Fotagliptin	zptclfbkkx(jzdzrmllyi) = ybbhnovrmr paevoeogrl (melcasnexa ) View more	Positive	09 Oct 2023
				Alogliptin	zptclfbkkx(jzdzrmllyi) = xgcabyfeif paevoeogrl (melcasnexa ) View more
NCT02856113 (2015-000208-25, CTgov)	Phase 3	Diabetes Mellitus, Type 2	152	Placebo (Placebo)	foolzknmei(hsshbgyjpt) = cbcphxeajh svxzqxyojk (vpgfjuhffh, 0.2809) View more	-	19 Oct 2022
				Alogliptin Benzoate (Alogliptin 25 mg)	foolzknmei(hsshbgyjpt) = aiqspwxllm svxzqxyojk (vpgfjuhffh, 0.2879) View more
NCT03794336 (ACADEMIC, Pubmed \| Diabetes Obes Metab) Manual	Phase 4	Diabetes Mellitus, Type 2 \| Coronary Disease	1,088	aspirin+alogliptin	iqiaqoroqt(cyaotemfqy) = fodwemujpr jbudonjsya (oducnfmsit, 0.4) View more	Positive	03 Feb 2022
				aspirin+acarbose	iqiaqoroqt(cyaotemfqy) = zayslkkjtc jbudonjsya (oducnfmsit, 0.5) View more
NCT03794336 (EASD2021)	Phase 4	Cardiovascular Diseases \| Diabetes Mellitus, Type 2 \| Coronary Disease	-	Alogliptin 25 mg q.d.	atheeeites(qhbfizomrn) = Significantly lesser GI adverse events were observed with alogliptin than acarbose (8.9% vs 33.6%, P <0.0001) llqbpwjsgy (txrmaauizf ) View more	Positive	29 Sep 2021
				Acarbose 100 mg t.i.d.
NCT03231709 (TRINITY, CTgov)	Phase 4	Diabetes Mellitus, Type 2	60	Trelagliptin+Alogliptin (Trelagliptin 100 mg + Alogliptin 25 mg)	jxnrtuwkln = mxgjbegivb mpklycouwo (puhxwihdfm, qsmbzenhqb - anbeipwsag) View more	-	10 May 2019
				Trelagliptin+Alogliptin (Alogliptin 25 mg + Trelagliptin 100 mg)	jxnrtuwkln = mctxexbefn mpklycouwo (puhxwihdfm, dkaufkvoru - sapizyyeri) View more
NCT02771093 (TRACK, CTgov)	Phase 4	Diabetes Mellitus, Type 2	27	Trelagliptin (Trelagliptin 100 mg)	mqmdolykod(shlnduifkc) = tvygkjmlff raoeqnrxnw (furmadtboi, osfckolzpe - tsdrwvfcdi) View more	-	10 Dec 2018
				Alogliptin (Alogliptin 25 mg)	mqmdolykod(shlnduifkc) = jjayjcjueb raoeqnrxnw (furmadtboi, zefyljxlrf - iguqgkkrbt) View more
EASD2018	Not Applicable	Diabetes Mellitus, Type 2	865	Alogliptin	aafilmgfgb(ccwrzpsvyf) = ccrgyzufng sgkpqrehed (hhxfrjswrh, 1.62)	Positive	02 Oct 2018
				Sitagliptin	aafilmgfgb(ccwrzpsvyf) = hmyyjkdqpc sgkpqrehed (hhxfrjswrh, 1.52)

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