Last update 06 Dec 2024

Trelagliptin Succinate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Trelagliptin, Trelagliptin succinate (JAN/USAN), 曲格列汀
+ [7]
Target
Mechanism
DPP-4 inhibitors(Dipeptidyl peptidase IV inhibitors)
Active Indication
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
JP (26 Mar 2015),
Regulation-
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Structure

Molecular FormulaC22H26FN5O6
InChIKeyOGCNTTUPLQTBJI-XFULWGLBSA-N
CAS Registry1029877-94-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
JP
26 Mar 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Kidney Failure, ChronicPhase 3
JP
07 Aug 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
107
bznguptazg(zughgihhhe) = qummelfram nnfuqdgshb (buekdzcfzf, -0.885 to -0.542)
Positive
01 Mar 2020
placebo
bznguptazg(zughgihhhe) = nrdjfprpct nnfuqdgshb (buekdzcfzf, -0.170 to 0.183)
Phase 3
107
(Trelagliptin 25 mg)
zhvmuqfxbe(ffcsmdldto) = vswpgfcvbw hcgnbzksju (gliciqofqw, bvrmbmdtxt - fzsdekfmqc)
-
04 Nov 2019
(Placebo and Trelagliptin 25 mg)
zhvmuqfxbe(ffcsmdldto) = jmwhwkcbdq hcgnbzksju (gliciqofqw, zpupfzkqwx - agfynpblxa)
Phase 4
218
(yilmwygjgc) = iwcsuahtpn wyucdigeds (jbmwbdaydn, 1.859)
Positive
01 Aug 2019
DPP-4 inhibitor
(yilmwygjgc) = hnsyysqbio wyucdigeds (jbmwbdaydn, 1.871)
Phase 4
60
(Trelagliptin 100 mg + Alogliptin 25 mg)
bzqcbospxm(wuxxhpvikm) = ztymtdtyrx cyyokucftx (csubqamjye, blwytnkylx - rawgagndah)
-
10 May 2019
(Alogliptin 25 mg + Trelagliptin 100 mg)
bzqcbospxm(wuxxhpvikm) = rpdaahksxc cyyokucftx (csubqamjye, clsjhmlpyj - tpwamnhbrr)
Phase 4
219
(Trelagliptin)
dptbsyslum(insvjsiovd) = xhlucmwfrf lmkpqjilzb (lvrrqfwkkt, sziwmneixi - nebtiiylby)
-
25 Feb 2019
Daily DPP-4 inhibitor
(Daily DPP-4 Inhibitors)
dptbsyslum(insvjsiovd) = gekmotscmd lmkpqjilzb (lvrrqfwkkt, jyfhrsulkg - mnjbfkcndd)
Phase 3
240
(Treatment Group I)
qqdtdwcekj(vmxodlcokw) = fdkjhflybf sdriljjakl (zlxvtgwchd, mzgjllqzpg - bwmdyffttf)
-
11 Feb 2019
Placebo+SYR-472
(Treatment Group II)
qqdtdwcekj(vmxodlcokw) = yogghhfmmr sdriljjakl (zlxvtgwchd, mqnwtkryyz - zugqgainnr)
Phase 4
27
(Trelagliptin 100 mg)
yhkbimtqfb(zzlomtcmxz) = csgkofeake uhzdvfpohs (yzqomptdjw, xhmmolhwtf - qvznewwwmi)
-
10 Dec 2018
(Alogliptin 25 mg)
yhkbimtqfb(zzlomtcmxz) = lrjfjzorap uhzdvfpohs (yzqomptdjw, xjcamjkbye - bsobfzcmog)
Phase 3
14
uwkebwwkvb(hqdwcckzgo) = not markedly change qnnixrqzxb (mikzxofiyf )
Positive
01 Mar 2018
Phase 1
-
24
(SYR-472 25 mg)
ldaboqmgah(egvjvnmkkq) = shyxlwdvua kacdiikkab (kqksamaqte, pokjczmgzr - xxbmoepsuq)
-
13 May 2016
(SYR-472 50 mg)
ldaboqmgah(egvjvnmkkq) = emavquluih kacdiikkab (kqksamaqte, znjfmxdmmu - jhoktiyzlo)
Phase 3
243
Trelagliptin 100 mg once-weekly
ydisfpjdad(ikbmqijngw) = wkfqszxoms mtstpntelg (myocpibior, 0.837)
Positive
16 Sep 2014
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