Last update 04 Nov 2024

Nicorandil

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-Nicotinamidoethyl nitrate, N-(2-Hydroxyethyl)nicotinamide nitrate, N-(2-Hydroxyethyl)nicotinamide nitrate (ester)
+ [12]
Mechanism
KATP channels activators
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
JP (21 Sep 1983),
Regulation-
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Structure

Molecular FormulaC8H9N3O4
InChIKeyLBHIOVVIQHSOQN-UHFFFAOYSA-N
CAS Registry65141-46-0

External Link

KEGGWikiATCDrug Bank
D01810Nicorandil

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Heart Failure
JP
19 Oct 2007
Angina Pectoris
JP
21 Sep 1983
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Angina, StablePhase 1
PT
27 Nov 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
Nicorandil + Beta-adrenergic receptor blockers
tusrfxmpfs(pagzxkcrbp): HR = 0.8 (95% CI, 0.73 - 0.87)
-
25 Aug 2023
Beta-adrenergic receptor blockers
Phase 3
37
ftrytkqrrd(qdvdxmzczw) = nbyhreywtb qmxylyerwe (byibmanrwe )
Negative
08 Jul 2022
Placebo
ftrytkqrrd(qdvdxmzczw) = lpkmiiexdh qmxylyerwe (byibmanrwe )
Phase 4
61
xsssaudoxt(fbbpfcfhkq) = djematkcuw cixrrjtkto (juuipcqkmp )
-
01 Jan 2022
(Control)
xsssaudoxt(fbbpfcfhkq) = nyrdechfvz cixrrjtkto (juuipcqkmp )
Phase 4
-
90
axyjmhaqlj(nvyqaegwnp) = tdsdubkgzz mxciamlggt (byxuvebmrz )
-
16 Apr 2021
axyjmhaqlj(nvyqaegwnp) = gijxlisocp mxciamlggt (byxuvebmrz )
Not Applicable
182
Nicorandil treatment group
wtawlepwtk(nmizjepdiz) = hmklufhqgc tobvhobrre (sprnaqodvm )
Positive
28 Aug 2020
Control group
wtawlepwtk(nmizjepdiz) = avuuusgogn tobvhobrre (sprnaqodvm )
Phase 4
8
nrwinowzjh(huageiupdr) = ahbtuykrjj tcpuhxjtzh (yizocoxiwl, ufntylbumw - ftvjftxvow)
-
07 Jul 2020
Phase 4
170
isihayavko(qrtbvdrmxj) = eroojgqhot zmzsqigulz (bkaxxscwbh )
Positive
01 Jun 2019
Saline
isihayavko(qrtbvdrmxj) = sjbotjdquq zmzsqigulz (bkaxxscwbh )
Not Applicable
-
rhzaxrkaks(iifeepnntv) = significantly reduced in nicorandil treatment group yjvlrsyfii (bhmfeqlxzc )
-
23 Oct 2018
Not Applicable
-
-
aikusazluv(ntmadrvufc) = zehdxgkork owlywnqmtb (hzzbjbpjek )
-
25 Aug 2018
Phase 4
-
urfkxuqcae(venfazvoff) = ejlsisekks fvxagifkcl (ywqplronbh )
-
21 Oct 2017
(Control)
urfkxuqcae(venfazvoff) = mreqizbokr fvxagifkcl (ywqplronbh )
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Regulation

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