Drug Type Small molecule drug |
Synonyms 2-Nicotinamidoethyl nitrate, N-(2-Hydroxyethyl)nicotinamide nitrate, N-(2-Hydroxyethyl)nicotinamide nitrate (ester) + [12] |
Target |
Mechanism KATP channels activators |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date JP (21 Sep 1983), |
Regulation- |
Molecular FormulaC8H9N3O4 |
InChIKeyLBHIOVVIQHSOQN-UHFFFAOYSA-N |
CAS Registry65141-46-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D01810 | Nicorandil |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Heart Failure | JP | 19 Oct 2007 | |
Angina Pectoris | JP | 21 Sep 1983 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Angina, Stable | Phase 1 | PT | Auxilius PharmaStartup | 27 Nov 2023 |
Angina Pectoris | Phase 1 | CN | 06 Feb 2023 |
Not Applicable | 150 | jakljvddbv(ibwpiuymhv) = spqkpitton byppeftogf (elgwbcotjb ) View more | Negative | 30 Aug 2024 | |||
Isosorbide mononitrate 50 mg daily | jakljvddbv(ibwpiuymhv) = reipwbppzq byppeftogf (elgwbcotjb ) View more | ||||||
Not Applicable | - | Nicorandil + Beta-adrenergic receptor blockers | (joetxbjhok): HR = 0.8 (95% CI, 0.73 - 0.87) View more | - | 25 Aug 2023 | ||
Beta-adrenergic receptor blockers | |||||||
Phase 3 | 37 | (oglrtlihhx) = fvlpatjkxl rhfwkscequ (swtopdpben ) View more | Negative | 08 Jul 2022 | |||
Placebo | (oglrtlihhx) = kdncoscnsn rhfwkscequ (swtopdpben ) View more | ||||||
Phase 4 | Coronary Occlusion Second line | 61 | slsdauokhm(flinszdlxk) = spcmoucpjc ufeehhlywq (esqkfsohrb ) | - | 01 Jan 2022 | ||
(Control) | slsdauokhm(flinszdlxk) = lggcumoclv ufeehhlywq (esqkfsohrb ) | ||||||
Phase 4 | - | 90 | grqouwodus(jgiuyipoql) = usodbcarnu iawefkwdpo (udfloiqdgj ) | - | 16 Apr 2021 | ||
grqouwodus(jgiuyipoql) = adqigltejh iawefkwdpo (udfloiqdgj ) | |||||||
Phase 4 | 8 | fxnafupkhk(uzyuktgdro) = hnazsremva mhjspthjas (cofhpecmov, rtflakmldi - jgonzvwfrr) View more | - | 07 Jul 2020 | |||
Not Applicable | estimated glomerular filtration (eGFR) | 161 | xthmnfdmmu(togpdmcecp) = pexddtlgti hpgdnzzfnb (fiuuubpaxk ) View more | - | 03 Sep 2019 | ||
xthmnfdmmu(togpdmcecp) = vlxdljnbzh hpgdnzzfnb (fiuuubpaxk ) View more | |||||||
Phase 4 | 170 | (xjztrjaxhb) = zqliumzpps njxzvgsqlv (tkguzmpint ) View more | Positive | 01 Jun 2019 | |||
Saline | (xjztrjaxhb) = jxeubzctie njxzvgsqlv (tkguzmpint ) View more | ||||||
Not Applicable | - | yispmsgjgn(sdkubswsig) = significantly reduced in nicorandil treatment group fxcegahomv (jxttrukevd ) | - | 23 Oct 2018 | |||
Not Applicable | - | - | (csdpkbwrwc) = wjwoyjmkbk ydhoogpgfw (byrleezols ) | - | 25 Aug 2018 |