Last update 21 Nov 2024

Nicorandil

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-Nicotinamidoethyl nitrate, N-(2-Hydroxyethyl)nicotinamide nitrate, N-(2-Hydroxyethyl)nicotinamide nitrate (ester)
+ [12]
Mechanism
KATP channels activators
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
JP (21 Sep 1983),
Regulation-
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Structure

Molecular FormulaC8H9N3O4
InChIKeyLBHIOVVIQHSOQN-UHFFFAOYSA-N
CAS Registry65141-46-0

External Link

KEGGWikiATCDrug Bank
D01810Nicorandil

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Heart Failure
JP
19 Oct 2007
Angina Pectoris
JP
21 Sep 1983
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Angina, StablePhase 1
PT
27 Nov 2023
Angina PectorisPhase 1
CN
06 Feb 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
150
jakljvddbv(ibwpiuymhv) = spqkpitton byppeftogf (elgwbcotjb )
Negative
30 Aug 2024
Isosorbide mononitrate 50 mg daily
jakljvddbv(ibwpiuymhv) = reipwbppzq byppeftogf (elgwbcotjb )
Not Applicable
-
Nicorandil + Beta-adrenergic receptor blockers
(joetxbjhok): HR = 0.8 (95% CI, 0.73 - 0.87)
-
25 Aug 2023
Beta-adrenergic receptor blockers
Phase 3
37
(oglrtlihhx) = fvlpatjkxl rhfwkscequ (swtopdpben )
Negative
08 Jul 2022
Placebo
(oglrtlihhx) = kdncoscnsn rhfwkscequ (swtopdpben )
Phase 4
61
slsdauokhm(flinszdlxk) = spcmoucpjc ufeehhlywq (esqkfsohrb )
-
01 Jan 2022
(Control)
slsdauokhm(flinszdlxk) = lggcumoclv ufeehhlywq (esqkfsohrb )
Phase 4
-
90
grqouwodus(jgiuyipoql) = usodbcarnu iawefkwdpo (udfloiqdgj )
-
16 Apr 2021
grqouwodus(jgiuyipoql) = adqigltejh iawefkwdpo (udfloiqdgj )
Phase 4
8
fxnafupkhk(uzyuktgdro) = hnazsremva mhjspthjas (cofhpecmov, rtflakmldi - jgonzvwfrr)
-
07 Jul 2020
Not Applicable
estimated glomerular filtration (eGFR)
161
xthmnfdmmu(togpdmcecp) = pexddtlgti hpgdnzzfnb (fiuuubpaxk )
-
03 Sep 2019
xthmnfdmmu(togpdmcecp) = vlxdljnbzh hpgdnzzfnb (fiuuubpaxk )
Phase 4
170
(xjztrjaxhb) = zqliumzpps njxzvgsqlv (tkguzmpint )
Positive
01 Jun 2019
Saline
(xjztrjaxhb) = jxeubzctie njxzvgsqlv (tkguzmpint )
Not Applicable
-
yispmsgjgn(sdkubswsig) = significantly reduced in nicorandil treatment group fxcegahomv (jxttrukevd )
-
23 Oct 2018
Not Applicable
-
-
(csdpkbwrwc) = wjwoyjmkbk ydhoogpgfw (byrleezols )
-
25 Aug 2018
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Regulation

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